Endo-1,4-beta-xylanase z-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endo-1,4-beta-xylanase z precursor-like protein

Species:

Leishmania mexicana

UniProt:

E9AUQ6_LEIMU

TriTrypDb:

LmxM.20.1170

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUQ6

Function

Biological processes
Term	Name	Level	Count
GO:0000272	polysaccharide catabolic process	5	4
GO:0005975	carbohydrate metabolic process	3	4
GO:0005976	polysaccharide metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0009056	catabolic process	2	4
GO:0009057	macromolecule catabolic process	4	4
GO:0009987	cellular process	1	4
GO:0010383	cell wall polysaccharide metabolic process	5	4
GO:0010410	hemicellulose metabolic process	6	4
GO:0016052	carbohydrate catabolic process	4	4
GO:0016998	cell wall macromolecule catabolic process	5	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044036	cell wall macromolecule metabolic process	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044248	cellular catabolic process	3	4
GO:0044260	obsolete cellular macromolecule metabolic process	3	4
GO:0044262	obsolete cellular carbohydrate metabolic process	3	4
GO:0044264	obsolete cellular polysaccharide metabolic process	4	4
GO:0044265	obsolete cellular macromolecule catabolic process	4	4
GO:0044347	cell wall polysaccharide catabolic process	6	4
GO:0045491	xylan metabolic process	7	4
GO:0045493	xylan catabolic process	8	4
GO:0071704	organic substance metabolic process	2	4
GO:1901575	organic substance catabolic process	3	4
GO:2000895	hemicellulose catabolic process	7	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016787	hydrolase activity	2	4
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	4
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	1
GO:0031176	endo-1,4-beta-xylanase activity	6	1
GO:0097599	xylanase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	384	386	PF00675	0.455
CLV_PCSK_KEX2_1	384	386	PF00082	0.455
CLV_PCSK_SKI1_1	352	356	PF00082	0.333
CLV_PCSK_SKI1_1	365	369	PF00082	0.333
DEG_SCF_FBW7_1	126	133	PF00400	0.519
DOC_CKS1_1	127	132	PF01111	0.459
DOC_MAPK_FxFP_2	61	64	PF00069	0.340
DOC_MAPK_MEF2A_6	201	208	PF00069	0.388
DOC_MAPK_MEF2A_6	237	245	PF00069	0.333
DOC_PP1_RVXF_1	350	356	PF00149	0.333
DOC_PP4_FxxP_1	408	411	PF00568	0.451
DOC_PP4_FxxP_1	61	64	PF00568	0.444
DOC_USP7_MATH_1	64	68	PF00917	0.509
DOC_USP7_MATH_1	87	91	PF00917	0.572
DOC_WW_Pin1_4	126	131	PF00397	0.414
DOC_WW_Pin1_4	16	21	PF00397	0.655
DOC_WW_Pin1_4	247	252	PF00397	0.373
LIG_14-3-3_CanoR_1	18	27	PF00244	0.532
LIG_14-3-3_CanoR_1	304	313	PF00244	0.222
LIG_APCC_ABBA_1	273	278	PF00400	0.333
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_deltaCOP1_diTrp_1	394	403	PF00928	0.329
LIG_eIF4E_1	203	209	PF01652	0.388
LIG_FHA_1	127	133	PF00498	0.463
LIG_FHA_1	237	243	PF00498	0.335
LIG_FHA_1	268	274	PF00498	0.478
LIG_FHA_1	83	89	PF00498	0.514
LIG_FHA_2	179	185	PF00498	0.388
LIG_FHA_2	281	287	PF00498	0.388
LIG_FHA_2	306	312	PF00498	0.388
LIG_FHA_2	330	336	PF00498	0.441
LIG_LIR_Gen_1	129	137	PF02991	0.293
LIG_LIR_Nem_3	129	134	PF02991	0.361
LIG_LIR_Nem_3	200	206	PF02991	0.306
LIG_LIR_Nem_3	324	330	PF02991	0.366
LIG_LIR_Nem_3	56	62	PF02991	0.503
LIG_LYPXL_yS_3	203	206	PF13949	0.333
LIG_MYND_1	126	130	PF01753	0.522
LIG_PCNA_yPIPBox_3	282	296	PF02747	0.441
LIG_SH2_PTP2	145	148	PF00017	0.395
LIG_SH2_SRC	145	148	PF00017	0.395
LIG_SH2_SRC	188	191	PF00017	0.333
LIG_SH2_STAT5	131	134	PF00017	0.450
LIG_SH2_STAT5	145	148	PF00017	0.376
LIG_SH2_STAT5	173	176	PF00017	0.432
LIG_SH2_STAT5	177	180	PF00017	0.431
LIG_SH2_STAT5	188	191	PF00017	0.214
LIG_SH2_STAT5	207	210	PF00017	0.333
LIG_SH2_STAT5	276	279	PF00017	0.360
LIG_SH2_STAT5	387	390	PF00017	0.290
LIG_SH2_STAT5	62	65	PF00017	0.518
LIG_SH3_3	124	130	PF00018	0.332
LIG_SH3_3	145	151	PF00018	0.412
LIG_SH3_3	256	262	PF00018	0.222
LIG_SH3_3	90	96	PF00018	0.463
LIG_SUMO_SIM_anti_2	239	248	PF11976	0.388
LIG_SUMO_SIM_par_1	118	123	PF11976	0.490
LIG_TRAF2_1	181	184	PF00917	0.388
LIG_TRAF2_1	42	45	PF00917	0.423
LIG_TYR_ITSM	127	134	PF00017	0.298
LIG_UBA3_1	241	246	PF00899	0.441
LIG_WW_1	190	193	PF00397	0.333
MOD_CK1_1	197	203	PF00069	0.441
MOD_CK1_1	247	253	PF00069	0.441
MOD_CK1_1	28	34	PF00069	0.719
MOD_CK2_1	178	184	PF00069	0.388
MOD_CMANNOS	393	396	PF00535	0.332
MOD_GlcNHglycan	1	4	PF01048	0.687
MOD_GlcNHglycan	109	112	PF01048	0.513
MOD_GlcNHglycan	197	200	PF01048	0.441
MOD_GlcNHglycan	247	250	PF01048	0.419
MOD_GlcNHglycan	319	322	PF01048	0.333
MOD_GSK3_1	10	17	PF00069	0.661
MOD_GSK3_1	126	133	PF00069	0.519
MOD_GSK3_1	19	26	PF00069	0.692
MOD_GSK3_1	296	303	PF00069	0.302
MOD_GSK3_1	317	324	PF00069	0.222
MOD_N-GLC_1	53	58	PF02516	0.520
MOD_N-GLC_2	154	156	PF02516	0.576
MOD_NEK2_1	245	250	PF00069	0.441
MOD_NEK2_1	305	310	PF00069	0.331
MOD_NEK2_1	322	327	PF00069	0.381
MOD_PIKK_1	25	31	PF00454	0.740
MOD_PKA_2	160	166	PF00069	0.537
MOD_Plk_2-3	267	273	PF00069	0.388
MOD_Plk_4	342	348	PF00069	0.222
MOD_Plk_4	65	71	PF00069	0.438
MOD_ProDKin_1	126	132	PF00069	0.408
MOD_ProDKin_1	16	22	PF00069	0.659
MOD_ProDKin_1	247	253	PF00069	0.373
MOD_SUMO_rev_2	230	239	PF00179	0.388
TRG_ENDOCYTIC_2	131	134	PF00928	0.450
TRG_ENDOCYTIC_2	145	148	PF00928	0.376
TRG_ENDOCYTIC_2	203	206	PF00928	0.333
TRG_ENDOCYTIC_2	315	318	PF00928	0.357
TRG_ER_diArg_1	384	386	PF00400	0.455
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM32	Leptomonas seymouri	55%	100%
A0A1X0NWX5	Trypanosomatidae	41%	100%
A0A3Q8IKN0	Leishmania donovani	87%	100%
A4HYV9	Leishmania infantum	87%	99%
P31471	Escherichia coli (strain K12)	25%	100%