Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AUN7_LEIMU

TriTrypDb:

LmxM.20.0990

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	24	26	PF00675	0.667
CLV_NRD_NRD_1	335	337	PF00675	0.601
CLV_NRD_NRD_1	46	48	PF00675	0.599
CLV_PCSK_KEX2_1	140	142	PF00082	0.513
CLV_PCSK_KEX2_1	24	26	PF00082	0.667
CLV_PCSK_KEX2_1	294	296	PF00082	0.585
CLV_PCSK_KEX2_1	335	337	PF00082	0.601
CLV_PCSK_KEX2_1	46	48	PF00082	0.599
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.513
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.585
CLV_PCSK_PC7_1	331	337	PF00082	0.600
CLV_PCSK_SKI1_1	24	28	PF00082	0.628
CLV_PCSK_SKI1_1	303	307	PF00082	0.585
CLV_PCSK_SKI1_1	327	331	PF00082	0.621
DEG_APCC_DBOX_1	330	338	PF00400	0.571
DEG_Nend_UBRbox_1	1	4	PF02207	0.589
DOC_ANK_TNKS_1	140	147	PF00023	0.518
DOC_CKS1_1	277	282	PF01111	0.548
DOC_MAPK_MEF2A_6	10	18	PF00069	0.465
DOC_MAPK_MEF2A_6	364	372	PF00069	0.545
DOC_PP1_RVXF_1	28	34	PF00149	0.476
DOC_PP2B_LxvP_1	274	277	PF13499	0.626
DOC_PP4_FxxP_1	142	145	PF00568	0.512
DOC_PP4_FxxP_1	410	413	PF00568	0.473
DOC_USP7_MATH_1	179	183	PF00917	0.478
DOC_USP7_MATH_1	278	282	PF00917	0.633
DOC_USP7_MATH_1	79	83	PF00917	0.671
DOC_USP7_MATH_1	84	88	PF00917	0.597
DOC_WW_Pin1_4	19	24	PF00397	0.561
DOC_WW_Pin1_4	276	281	PF00397	0.550
LIG_14-3-3_CanoR_1	181	189	PF00244	0.547
LIG_14-3-3_CanoR_1	198	208	PF00244	0.537
LIG_14-3-3_CanoR_1	30	34	PF00244	0.545
LIG_14-3-3_CanoR_1	397	402	PF00244	0.491
LIG_14-3-3_CanoR_1	470	476	PF00244	0.564
LIG_Actin_WH2_2	322	337	PF00022	0.573
LIG_APCC_ABBA_1	252	257	PF00400	0.494
LIG_BRCT_BRCA1_1	406	410	PF00533	0.493
LIG_BRCT_BRCA1_1	455	459	PF00533	0.596
LIG_DLG_GKlike_1	164	172	PF00625	0.557
LIG_FHA_1	122	128	PF00498	0.579
LIG_FHA_1	219	225	PF00498	0.632
LIG_FHA_1	277	283	PF00498	0.628
LIG_FHA_1	304	310	PF00498	0.440
LIG_FHA_1	352	358	PF00498	0.470
LIG_FHA_1	437	443	PF00498	0.503
LIG_FHA_1	87	93	PF00498	0.589
LIG_FHA_2	198	204	PF00498	0.625
LIG_FHA_2	319	325	PF00498	0.444
LIG_FHA_2	67	73	PF00498	0.534
LIG_LIR_Apic_2	407	413	PF02991	0.482
LIG_LIR_Apic_2	56	62	PF02991	0.707
LIG_LIR_Gen_1	307	316	PF02991	0.533
LIG_LIR_Gen_1	365	373	PF02991	0.541
LIG_LIR_Nem_3	307	313	PF02991	0.478
LIG_LIR_Nem_3	365	369	PF02991	0.491
LIG_SH2_CRK	59	63	PF00017	0.587
LIG_SH2_NCK_1	155	159	PF00017	0.580
LIG_SH2_NCK_1	59	63	PF00017	0.612
LIG_SH2_PTP2	310	313	PF00017	0.540
LIG_SH2_SRC	155	158	PF00017	0.572
LIG_SH2_STAP1	353	357	PF00017	0.527
LIG_SH2_STAT5	130	133	PF00017	0.525
LIG_SH2_STAT5	174	177	PF00017	0.526
LIG_SH2_STAT5	262	265	PF00017	0.477
LIG_SH2_STAT5	310	313	PF00017	0.477
LIG_SH2_STAT5	353	356	PF00017	0.462
LIG_SH2_STAT5	361	364	PF00017	0.476
LIG_SH3_3	1	7	PF00018	0.623
LIG_SH3_3	142	148	PF00018	0.521
LIG_SH3_3	274	280	PF00018	0.546
LIG_SH3_3	354	360	PF00018	0.645
LIG_SH3_3	49	55	PF00018	0.603
LIG_SUMO_SIM_anti_2	221	226	PF11976	0.462
LIG_SUMO_SIM_anti_2	439	444	PF11976	0.498
LIG_SUMO_SIM_par_1	14	20	PF11976	0.463
LIG_SUMO_SIM_par_1	264	271	PF11976	0.538
LIG_SUMO_SIM_par_1	87	93	PF11976	0.587
LIG_TYR_ITIM	153	158	PF00017	0.574
LIG_TYR_ITIM	308	313	PF00017	0.538
LIG_WRC_WIRS_1	363	368	PF05994	0.541
MOD_CDC14_SPxK_1	22	25	PF00782	0.552
MOD_CDK_SPK_2	19	24	PF00069	0.619
MOD_CDK_SPxK_1	19	25	PF00069	0.551
MOD_CK1_1	116	122	PF00069	0.623
MOD_CK1_1	182	188	PF00069	0.663
MOD_CK1_1	315	321	PF00069	0.580
MOD_CK1_1	32	38	PF00069	0.667
MOD_CK1_1	400	406	PF00069	0.617
MOD_CK1_1	453	459	PF00069	0.525
MOD_CK1_1	465	471	PF00069	0.617
MOD_CK1_1	93	99	PF00069	0.610
MOD_CK2_1	119	125	PF00069	0.610
MOD_CK2_1	185	191	PF00069	0.460
MOD_CK2_1	318	324	PF00069	0.435
MOD_CK2_1	66	72	PF00069	0.541
MOD_CK2_1	79	85	PF00069	0.533
MOD_GlcNHglycan	148	151	PF01048	0.568
MOD_GlcNHglycan	159	162	PF01048	0.492
MOD_GlcNHglycan	185	188	PF01048	0.654
MOD_GlcNHglycan	27	30	PF01048	0.623
MOD_GlcNHglycan	314	317	PF01048	0.563
MOD_GlcNHglycan	394	397	PF01048	0.643
MOD_GlcNHglycan	403	406	PF01048	0.570
MOD_GlcNHglycan	417	420	PF01048	0.588
MOD_GlcNHglycan	472	475	PF01048	0.561
MOD_GlcNHglycan	491	494	PF01048	0.622
MOD_GlcNHglycan	496	499	PF01048	0.698
MOD_GlcNHglycan	55	58	PF01048	0.615
MOD_GlcNHglycan	82	85	PF01048	0.630
MOD_GlcNHglycan	92	95	PF01048	0.578
MOD_GSK3_1	110	117	PF00069	0.541
MOD_GSK3_1	164	171	PF00069	0.582
MOD_GSK3_1	179	186	PF00069	0.526
MOD_GSK3_1	214	221	PF00069	0.539
MOD_GSK3_1	242	249	PF00069	0.485
MOD_GSK3_1	25	32	PF00069	0.600
MOD_GSK3_1	347	354	PF00069	0.583
MOD_GSK3_1	397	404	PF00069	0.648
MOD_GSK3_1	460	467	PF00069	0.660
MOD_GSK3_1	80	87	PF00069	0.745
MOD_LATS_1	162	168	PF00433	0.562
MOD_N-GLC_1	114	119	PF02516	0.483
MOD_N-GLC_1	318	323	PF02516	0.577
MOD_NEK2_1	168	173	PF00069	0.517
MOD_NEK2_1	180	185	PF00069	0.615
MOD_NEK2_1	204	209	PF00069	0.611
MOD_NEK2_1	218	223	PF00069	0.404
MOD_NEK2_1	347	352	PF00069	0.512
MOD_NEK2_1	368	373	PF00069	0.400
MOD_NEK2_1	392	397	PF00069	0.630
MOD_NEK2_1	401	406	PF00069	0.522
MOD_NEK2_1	42	47	PF00069	0.531
MOD_NEK2_1	451	456	PF00069	0.471
MOD_NEK2_1	460	465	PF00069	0.544
MOD_NEK2_1	494	499	PF00069	0.518
MOD_NEK2_1	8	13	PF00069	0.613
MOD_NEK2_1	90	95	PF00069	0.574
MOD_NEK2_2	256	261	PF00069	0.535
MOD_PIKK_1	110	116	PF00454	0.614
MOD_PIKK_1	191	197	PF00454	0.479
MOD_PIKK_1	228	234	PF00454	0.454
MOD_PKA_1	489	495	PF00069	0.535
MOD_PKA_2	180	186	PF00069	0.438
MOD_PKA_2	197	203	PF00069	0.542
MOD_PKA_2	29	35	PF00069	0.610
MOD_PKA_2	469	475	PF00069	0.506
MOD_Plk_1	191	197	PF00069	0.479
MOD_Plk_1	214	220	PF00069	0.482
MOD_Plk_1	256	262	PF00069	0.455
MOD_Plk_4	304	310	PF00069	0.538
MOD_Plk_4	368	374	PF00069	0.394
MOD_Plk_4	436	442	PF00069	0.566
MOD_Plk_4	93	99	PF00069	0.498
MOD_ProDKin_1	19	25	PF00069	0.563
MOD_ProDKin_1	276	282	PF00069	0.552
MOD_SUMO_for_1	293	296	PF00179	0.586
TRG_ENDOCYTIC_2	139	142	PF00928	0.715
TRG_ENDOCYTIC_2	155	158	PF00928	0.390
TRG_ENDOCYTIC_2	310	313	PF00928	0.477
TRG_ER_diArg_1	23	25	PF00400	0.552
TRG_ER_diArg_1	334	336	PF00400	0.604
TRG_ER_diArg_1	46	48	PF00400	0.599
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P496	Leptomonas seymouri	41%	90%
A0A3S7WVY4	Leishmania donovani	83%	99%
E9AGU1	Leishmania infantum	83%	99%
Q4QCU7	Leishmania major	78%	100%