LeishMANIAdb
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DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF4379 domain-containing protein
Gene product:
conserved protein, unknown function
Species:
Leishmania mexicana
UniProt:
E9AUN3_LEIMU
TriTrypDb:
LmxM.20.0950
Length:
700

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUN3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUN3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 584 588 PF00656 0.531
CLV_NRD_NRD_1 229 231 PF00675 0.555
CLV_NRD_NRD_1 334 336 PF00675 0.743
CLV_NRD_NRD_1 364 366 PF00675 0.721
CLV_NRD_NRD_1 471 473 PF00675 0.683
CLV_NRD_NRD_1 554 556 PF00675 0.736
CLV_NRD_NRD_1 574 576 PF00675 0.710
CLV_NRD_NRD_1 607 609 PF00675 0.620
CLV_NRD_NRD_1 632 634 PF00675 0.645
CLV_NRD_NRD_1 639 641 PF00675 0.665
CLV_NRD_NRD_1 681 683 PF00675 0.639
CLV_NRD_NRD_1 688 690 PF00675 0.641
CLV_PCSK_FUR_1 637 641 PF00082 0.817
CLV_PCSK_FUR_1 686 690 PF00082 0.749
CLV_PCSK_KEX2_1 229 231 PF00082 0.555
CLV_PCSK_KEX2_1 334 336 PF00082 0.743
CLV_PCSK_KEX2_1 364 366 PF00082 0.683
CLV_PCSK_KEX2_1 471 473 PF00082 0.647
CLV_PCSK_KEX2_1 554 556 PF00082 0.736
CLV_PCSK_KEX2_1 574 576 PF00082 0.713
CLV_PCSK_KEX2_1 607 609 PF00082 0.618
CLV_PCSK_KEX2_1 632 634 PF00082 0.672
CLV_PCSK_KEX2_1 639 641 PF00082 0.697
CLV_PCSK_KEX2_1 688 690 PF00082 0.662
CLV_PCSK_KEX2_1 86 88 PF00082 0.265
CLV_PCSK_PC1ET2_1 86 88 PF00082 0.265
CLV_PCSK_PC7_1 570 576 PF00082 0.716
CLV_PCSK_SKI1_1 194 198 PF00082 0.577
CLV_PCSK_SKI1_1 323 327 PF00082 0.668
CLV_PCSK_SKI1_1 335 339 PF00082 0.670
CLV_PCSK_SKI1_1 349 353 PF00082 0.699
CLV_PCSK_SKI1_1 561 565 PF00082 0.492
DEG_APCC_DBOX_1 193 201 PF00400 0.622
DEG_APCC_DBOX_1 372 380 PF00400 0.716
DEG_COP1_1 51 60 PF00400 0.391
DEG_SCF_FBW7_1 484 491 PF00400 0.524
DEG_SPOP_SBC_1 602 606 PF00917 0.774
DOC_CKS1_1 485 490 PF01111 0.811
DOC_CKS1_1 678 683 PF01111 0.721
DOC_CYCLIN_RxL_1 320 329 PF00134 0.770
DOC_MAPK_DCC_7 239 247 PF00069 0.680
DOC_MAPK_gen_1 38 47 PF00069 0.621
DOC_MAPK_MEF2A_6 239 247 PF00069 0.742
DOC_MAPK_MEF2A_6 38 47 PF00069 0.633
DOC_PP1_RVXF_1 172 179 PF00149 0.568
DOC_PP2B_LxvP_1 643 646 PF13499 0.682
DOC_PP4_FxxP_1 196 199 PF00568 0.451
DOC_PP4_FxxP_1 252 255 PF00568 0.480
DOC_PP4_FxxP_1 675 678 PF00568 0.740
DOC_USP7_MATH_1 116 120 PF00917 0.700
DOC_USP7_MATH_1 122 126 PF00917 0.773
DOC_USP7_MATH_1 192 196 PF00917 0.661
DOC_USP7_MATH_1 269 273 PF00917 0.701
DOC_USP7_MATH_1 31 35 PF00917 0.726
DOC_USP7_MATH_1 310 314 PF00917 0.728
DOC_USP7_MATH_1 336 340 PF00917 0.734
DOC_USP7_MATH_1 392 396 PF00917 0.643
DOC_USP7_MATH_1 602 606 PF00917 0.757
DOC_USP7_MATH_1 625 629 PF00917 0.622
DOC_USP7_MATH_1 664 668 PF00917 0.785
DOC_WW_Pin1_4 186 191 PF00397 0.554
DOC_WW_Pin1_4 206 211 PF00397 0.595
DOC_WW_Pin1_4 326 331 PF00397 0.747
DOC_WW_Pin1_4 374 379 PF00397 0.775
DOC_WW_Pin1_4 472 477 PF00397 0.818
DOC_WW_Pin1_4 484 489 PF00397 0.743
DOC_WW_Pin1_4 641 646 PF00397 0.736
DOC_WW_Pin1_4 677 682 PF00397 0.699
LIG_14-3-3_CanoR_1 308 317 PF00244 0.674
LIG_14-3-3_CanoR_1 373 377 PF00244 0.601
LIG_14-3-3_CanoR_1 455 465 PF00244 0.696
LIG_14-3-3_CanoR_1 555 565 PF00244 0.722
LIG_14-3-3_CanoR_1 80 88 PF00244 0.480
LIG_Actin_WH2_2 439 457 PF00022 0.494
LIG_BRCT_BRCA1_1 248 252 PF00533 0.609
LIG_BRCT_BRCA1_1 671 675 PF00533 0.507
LIG_CSL_BTD_1 177 180 PF09270 0.624
LIG_FHA_1 10 16 PF00498 0.484
LIG_FHA_1 171 177 PF00498 0.499
LIG_FHA_1 345 351 PF00498 0.631
LIG_FHA_1 35 41 PF00498 0.719
LIG_FHA_1 375 381 PF00498 0.769
LIG_FHA_1 522 528 PF00498 0.666
LIG_FHA_1 614 620 PF00498 0.750
LIG_FHA_1 657 663 PF00498 0.592
LIG_FHA_1 72 78 PF00498 0.447
LIG_FHA_2 145 151 PF00498 0.593
LIG_FHA_2 394 400 PF00498 0.594
LIG_FHA_2 524 530 PF00498 0.751
LIG_LIR_Apic_2 195 199 PF02991 0.452
LIG_LIR_Apic_2 249 255 PF02991 0.479
LIG_LIR_Apic_2 672 678 PF02991 0.563
LIG_LIR_Gen_1 402 411 PF02991 0.677
LIG_LIR_Gen_1 595 602 PF02991 0.646
LIG_LIR_Nem_3 221 225 PF02991 0.601
LIG_LIR_Nem_3 402 408 PF02991 0.629
LIG_LIR_Nem_3 595 600 PF02991 0.643
LIG_Pex14_1 405 409 PF04695 0.598
LIG_SH2_NCK_1 205 209 PF00017 0.565
LIG_SH2_PTP2 421 424 PF00017 0.710
LIG_SH2_SRC 421 424 PF00017 0.710
LIG_SH2_STAT5 356 359 PF00017 0.644
LIG_SH2_STAT5 421 424 PF00017 0.660
LIG_SH2_STAT5 429 432 PF00017 0.655
LIG_SH3_2 678 683 PF14604 0.652
LIG_SH3_3 184 190 PF00018 0.622
LIG_SH3_3 33 39 PF00018 0.635
LIG_SH3_3 44 50 PF00018 0.493
LIG_SH3_3 467 473 PF00018 0.700
LIG_SH3_3 514 520 PF00018 0.802
LIG_SH3_3 675 681 PF00018 0.651
LIG_SUMO_SIM_anti_2 581 588 PF11976 0.434
LIG_SUMO_SIM_par_1 243 250 PF11976 0.704
LIG_TRAF2_1 209 212 PF00917 0.569
LIG_TRFH_1 641 645 PF08558 0.558
MOD_CDK_SPK_2 472 477 PF00069 0.740
MOD_CDK_SPK_2 677 682 PF00069 0.666
MOD_CDK_SPxK_1 677 683 PF00069 0.669
MOD_CDK_SPxxK_3 472 479 PF00069 0.805
MOD_CK1_1 166 172 PF00069 0.564
MOD_CK1_1 19 25 PF00069 0.743
MOD_CK1_1 272 278 PF00069 0.770
MOD_CK1_1 312 318 PF00069 0.718
MOD_CK1_1 329 335 PF00069 0.697
MOD_CK1_1 34 40 PF00069 0.746
MOD_CK1_1 386 392 PF00069 0.715
MOD_CK1_1 403 409 PF00069 0.477
MOD_CK1_1 459 465 PF00069 0.598
MOD_CK1_1 547 553 PF00069 0.655
MOD_CK1_1 573 579 PF00069 0.757
MOD_CK2_1 206 212 PF00069 0.549
MOD_CK2_1 366 372 PF00069 0.759
MOD_CK2_1 393 399 PF00069 0.721
MOD_CK2_1 436 442 PF00069 0.660
MOD_CK2_1 523 529 PF00069 0.709
MOD_CK2_1 595 601 PF00069 0.662
MOD_CK2_1 66 72 PF00069 0.491
MOD_DYRK1A_RPxSP_1 472 476 PF00069 0.799
MOD_GlcNHglycan 110 113 PF01048 0.687
MOD_GlcNHglycan 115 119 PF01048 0.728
MOD_GlcNHglycan 120 123 PF01048 0.728
MOD_GlcNHglycan 18 21 PF01048 0.560
MOD_GlcNHglycan 206 209 PF01048 0.588
MOD_GlcNHglycan 263 266 PF01048 0.678
MOD_GlcNHglycan 274 277 PF01048 0.582
MOD_GlcNHglycan 295 298 PF01048 0.679
MOD_GlcNHglycan 312 315 PF01048 0.727
MOD_GlcNHglycan 338 341 PF01048 0.690
MOD_GlcNHglycan 414 417 PF01048 0.559
MOD_GlcNHglycan 423 427 PF01048 0.535
MOD_GlcNHglycan 438 441 PF01048 0.715
MOD_GlcNHglycan 493 496 PF01048 0.694
MOD_GlcNHglycan 501 505 PF01048 0.732
MOD_GlcNHglycan 543 549 PF01048 0.741
MOD_GlcNHglycan 575 578 PF01048 0.740
MOD_GlcNHglycan 587 590 PF01048 0.649
MOD_GlcNHglycan 665 669 PF01048 0.734
MOD_GlcNHglycan 671 674 PF01048 0.725
MOD_GlcNHglycan 695 698 PF01048 0.720
MOD_GSK3_1 114 121 PF00069 0.692
MOD_GSK3_1 140 147 PF00069 0.569
MOD_GSK3_1 159 166 PF00069 0.367
MOD_GSK3_1 181 188 PF00069 0.661
MOD_GSK3_1 336 343 PF00069 0.647
MOD_GSK3_1 379 386 PF00069 0.716
MOD_GSK3_1 399 406 PF00069 0.687
MOD_GSK3_1 450 457 PF00069 0.797
MOD_GSK3_1 484 491 PF00069 0.603
MOD_GSK3_1 496 503 PF00069 0.662
MOD_GSK3_1 581 588 PF00069 0.661
MOD_GSK3_1 613 620 PF00069 0.750
MOD_GSK3_1 7 14 PF00069 0.516
MOD_N-GLC_1 159 164 PF02516 0.343
MOD_NEK2_1 144 149 PF00069 0.494
MOD_NEK2_1 383 388 PF00069 0.588
MOD_NEK2_1 454 459 PF00069 0.720
MOD_NEK2_1 521 526 PF00069 0.665
MOD_NEK2_1 585 590 PF00069 0.661
MOD_NEK2_1 623 628 PF00069 0.756
MOD_NEK2_2 344 349 PF00069 0.710
MOD_PIKK_1 381 387 PF00454 0.527
MOD_PIKK_1 456 462 PF00454 0.654
MOD_PKA_2 272 278 PF00069 0.742
MOD_PKA_2 293 299 PF00069 0.745
MOD_PKA_2 372 378 PF00069 0.597
MOD_PKA_2 454 460 PF00069 0.720
MOD_PKA_2 573 579 PF00069 0.517
MOD_PKA_2 631 637 PF00069 0.660
MOD_PKA_2 79 85 PF00069 0.482
MOD_Plk_1 441 447 PF00069 0.616
MOD_Plk_1 500 506 PF00069 0.733
MOD_Plk_1 71 77 PF00069 0.427
MOD_Plk_2-3 595 601 PF00069 0.700
MOD_Plk_4 159 165 PF00069 0.338
MOD_Plk_4 461 467 PF00069 0.791
MOD_Plk_4 581 587 PF00069 0.673
MOD_Plk_4 72 78 PF00069 0.441
MOD_ProDKin_1 186 192 PF00069 0.547
MOD_ProDKin_1 206 212 PF00069 0.593
MOD_ProDKin_1 326 332 PF00069 0.748
MOD_ProDKin_1 374 380 PF00069 0.774
MOD_ProDKin_1 472 478 PF00069 0.819
MOD_ProDKin_1 484 490 PF00069 0.745
MOD_ProDKin_1 641 647 PF00069 0.736
MOD_ProDKin_1 677 683 PF00069 0.702
MOD_SUMO_for_1 299 302 PF00179 0.595
MOD_SUMO_rev_2 442 451 PF00179 0.494
TRG_DiLeu_BaEn_1 72 77 PF01217 0.491
TRG_DiLeu_BaLyEn_6 220 225 PF01217 0.653
TRG_ENDOCYTIC_2 356 359 PF00928 0.534
TRG_ER_diArg_1 228 230 PF00400 0.561
TRG_ER_diArg_1 470 472 PF00400 0.674
TRG_ER_diArg_1 476 479 PF00400 0.677
TRG_ER_diArg_1 607 609 PF00400 0.574
TRG_ER_diArg_1 637 640 PF00400 0.727
TRG_ER_diArg_1 686 689 PF00400 0.703
TRG_Pf-PMV_PEXEL_1 223 227 PF00026 0.591

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYJ6 Leptomonas seymouri 36% 86%
A0A1X0NWB7 Trypanosomatidae 26% 98%
A0A3Q8IEV0 Leishmania donovani 87% 100%
A0A3R7M1N2 Trypanosoma rangeli 30% 100%
A4HYT7 Leishmania infantum 87% 100%
E9AIE6 Leishmania braziliensis 69% 100%
Q4QCV1 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS