AATF-Che1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AATF protein, putative

Species:

Leishmania mexicana

UniProt:

E9AUN0_LEIMU

TriTrypDb:

LmxM.20.0920

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	7
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9AUN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUN0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.792
CLV_C14_Caspase3-7	234	238	PF00656	0.554
CLV_C14_Caspase3-7	50	54	PF00656	0.747
CLV_NRD_NRD_1	18	20	PF00675	0.656
CLV_NRD_NRD_1	191	193	PF00675	0.556
CLV_NRD_NRD_1	195	197	PF00675	0.514
CLV_NRD_NRD_1	223	225	PF00675	0.612
CLV_NRD_NRD_1	399	401	PF00675	0.340
CLV_NRD_NRD_1	527	529	PF00675	0.371
CLV_NRD_NRD_1	554	556	PF00675	0.396
CLV_NRD_NRD_1	92	94	PF00675	0.518
CLV_PCSK_FUR_1	192	196	PF00082	0.663
CLV_PCSK_KEX2_1	193	195	PF00082	0.555
CLV_PCSK_KEX2_1	223	225	PF00082	0.584
CLV_PCSK_KEX2_1	527	529	PF00082	0.292
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.536
CLV_PCSK_PC7_1	523	529	PF00082	0.292
CLV_PCSK_SKI1_1	195	199	PF00082	0.643
CLV_PCSK_SKI1_1	307	311	PF00082	0.398
CLV_PCSK_SKI1_1	326	330	PF00082	0.193
CLV_PCSK_SKI1_1	33	37	PF00082	0.740
CLV_PCSK_SKI1_1	403	407	PF00082	0.357
CLV_PCSK_SKI1_1	538	542	PF00082	0.452
CLV_PCSK_SKI1_1	595	599	PF00082	0.337
CLV_Separin_Metazoa	524	528	PF03568	0.371
DOC_CYCLIN_RxL_1	323	333	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	222	228	PF00134	0.638
DOC_MAPK_gen_1	403	413	PF00069	0.357
DOC_MAPK_gen_1	473	483	PF00069	0.466
DOC_MAPK_MEF2A_6	406	415	PF00069	0.383
DOC_PP1_RVXF_1	222	229	PF00149	0.544
DOC_PP1_RVXF_1	572	579	PF00149	0.292
DOC_PP2B_LxvP_1	411	414	PF13499	0.357
DOC_PP4_FxxP_1	578	581	PF00568	0.312
DOC_USP7_MATH_1	104	108	PF00917	0.744
DOC_USP7_MATH_1	184	188	PF00917	0.507
DOC_USP7_MATH_1	341	345	PF00917	0.436
DOC_USP7_MATH_1	381	385	PF00917	0.491
DOC_USP7_MATH_1	399	403	PF00917	0.433
DOC_USP7_MATH_1	492	496	PF00917	0.533
DOC_USP7_MATH_1	531	535	PF00917	0.357
DOC_USP7_UBL2_3	17	21	PF12436	0.480
DOC_USP7_UBL2_3	90	94	PF12436	0.776
DOC_WW_Pin1_4	124	129	PF00397	0.533
LIG_14-3-3_CanoR_1	19	24	PF00244	0.573
LIG_14-3-3_CanoR_1	223	229	PF00244	0.697
LIG_14-3-3_CanoR_1	255	263	PF00244	0.592
LIG_Actin_WH2_2	412	430	PF00022	0.232
LIG_APCC_ABBA_1	413	418	PF00400	0.232
LIG_BRCT_BRCA1_1	66	70	PF00533	0.658
LIG_eIF4E_1	323	329	PF01652	0.419
LIG_eIF4E_1	436	442	PF01652	0.337
LIG_FHA_1	204	210	PF00498	0.602
LIG_FHA_1	287	293	PF00498	0.529
LIG_FHA_1	313	319	PF00498	0.434
LIG_FHA_1	543	549	PF00498	0.390
LIG_FHA_2	199	205	PF00498	0.553
LIG_FHA_2	24	30	PF00498	0.577
LIG_FHA_2	405	411	PF00498	0.425
LIG_FHA_2	430	436	PF00498	0.357
LIG_FHA_2	492	498	PF00498	0.608
LIG_FXI_DFP_1	62	66	PF00024	0.456
LIG_LIR_Gen_1	360	370	PF02991	0.411
LIG_LIR_Gen_1	59	70	PF02991	0.666
LIG_LIR_Nem_3	136	142	PF02991	0.530
LIG_LIR_Nem_3	360	366	PF02991	0.386
LIG_LIR_Nem_3	59	65	PF02991	0.634
LIG_NRBOX	305	311	PF00104	0.400
LIG_PCNA_yPIPBox_3	361	374	PF02747	0.423
LIG_SH2_CRK	300	304	PF00017	0.313
LIG_SH2_NCK_1	378	382	PF00017	0.395
LIG_SH2_NCK_1	516	520	PF00017	0.493
LIG_SH2_SRC	51	54	PF00017	0.713
LIG_SH2_SRC	516	519	PF00017	0.475
LIG_SH2_STAP1	205	209	PF00017	0.573
LIG_SH2_STAP1	324	328	PF00017	0.307
LIG_SH2_STAT5	205	208	PF00017	0.465
LIG_SUMO_SIM_anti_2	479	485	PF11976	0.480
LIG_TRAF2_1	162	165	PF00917	0.631
LIG_TRAF2_1	201	204	PF00917	0.610
MOD_CK1_1	102	108	PF00069	0.743
MOD_CK1_1	12	18	PF00069	0.687
MOD_CK1_1	227	233	PF00069	0.509
MOD_CK1_1	281	287	PF00069	0.592
MOD_CK1_1	465	471	PF00069	0.645
MOD_CK2_1	115	121	PF00069	0.585
MOD_CK2_1	19	25	PF00069	0.638
MOD_CK2_1	198	204	PF00069	0.563
MOD_CK2_1	5	11	PF00069	0.749
MOD_CK2_1	531	537	PF00069	0.413
MOD_GlcNHglycan	102	105	PF01048	0.624
MOD_GlcNHglycan	186	189	PF01048	0.545
MOD_GlcNHglycan	229	232	PF01048	0.608
MOD_GlcNHglycan	268	271	PF01048	0.668
MOD_GlcNHglycan	280	283	PF01048	0.647
MOD_GlcNHglycan	33	36	PF01048	0.584
MOD_GlcNHglycan	383	386	PF01048	0.404
MOD_GlcNHglycan	397	400	PF01048	0.480
MOD_GlcNHglycan	445	448	PF01048	0.573
MOD_GlcNHglycan	464	467	PF01048	0.533
MOD_GlcNHglycan	493	497	PF01048	0.512
MOD_GlcNHglycan	7	10	PF01048	0.592
MOD_GlcNHglycan	86	89	PF01048	0.721
MOD_GSK3_1	184	191	PF00069	0.477
MOD_GSK3_1	19	26	PF00069	0.616
MOD_GSK3_1	266	273	PF00069	0.637
MOD_GSK3_1	312	319	PF00069	0.402
MOD_GSK3_1	395	402	PF00069	0.442
MOD_GSK3_1	465	472	PF00069	0.554
MOD_GSK3_1	5	12	PF00069	0.643
MOD_GSK3_1	77	84	PF00069	0.755
MOD_GSK3_1	99	106	PF00069	0.708
MOD_LATS_1	489	495	PF00433	0.603
MOD_N-GLC_1	210	215	PF02516	0.510
MOD_N-GLC_1	4	9	PF02516	0.699
MOD_N-GLC_1	476	481	PF02516	0.515
MOD_NEK2_1	115	120	PF00069	0.517
MOD_NEK2_1	23	28	PF00069	0.453
MOD_NEK2_1	254	259	PF00069	0.581
MOD_NEK2_1	31	36	PF00069	0.593
MOD_NEK2_1	395	400	PF00069	0.215
MOD_NEK2_1	4	9	PF00069	0.650
MOD_NEK2_2	324	329	PF00069	0.437
MOD_PIKK_1	254	260	PF00454	0.537
MOD_PIKK_1	531	537	PF00454	0.481
MOD_PKA_1	19	25	PF00069	0.540
MOD_PKA_2	254	260	PF00069	0.568
MOD_PKA_2	399	405	PF00069	0.379
MOD_PKA_2	559	565	PF00069	0.286
MOD_PKA_2	77	83	PF00069	0.811
MOD_PKA_2	9	15	PF00069	0.650
MOD_Plk_1	115	121	PF00069	0.535
MOD_Plk_1	203	209	PF00069	0.604
MOD_Plk_1	409	415	PF00069	0.245
MOD_Plk_1	476	482	PF00069	0.501
MOD_Plk_4	373	379	PF00069	0.379
MOD_Plk_4	9	15	PF00069	0.712
MOD_ProDKin_1	124	130	PF00069	0.529
MOD_SUMO_for_1	405	408	PF00179	0.432
MOD_SUMO_rev_2	116	125	PF00179	0.663
MOD_SUMO_rev_2	204	214	PF00179	0.603
MOD_SUMO_rev_2	281	289	PF00179	0.633
MOD_SUMO_rev_2	493	500	PF00179	0.486
MOD_SUMO_rev_2	534	540	PF00179	0.357
TRG_DiLeu_BaEn_4	243	249	PF01217	0.533
TRG_ENDOCYTIC_2	300	303	PF00928	0.326
TRG_ENDOCYTIC_2	363	366	PF00928	0.419
TRG_ENDOCYTIC_2	416	419	PF00928	0.371
TRG_ENDOCYTIC_2	62	65	PF00928	0.566
TRG_ER_diArg_1	109	112	PF00400	0.651
TRG_ER_diArg_1	192	195	PF00400	0.616
TRG_ER_diArg_1	222	224	PF00400	0.612
TRG_ER_diArg_1	304	307	PF00400	0.314
TRG_ER_diArg_1	526	528	PF00400	0.371
TRG_NLS_MonoCore_2	191	196	PF00514	0.562
TRG_NLS_MonoCore_2	89	94	PF00514	0.519
TRG_NLS_MonoExtC_3	191	196	PF00514	0.585
TRG_NLS_MonoExtC_3	399	404	PF00514	0.424
TRG_NLS_MonoExtC_3	89	94	PF00514	0.501
TRG_NLS_MonoExtN_4	17	23	PF00514	0.575
TRG_NLS_MonoExtN_4	192	197	PF00514	0.553
TRG_NLS_MonoExtN_4	400	407	PF00514	0.348
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	326	331	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P4	Leptomonas seymouri	63%	99%
A0A0S4JJ09	Bodo saltans	30%	100%
A0A1X0NXQ8	Trypanosomatidae	38%	100%
A0A3Q8IA20	Leishmania donovani	89%	100%
A0A3R7KQ11	Trypanosoma rangeli	40%	100%
A4HYT4	Leishmania infantum	89%	85%
C9ZIB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AIE3	Leishmania braziliensis	79%	100%
Q4QCV4	Leishmania major	90%	99%
V5BQR9	Trypanosoma cruzi	37%	100%