Calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calpain-like cysteine peptidase

Species:

Leishmania mexicana

UniProt:

E9AUQ7_LEIMU

TriTrypDb:

LmxM.20.1180

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 16

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 20

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 98
NetGPI	no	yes: 0, no: 100

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	3
GO:0005930	axoneme	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005856	cytoskeleton	5	1
GO:0020016	ciliary pocket	2	1
GO:0020038	subpellicular network	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9AUQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUQ7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	101
GO:0006807	nitrogen compound metabolic process	2	101
GO:0008152	metabolic process	1	101
GO:0019538	protein metabolic process	3	101
GO:0043170	macromolecule metabolic process	3	101
GO:0044238	primary metabolic process	2	101
GO:0071704	organic substance metabolic process	2	101
GO:1901564	organonitrogen compound metabolic process	3	101

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	101
GO:0004175	endopeptidase activity	4	101
GO:0004197	cysteine-type endopeptidase activity	5	101
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	101
GO:0008233	peptidase activity	3	101
GO:0008234	cysteine-type peptidase activity	4	101
GO:0016787	hydrolase activity	2	101
GO:0140096	catalytic activity, acting on a protein	2	101

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	416	420	PF00656	0.579
CLV_C14_Caspase3-7	491	495	PF00656	0.498
CLV_C14_Caspase3-7	730	734	PF00656	0.598
CLV_NRD_NRD_1	398	400	PF00675	0.519
CLV_NRD_NRD_1	734	736	PF00675	0.441
CLV_PCSK_KEX2_1	397	399	PF00082	0.479
CLV_PCSK_KEX2_1	787	789	PF00082	0.459
CLV_PCSK_KEX2_1	887	889	PF00082	0.542
CLV_PCSK_KEX2_1	917	919	PF00082	0.531
CLV_PCSK_PC1ET2_1	787	789	PF00082	0.468
CLV_PCSK_PC1ET2_1	887	889	PF00082	0.555
CLV_PCSK_PC1ET2_1	917	919	PF00082	0.572
CLV_PCSK_SKI1_1	240	244	PF00082	0.654
CLV_PCSK_SKI1_1	398	402	PF00082	0.604
CLV_PCSK_SKI1_1	453	457	PF00082	0.315
CLV_PCSK_SKI1_1	560	564	PF00082	0.251
CLV_PCSK_SKI1_1	682	686	PF00082	0.320
DEG_SIAH_1	230	238	PF03145	0.450
DOC_MAPK_gen_1	383	391	PF00069	0.355
DOC_MAPK_MEF2A_6	383	391	PF00069	0.468
DOC_PIKK_1	62	70	PF02985	0.553
DOC_PIKK_1	75	83	PF02985	0.544
DOC_PP1_RVXF_1	532	538	PF00149	0.533
DOC_PP4_FxxP_1	302	305	PF00568	0.354
DOC_PP4_FxxP_1	435	438	PF00568	0.576
DOC_PP4_FxxP_1	515	518	PF00568	0.536
DOC_USP7_MATH_1	449	453	PF00917	0.527
DOC_USP7_MATH_1	502	506	PF00917	0.535
DOC_USP7_MATH_2	468	474	PF00917	0.588
DOC_USP7_UBL2_3	578	582	PF12436	0.531
DOC_USP7_UBL2_3	732	736	PF12436	0.551
DOC_WW_Pin1_4	49	54	PF00397	0.715
DOC_WW_Pin1_4	638	643	PF00397	0.537
DOC_WW_Pin1_4	771	776	PF00397	0.452
LIG_14-3-3_CanoR_1	240	246	PF00244	0.681
LIG_14-3-3_CanoR_1	397	405	PF00244	0.584
LIG_14-3-3_CanoR_1	479	483	PF00244	0.514
LIG_14-3-3_CanoR_1	534	538	PF00244	0.513
LIG_14-3-3_CanoR_1	824	833	PF00244	0.578
LIG_Actin_WH2_2	545	562	PF00022	0.615
LIG_BIR_II_1	1	5	PF00653	0.567
LIG_BIR_III_2	708	712	PF00653	0.435
LIG_BRCT_BRCA1_1	451	455	PF00533	0.568
LIG_BRCT_BRCA1_1	882	886	PF00533	0.529
LIG_Clathr_ClatBox_1	906	910	PF01394	0.624
LIG_CtBP_PxDLS_1	468	472	PF00389	0.437
LIG_deltaCOP1_diTrp_1	695	700	PF00928	0.527
LIG_deltaCOP1_diTrp_1	828	832	PF00928	0.492
LIG_eIF4E_1	657	663	PF01652	0.552
LIG_FHA_1	128	134	PF00498	0.702
LIG_FHA_1	237	243	PF00498	0.702
LIG_FHA_1	379	385	PF00498	0.387
LIG_FHA_1	399	405	PF00498	0.542
LIG_FHA_1	407	413	PF00498	0.530
LIG_FHA_1	758	764	PF00498	0.472
LIG_FHA_1	777	783	PF00498	0.500
LIG_FHA_2	11	17	PF00498	0.828
LIG_FHA_2	365	371	PF00498	0.475
LIG_FHA_2	414	420	PF00498	0.571
LIG_FHA_2	667	673	PF00498	0.545
LIG_FHA_2	703	709	PF00498	0.597
LIG_LIR_Apic_2	198	204	PF02991	0.866
LIG_LIR_Apic_2	300	305	PF02991	0.348
LIG_LIR_Gen_1	164	171	PF02991	0.596
LIG_LIR_Gen_1	577	587	PF02991	0.538
LIG_LIR_Gen_1	603	610	PF02991	0.566
LIG_LIR_Gen_1	621	632	PF02991	0.512
LIG_LIR_Gen_1	655	663	PF02991	0.552
LIG_LIR_Gen_1	776	782	PF02991	0.416
LIG_LIR_Gen_1	827	838	PF02991	0.481
LIG_LIR_Gen_1	9	20	PF02991	0.576
LIG_LIR_Nem_3	164	168	PF02991	0.581
LIG_LIR_Nem_3	316	322	PF02991	0.355
LIG_LIR_Nem_3	452	458	PF02991	0.552
LIG_LIR_Nem_3	549	554	PF02991	0.559
LIG_LIR_Nem_3	570	575	PF02991	0.530
LIG_LIR_Nem_3	577	583	PF02991	0.532
LIG_LIR_Nem_3	586	590	PF02991	0.529
LIG_LIR_Nem_3	621	627	PF02991	0.539
LIG_LIR_Nem_3	655	660	PF02991	0.520
LIG_LIR_Nem_3	776	781	PF02991	0.436
LIG_LIR_Nem_3	794	799	PF02991	0.484
LIG_LIR_Nem_3	810	815	PF02991	0.510
LIG_LIR_Nem_3	827	833	PF02991	0.504
LIG_LIR_Nem_3	883	889	PF02991	0.433
LIG_LIR_Nem_3	897	902	PF02991	0.530
LIG_LIR_Nem_3	9	15	PF02991	0.581
LIG_Pex14_2	161	165	PF04695	0.619
LIG_Pex14_2	727	731	PF04695	0.529
LIG_SH2_CRK	201	205	PF00017	0.837
LIG_SH2_CRK	580	584	PF00017	0.532
LIG_SH2_CRK	587	591	PF00017	0.528
LIG_SH2_CRK	635	639	PF00017	0.549
LIG_SH2_CRK	657	661	PF00017	0.532
LIG_SH2_CRK	796	800	PF00017	0.457
LIG_SH2_CRK	812	816	PF00017	0.549
LIG_SH2_GRB2like	393	396	PF00017	0.570
LIG_SH2_GRB2like	737	740	PF00017	0.504
LIG_SH2_NCK_1	201	205	PF00017	0.589
LIG_SH2_NCK_1	657	661	PF00017	0.548
LIG_SH2_PTP2	849	852	PF00017	0.453
LIG_SH2_SRC	551	554	PF00017	0.546
LIG_SH2_SRC	675	678	PF00017	0.566
LIG_SH2_STAP1	328	332	PF00017	0.375
LIG_SH2_STAP1	561	565	PF00017	0.558
LIG_SH2_STAP1	751	755	PF00017	0.396
LIG_SH2_STAT5	358	361	PF00017	0.403
LIG_SH2_STAT5	551	554	PF00017	0.537
LIG_SH2_STAT5	635	638	PF00017	0.559
LIG_SH2_STAT5	668	671	PF00017	0.513
LIG_SH2_STAT5	675	678	PF00017	0.526
LIG_SH2_STAT5	737	740	PF00017	0.527
LIG_SH2_STAT5	849	852	PF00017	0.400
LIG_SH2_STAT5	867	870	PF00017	0.411
LIG_SH3_3	113	119	PF00018	0.556
LIG_SH3_3	207	213	PF00018	0.790
LIG_SH3_3	23	29	PF00018	0.743
LIG_SH3_3	360	366	PF00018	0.375
LIG_SH3_3	435	441	PF00018	0.566
LIG_SH3_3	451	457	PF00018	0.597
LIG_SH3_3	769	775	PF00018	0.436
LIG_SH3_3	858	864	PF00018	0.649
LIG_SH3_3	906	912	PF00018	0.509
LIG_SUMO_SIM_anti_2	837	843	PF11976	0.436
LIG_SUMO_SIM_par_1	130	137	PF11976	0.765
LIG_SUMO_SIM_par_1	387	392	PF11976	0.326
LIG_SUMO_SIM_par_1	765	771	PF11976	0.456
LIG_SUMO_SIM_par_1	797	802	PF11976	0.432
LIG_TRAF2_1	119	122	PF00917	0.830
LIG_TRAF2_1	148	151	PF00917	0.672
LIG_TRAF2_1	184	187	PF00917	0.599
LIG_TRAF2_1	189	192	PF00917	0.898
LIG_TRAF2_1	19	22	PF00917	0.800
LIG_TRAF2_1	40	43	PF00917	0.569
LIG_TRAF2_1	53	56	PF00917	0.813
LIG_TRAF2_1	66	69	PF00917	0.659
LIG_TRAF2_1	79	82	PF00917	0.548
LIG_TRAF2_1	92	95	PF00917	0.551
LIG_TRAF2_2	104	109	PF00917	0.562
LIG_TRAF2_2	29	34	PF00917	0.567
LIG_TYR_ITIM	307	312	PF00017	0.389
LIG_UBA3_1	307	315	PF00899	0.406
LIG_UBA3_1	726	732	PF00899	0.435
LIG_UBA3_1	840	848	PF00899	0.504
LIG_WRPW_2	455	458	PF00400	0.435
MOD_CDK_SPxK_1	638	644	PF00069	0.545
MOD_CK1_1	172	178	PF00069	0.666
MOD_CK1_1	373	379	PF00069	0.331
MOD_CK1_1	500	506	PF00069	0.552
MOD_CK2_1	10	16	PF00069	0.826
MOD_CK2_1	256	262	PF00069	0.538
MOD_CK2_1	364	370	PF00069	0.535
MOD_CK2_1	49	55	PF00069	0.649
MOD_CK2_1	500	506	PF00069	0.521
MOD_CK2_1	666	672	PF00069	0.589
MOD_CK2_1	799	805	PF00069	0.438
MOD_CMANNOS	728	731	PF00535	0.325
MOD_GlcNHglycan	171	174	PF01048	0.647
MOD_GlcNHglycan	214	217	PF01048	0.777
MOD_GlcNHglycan	231	234	PF01048	0.692
MOD_GlcNHglycan	430	433	PF01048	0.566
MOD_GlcNHglycan	554	557	PF01048	0.370
MOD_GlcNHglycan	563	566	PF01048	0.370
MOD_GlcNHglycan	591	594	PF01048	0.328
MOD_GlcNHglycan	695	699	PF01048	0.382
MOD_GlcNHglycan	764	767	PF01048	0.548
MOD_GlcNHglycan	818	821	PF01048	0.485
MOD_GSK3_1	366	373	PF00069	0.330
MOD_GSK3_1	600	607	PF00069	0.528
MOD_GSK3_1	633	640	PF00069	0.537
MOD_GSK3_1	690	697	PF00069	0.527
MOD_GSK3_1	776	783	PF00069	0.484
MOD_GSK3_1	824	831	PF00069	0.465
MOD_N-GLC_1	322	327	PF02516	0.381
MOD_N-GLC_1	346	351	PF02516	0.399
MOD_N-GLC_1	406	411	PF02516	0.600
MOD_N-GLC_1	791	796	PF02516	0.619
MOD_N-GLC_1	816	821	PF02516	0.463
MOD_NEK2_1	263	268	PF00069	0.569
MOD_NEK2_1	345	350	PF00069	0.333
MOD_NEK2_1	478	483	PF00069	0.503
MOD_NEK2_1	492	497	PF00069	0.552
MOD_NEK2_1	583	588	PF00069	0.537
MOD_NEK2_1	610	615	PF00069	0.586
MOD_NEK2_1	727	732	PF00069	0.541
MOD_NEK2_1	816	821	PF00069	0.513
MOD_NEK2_2	604	609	PF00069	0.617
MOD_NEK2_2	880	885	PF00069	0.614
MOD_PIKK_1	120	126	PF00454	0.819
MOD_PIKK_1	138	144	PF00454	0.823
MOD_PIKK_1	370	376	PF00454	0.503
MOD_PIKK_1	470	476	PF00454	0.595
MOD_PIKK_1	780	786	PF00454	0.415
MOD_PIKK_1	924	930	PF00454	0.603
MOD_PKA_1	398	404	PF00069	0.415
MOD_PKA_2	398	404	PF00069	0.488
MOD_PKA_2	478	484	PF00069	0.431
MOD_PKA_2	533	539	PF00069	0.512
MOD_PKA_2	823	829	PF00069	0.586
MOD_Plk_1	282	288	PF00069	0.647
MOD_Plk_1	322	328	PF00069	0.384
MOD_Plk_1	345	351	PF00069	0.349
MOD_Plk_1	610	616	PF00069	0.568
MOD_Plk_1	836	842	PF00069	0.427
MOD_Plk_1	880	886	PF00069	0.500
MOD_Plk_2-3	127	133	PF00069	0.547
MOD_Plk_2-3	612	618	PF00069	0.579
MOD_Plk_4	282	288	PF00069	0.649
MOD_Plk_4	492	498	PF00069	0.536
MOD_Plk_4	547	553	PF00069	0.562
MOD_Plk_4	633	639	PF00069	0.569
MOD_Plk_4	666	672	PF00069	0.547
MOD_Plk_4	836	842	PF00069	0.481
MOD_ProDKin_1	49	55	PF00069	0.716
MOD_ProDKin_1	638	644	PF00069	0.537
MOD_ProDKin_1	771	777	PF00069	0.448
MOD_SUMO_for_1	294	297	PF00179	0.354
MOD_SUMO_for_1	900	903	PF00179	0.493
MOD_SUMO_rev_2	109	116	PF00179	0.763
MOD_SUMO_rev_2	611	620	PF00179	0.536
MOD_SUMO_rev_2	672	681	PF00179	0.579
MOD_SUMO_rev_2	794	799	PF00179	0.528
TRG_DiLeu_BaEn_4	113	119	PF01217	0.557
TRG_ENDOCYTIC_2	309	312	PF00928	0.375
TRG_ENDOCYTIC_2	551	554	PF00928	0.555
TRG_ENDOCYTIC_2	580	583	PF00928	0.530
TRG_ENDOCYTIC_2	587	590	PF00928	0.532
TRG_ENDOCYTIC_2	635	638	PF00928	0.533
TRG_ENDOCYTIC_2	657	660	PF00928	0.539
TRG_ENDOCYTIC_2	668	671	PF00928	0.553
TRG_ENDOCYTIC_2	796	799	PF00928	0.430
TRG_ENDOCYTIC_2	812	815	PF00928	0.277
TRG_ENDOCYTIC_2	849	852	PF00928	0.387
TRG_ER_diArg_1	237	240	PF00400	0.675
TRG_ER_diArg_1	397	399	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	398	402	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T6	Leptomonas seymouri	33%	100%
A0A0N1I8N2	Leptomonas seymouri	29%	95%
A0A0N1IGQ2	Leptomonas seymouri	32%	100%
A0A0N1ILF1	Leptomonas seymouri	42%	100%
A0A0N1IMH1	Leptomonas seymouri	34%	100%
A0A0N1P9P1	Leptomonas seymouri	40%	100%
A0A0N1PCA9	Leptomonas seymouri	35%	100%
A0A0N1PE91	Leptomonas seymouri	27%	100%
A0A0N1PFI4	Leptomonas seymouri	36%	100%
A0A0S4JLK6	Bodo saltans	28%	100%
A0A0S4KGT2	Bodo saltans	40%	100%
A0A1X0NJ19	Trypanosomatidae	28%	76%
A0A1X0NJK2	Trypanosomatidae	31%	100%
A0A1X0NJX8	Trypanosomatidae	34%	100%
A0A1X0NKT7	Trypanosomatidae	32%	100%
A0A1X0NKX8	Trypanosomatidae	31%	100%
A0A1X0NMT3	Trypanosomatidae	40%	100%
A0A1X0NW84	Trypanosomatidae	40%	100%
A0A1X0NW85	Trypanosomatidae	39%	100%
A0A1X0NW89	Trypanosomatidae	54%	100%
A0A1X0NWA6	Trypanosomatidae	31%	100%
A0A1X0NWW1	Trypanosomatidae	40%	100%
A0A3Q8IBS3	Leishmania donovani	88%	100%
A0A3Q8IDD4	Leishmania donovani	34%	100%
A0A3Q8IJT4	Leishmania donovani	25%	100%
A0A3S5H5A5	Leishmania donovani	41%	100%
A0A3S5ISG2	Trypanosoma rangeli	31%	100%
A0A3S7WW13	Leishmania donovani	27%	85%
A0A3S7WW18	Leishmania donovani	92%	100%
A0A3S7WW41	Leishmania donovani	35%	100%
A0A3S7WW71	Leishmania donovani	40%	100%
A0A3S7X430	Leishmania donovani	34%	100%
A0A3S7X438	Leishmania donovani	30%	99%
A0A3S7X460	Leishmania donovani	35%	100%
A0A3S7X463	Leishmania donovani	27%	100%
A0A3S7X470	Leishmania donovani	35%	100%
A0A422MYU1	Trypanosoma rangeli	52%	100%
A0A422MYX0	Trypanosoma rangeli	38%	100%
A4H3W4	Leishmania braziliensis	40%	100%
A4HE81	Leishmania braziliensis	34%	100%
A4HJ14	Leishmania braziliensis	35%	100%
A4HJ22	Leishmania braziliensis	31%	100%
A4HJ24	Leishmania braziliensis	34%	100%
A4HS39	Leishmania infantum	41%	100%
A4HYN0	Leishmania infantum	93%	100%
A4HYW1	Leishmania infantum	90%	92%
A4HYW2	Leishmania infantum	40%	100%
A4HYW3	Leishmania infantum	36%	100%
A4HYW4	Leishmania infantum	28%	93%
A4I1J4	Leishmania infantum	34%	100%
A4I6E4	Leishmania infantum	35%	100%
A4I6E6	Leishmania infantum	35%	100%
A4I6F0	Leishmania infantum	30%	99%
A4I6K4	Leishmania infantum	34%	100%
A4I6K5	Leishmania infantum	27%	100%
A4I6K6	Leishmania infantum	25%	100%
C9ZIE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	87%
C9ZIE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZIE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZN52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZN53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZWY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZY36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E8NHG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AIH1	Leishmania braziliensis	84%	100%
E9AIH3	Leishmania braziliensis	40%	100%
E9AIH4	Leishmania braziliensis	36%	100%
E9AK26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AUQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AUR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AXM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B1J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B1J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B1J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B1J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4Q6L7	Leishmania major	35%	100%
Q4Q6L9	Leishmania major	35%	100%
Q4Q6M0	Leishmania major	31%	100%
Q4Q6M2	Leishmania major	25%	100%
Q4Q6M3	Leishmania major	26%	100%
Q4Q6M4	Leishmania major	34%	100%
Q4Q9U3	Leishmania major	34%	100%
Q4QCS6	Leishmania major	36%	100%
Q4QCS7	Leishmania major	40%	100%
Q4QCS8	Leishmania major	91%	100%
Q4QCS9	Leishmania major	85%	100%
Q9U0T9	Leishmania major	41%	100%
V5AYJ1	Trypanosoma cruzi	30%	100%
V5B5I4	Trypanosoma cruzi	53%	100%
V5BA05	Trypanosoma cruzi	42%	100%
V5BEL3	Trypanosoma cruzi	36%	100%
V5BII7	Trypanosoma cruzi	29%	76%
V5BN20	Trypanosoma cruzi	35%	100%
V5D9Y2	Trypanosoma cruzi	41%	100%
V5DES7	Trypanosoma cruzi	32%	100%