Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUN8_LEIMU

TriTrypDb:

LmxM.20.1000

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUN8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.530
CLV_C14_Caspase3-7	459	463	PF00656	0.572
CLV_C14_Caspase3-7	470	474	PF00656	0.602
CLV_C14_Caspase3-7	56	60	PF00656	0.641
CLV_NRD_NRD_1	204	206	PF00675	0.734
CLV_NRD_NRD_1	213	215	PF00675	0.652
CLV_NRD_NRD_1	218	220	PF00675	0.591
CLV_NRD_NRD_1	316	318	PF00675	0.678
CLV_NRD_NRD_1	393	395	PF00675	0.621
CLV_NRD_NRD_1	43	45	PF00675	0.619
CLV_NRD_NRD_1	439	441	PF00675	0.688
CLV_NRD_NRD_1	486	488	PF00675	0.737
CLV_NRD_NRD_1	489	491	PF00675	0.718
CLV_NRD_NRD_1	652	654	PF00675	0.516
CLV_PCSK_FUR_1	314	318	PF00082	0.484
CLV_PCSK_FUR_1	389	393	PF00082	0.745
CLV_PCSK_KEX2_1	213	215	PF00082	0.690
CLV_PCSK_KEX2_1	218	220	PF00082	0.660
CLV_PCSK_KEX2_1	316	318	PF00082	0.666
CLV_PCSK_KEX2_1	391	393	PF00082	0.742
CLV_PCSK_KEX2_1	43	45	PF00082	0.619
CLV_PCSK_KEX2_1	439	441	PF00082	0.688
CLV_PCSK_KEX2_1	578	580	PF00082	0.706
CLV_PCSK_KEX2_1	652	654	PF00082	0.516
CLV_PCSK_KEX2_1	75	77	PF00082	0.741
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.621
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.742
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.563
CLV_PCSK_PC1ET2_1	578	580	PF00082	0.706
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.646
CLV_PCSK_PC7_1	214	220	PF00082	0.706
CLV_PCSK_PC7_1	389	395	PF00082	0.629
CLV_PCSK_SKI1_1	12	16	PF00082	0.637
CLV_PCSK_SKI1_1	18	22	PF00082	0.588
CLV_PCSK_SKI1_1	218	222	PF00082	0.714
CLV_PCSK_SKI1_1	29	33	PF00082	0.376
CLV_PCSK_SKI1_1	417	421	PF00082	0.684
CLV_PCSK_SKI1_1	44	48	PF00082	0.440
CLV_PCSK_SKI1_1	461	465	PF00082	0.657
CLV_PCSK_SKI1_1	533	537	PF00082	0.691
DEG_Nend_UBRbox_2	1	3	PF02207	0.600
DEG_SCF_FBW7_1	428	435	PF00400	0.637
DEG_SCF_FBW7_1	516	522	PF00400	0.593
DEG_SPOP_SBC_1	113	117	PF00917	0.638
DEG_SPOP_SBC_1	186	190	PF00917	0.687
DEG_SPOP_SBC_1	636	640	PF00917	0.715
DOC_CKS1_1	429	434	PF01111	0.634
DOC_CKS1_1	516	521	PF01111	0.630
DOC_CYCLIN_yCln2_LP_2	277	283	PF00134	0.651
DOC_MAPK_gen_1	316	325	PF00069	0.696
DOC_MAPK_gen_1	436	444	PF00069	0.683
DOC_PP1_RVXF_1	10	16	PF00149	0.529
DOC_PP2B_LxvP_1	277	280	PF13499	0.667
DOC_USP7_MATH_1	112	116	PF00917	0.639
DOC_USP7_MATH_1	126	130	PF00917	0.617
DOC_USP7_MATH_1	138	142	PF00917	0.573
DOC_USP7_MATH_1	146	150	PF00917	0.534
DOC_USP7_MATH_1	151	155	PF00917	0.654
DOC_USP7_MATH_1	199	203	PF00917	0.582
DOC_USP7_MATH_1	283	287	PF00917	0.564
DOC_USP7_MATH_1	339	343	PF00917	0.620
DOC_USP7_MATH_1	377	381	PF00917	0.747
DOC_USP7_MATH_1	432	436	PF00917	0.625
DOC_USP7_MATH_1	454	458	PF00917	0.720
DOC_USP7_MATH_1	466	470	PF00917	0.593
DOC_USP7_MATH_1	486	490	PF00917	0.582
DOC_USP7_MATH_1	494	498	PF00917	0.651
DOC_USP7_MATH_1	502	506	PF00917	0.559
DOC_USP7_MATH_1	528	532	PF00917	0.596
DOC_USP7_MATH_1	60	64	PF00917	0.763
DOC_USP7_MATH_1	632	636	PF00917	0.719
DOC_USP7_UBL2_3	43	47	PF12436	0.582
DOC_WD40_RPTOR_TOS_1	704	710	PF00400	0.684
DOC_WW_Pin1_4	119	124	PF00397	0.588
DOC_WW_Pin1_4	190	195	PF00397	0.598
DOC_WW_Pin1_4	244	249	PF00397	0.724
DOC_WW_Pin1_4	424	429	PF00397	0.791
DOC_WW_Pin1_4	478	483	PF00397	0.716
DOC_WW_Pin1_4	515	520	PF00397	0.688
DOC_WW_Pin1_4	534	539	PF00397	0.557
DOC_WW_Pin1_4	562	567	PF00397	0.601
DOC_WW_Pin1_4	577	582	PF00397	0.728
DOC_WW_Pin1_4	586	591	PF00397	0.634
DOC_WW_Pin1_4	620	625	PF00397	0.748
DOC_WW_Pin1_4	644	649	PF00397	0.696
DOC_WW_Pin1_4	685	690	PF00397	0.694
LIG_14-3-3_CanoR_1	18	28	PF00244	0.530
LIG_14-3-3_CanoR_1	200	204	PF00244	0.633
LIG_14-3-3_CanoR_1	316	325	PF00244	0.633
LIG_14-3-3_CanoR_1	410	419	PF00244	0.694
LIG_14-3-3_CanoR_1	533	538	PF00244	0.608
LIG_14-3-3_CanoR_1	579	585	PF00244	0.738
LIG_14-3-3_CanoR_1	617	624	PF00244	0.587
LIG_14-3-3_CanoR_1	634	644	PF00244	0.693
LIG_14-3-3_CanoR_1	652	659	PF00244	0.522
LIG_14-3-3_CanoR_1	81	89	PF00244	0.533
LIG_FHA_1	20	26	PF00498	0.495
LIG_FHA_1	215	221	PF00498	0.738
LIG_FHA_1	318	324	PF00498	0.637
LIG_FHA_1	418	424	PF00498	0.662
LIG_FHA_1	508	514	PF00498	0.701
LIG_FHA_1	516	522	PF00498	0.658
LIG_FHA_1	548	554	PF00498	0.744
LIG_FHA_1	587	593	PF00498	0.724
LIG_FHA_1	6	12	PF00498	0.550
LIG_FHA_1	636	642	PF00498	0.713
LIG_FHA_2	191	197	PF00498	0.626
LIG_FHA_2	397	403	PF00498	0.744
LIG_FHA_2	468	474	PF00498	0.720
LIG_FHA_2	54	60	PF00498	0.639
LIG_FHA_2	603	609	PF00498	0.688
LIG_FHA_2	697	703	PF00498	0.677
LIG_GSK3_LRP6_1	562	567	PF00069	0.539
LIG_LIR_Gen_1	234	244	PF02991	0.521
LIG_LIR_Nem_3	234	240	PF02991	0.526
LIG_LIR_Nem_3	654	659	PF02991	0.663
LIG_MYND_1	404	408	PF01753	0.609
LIG_MYND_1	519	523	PF01753	0.677
LIG_MYND_1	644	648	PF01753	0.647
LIG_NRBOX	27	33	PF00104	0.524
LIG_SH2_GRB2like	594	597	PF00017	0.731
LIG_SH2_STAT5	38	41	PF00017	0.473
LIG_SH2_STAT5	720	723	PF00017	0.684
LIG_SH3_2	482	487	PF14604	0.665
LIG_SH3_3	120	126	PF00018	0.624
LIG_SH3_3	380	386	PF00018	0.692
LIG_SH3_3	401	407	PF00018	0.734
LIG_SH3_3	479	485	PF00018	0.736
LIG_SH3_3	514	520	PF00018	0.717
LIG_SH3_3	522	528	PF00018	0.647
LIG_SH3_3	560	566	PF00018	0.573
LIG_SH3_3	598	604	PF00018	0.673
LIG_TRAF2_1	222	225	PF00917	0.689
LIG_TRAF2_1	248	251	PF00917	0.730
LIG_TRAF2_1	296	299	PF00917	0.705
MOD_CDC14_SPxK_1	484	487	PF00782	0.615
MOD_CDK_SPxK_1	428	434	PF00069	0.680
MOD_CDK_SPxK_1	481	487	PF00069	0.615
MOD_CDK_SPxxK_3	481	488	PF00069	0.692
MOD_CDK_SPxxK_3	534	541	PF00069	0.613
MOD_CDK_SPxxK_3	620	627	PF00069	0.672
MOD_CK1_1	190	196	PF00069	0.678
MOD_CK1_1	342	348	PF00069	0.787
MOD_CK1_1	418	424	PF00069	0.684
MOD_CK1_1	469	475	PF00069	0.679
MOD_CK1_1	478	484	PF00069	0.636
MOD_CK1_1	489	495	PF00069	0.581
MOD_CK1_1	497	503	PF00069	0.609
MOD_CK1_1	580	586	PF00069	0.735
MOD_CK1_1	595	601	PF00069	0.560
MOD_CK1_1	623	629	PF00069	0.738
MOD_CK1_1	635	641	PF00069	0.585
MOD_CK1_1	69	75	PF00069	0.628
MOD_CK1_1	715	721	PF00069	0.677
MOD_CK2_1	151	157	PF00069	0.739
MOD_CK2_1	419	425	PF00069	0.735
MOD_CK2_1	471	477	PF00069	0.692
MOD_CK2_1	637	643	PF00069	0.523
MOD_CK2_1	696	702	PF00069	0.676
MOD_CK2_1	706	712	PF00069	0.573
MOD_Cter_Amidation	389	392	PF01082	0.747
MOD_GlcNHglycan	126	129	PF01048	0.728
MOD_GlcNHglycan	172	175	PF01048	0.746
MOD_GlcNHglycan	189	192	PF01048	0.795
MOD_GlcNHglycan	281	284	PF01048	0.695
MOD_GlcNHglycan	285	288	PF01048	0.562
MOD_GlcNHglycan	451	454	PF01048	0.782
MOD_GlcNHglycan	456	459	PF01048	0.744
MOD_GlcNHglycan	477	480	PF01048	0.704
MOD_GlcNHglycan	492	495	PF01048	0.566
MOD_GlcNHglycan	496	499	PF01048	0.535
MOD_GlcNHglycan	530	533	PF01048	0.603
MOD_GlcNHglycan	598	601	PF01048	0.553
MOD_GlcNHglycan	618	621	PF01048	0.698
MOD_GlcNHglycan	634	637	PF01048	0.610
MOD_GlcNHglycan	677	680	PF01048	0.609
MOD_GlcNHglycan	714	717	PF01048	0.682
MOD_GSK3_1	112	119	PF00069	0.680
MOD_GSK3_1	126	133	PF00069	0.668
MOD_GSK3_1	147	154	PF00069	0.737
MOD_GSK3_1	182	189	PF00069	0.709
MOD_GSK3_1	231	238	PF00069	0.645
MOD_GSK3_1	279	286	PF00069	0.569
MOD_GSK3_1	339	346	PF00069	0.824
MOD_GSK3_1	392	399	PF00069	0.702
MOD_GSK3_1	411	418	PF00069	0.647
MOD_GSK3_1	419	426	PF00069	0.764
MOD_GSK3_1	428	435	PF00069	0.606
MOD_GSK3_1	449	456	PF00069	0.777
MOD_GSK3_1	467	474	PF00069	0.548
MOD_GSK3_1	486	493	PF00069	0.548
MOD_GSK3_1	49	56	PF00069	0.615
MOD_GSK3_1	497	504	PF00069	0.616
MOD_GSK3_1	507	514	PF00069	0.655
MOD_GSK3_1	515	522	PF00069	0.566
MOD_GSK3_1	541	548	PF00069	0.713
MOD_GSK3_1	592	599	PF00069	0.675
MOD_GSK3_1	616	623	PF00069	0.740
MOD_GSK3_1	632	639	PF00069	0.565
MOD_GSK3_1	691	698	PF00069	0.657
MOD_GSK3_1	702	709	PF00069	0.595
MOD_GSK3_1	711	718	PF00069	0.492
MOD_LATS_1	539	545	PF00433	0.553
MOD_N-GLC_1	595	600	PF02516	0.720
MOD_N-GLC_1	632	637	PF02516	0.654
MOD_NEK2_1	130	135	PF00069	0.692
MOD_NEK2_1	137	142	PF00069	0.685
MOD_NEK2_1	144	149	PF00069	0.639
MOD_NEK2_1	161	166	PF00069	0.596
MOD_NEK2_1	232	237	PF00069	0.713
MOD_NEK2_1	419	424	PF00069	0.711
MOD_NEK2_1	48	53	PF00069	0.677
MOD_NEK2_1	691	696	PF00069	0.686
MOD_PIKK_1	121	127	PF00454	0.657
MOD_PIKK_1	130	136	PF00454	0.688
MOD_PIKK_1	162	168	PF00454	0.541
MOD_PIKK_1	246	252	PF00454	0.683
MOD_PIKK_1	377	383	PF00454	0.742
MOD_PIKK_1	411	417	PF00454	0.713
MOD_PIKK_1	53	59	PF00454	0.502
MOD_PIKK_1	625	631	PF00454	0.629
MOD_PIKK_1	651	657	PF00454	0.658
MOD_PIKK_1	691	697	PF00454	0.685
MOD_PK_1	75	81	PF00069	0.590
MOD_PKA_1	214	220	PF00069	0.706
MOD_PKA_1	317	323	PF00069	0.693
MOD_PKA_1	392	398	PF00069	0.628
MOD_PKA_1	490	496	PF00069	0.732
MOD_PKA_1	75	81	PF00069	0.590
MOD_PKA_2	162	168	PF00069	0.593
MOD_PKA_2	199	205	PF00069	0.634
MOD_PKA_2	342	348	PF00069	0.726
MOD_PKA_2	349	355	PF00069	0.696
MOD_PKA_2	392	398	PF00069	0.708
MOD_PKA_2	486	492	PF00069	0.695
MOD_PKA_2	596	602	PF00069	0.719
MOD_PKA_2	616	622	PF00069	0.563
MOD_PKA_2	651	657	PF00069	0.595
MOD_PKA_2	75	81	PF00069	0.590
MOD_Plk_1	179	185	PF00069	0.524
MOD_Plk_1	461	467	PF00069	0.682
MOD_Plk_1	66	72	PF00069	0.509
MOD_Plk_1	702	708	PF00069	0.686
MOD_Plk_2-3	326	332	PF00069	0.545
MOD_Plk_2-3	702	708	PF00069	0.686
MOD_Plk_4	126	132	PF00069	0.750
MOD_Plk_4	637	643	PF00069	0.710
MOD_Plk_4	75	81	PF00069	0.590
MOD_ProDKin_1	119	125	PF00069	0.589
MOD_ProDKin_1	190	196	PF00069	0.600
MOD_ProDKin_1	244	250	PF00069	0.723
MOD_ProDKin_1	424	430	PF00069	0.787
MOD_ProDKin_1	478	484	PF00069	0.717
MOD_ProDKin_1	515	521	PF00069	0.692
MOD_ProDKin_1	534	540	PF00069	0.557
MOD_ProDKin_1	562	568	PF00069	0.603
MOD_ProDKin_1	577	583	PF00069	0.728
MOD_ProDKin_1	586	592	PF00069	0.633
MOD_ProDKin_1	620	626	PF00069	0.747
MOD_ProDKin_1	644	650	PF00069	0.698
MOD_ProDKin_1	685	691	PF00069	0.692
MOD_SUMO_rev_2	326	335	PF00179	0.684
TRG_DiLeu_BaEn_4	571	577	PF01217	0.559
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.619
TRG_DiLeu_BaLyEn_6	641	646	PF01217	0.694
TRG_ENDOCYTIC_2	101	104	PF00928	0.479
TRG_ER_diArg_1	218	220	PF00400	0.661
TRG_ER_diArg_1	392	394	PF00400	0.626
TRG_NLS_MonoCore_2	390	395	PF00514	0.626
TRG_NLS_MonoExtC_3	390	396	PF00514	0.689
TRG_NLS_MonoExtC_3	486	491	PF00514	0.668
TRG_NLS_MonoExtN_4	314	321	PF00514	0.652
TRG_NLS_MonoExtN_4	389	395	PF00514	0.741
TRG_NLS_MonoExtN_4	43	48	PF00514	0.588
TRG_NLS_MonoExtN_4	485	491	PF00514	0.664
TRG_Pf-PMV_PEXEL_1	667	671	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WW49	Leishmania donovani	82%	100%
A4HYU1	Leishmania infantum	82%	100%
E9AIF0	Leishmania braziliensis	63%	97%
Q4QCU6	Leishmania major	82%	99%