Putative calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C2, putative

Species:

Leishmania mexicana

UniProt:

E9AUR1_LEIMU

TriTrypDb:

LmxM.20.1210

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 69
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	3
GO:0005930	axoneme	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005856	cytoskeleton	5	1
GO:0020016	ciliary pocket	2	1
GO:0020038	subpellicular network	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9AUR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUR1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	71
GO:0006807	nitrogen compound metabolic process	2	71
GO:0008152	metabolic process	1	71
GO:0019538	protein metabolic process	3	71
GO:0043170	macromolecule metabolic process	3	71
GO:0044238	primary metabolic process	2	71
GO:0071704	organic substance metabolic process	2	71
GO:1901564	organonitrogen compound metabolic process	3	71

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	71
GO:0004175	endopeptidase activity	4	71
GO:0004197	cysteine-type endopeptidase activity	5	71
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	71
GO:0008233	peptidase activity	3	71
GO:0008234	cysteine-type peptidase activity	4	71
GO:0016787	hydrolase activity	2	71
GO:0140096	catalytic activity, acting on a protein	2	71

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.557
CLV_MEL_PAP_1	341	347	PF00089	0.492
CLV_NRD_NRD_1	297	299	PF00675	0.363
CLV_NRD_NRD_1	67	69	PF00675	0.283
CLV_PCSK_KEX2_1	297	299	PF00082	0.350
CLV_PCSK_KEX2_1	67	69	PF00082	0.271
CLV_PCSK_SKI1_1	102	106	PF00082	0.266
CLV_PCSK_SKI1_1	244	248	PF00082	0.254
CLV_PCSK_SKI1_1	331	335	PF00082	0.469
CLV_PCSK_SKI1_1	535	539	PF00082	0.517
DEG_APCC_DBOX_1	147	155	PF00400	0.366
DEG_SCF_FBW7_1	263	268	PF00400	0.464
DEG_SCF_FBW7_1	424	430	PF00400	0.292
DEG_SPOP_SBC_1	122	126	PF00917	0.372
DOC_CKS1_1	424	429	PF01111	0.239
DOC_CYCLIN_RxL_1	197	208	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	421	427	PF00134	0.225
DOC_MAPK_gen_1	297	304	PF00069	0.280
DOC_MAPK_gen_1	67	77	PF00069	0.468
DOC_MAPK_MEF2A_6	68	77	PF00069	0.482
DOC_PP1_RVXF_1	198	205	PF00149	0.473
DOC_PP2B_LxvP_1	73	76	PF13499	0.490
DOC_PP4_FxxP_1	15	18	PF00568	0.486
DOC_PP4_FxxP_1	320	323	PF00568	0.450
DOC_USP7_MATH_1	165	169	PF00917	0.504
DOC_USP7_MATH_1	173	177	PF00917	0.535
DOC_USP7_MATH_1	265	269	PF00917	0.471
DOC_USP7_UBL2_3	80	84	PF12436	0.481
DOC_WW_Pin1_4	233	238	PF00397	0.494
DOC_WW_Pin1_4	261	266	PF00397	0.660
DOC_WW_Pin1_4	423	428	PF00397	0.331
DOC_WW_Pin1_4	535	540	PF00397	0.433
LIG_14-3-3_CanoR_1	156	162	PF00244	0.592
LIG_14-3-3_CanoR_1	34	38	PF00244	0.478
LIG_14-3-3_CanoR_1	344	348	PF00244	0.400
LIG_14-3-3_CanoR_1	398	404	PF00244	0.444
LIG_14-3-3_CanoR_1	410	414	PF00244	0.529
LIG_14-3-3_CanoR_1	496	502	PF00244	0.442
LIG_APCC_ABBA_1	322	327	PF00400	0.248
LIG_APCC_ABBA_1	468	473	PF00400	0.356
LIG_APCC_ABBAyCdc20_2	321	327	PF00400	0.246
LIG_APCC_ABBAyCdc20_2	525	531	PF00400	0.276
LIG_BIR_II_1	1	5	PF00653	0.183
LIG_BIR_III_4	224	228	PF00653	0.366
LIG_BRCT_BRCA1_1	123	127	PF00533	0.535
LIG_BRCT_BRCA1_1	491	495	PF00533	0.449
LIG_CSL_BTD_1	73	76	PF09270	0.465
LIG_deltaCOP1_diTrp_1	305	313	PF00928	0.417
LIG_deltaCOP1_diTrp_1	478	485	PF00928	0.287
LIG_EH1_1	195	203	PF00400	0.521
LIG_FHA_1	34	40	PF00498	0.499
LIG_FHA_1	6	12	PF00498	0.469
LIG_FHA_2	360	366	PF00498	0.527
LIG_FHA_2	369	375	PF00498	0.590
LIG_FHA_2	400	406	PF00498	0.335
LIG_FHA_2	424	430	PF00498	0.281
LIG_FHA_2	536	542	PF00498	0.567
LIG_LIR_Apic_2	430	436	PF02991	0.332
LIG_LIR_Apic_2	484	489	PF02991	0.416
LIG_LIR_Gen_1	305	313	PF02991	0.402
LIG_LIR_Gen_1	408	419	PF02991	0.473
LIG_LIR_Gen_1	79	89	PF02991	0.489
LIG_LIR_Nem_3	305	309	PF02991	0.377
LIG_LIR_Nem_3	377	382	PF02991	0.498
LIG_LIR_Nem_3	420	425	PF02991	0.387
LIG_LIR_Nem_3	429	435	PF02991	0.335
LIG_LIR_Nem_3	484	488	PF02991	0.400
LIG_LIR_Nem_3	49	54	PF02991	0.521
LIG_LIR_Nem_3	541	546	PF02991	0.570
LIG_LIR_Nem_3	72	77	PF02991	0.475
LIG_LYPXL_S_1	195	199	PF13949	0.179
LIG_LYPXL_yS_3	196	199	PF13949	0.379
LIG_LYPXL_yS_3	379	382	PF13949	0.436
LIG_MYND_3	75	79	PF01753	0.382
LIG_Pex14_1	306	310	PF04695	0.251
LIG_Pex14_1	481	485	PF04695	0.261
LIG_RPA_C_Fungi	383	395	PF08784	0.328
LIG_SH2_CRK	486	490	PF00017	0.265
LIG_SH2_CRK	89	93	PF00017	0.341
LIG_SH2_GRB2like	60	63	PF00017	0.497
LIG_SH2_GRB2like	89	92	PF00017	0.317
LIG_SH2_PTP2	301	304	PF00017	0.232
LIG_SH2_SRC	112	115	PF00017	0.253
LIG_SH2_STAP1	89	93	PF00017	0.325
LIG_SH2_STAT3	137	140	PF00017	0.270
LIG_SH2_STAT5	301	304	PF00017	0.402
LIG_SH2_STAT5	466	469	PF00017	0.368
LIG_SH2_STAT5	51	54	PF00017	0.355
LIG_SH2_STAT5	60	63	PF00017	0.355
LIG_SH3_3	164	170	PF00018	0.170
LIG_SH3_3	215	221	PF00018	0.320
LIG_SH3_3	274	280	PF00018	0.487
LIG_SH3_3	401	407	PF00018	0.491
LIG_SH3_3	421	427	PF00018	0.418
LIG_SH3_3	435	441	PF00018	0.466
LIG_SH3_3	453	459	PF00018	0.637
LIG_SUMO_SIM_anti_2	119	126	PF11976	0.176
LIG_SUMO_SIM_anti_2	212	217	PF11976	0.262
LIG_SUMO_SIM_par_1	380	385	PF11976	0.411
LIG_TRAF2_1	387	390	PF00917	0.534
LIG_TRFH_1	423	427	PF08558	0.421
LIG_TRFH_1	432	436	PF08558	0.381
LIG_TRFH_1	486	490	PF08558	0.265
LIG_WW_3	460	464	PF00397	0.343
MOD_CDK_SPxK_1	261	267	PF00069	0.460
MOD_CK1_1	121	127	PF00069	0.310
MOD_CK1_1	168	174	PF00069	0.386
MOD_CK1_1	287	293	PF00069	0.552
MOD_CK1_1	502	508	PF00069	0.460
MOD_CK1_1	509	515	PF00069	0.444
MOD_CK2_1	160	166	PF00069	0.373
MOD_CK2_1	368	374	PF00069	0.668
MOD_CK2_1	530	536	PF00069	0.458
MOD_CMANNOS	303	306	PF00535	0.377
MOD_GlcNHglycan	170	173	PF01048	0.371
MOD_GlcNHglycan	175	178	PF01048	0.361
MOD_GlcNHglycan	258	262	PF01048	0.686
MOD_GlcNHglycan	272	276	PF01048	0.474
MOD_GlcNHglycan	286	289	PF01048	0.625
MOD_GlcNHglycan	313	316	PF01048	0.404
MOD_GlcNHglycan	491	494	PF01048	0.391
MOD_GSK3_1	118	125	PF00069	0.383
MOD_GSK3_1	257	264	PF00069	0.679
MOD_GSK3_1	284	291	PF00069	0.584
MOD_GSK3_1	333	340	PF00069	0.395
MOD_GSK3_1	355	362	PF00069	0.480
MOD_GSK3_1	364	371	PF00069	0.660
MOD_GSK3_1	405	412	PF00069	0.418
MOD_GSK3_1	423	430	PF00069	0.395
MOD_GSK3_1	502	509	PF00069	0.420
MOD_GSK3_1	52	59	PF00069	0.373
MOD_GSK3_1	523	530	PF00069	0.396
MOD_GSK3_1	87	94	PF00069	0.308
MOD_NEK2_1	334	339	PF00069	0.473
MOD_NEK2_1	359	364	PF00069	0.515
MOD_NEK2_1	417	422	PF00069	0.345
MOD_NEK2_1	499	504	PF00069	0.455
MOD_PIKK_1	17	23	PF00454	0.295
MOD_PIKK_1	397	403	PF00454	0.544
MOD_PKA_2	155	161	PF00069	0.298
MOD_PKA_2	33	39	PF00069	0.310
MOD_PKA_2	343	349	PF00069	0.442
MOD_PKA_2	397	403	PF00069	0.484
MOD_PKA_2	409	415	PF00069	0.446
MOD_PKA_2	497	503	PF00069	0.434
MOD_Plk_1	118	124	PF00069	0.376
MOD_Plk_1	165	171	PF00069	0.391
MOD_Plk_1	211	217	PF00069	0.423
MOD_Plk_1	364	370	PF00069	0.735
MOD_Plk_1	374	380	PF00069	0.382
MOD_Plk_1	417	423	PF00069	0.420
MOD_Plk_4	211	217	PF00069	0.400
MOD_Plk_4	417	423	PF00069	0.464
MOD_Plk_4	509	515	PF00069	0.481
MOD_Plk_4	523	529	PF00069	0.462
MOD_Plk_4	56	62	PF00069	0.376
MOD_ProDKin_1	233	239	PF00069	0.347
MOD_ProDKin_1	261	267	PF00069	0.663
MOD_ProDKin_1	423	429	PF00069	0.331
MOD_ProDKin_1	535	541	PF00069	0.433
TRG_DiLeu_BaEn_4	389	395	PF01217	0.275
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.399
TRG_ENDOCYTIC_2	196	199	PF00928	0.359
TRG_ENDOCYTIC_2	301	304	PF00928	0.232
TRG_ENDOCYTIC_2	310	313	PF00928	0.261
TRG_ENDOCYTIC_2	379	382	PF00928	0.440
TRG_ENDOCYTIC_2	432	435	PF00928	0.343
TRG_ENDOCYTIC_2	51	54	PF00928	0.394
TRG_ENDOCYTIC_2	82	85	PF00928	0.335
TRG_ENDOCYTIC_2	89	92	PF00928	0.344
TRG_ER_diArg_1	495	498	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	437	442	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T6	Leptomonas seymouri	28%	79%
A0A0N1IGQ2	Leptomonas seymouri	27%	78%
A0A0N1ILF1	Leptomonas seymouri	32%	80%
A0A0N1IMH1	Leptomonas seymouri	29%	70%
A0A0N1PCA9	Leptomonas seymouri	29%	74%
A0A0N1PFI4	Leptomonas seymouri	29%	71%
A0A0S4JLK6	Bodo saltans	25%	68%
A0A0S4KGT2	Bodo saltans	31%	73%
A0A0S4KKP7	Bodo saltans	23%	74%
A0A1X0NJK2	Trypanosomatidae	28%	72%
A0A1X0NJX8	Trypanosomatidae	29%	71%
A0A1X0NKX8	Trypanosomatidae	27%	67%
A0A1X0NW84	Trypanosomatidae	32%	79%
A0A1X0NW85	Trypanosomatidae	32%	81%
A0A1X0NWW1	Trypanosomatidae	33%	76%
A0A3Q8IDD4	Leishmania donovani	25%	78%
A0A3S5ISG2	Trypanosoma rangeli	29%	71%
A0A3S7WW18	Leishmania donovani	28%	67%
A0A3S7WW41	Leishmania donovani	29%	74%
A0A3S7WW71	Leishmania donovani	30%	80%
A0A3S7X430	Leishmania donovani	29%	70%
A0A3S7X460	Leishmania donovani	29%	71%
A0A3S7X470	Leishmania donovani	27%	76%
A0A422MYX0	Trypanosoma rangeli	34%	76%
A4HE81	Leishmania braziliensis	26%	100%
A4HJ14	Leishmania braziliensis	30%	70%
A4HJ23	Leishmania braziliensis	29%	95%
A4HJ24	Leishmania braziliensis	29%	100%
A4HYN0	Leishmania infantum	28%	67%
A4HYW2	Leishmania infantum	30%	80%
A4HYW3	Leishmania infantum	29%	74%
A4I1J4	Leishmania infantum	25%	78%
A4I6E4	Leishmania infantum	28%	76%
A4I6E6	Leishmania infantum	29%	71%
A4I6K4	Leishmania infantum	29%	70%
C9ZIE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	80%
C9ZIE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	75%
C9ZN52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	69%
C9ZWY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	68%
E8NHF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	99%
E8NHG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	70%
E8NHM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	82%
E9AIH1	Leishmania braziliensis	28%	67%
E9AIH3	Leishmania braziliensis	30%	100%
E9AIH4	Leishmania braziliensis	29%	100%
E9AIH6	Leishmania braziliensis	76%	99%
E9AK26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	69%
E9AUQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AUQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AUR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AXM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	78%
E9B1J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	70%
E9B1J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	78%
Q4Q6L7	Leishmania major	28%	100%
Q4Q6L9	Leishmania major	27%	100%
Q4Q9U3	Leishmania major	25%	100%
Q4QCS5	Leishmania major	88%	100%
Q4QCS6	Leishmania major	29%	100%
Q4QCS7	Leishmania major	30%	100%
Q4QCS8	Leishmania major	28%	67%
V5AYJ1	Trypanosoma cruzi	26%	77%
V5BA05	Trypanosoma cruzi	34%	83%
V5BEL3	Trypanosoma cruzi	31%	79%
V5BN20	Trypanosoma cruzi	30%	71%
V5DES7	Trypanosoma cruzi	29%	69%