DNAj-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNAj-like protein

Gene product:

DNAj-like protein

Species:

Leishmania mexicana

UniProt:

E9AUQ2_LEIMU

TriTrypDb:

LmxM.20.1130

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUQ2

Function

Biological processes
Term	Name	Level	Count
GO:0006450	regulation of translational fidelity	3	11
GO:0006457	protein folding	2	11
GO:0006458	'de novo' protein folding	3	11
GO:0009987	cellular process	1	11
GO:0051083	'de novo' cotranslational protein folding	4	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0030544	Hsp70 protein binding	4	11
GO:0031072	heat shock protein binding	3	11
GO:0043021	ribonucleoprotein complex binding	3	11
GO:0043022	ribosome binding	4	11
GO:0044877	protein-containing complex binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.475
CLV_C14_Caspase3-7	89	93	PF00656	0.572
CLV_NRD_NRD_1	121	123	PF00675	0.516
CLV_NRD_NRD_1	160	162	PF00675	0.257
CLV_NRD_NRD_1	314	316	PF00675	0.365
CLV_NRD_NRD_1	324	326	PF00675	0.396
CLV_NRD_NRD_1	353	355	PF00675	0.450
CLV_NRD_NRD_1	358	360	PF00675	0.465
CLV_NRD_NRD_1	410	412	PF00675	0.374
CLV_PCSK_FUR_1	320	324	PF00082	0.396
CLV_PCSK_FUR_1	408	412	PF00082	0.473
CLV_PCSK_KEX2_1	160	162	PF00082	0.257
CLV_PCSK_KEX2_1	285	287	PF00082	0.387
CLV_PCSK_KEX2_1	305	307	PF00082	0.268
CLV_PCSK_KEX2_1	322	324	PF00082	0.450
CLV_PCSK_KEX2_1	331	333	PF00082	0.451
CLV_PCSK_KEX2_1	352	354	PF00082	0.484
CLV_PCSK_KEX2_1	410	412	PF00082	0.398
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.387
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.221
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.461
CLV_PCSK_PC7_1	156	162	PF00082	0.151
CLV_PCSK_PC7_1	320	326	PF00082	0.409
CLV_PCSK_SKI1_1	125	129	PF00082	0.390
CLV_PCSK_SKI1_1	331	335	PF00082	0.502
CLV_PCSK_SKI1_1	339	343	PF00082	0.459
CLV_PCSK_SKI1_1	431	435	PF00082	0.450
CLV_PCSK_SKI1_1	539	543	PF00082	0.501
CLV_PCSK_SKI1_1	612	616	PF00082	0.418
CLV_PCSK_SKI1_1	625	629	PF00082	0.389
CLV_PCSK_SKI1_1	633	637	PF00082	0.369
CLV_Separin_Metazoa	250	254	PF03568	0.463
DEG_Nend_UBRbox_3	1	3	PF02207	0.580
DOC_MAPK_gen_1	122	129	PF00069	0.421
DOC_MAPK_gen_1	305	311	PF00069	0.438
DOC_MAPK_gen_1	337	346	PF00069	0.518
DOC_PP1_RVXF_1	14	21	PF00149	0.652
DOC_USP7_MATH_1	197	201	PF00917	0.233
DOC_USP7_MATH_1	558	562	PF00917	0.541
DOC_USP7_MATH_1	581	585	PF00917	0.687
DOC_USP7_MATH_1	591	595	PF00917	0.615
DOC_USP7_UBL2_3	12	16	PF12436	0.584
DOC_USP7_UBL2_3	124	128	PF12436	0.411
DOC_USP7_UBL2_3	301	305	PF12436	0.460
DOC_USP7_UBL2_3	527	531	PF12436	0.415
DOC_USP7_UBL2_3	605	609	PF12436	0.529
DOC_USP7_UBL2_3	618	622	PF12436	0.407
DOC_WW_Pin1_4	243	248	PF00397	0.491
DOC_WW_Pin1_4	396	401	PF00397	0.524
DOC_WW_Pin1_4	506	511	PF00397	0.443
DOC_WW_Pin1_4	579	584	PF00397	0.679
DOC_WW_Pin1_4	587	592	PF00397	0.596
LIG_14-3-3_CanoR_1	116	121	PF00244	0.604
LIG_14-3-3_CanoR_1	548	557	PF00244	0.426
LIG_BIR_III_2	206	210	PF00653	0.505
LIG_BIR_III_2	35	39	PF00653	0.529
LIG_BRCT_BRCA1_1	200	204	PF00533	0.382
LIG_Clathr_ClatBox_1	273	277	PF01394	0.470
LIG_deltaCOP1_diTrp_1	256	264	PF00928	0.330
LIG_FHA_1	399	405	PF00498	0.426
LIG_FHA_1	562	568	PF00498	0.470
LIG_FHA_1	57	63	PF00498	0.473
LIG_FHA_2	128	134	PF00498	0.295
LIG_FHA_2	164	170	PF00498	0.281
LIG_FHA_2	507	513	PF00498	0.607
LIG_FHA_2	516	522	PF00498	0.523
LIG_FHA_2	632	638	PF00498	0.482
LIG_FHA_2	96	102	PF00498	0.455
LIG_LIR_Gen_1	137	144	PF02991	0.292
LIG_LIR_Gen_1	246	255	PF02991	0.470
LIG_LIR_Gen_1	266	274	PF02991	0.359
LIG_LIR_Gen_1	538	547	PF02991	0.394
LIG_LIR_Gen_1	621	630	PF02991	0.362
LIG_LIR_Gen_1	637	645	PF02991	0.341
LIG_LIR_Nem_3	137	142	PF02991	0.287
LIG_LIR_Nem_3	176	182	PF02991	0.267
LIG_LIR_Nem_3	220	225	PF02991	0.340
LIG_LIR_Nem_3	246	251	PF02991	0.483
LIG_LIR_Nem_3	256	261	PF02991	0.327
LIG_LIR_Nem_3	263	267	PF02991	0.309
LIG_LIR_Nem_3	45	50	PF02991	0.581
LIG_LIR_Nem_3	538	543	PF02991	0.354
LIG_LIR_Nem_3	621	626	PF02991	0.361
LIG_LIR_Nem_3	637	642	PF02991	0.332
LIG_PCNA_PIPBox_1	383	392	PF02747	0.410
LIG_PCNA_yPIPBox_3	376	390	PF02747	0.417
LIG_Pex14_1	43	47	PF04695	0.603
LIG_Pex14_2	218	222	PF04695	0.335
LIG_Pex14_2	254	258	PF04695	0.308
LIG_SH2_CRK	47	51	PF00017	0.584
LIG_SH2_SRC	248	251	PF00017	0.500
LIG_SH2_STAP1	248	252	PF00017	0.477
LIG_SH3_3	233	239	PF00018	0.465
LIG_SH3_3	406	412	PF00018	0.370
LIG_SH3_3	435	441	PF00018	0.323
LIG_SH3_3	577	583	PF00018	0.708
LIG_Sin3_3	465	472	PF02671	0.489
LIG_SUMO_SIM_par_1	2	7	PF11976	0.628
LIG_SUMO_SIM_par_1	272	279	PF11976	0.459
LIG_SUMO_SIM_par_1	58	64	PF11976	0.499
LIG_TRAF2_1	347	350	PF00917	0.459
LIG_TRAF2_1	513	516	PF00917	0.614
LIG_TRAF2_1	87	90	PF00917	0.545
LIG_TYR_ITSM	244	251	PF00017	0.495
LIG_WRC_WIRS_1	117	122	PF05994	0.405
LIG_WRC_WIRS_1	219	224	PF05994	0.420
MOD_CDK_SPxxK_3	396	403	PF00069	0.530
MOD_CK1_1	240	246	PF00069	0.454
MOD_CK1_1	419	425	PF00069	0.445
MOD_CK1_1	561	567	PF00069	0.575
MOD_CK1_1	584	590	PF00069	0.718
MOD_CK2_1	591	597	PF00069	0.605
MOD_CK2_1	631	637	PF00069	0.495
MOD_CK2_1	95	101	PF00069	0.723
MOD_GlcNHglycan	571	574	PF01048	0.594
MOD_GlcNHglycan	576	579	PF01048	0.615
MOD_GlcNHglycan	586	589	PF01048	0.658
MOD_GSK3_1	256	263	PF00069	0.452
MOD_GSK3_1	418	425	PF00069	0.425
MOD_GSK3_1	56	63	PF00069	0.537
MOD_GSK3_1	569	576	PF00069	0.567
MOD_GSK3_1	587	594	PF00069	0.653
MOD_N-GLC_1	172	177	PF02516	0.363
MOD_N-GLC_1	422	427	PF02516	0.547
MOD_N-GLC_1	597	602	PF02516	0.511
MOD_NEK2_1	18	23	PF00069	0.433
MOD_NEK2_1	218	223	PF00069	0.442
MOD_NEK2_1	418	423	PF00069	0.422
MOD_NEK2_1	56	61	PF00069	0.528
MOD_NEK2_1	644	649	PF00069	0.436
MOD_PIKK_1	18	24	PF00454	0.655
MOD_PIKK_1	599	605	PF00454	0.347
MOD_PIKK_1	61	67	PF00454	0.540
MOD_PK_1	231	237	PF00069	0.462
MOD_PKA_1	230	236	PF00069	0.366
MOD_PKA_2	256	262	PF00069	0.445
MOD_PKA_2	549	555	PF00069	0.554
MOD_Plk_1	265	271	PF00069	0.342
MOD_Plk_1	276	282	PF00069	0.403
MOD_Plk_1	520	526	PF00069	0.435
MOD_Plk_1	597	603	PF00069	0.456
MOD_Plk_2-3	148	154	PF00069	0.276
MOD_ProDKin_1	243	249	PF00069	0.491
MOD_ProDKin_1	396	402	PF00069	0.525
MOD_ProDKin_1	506	512	PF00069	0.439
MOD_ProDKin_1	579	585	PF00069	0.679
MOD_ProDKin_1	587	593	PF00069	0.591
MOD_SUMO_for_1	142	145	PF00179	0.388
MOD_SUMO_for_1	498	501	PF00179	0.504
MOD_SUMO_rev_2	297	307	PF00179	0.520
MOD_SUMO_rev_2	326	333	PF00179	0.482
MOD_SUMO_rev_2	363	369	PF00179	0.475
TRG_DiLeu_BaEn_1	391	396	PF01217	0.503
TRG_DiLeu_BaEn_2	639	645	PF01217	0.432
TRG_DiLeu_BaEn_4	328	334	PF01217	0.403
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.442
TRG_ENDOCYTIC_2	117	120	PF00928	0.413
TRG_ENDOCYTIC_2	139	142	PF00928	0.292
TRG_ENDOCYTIC_2	248	251	PF00928	0.481
TRG_ENDOCYTIC_2	47	50	PF00928	0.571
TRG_ER_diArg_1	159	161	PF00400	0.257
TRG_ER_diArg_1	306	309	PF00400	0.555
TRG_ER_diArg_1	319	322	PF00400	0.368
TRG_ER_diArg_1	323	325	PF00400	0.426
TRG_ER_diArg_1	352	354	PF00400	0.423
TRG_ER_diArg_1	408	411	PF00400	0.464
TRG_ER_diArg_1	441	444	PF00400	0.632
TRG_ER_diArg_1	547	550	PF00400	0.531
TRG_NES_CRM1_1	176	191	PF08389	0.336
TRG_NLS_MonoCore_2	121	126	PF00514	0.588
TRG_NLS_MonoExtN_4	122	127	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT7	Leptomonas seymouri	74%	100%
A0A0S4KI36	Bodo saltans	48%	100%
A0A1X0NWB2	Trypanosomatidae	50%	97%
A0A3Q8IAL4	Leishmania donovani	94%	100%
A0A422NLR6	Trypanosoma rangeli	58%	100%
A4HYV5	Leishmania infantum	94%	100%
C9ZID5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AIG2	Leishmania braziliensis	86%	100%
P54103	Mus musculus	28%	100%
Q1RMH9	Bos taurus	27%	100%
Q4QCT3	Leishmania major	92%	100%
Q4R8H2	Macaca fascicularis	26%	100%
Q7TQ20	Rattus norvegicus	29%	100%
Q99543	Homo sapiens	27%	100%