ERCC4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUM9_LEIMU

TriTrypDb:

LmxM.20.0910

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.625
CLV_MEL_PAP_1	30	36	PF00089	0.422
CLV_NRD_NRD_1	232	234	PF00675	0.554
CLV_NRD_NRD_1	262	264	PF00675	0.512
CLV_NRD_NRD_1	75	77	PF00675	0.482
CLV_PCSK_KEX2_1	103	105	PF00082	0.685
CLV_PCSK_KEX2_1	232	234	PF00082	0.537
CLV_PCSK_KEX2_1	75	77	PF00082	0.482
CLV_PCSK_KEX2_1	84	86	PF00082	0.407
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.685
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.537
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.500
CLV_PCSK_SKI1_1	81	85	PF00082	0.481
DEG_SPOP_SBC_1	164	168	PF00917	0.695
DEG_SPOP_SBC_1	242	246	PF00917	0.649
DOC_ANK_TNKS_1	183	190	PF00023	0.552
DOC_MAPK_gen_1	229	239	PF00069	0.514
DOC_MAPK_MEF2A_6	232	241	PF00069	0.514
DOC_MAPK_MEF2A_6	55	62	PF00069	0.521
DOC_USP7_MATH_1	137	141	PF00917	0.720
DOC_USP7_MATH_1	163	167	PF00917	0.749
DOC_USP7_MATH_1	170	174	PF00917	0.744
DOC_USP7_MATH_1	242	246	PF00917	0.722
DOC_USP7_MATH_1	7	11	PF00917	0.486
DOC_USP7_UBL2_3	108	112	PF12436	0.348
DOC_WW_Pin1_4	107	112	PF00397	0.535
DOC_WW_Pin1_4	166	171	PF00397	0.646
LIG_14-3-3_CanoR_1	172	181	PF00244	0.545
LIG_14-3-3_CanoR_1	31	40	PF00244	0.492
LIG_CtBP_PxDLS_1	189	194	PF00389	0.514
LIG_FHA_1	111	117	PF00498	0.534
LIG_FHA_1	253	259	PF00498	0.790
LIG_FHA_1	89	95	PF00498	0.419
LIG_FHA_2	134	140	PF00498	0.574
LIG_FHA_2	62	68	PF00498	0.319
LIG_LIR_Gen_1	26	34	PF02991	0.524
LIG_LIR_Nem_3	26	30	PF02991	0.523
LIG_SH2_CRK	80	84	PF00017	0.517
LIG_SH2_STAT5	24	27	PF00017	0.450
LIG_SH2_STAT5	78	81	PF00017	0.530
LIG_SH3_3	236	242	PF00018	0.512
LIG_SUMO_SIM_par_1	13	19	PF11976	0.365
LIG_SUMO_SIM_par_1	58	65	PF11976	0.497
LIG_WRC_WIRS_1	24	29	PF05994	0.464
MOD_CDC14_SPxK_1	169	172	PF00782	0.648
MOD_CDK_SPK_2	107	112	PF00069	0.354
MOD_CDK_SPxK_1	166	172	PF00069	0.648
MOD_CK1_1	107	113	PF00069	0.535
MOD_CK1_1	141	147	PF00069	0.614
MOD_CK1_1	166	172	PF00069	0.735
MOD_CK1_1	193	199	PF00069	0.537
MOD_CK1_1	243	249	PF00069	0.678
MOD_CK1_1	253	259	PF00069	0.488
MOD_CK1_1	61	67	PF00069	0.504
MOD_CK2_1	141	147	PF00069	0.682
MOD_CK2_1	253	259	PF00069	0.621
MOD_CK2_1	61	67	PF00069	0.322
MOD_CK2_1	7	13	PF00069	0.510
MOD_Cter_Amidation	230	233	PF01082	0.510
MOD_GlcNHglycan	158	161	PF01048	0.709
MOD_GlcNHglycan	172	175	PF01048	0.564
MOD_GlcNHglycan	252	255	PF01048	0.755
MOD_GlcNHglycan	3	6	PF01048	0.635
MOD_GlcNHglycan	9	12	PF01048	0.535
MOD_GSK3_1	133	140	PF00069	0.689
MOD_GSK3_1	164	171	PF00069	0.663
MOD_GSK3_1	190	197	PF00069	0.568
MOD_GSK3_1	211	218	PF00069	0.659
MOD_GSK3_1	240	247	PF00069	0.716
MOD_GSK3_1	32	39	PF00069	0.574
MOD_N-GLC_1	116	121	PF02516	0.477
MOD_NEK2_1	116	121	PF00069	0.526
MOD_NEK2_1	211	216	PF00069	0.667
MOD_NEK2_1	25	30	PF00069	0.575
MOD_NEK2_1	88	93	PF00069	0.413
MOD_PIKK_1	211	217	PF00454	0.663
MOD_PIKK_1	224	230	PF00454	0.553
MOD_PIKK_1	68	74	PF00454	0.472
MOD_PKA_2	121	127	PF00069	0.588
MOD_PKA_2	32	38	PF00069	0.437
MOD_Plk_1	116	122	PF00069	0.486
MOD_Plk_1	40	46	PF00069	0.447
MOD_Plk_4	116	122	PF00069	0.534
MOD_Plk_4	58	64	PF00069	0.495
MOD_ProDKin_1	107	113	PF00069	0.535
MOD_ProDKin_1	166	172	PF00069	0.648
MOD_SUMO_for_1	83	86	PF00179	0.489
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.464
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.534
TRG_ENDOCYTIC_2	24	27	PF00928	0.450
TRG_ENDOCYTIC_2	80	83	PF00928	0.513
TRG_ER_diArg_1	29	32	PF00400	0.468
TRG_ER_diArg_1	75	77	PF00400	0.482
TRG_ER_diArg_1	94	97	PF00400	0.550
TRG_NLS_MonoExtN_4	229	236	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBK6	Leishmania donovani	78%	95%
A4HYT3	Leishmania infantum	78%	95%
E9AIE2	Leishmania braziliensis	62%	95%
Q4QCV5	Leishmania major	77%	100%