PPIase cyclophilin-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 15, putative

Species:

Leishmania mexicana

UniProt:

E9AUN2_LEIMU

TriTrypDb:

LmxM.20.0940

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUN2

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018208	peptidyl-proline modification	6	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016859	cis-trans isomerase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.695
CLV_NRD_NRD_1	257	259	PF00675	0.754
CLV_NRD_NRD_1	320	322	PF00675	0.672
CLV_NRD_NRD_1	381	383	PF00675	0.524
CLV_NRD_NRD_1	391	393	PF00675	0.556
CLV_NRD_NRD_1	401	403	PF00675	0.473
CLV_PCSK_FUR_1	254	258	PF00082	0.750
CLV_PCSK_KEX2_1	183	185	PF00082	0.567
CLV_PCSK_KEX2_1	256	258	PF00082	0.740
CLV_PCSK_KEX2_1	318	320	PF00082	0.605
CLV_PCSK_KEX2_1	391	393	PF00082	0.587
CLV_PCSK_KEX2_1	401	403	PF00082	0.743
CLV_PCSK_KEX2_1	436	438	PF00082	0.642
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.588
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.605
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.784
CLV_PCSK_SKI1_1	271	275	PF00082	0.621
CLV_PCSK_SKI1_1	386	390	PF00082	0.631
CLV_PCSK_SKI1_1	98	102	PF00082	0.409
DEG_Nend_UBRbox_3	1	3	PF02207	0.385
DEG_SPOP_SBC_1	395	399	PF00917	0.744
DOC_CKS1_1	157	162	PF01111	0.599
DOC_CKS1_1	62	67	PF01111	0.533
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.539
DOC_MAPK_FxFP_2	7	10	PF00069	0.366
DOC_MAPK_gen_1	299	308	PF00069	0.431
DOC_MAPK_gen_1	83	92	PF00069	0.402
DOC_MAPK_HePTP_8	296	308	PF00069	0.428
DOC_MAPK_MEF2A_6	299	308	PF00069	0.431
DOC_PP2B_LxvP_1	140	143	PF13499	0.573
DOC_PP2B_LxvP_1	43	46	PF13499	0.530
DOC_PP4_FxxP_1	20	23	PF00568	0.411
DOC_PP4_FxxP_1	7	10	PF00568	0.366
DOC_USP7_MATH_1	125	129	PF00917	0.549
DOC_USP7_MATH_1	222	226	PF00917	0.719
DOC_USP7_MATH_1	23	27	PF00917	0.523
DOC_USP7_MATH_1	287	291	PF00917	0.731
DOC_USP7_MATH_1	313	317	PF00917	0.669
DOC_USP7_MATH_1	393	397	PF00917	0.726
DOC_USP7_MATH_1	419	423	PF00917	0.694
DOC_USP7_MATH_2	46	52	PF00917	0.464
DOC_USP7_UBL2_3	427	431	PF12436	0.770
DOC_USP7_UBL2_3	432	436	PF12436	0.678
DOC_WW_Pin1_4	156	161	PF00397	0.571
DOC_WW_Pin1_4	61	66	PF00397	0.555
LIG_14-3-3_CanoR_1	109	113	PF00244	0.554
LIG_14-3-3_CanoR_1	184	193	PF00244	0.592
LIG_14-3-3_CanoR_1	28	33	PF00244	0.391
LIG_14-3-3_CanoR_1	336	342	PF00244	0.704
LIG_Actin_WH2_2	168	185	PF00022	0.556
LIG_BRCT_BRCA1_1	289	293	PF00533	0.673
LIG_BRCT_BRCA1_1	296	300	PF00533	0.634
LIG_BRCT_BRCA1_1	421	425	PF00533	0.590
LIG_BRCT_BRCA1_1	5	9	PF00533	0.469
LIG_BRCT_BRCA1_2	289	295	PF00533	0.700
LIG_BRCT_BRCA1_2	296	302	PF00533	0.651
LIG_BRCT_BRCA1_2	421	427	PF00533	0.589
LIG_FHA_1	174	180	PF00498	0.469
LIG_FHA_1	335	341	PF00498	0.629
LIG_FHA_1	95	101	PF00498	0.388
LIG_FHA_2	156	162	PF00498	0.574
LIG_FHA_2	233	239	PF00498	0.602
LIG_FHA_2	54	60	PF00498	0.529
LIG_FHA_2	62	68	PF00498	0.473
LIG_LIR_Apic_2	19	23	PF02991	0.497
LIG_LIR_Apic_2	4	10	PF02991	0.364
LIG_LIR_Apic_2	59	65	PF02991	0.523
LIG_LIR_Gen_1	148	157	PF02991	0.378
LIG_LIR_Gen_1	165	172	PF02991	0.320
LIG_LIR_Gen_1	212	221	PF02991	0.471
LIG_LIR_Nem_3	134	140	PF02991	0.465
LIG_LIR_Nem_3	148	154	PF02991	0.304
LIG_LIR_Nem_3	165	169	PF02991	0.520
LIG_LIR_Nem_3	19	24	PF02991	0.474
LIG_LIR_Nem_3	212	216	PF02991	0.619
LIG_LIR_Nem_3	290	296	PF02991	0.635
LIG_LIR_Nem_3	99	104	PF02991	0.398
LIG_MLH1_MIPbox_1	290	294	PF16413	0.679
LIG_PTB_Apo_2	31	38	PF02174	0.351
LIG_REV1ctd_RIR_1	291	299	PF16727	0.713
LIG_REV1ctd_RIR_1	355	363	PF16727	0.638
LIG_SH2_CRK	137	141	PF00017	0.539
LIG_SH2_NCK_1	62	66	PF00017	0.532
LIG_SH2_PTP2	151	154	PF00017	0.411
LIG_SH2_STAT5	151	154	PF00017	0.411
LIG_SH2_STAT5	213	216	PF00017	0.545
LIG_SH3_1	241	247	PF00018	0.706
LIG_SH3_3	107	113	PF00018	0.496
LIG_SH3_3	154	160	PF00018	0.524
LIG_SH3_3	241	247	PF00018	0.706
LIG_TYR_ITIM	135	140	PF00017	0.519
LIG_TYR_ITIM	211	216	PF00017	0.609
MOD_CDK_SPxxK_3	156	163	PF00069	0.500
MOD_CK1_1	217	223	PF00069	0.708
MOD_CK1_1	396	402	PF00069	0.723
MOD_CK1_1	410	416	PF00069	0.593
MOD_CK1_1	94	100	PF00069	0.408
MOD_CK2_1	155	161	PF00069	0.538
MOD_CK2_1	53	59	PF00069	0.497
MOD_CK2_1	85	91	PF00069	0.505
MOD_GlcNHglycan	176	179	PF01048	0.444
MOD_GlcNHglycan	204	207	PF01048	0.416
MOD_GlcNHglycan	290	293	PF01048	0.648
MOD_GlcNHglycan	296	299	PF01048	0.606
MOD_GlcNHglycan	310	313	PF01048	0.720
MOD_GlcNHglycan	39	42	PF01048	0.501
MOD_GlcNHglycan	414	417	PF01048	0.719
MOD_GlcNHglycan	421	424	PF01048	0.730
MOD_GlcNHglycan	50	53	PF01048	0.354
MOD_GlcNHglycan	78	81	PF01048	0.427
MOD_GSK3_1	119	126	PF00069	0.582
MOD_GSK3_1	211	218	PF00069	0.561
MOD_GSK3_1	331	338	PF00069	0.628
MOD_GSK3_1	393	400	PF00069	0.727
MOD_GSK3_1	403	410	PF00069	0.670
MOD_GSK3_1	419	426	PF00069	0.661
MOD_GSK3_1	92	99	PF00069	0.396
MOD_NEK2_1	211	216	PF00069	0.571
MOD_NEK2_1	288	293	PF00069	0.630
MOD_NEK2_1	294	299	PF00069	0.567
MOD_NEK2_1	335	340	PF00069	0.624
MOD_NEK2_1	37	42	PF00069	0.395
MOD_NEK2_1	425	430	PF00069	0.763
MOD_NEK2_1	76	81	PF00069	0.411
MOD_PIKK_1	184	190	PF00454	0.588
MOD_PIKK_1	23	29	PF00454	0.427
MOD_PK_1	119	125	PF00069	0.596
MOD_PKA_2	108	114	PF00069	0.558
MOD_PKA_2	242	248	PF00069	0.774
MOD_PKA_2	335	341	PF00069	0.616
MOD_Plk_1	211	217	PF00069	0.532
MOD_Plk_1	3	9	PF00069	0.473
MOD_Plk_2-3	85	91	PF00069	0.516
MOD_Plk_4	131	137	PF00069	0.421
MOD_Plk_4	16	22	PF00069	0.490
MOD_Plk_4	3	9	PF00069	0.470
MOD_Plk_4	85	91	PF00069	0.455
MOD_Plk_4	96	102	PF00069	0.340
MOD_ProDKin_1	156	162	PF00069	0.570
MOD_ProDKin_1	61	67	PF00069	0.556
MOD_SUMO_rev_2	177	185	PF00179	0.549
MOD_SUMO_rev_2	66	71	PF00179	0.391
TRG_ENDOCYTIC_2	137	140	PF00928	0.482
TRG_ENDOCYTIC_2	150	153	PF00928	0.332
TRG_ENDOCYTIC_2	213	216	PF00928	0.618
TRG_ER_diArg_1	254	257	PF00400	0.685
TRG_ER_diArg_1	319	321	PF00400	0.742
TRG_ER_diLys_1	434	438	PF00400	0.580
TRG_NLS_Bipartite_1	183	203	PF00514	0.590
TRG_NLS_MonoCore_2	317	322	PF00514	0.672
TRG_NLS_MonoExtC_3	317	323	PF00514	0.611
TRG_NLS_MonoExtC_3	430	435	PF00514	0.743
TRG_NLS_MonoExtN_4	198	203	PF00514	0.577
TRG_NLS_MonoExtN_4	315	322	PF00514	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC45	Leptomonas seymouri	58%	100%
A0A0S4KRJ3	Bodo saltans	32%	100%
A0A1X0NWC9	Trypanosomatidae	33%	100%
A0A3S7WVY2	Leishmania donovani	86%	100%
A0A422NPI7	Trypanosoma rangeli	36%	100%
A4HYT6	Leishmania infantum	87%	95%
C9ZIB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AIE5	Leishmania braziliensis	72%	98%
Q4QCV2	Leishmania major	87%	100%
V5DRZ7	Trypanosoma cruzi	37%	100%