Putative RNA editing complex protein MP90

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-editing nuclease 1

Species:

Leishmania mexicana

UniProt:

E9AUM8_LEIMU

TriTrypDb:

LmxM.20.0900

Length:

895

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUM8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004521	RNA endonuclease activity	5	7
GO:0004525	ribonuclease III activity	6	7
GO:0004540	RNA nuclease activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	7
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	7
GO:0032296	double-stranded RNA-specific ribonuclease activity	5	7
GO:0140098	catalytic activity, acting on RNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	520	524	PF00656	0.739
CLV_C14_Caspase3-7	90	94	PF00656	0.638
CLV_NRD_NRD_1	255	257	PF00675	0.547
CLV_NRD_NRD_1	3	5	PF00675	0.864
CLV_NRD_NRD_1	693	695	PF00675	0.763
CLV_PCSK_FUR_1	253	257	PF00082	0.558
CLV_PCSK_KEX2_1	214	216	PF00082	0.478
CLV_PCSK_KEX2_1	253	255	PF00082	0.567
CLV_PCSK_KEX2_1	3	5	PF00082	0.864
CLV_PCSK_KEX2_1	412	414	PF00082	0.621
CLV_PCSK_KEX2_1	426	428	PF00082	0.603
CLV_PCSK_KEX2_1	693	695	PF00082	0.763
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.478
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.621
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.603
CLV_PCSK_SKI1_1	203	207	PF00082	0.616
CLV_PCSK_SKI1_1	224	228	PF00082	0.601
CLV_PCSK_SKI1_1	256	260	PF00082	0.620
CLV_PCSK_SKI1_1	277	281	PF00082	0.574
CLV_PCSK_SKI1_1	458	462	PF00082	0.729
CLV_PCSK_SKI1_1	591	595	PF00082	0.786
CLV_PCSK_SKI1_1	693	697	PF00082	0.685
CLV_PCSK_SKI1_1	707	711	PF00082	0.628
CLV_PCSK_SKI1_1	798	802	PF00082	0.663
CLV_PCSK_SKI1_1	867	871	PF00082	0.629
DEG_APCC_DBOX_1	692	700	PF00400	0.678
DEG_SCF_FBW7_1	747	754	PF00400	0.835
DEG_SCF_TRCP1_1	93	98	PF00400	0.556
DEG_SPOP_SBC_1	530	534	PF00917	0.552
DEG_SPOP_SBC_1	66	70	PF00917	0.773
DOC_ANK_TNKS_1	838	845	PF00023	0.674
DOC_CDC14_PxL_1	352	360	PF14671	0.700
DOC_CDC14_PxL_1	586	594	PF14671	0.683
DOC_CKS1_1	398	403	PF01111	0.292
DOC_CKS1_1	566	571	PF01111	0.707
DOC_CKS1_1	593	598	PF01111	0.696
DOC_CKS1_1	678	683	PF01111	0.504
DOC_CYCLIN_RxL_1	602	613	PF00134	0.719
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.299
DOC_MAPK_DCC_7	601	609	PF00069	0.440
DOC_MAPK_FxFP_2	50	53	PF00069	0.692
DOC_MAPK_gen_1	224	234	PF00069	0.543
DOC_MAPK_gen_1	253	259	PF00069	0.620
DOC_MAPK_gen_1	554	562	PF00069	0.733
DOC_MAPK_MEF2A_6	227	236	PF00069	0.565
DOC_MAPK_MEF2A_6	300	309	PF00069	0.481
DOC_MAPK_MEF2A_6	396	405	PF00069	0.302
DOC_PP1_RVXF_1	253	260	PF00149	0.639
DOC_PP1_RVXF_1	30	36	PF00149	0.779
DOC_PP4_FxxP_1	194	197	PF00568	0.521
DOC_PP4_FxxP_1	35	38	PF00568	0.709
DOC_PP4_FxxP_1	421	424	PF00568	0.777
DOC_PP4_FxxP_1	468	471	PF00568	0.619
DOC_PP4_FxxP_1	50	53	PF00568	0.444
DOC_PP4_FxxP_1	566	569	PF00568	0.708
DOC_PP4_FxxP_1	593	596	PF00568	0.687
DOC_USP7_MATH_1	13	17	PF00917	0.833
DOC_USP7_MATH_1	38	42	PF00917	0.627
DOC_USP7_MATH_1	444	448	PF00917	0.756
DOC_USP7_MATH_1	478	482	PF00917	0.794
DOC_USP7_MATH_1	517	521	PF00917	0.698
DOC_USP7_MATH_1	529	533	PF00917	0.770
DOC_USP7_MATH_1	614	618	PF00917	0.636
DOC_USP7_MATH_1	67	71	PF00917	0.740
DOC_USP7_MATH_1	721	725	PF00917	0.767
DOC_USP7_MATH_1	749	753	PF00917	0.644
DOC_USP7_MATH_1	838	842	PF00917	0.766
DOC_USP7_MATH_1	855	859	PF00917	0.593
DOC_WW_Pin1_4	2	7	PF00397	0.769
DOC_WW_Pin1_4	397	402	PF00397	0.296
DOC_WW_Pin1_4	489	494	PF00397	0.811
DOC_WW_Pin1_4	560	565	PF00397	0.695
DOC_WW_Pin1_4	57	62	PF00397	0.653
DOC_WW_Pin1_4	592	597	PF00397	0.691
DOC_WW_Pin1_4	651	656	PF00397	0.759
DOC_WW_Pin1_4	677	682	PF00397	0.562
DOC_WW_Pin1_4	713	718	PF00397	0.671
DOC_WW_Pin1_4	726	731	PF00397	0.739
DOC_WW_Pin1_4	747	752	PF00397	0.721
DOC_WW_Pin1_4	777	782	PF00397	0.489
DOC_WW_Pin1_4	827	832	PF00397	0.747
DOC_WW_Pin1_4	851	856	PF00397	0.828
LIG_14-3-3_CanoR_1	148	154	PF00244	0.690
LIG_14-3-3_CanoR_1	158	163	PF00244	0.496
LIG_14-3-3_CanoR_1	201	206	PF00244	0.501
LIG_14-3-3_CanoR_1	292	297	PF00244	0.633
LIG_14-3-3_CanoR_1	591	596	PF00244	0.787
LIG_14-3-3_CanoR_1	694	700	PF00244	0.739
LIG_14-3-3_CanoR_1	874	881	PF00244	0.664
LIG_Actin_WH2_2	379	395	PF00022	0.545
LIG_APCC_ABBA_1	279	284	PF00400	0.503
LIG_BRCT_BRCA1_1	129	133	PF00533	0.672
LIG_BRCT_BRCA1_1	562	566	PF00533	0.798
LIG_BRCT_BRCA1_1	625	629	PF00533	0.700
LIG_CtBP_PxDLS_1	569	573	PF00389	0.703
LIG_deltaCOP1_diTrp_1	871	875	PF00928	0.451
LIG_EH1_1	179	187	PF00400	0.488
LIG_eIF4E_1	636	642	PF01652	0.594
LIG_EVH1_2	8	12	PF00568	0.831
LIG_FHA_1	102	108	PF00498	0.851
LIG_FHA_1	112	118	PF00498	0.657
LIG_FHA_1	169	175	PF00498	0.485
LIG_FHA_1	240	246	PF00498	0.621
LIG_FHA_1	293	299	PF00498	0.615
LIG_FHA_1	313	319	PF00498	0.420
LIG_FHA_1	398	404	PF00498	0.591
LIG_FHA_1	428	434	PF00498	0.526
LIG_FHA_1	513	519	PF00498	0.588
LIG_FHA_1	581	587	PF00498	0.678
LIG_FHA_1	593	599	PF00498	0.703
LIG_FHA_1	821	827	PF00498	0.755
LIG_FHA_2	150	156	PF00498	0.710
LIG_FHA_2	481	487	PF00498	0.712
LIG_FHA_2	548	554	PF00498	0.594
LIG_FHA_2	622	628	PF00498	0.635
LIG_FHA_2	752	758	PF00498	0.830
LIG_FHA_2	817	823	PF00498	0.733
LIG_GBD_Chelix_1	339	347	PF00786	0.546
LIG_LIR_Apic_2	191	197	PF02991	0.487
LIG_LIR_Apic_2	418	424	PF02991	0.760
LIG_LIR_Apic_2	467	471	PF02991	0.610
LIG_LIR_Apic_2	49	53	PF02991	0.691
LIG_LIR_Apic_2	563	569	PF02991	0.712
LIG_LIR_Apic_2	776	781	PF02991	0.673
LIG_LIR_Gen_1	130	141	PF02991	0.535
LIG_LIR_Gen_1	187	197	PF02991	0.584
LIG_LIR_Gen_1	294	302	PF02991	0.504
LIG_LIR_Gen_1	310	321	PF02991	0.477
LIG_LIR_Gen_1	384	395	PF02991	0.441
LIG_LIR_Gen_1	626	636	PF02991	0.588
LIG_LIR_Nem_3	130	136	PF02991	0.536
LIG_LIR_Nem_3	187	192	PF02991	0.583
LIG_LIR_Nem_3	294	299	PF02991	0.512
LIG_LIR_Nem_3	310	316	PF02991	0.472
LIG_LIR_Nem_3	317	322	PF02991	0.483
LIG_LIR_Nem_3	341	347	PF02991	0.545
LIG_LIR_Nem_3	384	390	PF02991	0.434
LIG_LIR_Nem_3	635	639	PF02991	0.637
LIG_LIR_Nem_3	708	713	PF02991	0.551
LIG_NRBOX	317	323	PF00104	0.591
LIG_OCRL_FandH_1	343	355	PF00620	0.595
LIG_Rb_pABgroove_1	381	389	PF01858	0.433
LIG_Rb_pABgroove_1	483	491	PF01858	0.805
LIG_SH2_CRK	352	356	PF00017	0.659
LIG_SH2_CRK	387	391	PF00017	0.437
LIG_SH2_NCK_1	89	93	PF00017	0.748
LIG_SH2_PTP2	778	781	PF00017	0.775
LIG_SH2_SRC	20	23	PF00017	0.724
LIG_SH2_SRC	89	92	PF00017	0.747
LIG_SH2_STAP1	387	391	PF00017	0.437
LIG_SH2_STAP1	862	866	PF00017	0.634
LIG_SH2_STAT3	282	285	PF00017	0.516
LIG_SH2_STAT5	264	267	PF00017	0.494
LIG_SH2_STAT5	364	367	PF00017	0.720
LIG_SH2_STAT5	620	623	PF00017	0.624
LIG_SH2_STAT5	651	654	PF00017	0.673
LIG_SH2_STAT5	705	708	PF00017	0.633
LIG_SH2_STAT5	778	781	PF00017	0.775
LIG_SH3_1	3	9	PF00018	0.850
LIG_SH3_1	584	590	PF00018	0.683
LIG_SH3_3	157	163	PF00018	0.665
LIG_SH3_3	194	200	PF00018	0.501
LIG_SH3_3	3	9	PF00018	0.814
LIG_SH3_3	398	404	PF00018	0.299
LIG_SH3_3	558	564	PF00018	0.721
LIG_SH3_3	584	590	PF00018	0.683
LIG_SH3_3	600	606	PF00018	0.647
LIG_SH3_3	649	655	PF00018	0.693
LIG_SH3_3	675	681	PF00018	0.696
LIG_SH3_3	714	720	PF00018	0.784
LIG_SH3_3	828	834	PF00018	0.745
LIG_SUMO_SIM_anti_2	170	176	PF11976	0.487
LIG_SUMO_SIM_anti_2	388	393	PF11976	0.444
LIG_SUMO_SIM_par_1	374	380	PF11976	0.606
LIG_SUMO_SIM_par_1	567	573	PF11976	0.699
LIG_SxIP_EBH_1	608	621	PF03271	0.708
LIG_UBA3_1	222	228	PF00899	0.485
LIG_UBA3_1	389	393	PF00899	0.548
LIG_WRC_WIRS_1	881	886	PF05994	0.492
LIG_WW_3	27	31	PF00397	0.813
MOD_CDK_SPxK_1	747	753	PF00069	0.756
MOD_CDK_SPxxK_3	777	784	PF00069	0.488
MOD_CK1_1	149	155	PF00069	0.589
MOD_CK1_1	247	253	PF00069	0.557
MOD_CK1_1	294	300	PF00069	0.560
MOD_CK1_1	481	487	PF00069	0.733
MOD_CK1_1	492	498	PF00069	0.798
MOD_CK1_1	57	63	PF00069	0.715
MOD_CK1_1	68	74	PF00069	0.802
MOD_CK1_1	716	722	PF00069	0.639
MOD_CK1_1	731	737	PF00069	0.659
MOD_CK1_1	769	775	PF00069	0.751
MOD_CK1_1	77	83	PF00069	0.593
MOD_CK1_1	827	833	PF00069	0.762
MOD_CK1_1	877	883	PF00069	0.666
MOD_CK1_1	885	891	PF00069	0.687
MOD_CK2_1	480	486	PF00069	0.706
MOD_CK2_1	531	537	PF00069	0.599
MOD_CK2_1	547	553	PF00069	0.567
MOD_CK2_1	695	701	PF00069	0.584
MOD_CK2_1	837	843	PF00069	0.830
MOD_DYRK1A_RPxSP_1	4	8	PF00069	0.772
MOD_GlcNHglycan	117	120	PF01048	0.707
MOD_GlcNHglycan	446	449	PF01048	0.735
MOD_GlcNHglycan	450	453	PF01048	0.705
MOD_GlcNHglycan	507	511	PF01048	0.823
MOD_GlcNHglycan	533	536	PF01048	0.740
MOD_GlcNHglycan	574	577	PF01048	0.781
MOD_GlcNHglycan	612	615	PF01048	0.623
MOD_GlcNHglycan	688	691	PF01048	0.760
MOD_GlcNHglycan	747	750	PF01048	0.808
MOD_GlcNHglycan	76	79	PF01048	0.683
MOD_GlcNHglycan	768	771	PF01048	0.749
MOD_GlcNHglycan	826	829	PF01048	0.723
MOD_GlcNHglycan	840	843	PF01048	0.739
MOD_GlcNHglycan	857	860	PF01048	0.553
MOD_GlcNHglycan	884	887	PF01048	0.714
MOD_GlcNHglycan	93	96	PF01048	0.666
MOD_GSK3_1	111	118	PF00069	0.736
MOD_GSK3_1	123	130	PF00069	0.753
MOD_GSK3_1	235	242	PF00069	0.572
MOD_GSK3_1	287	294	PF00069	0.583
MOD_GSK3_1	321	328	PF00069	0.574
MOD_GSK3_1	38	45	PF00069	0.648
MOD_GSK3_1	444	451	PF00069	0.756
MOD_GSK3_1	531	538	PF00069	0.828
MOD_GSK3_1	560	567	PF00069	0.704
MOD_GSK3_1	568	575	PF00069	0.728
MOD_GSK3_1	610	617	PF00069	0.708
MOD_GSK3_1	628	635	PF00069	0.391
MOD_GSK3_1	65	72	PF00069	0.820
MOD_GSK3_1	682	689	PF00069	0.601
MOD_GSK3_1	716	723	PF00069	0.625
MOD_GSK3_1	728	735	PF00069	0.791
MOD_GSK3_1	73	80	PF00069	0.714
MOD_GSK3_1	745	752	PF00069	0.654
MOD_GSK3_1	769	776	PF00069	0.737
MOD_GSK3_1	816	823	PF00069	0.776
MOD_GSK3_1	833	840	PF00069	0.566
MOD_GSK3_1	847	854	PF00069	0.587
MOD_GSK3_1	885	892	PF00069	0.678
MOD_GSK3_1	91	98	PF00069	0.673
MOD_N-GLC_1	272	277	PF02516	0.580
MOD_N-GLC_1	478	483	PF02516	0.807
MOD_N-GLC_1	57	62	PF02516	0.801
MOD_N-GLC_2	795	797	PF02516	0.645
MOD_NEK2_1	321	326	PF00069	0.575
MOD_NEK2_1	570	575	PF00069	0.686
MOD_NEK2_1	580	585	PF00069	0.650
MOD_NEK2_1	663	668	PF00069	0.602
MOD_PIKK_1	874	880	PF00454	0.671
MOD_PKA_2	137	143	PF00069	0.578
MOD_PKA_2	208	214	PF00069	0.616
MOD_PKA_2	291	297	PF00069	0.634
MOD_PKA_2	838	844	PF00069	0.850
MOD_PKB_1	156	164	PF00069	0.667
MOD_PKB_1	201	209	PF00069	0.610
MOD_PKB_1	432	440	PF00069	0.837
MOD_Plk_1	478	484	PF00069	0.804
MOD_Plk_1	547	553	PF00069	0.552
MOD_Plk_1	889	895	PF00069	0.726
MOD_Plk_4	170	176	PF00069	0.560
MOD_Plk_4	184	190	PF00069	0.375
MOD_Plk_4	218	224	PF00069	0.475
MOD_Plk_4	464	470	PF00069	0.527
MOD_Plk_4	663	669	PF00069	0.708
MOD_ProDKin_1	2	8	PF00069	0.768
MOD_ProDKin_1	397	403	PF00069	0.297
MOD_ProDKin_1	489	495	PF00069	0.811
MOD_ProDKin_1	560	566	PF00069	0.695
MOD_ProDKin_1	57	63	PF00069	0.657
MOD_ProDKin_1	592	598	PF00069	0.693
MOD_ProDKin_1	651	657	PF00069	0.754
MOD_ProDKin_1	677	683	PF00069	0.562
MOD_ProDKin_1	713	719	PF00069	0.674
MOD_ProDKin_1	726	732	PF00069	0.738
MOD_ProDKin_1	747	753	PF00069	0.834
MOD_ProDKin_1	777	783	PF00069	0.486
MOD_ProDKin_1	827	833	PF00069	0.748
MOD_ProDKin_1	851	857	PF00069	0.823
TRG_DiLeu_BaEn_1	170	175	PF01217	0.588
TRG_DiLeu_BaEn_1	317	322	PF01217	0.585
TRG_DiLeu_BaEn_1	385	390	PF01217	0.433
TRG_DiLeu_BaEn_1	637	642	PF01217	0.696
TRG_DiLeu_BaEn_1	691	696	PF01217	0.709
TRG_DiLeu_BaLyEn_6	605	610	PF01217	0.707
TRG_DiLeu_LyEn_5	691	696	PF01217	0.709
TRG_ENDOCYTIC_2	352	355	PF00928	0.653
TRG_ENDOCYTIC_2	387	390	PF00928	0.435
TRG_ENDOCYTIC_2	636	639	PF00928	0.612
TRG_ER_diArg_1	200	203	PF00400	0.606
TRG_ER_diArg_1	252	255	PF00400	0.568
TRG_ER_diArg_1	417	420	PF00400	0.728
TRG_ER_diArg_1	693	695	PF00400	0.763

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEA0	Leptomonas seymouri	42%	86%
A0A3S7WW37	Leishmania donovani	89%	100%
A4HYT2	Leishmania infantum	90%	100%
E9AIE1	Leishmania braziliensis	76%	100%
Q4QCV6	Leishmania major	90%	100%