Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AUP3_LEIMU

TriTrypDb:

LmxM.20.1050

Length:

951

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUP3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.670
CLV_C14_Caspase3-7	491	495	PF00656	0.731
CLV_C14_Caspase3-7	516	520	PF00656	0.756
CLV_C14_Caspase3-7	522	526	PF00656	0.832
CLV_C14_Caspase3-7	527	531	PF00656	0.706
CLV_C14_Caspase3-7	535	539	PF00656	0.594
CLV_NRD_NRD_1	291	293	PF00675	0.658
CLV_NRD_NRD_1	294	296	PF00675	0.630
CLV_NRD_NRD_1	317	319	PF00675	0.828
CLV_NRD_NRD_1	381	383	PF00675	0.807
CLV_NRD_NRD_1	388	390	PF00675	0.742
CLV_NRD_NRD_1	547	549	PF00675	0.777
CLV_NRD_NRD_1	685	687	PF00675	0.837
CLV_NRD_NRD_1	743	745	PF00675	0.649
CLV_PCSK_FUR_1	292	296	PF00082	0.705
CLV_PCSK_KEX2_1	16	18	PF00082	0.578
CLV_PCSK_KEX2_1	293	295	PF00082	0.649
CLV_PCSK_KEX2_1	317	319	PF00082	0.828
CLV_PCSK_KEX2_1	388	390	PF00082	0.714
CLV_PCSK_KEX2_1	547	549	PF00082	0.840
CLV_PCSK_KEX2_1	685	687	PF00082	0.822
CLV_PCSK_KEX2_1	743	745	PF00082	0.649
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.578
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.784
CLV_PCSK_SKI1_1	431	435	PF00082	0.678
CLV_PCSK_SKI1_1	563	567	PF00082	0.842
CLV_PCSK_SKI1_1	939	943	PF00082	0.641
DEG_Nend_UBRbox_3	1	3	PF02207	0.719
DEG_SCF_FBW7_1	890	896	PF00400	0.825
DEG_SCF_FBW7_2	72	77	PF00400	0.794
DEG_SPOP_SBC_1	362	366	PF00917	0.744
DEG_SPOP_SBC_1	448	452	PF00917	0.585
DEG_SPOP_SBC_1	479	483	PF00917	0.746
DEG_SPOP_SBC_1	66	70	PF00917	0.664
DEG_SPOP_SBC_1	868	872	PF00917	0.530
DOC_ANK_TNKS_1	316	323	PF00023	0.743
DOC_CKS1_1	217	222	PF01111	0.551
DOC_CKS1_1	263	268	PF01111	0.622
DOC_CKS1_1	890	895	PF01111	0.743
DOC_MAPK_gen_1	269	279	PF00069	0.659
DOC_MAPK_MEF2A_6	800	808	PF00069	0.533
DOC_PP4_FxxP_1	279	282	PF00568	0.806
DOC_USP7_MATH_1	261	265	PF00917	0.779
DOC_USP7_MATH_1	282	286	PF00917	0.787
DOC_USP7_MATH_1	33	37	PF00917	0.831
DOC_USP7_MATH_1	362	366	PF00917	0.790
DOC_USP7_MATH_1	480	484	PF00917	0.784
DOC_USP7_MATH_1	540	544	PF00917	0.608
DOC_USP7_MATH_1	555	559	PF00917	0.550
DOC_USP7_MATH_1	592	596	PF00917	0.749
DOC_USP7_MATH_1	64	68	PF00917	0.775
DOC_USP7_MATH_1	663	667	PF00917	0.603
DOC_USP7_MATH_1	670	674	PF00917	0.741
DOC_USP7_MATH_1	759	763	PF00917	0.645
DOC_USP7_MATH_1	778	782	PF00917	0.635
DOC_USP7_MATH_1	830	834	PF00917	0.648
DOC_USP7_MATH_1	851	855	PF00917	0.702
DOC_USP7_MATH_1	869	873	PF00917	0.610
DOC_USP7_MATH_1	924	928	PF00917	0.750
DOC_USP7_UBL2_3	101	105	PF12436	0.544
DOC_WW_Pin1_4	193	198	PF00397	0.630
DOC_WW_Pin1_4	216	221	PF00397	0.710
DOC_WW_Pin1_4	225	230	PF00397	0.758
DOC_WW_Pin1_4	239	244	PF00397	0.608
DOC_WW_Pin1_4	253	258	PF00397	0.582
DOC_WW_Pin1_4	262	267	PF00397	0.600
DOC_WW_Pin1_4	345	350	PF00397	0.693
DOC_WW_Pin1_4	363	368	PF00397	0.615
DOC_WW_Pin1_4	393	398	PF00397	0.820
DOC_WW_Pin1_4	415	420	PF00397	0.751
DOC_WW_Pin1_4	449	454	PF00397	0.708
DOC_WW_Pin1_4	638	643	PF00397	0.699
DOC_WW_Pin1_4	692	697	PF00397	0.635
DOC_WW_Pin1_4	70	75	PF00397	0.836
DOC_WW_Pin1_4	701	706	PF00397	0.768
DOC_WW_Pin1_4	774	779	PF00397	0.764
DOC_WW_Pin1_4	889	894	PF00397	0.737
DOC_WW_Pin1_4	926	931	PF00397	0.715
LIG_14-3-3_CanoR_1	389	399	PF00244	0.821
LIG_14-3-3_CanoR_1	655	662	PF00244	0.786
LIG_14-3-3_CanoR_1	743	748	PF00244	0.833
LIG_14-3-3_CanoR_1	855	863	PF00244	0.671
LIG_APCC_ABBA_1	72	77	PF00400	0.580
LIG_APCC_ABBA_1	793	798	PF00400	0.766
LIG_BIR_III_4	710	714	PF00653	0.577
LIG_BRCT_BRCA1_1	395	399	PF00533	0.819
LIG_BRCT_BRCA1_1	482	486	PF00533	0.548
LIG_BRCT_BRCA1_1	510	514	PF00533	0.853
LIG_EH_1	178	182	PF12763	0.822
LIG_FHA_1	139	145	PF00498	0.846
LIG_FHA_1	217	223	PF00498	0.840
LIG_FHA_1	272	278	PF00498	0.721
LIG_FHA_1	639	645	PF00498	0.560
LIG_FHA_1	676	682	PF00498	0.842
LIG_FHA_1	778	784	PF00498	0.596
LIG_FHA_1	801	807	PF00498	0.587
LIG_FHA_1	927	933	PF00498	0.785
LIG_FHA_2	186	192	PF00498	0.770
LIG_FHA_2	225	231	PF00498	0.779
LIG_FHA_2	301	307	PF00498	0.705
LIG_FHA_2	748	754	PF00498	0.833
LIG_LIR_Apic_2	216	220	PF02991	0.545
LIG_LIR_Apic_2	23	27	PF02991	0.771
LIG_LIR_Apic_2	278	282	PF02991	0.797
LIG_LIR_Apic_2	36	41	PF02991	0.659
LIG_LIR_Apic_2	943	949	PF02991	0.807
LIG_LIR_Gen_1	248	257	PF02991	0.822
LIG_LIR_Gen_1	331	340	PF02991	0.749
LIG_LIR_Gen_1	568	579	PF02991	0.750
LIG_LIR_Gen_1	940	949	PF02991	0.811
LIG_LIR_Nem_3	248	252	PF02991	0.817
LIG_LIR_Nem_3	278	283	PF02991	0.807
LIG_LIR_Nem_3	331	337	PF02991	0.749
LIG_LIR_Nem_3	53	57	PF02991	0.822
LIG_LIR_Nem_3	817	822	PF02991	0.646
LIG_LIR_Nem_3	940	944	PF02991	0.819
LIG_MLH1_MIPbox_1	397	401	PF16413	0.817
LIG_MYND_1	349	353	PF01753	0.770
LIG_Pex14_1	549	553	PF04695	0.556
LIG_PTAP_UEV_1	196	201	PF05743	0.670
LIG_PTB_Apo_2	103	110	PF02174	0.551
LIG_PTB_Phospho_1	103	109	PF10480	0.550
LIG_RPA_C_Fungi	377	389	PF08784	0.716
LIG_SH2_CRK	24	28	PF00017	0.756
LIG_SH2_CRK	280	284	PF00017	0.795
LIG_SH2_NCK_1	109	113	PF00017	0.639
LIG_SH2_NCK_1	946	950	PF00017	0.724
LIG_SH2_STAP1	249	253	PF00017	0.820
LIG_SH2_STAP1	747	751	PF00017	0.763
LIG_SH2_STAT5	400	403	PF00017	0.694
LIG_SH2_STAT5	5	8	PF00017	0.572
LIG_SH2_STAT5	54	57	PF00017	0.763
LIG_SH2_STAT5	887	890	PF00017	0.816
LIG_SH3_1	217	223	PF00018	0.548
LIG_SH3_1	887	893	PF00018	0.820
LIG_SH3_3	157	163	PF00018	0.737
LIG_SH3_3	194	200	PF00018	0.788
LIG_SH3_3	217	223	PF00018	0.700
LIG_SH3_3	254	260	PF00018	0.610
LIG_SH3_3	343	349	PF00018	0.820
LIG_SH3_3	450	456	PF00018	0.636
LIG_SH3_3	60	66	PF00018	0.840
LIG_SH3_3	639	645	PF00018	0.692
LIG_SH3_3	863	869	PF00018	0.729
LIG_SH3_3	887	893	PF00018	0.750
LIG_SUMO_SIM_anti_2	336	341	PF11976	0.674
LIG_SxIP_EBH_1	655	666	PF03271	0.569
LIG_TRAF2_1	41	44	PF00917	0.744
LIG_TRAF2_1	74	77	PF00917	0.797
LIG_TRAF2_2	705	710	PF00917	0.573
MOD_CDK_SPK_2	345	350	PF00069	0.756
MOD_CDK_SPK_2	893	898	PF00069	0.695
MOD_CDK_SPxxK_3	262	269	PF00069	0.572
MOD_CK1_1	127	133	PF00069	0.769
MOD_CK1_1	143	149	PF00069	0.683
MOD_CK1_1	195	201	PF00069	0.772
MOD_CK1_1	361	367	PF00069	0.715
MOD_CK1_1	393	399	PF00069	0.791
MOD_CK1_1	481	487	PF00069	0.787
MOD_CK1_1	488	494	PF00069	0.655
MOD_CK1_1	523	529	PF00069	0.716
MOD_CK1_1	558	564	PF00069	0.844
MOD_CK1_1	582	588	PF00069	0.828
MOD_CK1_1	67	73	PF00069	0.864
MOD_CK1_1	688	694	PF00069	0.780
MOD_CK1_1	777	783	PF00069	0.739
MOD_CK1_1	835	841	PF00069	0.766
MOD_CK1_1	940	946	PF00069	0.816
MOD_CK2_1	185	191	PF00069	0.767
MOD_CK2_1	224	230	PF00069	0.779
MOD_CK2_1	300	306	PF00069	0.708
MOD_CK2_1	503	509	PF00069	0.671
MOD_GlcNHglycan	129	132	PF01048	0.672
MOD_GlcNHglycan	134	137	PF01048	0.695
MOD_GlcNHglycan	148	151	PF01048	0.623
MOD_GlcNHglycan	197	200	PF01048	0.668
MOD_GlcNHglycan	300	303	PF01048	0.740
MOD_GlcNHglycan	359	363	PF01048	0.751
MOD_GlcNHglycan	415	418	PF01048	0.662
MOD_GlcNHglycan	419	422	PF01048	0.670
MOD_GlcNHglycan	487	490	PF01048	0.825
MOD_GlcNHglycan	503	508	PF01048	0.762
MOD_GlcNHglycan	509	513	PF01048	0.824
MOD_GlcNHglycan	553	556	PF01048	0.810
MOD_GlcNHglycan	557	560	PF01048	0.811
MOD_GlcNHglycan	563	566	PF01048	0.758
MOD_GlcNHglycan	628	631	PF01048	0.736
MOD_GlcNHglycan	665	668	PF01048	0.825
MOD_GlcNHglycan	670	673	PF01048	0.766
MOD_GlcNHglycan	696	699	PF01048	0.724
MOD_GlcNHglycan	7	10	PF01048	0.787
MOD_GlcNHglycan	747	750	PF01048	0.728
MOD_GlcNHglycan	786	792	PF01048	0.732
MOD_GSK3_1	125	132	PF00069	0.668
MOD_GSK3_1	146	153	PF00069	0.699
MOD_GSK3_1	195	202	PF00069	0.663
MOD_GSK3_1	261	268	PF00069	0.796
MOD_GSK3_1	271	278	PF00069	0.771
MOD_GSK3_1	358	365	PF00069	0.718
MOD_GSK3_1	391	398	PF00069	0.645
MOD_GSK3_1	413	420	PF00069	0.623
MOD_GSK3_1	478	485	PF00069	0.681
MOD_GSK3_1	488	495	PF00069	0.719
MOD_GSK3_1	499	506	PF00069	0.840
MOD_GSK3_1	551	558	PF00069	0.798
MOD_GSK3_1	64	71	PF00069	0.859
MOD_GSK3_1	668	675	PF00069	0.725
MOD_GSK3_1	688	695	PF00069	0.694
MOD_GSK3_1	739	746	PF00069	0.682
MOD_GSK3_1	774	781	PF00069	0.781
MOD_GSK3_1	796	803	PF00069	0.642
MOD_GSK3_1	810	817	PF00069	0.641
MOD_GSK3_1	831	838	PF00069	0.690
MOD_GSK3_1	889	896	PF00069	0.825
MOD_LATS_1	183	189	PF00433	0.765
MOD_N-GLC_1	146	151	PF02516	0.662
MOD_N-GLC_1	413	418	PF02516	0.556
MOD_N-GLC_1	492	497	PF02516	0.834
MOD_N-GLC_1	555	560	PF02516	0.575
MOD_N-GLC_1	574	579	PF02516	0.769
MOD_N-GLC_1	688	693	PF02516	0.855
MOD_N-GLC_1	831	836	PF02516	0.668
MOD_N-GLC_1	924	929	PF02516	0.785
MOD_NEK2_1	124	129	PF00069	0.655
MOD_NEK2_1	573	578	PF00069	0.782
MOD_NEK2_1	579	584	PF00069	0.680
MOD_NEK2_1	809	814	PF00069	0.752
MOD_NEK2_1	932	937	PF00069	0.760
MOD_NEK2_2	275	280	PF00069	0.815
MOD_PIKK_1	129	135	PF00454	0.768
MOD_PIKK_1	237	243	PF00454	0.771
MOD_PIKK_1	328	334	PF00454	0.614
MOD_PIKK_1	832	838	PF00454	0.662
MOD_PIKK_1	869	875	PF00454	0.524
MOD_PK_1	125	131	PF00069	0.677
MOD_PKA_1	685	691	PF00069	0.775
MOD_PKA_1	743	749	PF00069	0.757
MOD_PKA_2	124	130	PF00069	0.682
MOD_PKA_2	271	277	PF00069	0.755
MOD_PKA_2	298	304	PF00069	0.645
MOD_PKA_2	313	319	PF00069	0.755
MOD_PKA_2	551	557	PF00069	0.634
MOD_PKA_2	654	660	PF00069	0.826
MOD_PKA_2	663	669	PF00069	0.838
MOD_PKA_2	685	691	PF00069	0.657
MOD_PKA_2	743	749	PF00069	0.757
MOD_Plk_1	125	131	PF00069	0.775
MOD_Plk_1	335	341	PF00069	0.701
MOD_Plk_1	43	49	PF00069	0.743
MOD_Plk_1	520	526	PF00069	0.749
MOD_Plk_1	574	580	PF00069	0.806
MOD_Plk_1	800	806	PF00069	0.683
MOD_Plk_2-3	462	468	PF00069	0.560
MOD_Plk_2-3	499	505	PF00069	0.763
MOD_Plk_4	247	253	PF00069	0.821
MOD_Plk_4	275	281	PF00069	0.812
MOD_Plk_4	335	341	PF00069	0.674
MOD_Plk_4	395	401	PF00069	0.818
MOD_Plk_4	50	56	PF00069	0.820
MOD_Plk_4	574	580	PF00069	0.806
MOD_Plk_4	592	598	PF00069	0.518
MOD_Plk_4	778	784	PF00069	0.708
MOD_ProDKin_1	193	199	PF00069	0.628
MOD_ProDKin_1	216	222	PF00069	0.711
MOD_ProDKin_1	225	231	PF00069	0.760
MOD_ProDKin_1	239	245	PF00069	0.607
MOD_ProDKin_1	253	259	PF00069	0.582
MOD_ProDKin_1	262	268	PF00069	0.601
MOD_ProDKin_1	345	351	PF00069	0.694
MOD_ProDKin_1	363	369	PF00069	0.615
MOD_ProDKin_1	393	399	PF00069	0.820
MOD_ProDKin_1	415	421	PF00069	0.751
MOD_ProDKin_1	449	455	PF00069	0.707
MOD_ProDKin_1	638	644	PF00069	0.702
MOD_ProDKin_1	692	698	PF00069	0.637
MOD_ProDKin_1	70	76	PF00069	0.836
MOD_ProDKin_1	701	707	PF00069	0.769
MOD_ProDKin_1	774	780	PF00069	0.768
MOD_ProDKin_1	889	895	PF00069	0.739
MOD_ProDKin_1	926	932	PF00069	0.717
MOD_SUMO_rev_2	530	539	PF00179	0.570
TRG_ENDOCYTIC_2	249	252	PF00928	0.818
TRG_ENDOCYTIC_2	280	283	PF00928	0.805
TRG_ENDOCYTIC_2	54	57	PF00928	0.825
TRG_ENDOCYTIC_2	571	574	PF00928	0.832
TRG_ENDOCYTIC_2	95	98	PF00928	0.709
TRG_ER_diArg_1	184	187	PF00400	0.763
TRG_ER_diArg_1	292	295	PF00400	0.628
TRG_ER_diArg_1	317	319	PF00400	0.828
TRG_ER_diArg_1	546	548	PF00400	0.766
TRG_ER_diArg_1	685	687	PF00400	0.852
TRG_ER_diArg_1	853	856	PF00400	0.576
TRG_NLS_MonoCore_2	291	296	PF00514	0.705
TRG_NLS_MonoExtC_3	292	298	PF00514	0.777
TRG_NLS_MonoExtN_4	292	297	PF00514	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBR5	Leishmania donovani	81%	99%
A4HYU6	Leishmania infantum	82%	99%
E9AIF4	Leishmania braziliensis	57%	100%
Q4QCU1	Leishmania major	82%	99%