Transcription elongation factor 1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transcription elongation factor 1 domain-containing protein

Species:

Leishmania mexicana

UniProt:

E9AUM7_LEIMU

TriTrypDb:

LmxM.20.0890

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AUM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUM7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003746	translation elongation factor activity	4	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.495
CLV_C14_Caspase3-7	213	217	PF00656	0.627
CLV_C14_Caspase3-7	219	223	PF00656	0.696
CLV_C14_Caspase3-7	268	272	PF00656	0.601
CLV_C14_Caspase3-7	3	7	PF00656	0.646
CLV_NRD_NRD_1	11	13	PF00675	0.673
CLV_NRD_NRD_1	152	154	PF00675	0.707
CLV_NRD_NRD_1	17	19	PF00675	0.697
CLV_NRD_NRD_1	171	173	PF00675	0.592
CLV_NRD_NRD_1	42	44	PF00675	0.731
CLV_PCSK_KEX2_1	11	13	PF00082	0.676
CLV_PCSK_KEX2_1	154	156	PF00082	0.705
CLV_PCSK_KEX2_1	171	173	PF00082	0.587
CLV_PCSK_KEX2_1	42	44	PF00082	0.733
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.705
DOC_CKS1_1	231	236	PF01111	0.838
DOC_MAPK_MEF2A_6	67	74	PF00069	0.375
DOC_PP4_FxxP_1	59	62	PF00568	0.411
DOC_USP7_MATH_1	160	164	PF00917	0.541
DOC_USP7_MATH_1	242	246	PF00917	0.557
DOC_USP7_MATH_1	99	103	PF00917	0.443
DOC_WW_Pin1_4	201	206	PF00397	0.522
DOC_WW_Pin1_4	230	235	PF00397	0.837
LIG_14-3-3_CanoR_1	71	75	PF00244	0.478
LIG_BIR_II_1	1	5	PF00653	0.812
LIG_FHA_1	188	194	PF00498	0.760
LIG_FHA_1	202	208	PF00498	0.652
LIG_FHA_1	48	54	PF00498	0.650
LIG_FHA_1	67	73	PF00498	0.411
LIG_FHA_2	217	223	PF00498	0.700
LIG_FHA_2	254	260	PF00498	0.693
LIG_HCF-1_HBM_1	36	39	PF13415	0.753
LIG_LIR_Apic_2	58	62	PF02991	0.411
LIG_LIR_Gen_1	122	128	PF02991	0.526
LIG_LIR_Gen_1	246	255	PF02991	0.760
LIG_LIR_Nem_3	115	120	PF02991	0.215
LIG_LIR_Nem_3	122	127	PF02991	0.474
LIG_LIR_Nem_3	246	252	PF02991	0.766
LIG_LIR_Nem_3	97	103	PF02991	0.478
LIG_LYPXL_yS_3	100	103	PF13949	0.513
LIG_MYND_3	107	111	PF01753	0.513
LIG_REV1ctd_RIR_1	115	123	PF16727	0.411
LIG_SH2_CRK	124	128	PF00017	0.502
LIG_SH2_STAP1	124	128	PF00017	0.524
LIG_SH2_STAT5	87	90	PF00017	0.411
LIG_SH3_3	228	234	PF00018	0.734
LIG_SH3_3	90	96	PF00018	0.457
LIG_TYR_ITIM	98	103	PF00017	0.513
LIG_WRC_WIRS_1	103	108	PF05994	0.222
LIG_WRC_WIRS_1	56	61	PF05994	0.411
MOD_CK1_1	102	108	PF00069	0.222
MOD_CK1_1	232	238	PF00069	0.839
MOD_CK1_1	27	33	PF00069	0.774
MOD_CK1_1	66	72	PF00069	0.411
MOD_GlcNHglycan	162	165	PF01048	0.753
MOD_GlcNHglycan	240	243	PF01048	0.534
MOD_GSK3_1	102	109	PF00069	0.222
MOD_GSK3_1	141	148	PF00069	0.708
MOD_GSK3_1	160	167	PF00069	0.733
MOD_GSK3_1	238	245	PF00069	0.583
MOD_GSK3_1	24	31	PF00069	0.791
MOD_GSK3_1	66	73	PF00069	0.478
MOD_GSK3_1	79	86	PF00069	0.322
MOD_NEK2_2	87	92	PF00069	0.411
MOD_PIKK_1	232	238	PF00454	0.548
MOD_PKA_2	70	76	PF00069	0.474
MOD_Plk_1	193	199	PF00069	0.753
MOD_Plk_1	35	41	PF00069	0.743
MOD_Plk_4	102	108	PF00069	0.222
MOD_ProDKin_1	201	207	PF00069	0.524
MOD_ProDKin_1	230	236	PF00069	0.837
MOD_SUMO_rev_2	105	114	PF00179	0.326
MOD_SUMO_rev_2	222	231	PF00179	0.590
MOD_SUMO_rev_2	60	69	PF00179	0.375
TRG_ENDOCYTIC_2	100	103	PF00928	0.513
TRG_ENDOCYTIC_2	124	127	PF00928	0.519
TRG_ER_diArg_1	10	12	PF00400	0.768
TRG_ER_diArg_1	170	172	PF00400	0.642
TRG_ER_diArg_1	42	44	PF00400	0.725
TRG_NLS_MonoExtC_3	17	23	PF00514	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P6	Leptomonas seymouri	47%	100%
A0A3Q8IBM0	Leishmania donovani	85%	100%
A4HYT1	Leishmania infantum	86%	100%
E9AIE0	Leishmania braziliensis	66%	93%
Q4QCV7	Leishmania major	84%	100%