Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUP2_LEIMU

TriTrypDb:

LmxM.20.1040

Length:

892

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUP2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.711
CLV_C14_Caspase3-7	425	429	PF00656	0.724
CLV_C14_Caspase3-7	49	53	PF00656	0.668
CLV_C14_Caspase3-7	497	501	PF00656	0.612
CLV_NRD_NRD_1	131	133	PF00675	0.631
CLV_NRD_NRD_1	156	158	PF00675	0.788
CLV_NRD_NRD_1	177	179	PF00675	0.655
CLV_NRD_NRD_1	342	344	PF00675	0.711
CLV_NRD_NRD_1	360	362	PF00675	0.625
CLV_NRD_NRD_1	545	547	PF00675	0.784
CLV_NRD_NRD_1	634	636	PF00675	0.643
CLV_NRD_NRD_1	685	687	PF00675	0.622
CLV_NRD_NRD_1	785	787	PF00675	0.597
CLV_NRD_NRD_1	82	84	PF00675	0.781
CLV_NRD_NRD_1	842	844	PF00675	0.563
CLV_PCSK_FUR_1	783	787	PF00082	0.604
CLV_PCSK_KEX2_1	131	133	PF00082	0.631
CLV_PCSK_KEX2_1	313	315	PF00082	0.678
CLV_PCSK_KEX2_1	360	362	PF00082	0.635
CLV_PCSK_KEX2_1	634	636	PF00082	0.643
CLV_PCSK_KEX2_1	685	687	PF00082	0.622
CLV_PCSK_KEX2_1	785	787	PF00082	0.597
CLV_PCSK_KEX2_1	826	828	PF00082	0.497
CLV_PCSK_KEX2_1	842	844	PF00082	0.639
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.791
CLV_PCSK_PC1ET2_1	826	828	PF00082	0.493
CLV_PCSK_PC7_1	781	787	PF00082	0.608
CLV_PCSK_SKI1_1	220	224	PF00082	0.770
CLV_PCSK_SKI1_1	305	309	PF00082	0.728
CLV_PCSK_SKI1_1	332	336	PF00082	0.804
CLV_PCSK_SKI1_1	344	348	PF00082	0.649
CLV_PCSK_SKI1_1	393	397	PF00082	0.692
CLV_PCSK_SKI1_1	546	550	PF00082	0.777
CLV_PCSK_SKI1_1	605	609	PF00082	0.746
CLV_PCSK_SKI1_1	686	690	PF00082	0.493
CLV_PCSK_SKI1_1	764	768	PF00082	0.395
CLV_PCSK_SKI1_1	807	811	PF00082	0.487
DEG_Nend_Nbox_1	1	3	PF02207	0.779
DEG_SCF_FBW7_1	626	632	PF00400	0.768
DEG_SPOP_SBC_1	117	121	PF00917	0.710
DEG_SPOP_SBC_1	201	205	PF00917	0.670
DOC_CKS1_1	245	250	PF01111	0.518
DOC_CKS1_1	451	456	PF01111	0.635
DOC_CKS1_1	626	631	PF01111	0.772
DOC_CKS1_1	73	78	PF01111	0.720
DOC_CKS1_1	787	792	PF01111	0.583
DOC_MAPK_gen_1	83	90	PF00069	0.723
DOC_PP2B_LxvP_1	2	5	PF13499	0.755
DOC_PP2B_LxvP_1	231	234	PF13499	0.758
DOC_PP4_FxxP_1	549	552	PF00568	0.711
DOC_USP7_MATH_1	101	105	PF00917	0.780
DOC_USP7_MATH_1	191	195	PF00917	0.761
DOC_USP7_MATH_1	234	238	PF00917	0.690
DOC_USP7_MATH_1	240	244	PF00917	0.677
DOC_USP7_MATH_1	283	287	PF00917	0.660
DOC_USP7_MATH_1	498	502	PF00917	0.688
DOC_USP7_MATH_1	527	531	PF00917	0.766
DOC_USP7_MATH_1	537	541	PF00917	0.613
DOC_USP7_MATH_1	563	567	PF00917	0.617
DOC_USP7_MATH_1	583	587	PF00917	0.626
DOC_USP7_MATH_1	591	595	PF00917	0.668
DOC_USP7_MATH_1	607	611	PF00917	0.596
DOC_USP7_MATH_1	672	676	PF00917	0.501
DOC_WW_Pin1_4	106	111	PF00397	0.514
DOC_WW_Pin1_4	244	249	PF00397	0.538
DOC_WW_Pin1_4	262	267	PF00397	0.641
DOC_WW_Pin1_4	372	377	PF00397	0.702
DOC_WW_Pin1_4	38	43	PF00397	0.637
DOC_WW_Pin1_4	418	423	PF00397	0.711
DOC_WW_Pin1_4	44	49	PF00397	0.639
DOC_WW_Pin1_4	445	450	PF00397	0.694
DOC_WW_Pin1_4	465	470	PF00397	0.458
DOC_WW_Pin1_4	482	487	PF00397	0.488
DOC_WW_Pin1_4	506	511	PF00397	0.726
DOC_WW_Pin1_4	533	538	PF00397	0.702
DOC_WW_Pin1_4	540	545	PF00397	0.655
DOC_WW_Pin1_4	597	602	PF00397	0.614
DOC_WW_Pin1_4	619	624	PF00397	0.682
DOC_WW_Pin1_4	625	630	PF00397	0.760
DOC_WW_Pin1_4	655	660	PF00397	0.712
DOC_WW_Pin1_4	705	710	PF00397	0.603
DOC_WW_Pin1_4	72	77	PF00397	0.699
DOC_WW_Pin1_4	786	791	PF00397	0.590
DOC_WW_Pin1_4	815	820	PF00397	0.544
DOC_WW_Pin1_4	859	864	PF00397	0.704
DOC_WW_Pin1_4	88	93	PF00397	0.798
LIG_14-3-3_CanoR_1	178	186	PF00244	0.781
LIG_14-3-3_CanoR_1	190	198	PF00244	0.608
LIG_14-3-3_CanoR_1	303	312	PF00244	0.719
LIG_14-3-3_CanoR_1	343	349	PF00244	0.550
LIG_14-3-3_CanoR_1	504	510	PF00244	0.552
LIG_14-3-3_CanoR_1	764	769	PF00244	0.402
LIG_14-3-3_CanoR_1	788	794	PF00244	0.577
LIG_14-3-3_CanoR_1	87	91	PF00244	0.611
LIG_APCC_ABBAyCdc20_2	157	163	PF00400	0.780
LIG_BIR_III_4	277	281	PF00653	0.610
LIG_BRCT_BRCA1_1	181	185	PF00533	0.633
LIG_BRCT_BRCA1_1	472	476	PF00533	0.619
LIG_DCNL_PONY_1	1	4	PF03556	0.762
LIG_FHA_1	160	166	PF00498	0.773
LIG_FHA_1	35	41	PF00498	0.529
LIG_FHA_1	394	400	PF00498	0.600
LIG_FHA_1	445	451	PF00498	0.705
LIG_FHA_1	466	472	PF00498	0.621
LIG_FHA_1	506	512	PF00498	0.519
LIG_FHA_1	565	571	PF00498	0.689
LIG_FHA_1	626	632	PF00498	0.646
LIG_FHA_2	136	142	PF00498	0.607
LIG_FHA_2	221	227	PF00498	0.520
LIG_FHA_2	47	53	PF00498	0.667
LIG_FHA_2	495	501	PF00498	0.609
LIG_Integrin_RGD_1	16	18	PF01839	0.690
LIG_Integrin_RGD_1	377	379	PF01839	0.700
LIG_LIR_Gen_1	473	484	PF02991	0.756
LIG_LIR_Gen_1	690	700	PF02991	0.540
LIG_LIR_Nem_3	18	24	PF02991	0.633
LIG_LIR_Nem_3	473	479	PF02991	0.662
LIG_LIR_Nem_3	690	695	PF02991	0.521
LIG_MYND_1	262	266	PF01753	0.655
LIG_NBox_RRM_1	806	816	PF00076	0.510
LIG_PCNA_yPIPBox_3	749	762	PF02747	0.469
LIG_Pex14_1	459	463	PF04695	0.623
LIG_SH2_CRK	24	28	PF00017	0.612
LIG_SH2_CRK	259	263	PF00017	0.743
LIG_SH2_CRK	61	65	PF00017	0.755
LIG_SH2_CRK	730	734	PF00017	0.590
LIG_SH2_GRB2like	325	328	PF00017	0.760
LIG_SH2_NCK_1	137	141	PF00017	0.510
LIG_SH2_NCK_1	463	467	PF00017	0.747
LIG_SH2_NCK_1	730	734	PF00017	0.672
LIG_SH2_SRC	19	22	PF00017	0.626
LIG_SH2_STAT3	853	856	PF00017	0.688
LIG_SH2_STAT5	137	140	PF00017	0.506
LIG_SH2_STAT5	246	249	PF00017	0.616
LIG_SH2_STAT5	457	460	PF00017	0.685
LIG_SH3_1	79	85	PF00018	0.783
LIG_SH3_2	82	87	PF14604	0.786
LIG_SH3_3	163	169	PF00018	0.650
LIG_SH3_3	260	266	PF00018	0.647
LIG_SH3_3	448	454	PF00018	0.616
LIG_SH3_3	476	482	PF00018	0.661
LIG_SH3_3	531	537	PF00018	0.784
LIG_SH3_3	549	555	PF00018	0.685
LIG_SH3_3	568	574	PF00018	0.681
LIG_SH3_3	645	651	PF00018	0.521
LIG_SH3_3	769	775	PF00018	0.698
LIG_SH3_3	79	85	PF00018	0.745
LIG_SH3_3	813	819	PF00018	0.671
LIG_SUMO_SIM_anti_2	694	699	PF11976	0.611
LIG_SUMO_SIM_par_1	344	349	PF11976	0.640
LIG_SUMO_SIM_par_1	694	699	PF11976	0.671
LIG_TRAF2_1	296	299	PF00917	0.516
LIG_UBA3_1	1	8	PF00899	0.762
LIG_WW_3	770	774	PF00397	0.695
MOD_CDK_SPK_2	372	377	PF00069	0.702
MOD_CDK_SPK_2	450	455	PF00069	0.751
MOD_CDK_SPK_2	482	487	PF00069	0.677
MOD_CDK_SPK_2	786	791	PF00069	0.590
MOD_CDK_SPxK_1	540	546	PF00069	0.644
MOD_CDK_SPxxK_3	540	547	PF00069	0.773
MOD_CDK_SPxxK_3	705	712	PF00069	0.584
MOD_CDK_SPxxK_3	72	79	PF00069	0.721
MOD_CK1_1	105	111	PF00069	0.641
MOD_CK1_1	148	154	PF00069	0.682
MOD_CK1_1	204	210	PF00069	0.691
MOD_CK1_1	221	227	PF00069	0.633
MOD_CK1_1	265	271	PF00069	0.782
MOD_CK1_1	317	323	PF00069	0.789
MOD_CK1_1	412	418	PF00069	0.672
MOD_CK1_1	505	511	PF00069	0.584
MOD_CK1_1	540	546	PF00069	0.657
MOD_CK1_1	557	563	PF00069	0.562
MOD_CK1_1	581	587	PF00069	0.633
MOD_CK2_1	117	123	PF00069	0.536
MOD_CK2_1	135	141	PF00069	0.611
MOD_CK2_1	220	226	PF00069	0.522
MOD_CK2_1	293	299	PF00069	0.517
MOD_CK2_1	533	539	PF00069	0.582
MOD_GlcNHglycan	10	13	PF01048	0.704
MOD_GlcNHglycan	104	107	PF01048	0.760
MOD_GlcNHglycan	138	141	PF01048	0.675
MOD_GlcNHglycan	146	150	PF01048	0.606
MOD_GlcNHglycan	193	196	PF01048	0.779
MOD_GlcNHglycan	223	226	PF01048	0.688
MOD_GlcNHglycan	248	251	PF01048	0.572
MOD_GlcNHglycan	281	284	PF01048	0.777
MOD_GlcNHglycan	285	288	PF01048	0.719
MOD_GlcNHglycan	305	308	PF01048	0.668
MOD_GlcNHglycan	366	369	PF01048	0.762
MOD_GlcNHglycan	387	390	PF01048	0.508
MOD_GlcNHglycan	417	420	PF01048	0.693
MOD_GlcNHglycan	422	425	PF01048	0.710
MOD_GlcNHglycan	428	431	PF01048	0.814
MOD_GlcNHglycan	504	507	PF01048	0.765
MOD_GlcNHglycan	521	524	PF01048	0.500
MOD_GlcNHglycan	529	532	PF01048	0.686
MOD_GlcNHglycan	539	542	PF01048	0.541
MOD_GlcNHglycan	559	562	PF01048	0.779
MOD_GlcNHglycan	593	596	PF01048	0.777
MOD_GlcNHglycan	597	600	PF01048	0.717
MOD_GlcNHglycan	609	612	PF01048	0.765
MOD_GlcNHglycan	623	626	PF01048	0.625
MOD_GlcNHglycan	674	677	PF01048	0.639
MOD_GlcNHglycan	99	102	PF01048	0.788
MOD_GSK3_1	141	148	PF00069	0.705
MOD_GSK3_1	149	156	PF00069	0.629
MOD_GSK3_1	196	203	PF00069	0.656
MOD_GSK3_1	204	211	PF00069	0.762
MOD_GSK3_1	214	221	PF00069	0.591
MOD_GSK3_1	240	247	PF00069	0.651
MOD_GSK3_1	279	286	PF00069	0.788
MOD_GSK3_1	289	296	PF00069	0.690
MOD_GSK3_1	299	306	PF00069	0.502
MOD_GSK3_1	332	339	PF00069	0.643
MOD_GSK3_1	34	41	PF00069	0.641
MOD_GSK3_1	344	351	PF00069	0.669
MOD_GSK3_1	385	392	PF00069	0.615
MOD_GSK3_1	4	11	PF00069	0.698
MOD_GSK3_1	409	416	PF00069	0.630
MOD_GSK3_1	42	49	PF00069	0.658
MOD_GSK3_1	440	447	PF00069	0.605
MOD_GSK3_1	494	501	PF00069	0.630
MOD_GSK3_1	502	509	PF00069	0.658
MOD_GSK3_1	533	540	PF00069	0.668
MOD_GSK3_1	578	585	PF00069	0.710
MOD_GSK3_1	591	598	PF00069	0.580
MOD_GSK3_1	603	610	PF00069	0.563
MOD_GSK3_1	621	628	PF00069	0.671
MOD_GSK3_1	639	646	PF00069	0.490
MOD_GSK3_1	657	664	PF00069	0.564
MOD_GSK3_1	97	104	PF00069	0.697
MOD_LATS_1	442	448	PF00433	0.724
MOD_N-GLC_1	208	213	PF02516	0.540
MOD_N-GLC_1	273	278	PF02516	0.709
MOD_N-GLC_1	336	341	PF02516	0.527
MOD_N-GLC_1	445	450	PF02516	0.649
MOD_N-GLC_1	557	562	PF02516	0.775
MOD_N-GLC_1	705	710	PF02516	0.585
MOD_N-GLC_1	97	102	PF02516	0.659
MOD_NEK2_1	34	39	PF00069	0.647
MOD_NEK2_1	369	374	PF00069	0.557
MOD_NEK2_1	603	608	PF00069	0.601
MOD_NEK2_1	696	701	PF00069	0.563
MOD_NEK2_1	716	721	PF00069	0.472
MOD_NEK2_1	729	734	PF00069	0.529
MOD_PIKK_1	398	404	PF00454	0.707
MOD_PIKK_1	707	713	PF00454	0.513
MOD_PK_1	314	320	PF00069	0.711
MOD_PKA_1	179	185	PF00069	0.667
MOD_PKA_1	83	89	PF00069	0.789
MOD_PKA_2	364	370	PF00069	0.781
MOD_PKA_2	426	432	PF00069	0.833
MOD_PKA_2	86	92	PF00069	0.570
MOD_PKB_1	303	311	PF00069	0.726
MOD_PKB_1	762	770	PF00069	0.403
MOD_Plk_1	145	151	PF00069	0.776
MOD_Plk_1	97	103	PF00069	0.613
MOD_Plk_2-3	820	826	PF00069	0.506
MOD_ProDKin_1	106	112	PF00069	0.515
MOD_ProDKin_1	244	250	PF00069	0.539
MOD_ProDKin_1	262	268	PF00069	0.644
MOD_ProDKin_1	372	378	PF00069	0.702
MOD_ProDKin_1	38	44	PF00069	0.634
MOD_ProDKin_1	418	424	PF00069	0.707
MOD_ProDKin_1	445	451	PF00069	0.689
MOD_ProDKin_1	465	471	PF00069	0.461
MOD_ProDKin_1	482	488	PF00069	0.489
MOD_ProDKin_1	506	512	PF00069	0.727
MOD_ProDKin_1	533	539	PF00069	0.704
MOD_ProDKin_1	540	546	PF00069	0.657
MOD_ProDKin_1	597	603	PF00069	0.614
MOD_ProDKin_1	619	625	PF00069	0.682
MOD_ProDKin_1	655	661	PF00069	0.715
MOD_ProDKin_1	705	711	PF00069	0.602
MOD_ProDKin_1	72	78	PF00069	0.701
MOD_ProDKin_1	786	792	PF00069	0.584
MOD_ProDKin_1	815	821	PF00069	0.542
MOD_ProDKin_1	859	865	PF00069	0.707
MOD_ProDKin_1	88	94	PF00069	0.798
MOD_SUMO_for_1	355	358	PF00179	0.641
TRG_DiLeu_BaEn_2	827	833	PF01217	0.502
TRG_DiLeu_BaEn_4	357	363	PF01217	0.761
TRG_ENDOCYTIC_2	24	27	PF00928	0.610
TRG_ENDOCYTIC_2	61	64	PF00928	0.642
TRG_ENDOCYTIC_2	730	733	PF00928	0.584
TRG_ER_diArg_1	360	362	PF00400	0.640
TRG_ER_diArg_1	634	636	PF00400	0.643
TRG_ER_diArg_1	720	723	PF00400	0.534
TRG_ER_diArg_1	759	762	PF00400	0.524
TRG_ER_diArg_1	780	783	PF00400	0.619
TRG_ER_diArg_1	784	786	PF00400	0.602
TRG_ER_diArg_1	842	845	PF00400	0.559
TRG_NES_CRM1_1	747	758	PF08389	0.463
TRG_NLS_MonoExtC_3	177	183	PF00514	0.787

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2V0	Leptomonas seymouri	33%	100%
A0A3S5H787	Leishmania donovani	88%	100%
A4HYU5	Leishmania infantum	88%	100%
E9AIP3	Leishmania braziliensis	70%	98%
Q4QCU2	Leishmania major	88%	100%