Putative ATP-dependent RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania mexicana

UniProt:

E9AUM5_LEIMU

TriTrypDb:

LmxM.20.0870

Length:

773

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUM5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	10
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016787	hydrolase activity	2	9
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0140657	ATP-dependent activity	1	10
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.648
CLV_C14_Caspase3-7	535	539	PF00656	0.384
CLV_MEL_PAP_1	148	154	PF00089	0.658
CLV_NRD_NRD_1	145	147	PF00675	0.503
CLV_NRD_NRD_1	195	197	PF00675	0.685
CLV_NRD_NRD_1	269	271	PF00675	0.363
CLV_NRD_NRD_1	365	367	PF00675	0.563
CLV_NRD_NRD_1	427	429	PF00675	0.580
CLV_NRD_NRD_1	436	438	PF00675	0.482
CLV_NRD_NRD_1	524	526	PF00675	0.260
CLV_NRD_NRD_1	705	707	PF00675	0.636
CLV_NRD_NRD_1	755	757	PF00675	0.682
CLV_PCSK_KEX2_1	145	147	PF00082	0.503
CLV_PCSK_KEX2_1	197	199	PF00082	0.387
CLV_PCSK_KEX2_1	269	271	PF00082	0.363
CLV_PCSK_KEX2_1	429	431	PF00082	0.568
CLV_PCSK_KEX2_1	436	438	PF00082	0.503
CLV_PCSK_KEX2_1	523	525	PF00082	0.260
CLV_PCSK_KEX2_1	614	616	PF00082	0.508
CLV_PCSK_KEX2_1	705	707	PF00082	0.623
CLV_PCSK_KEX2_1	757	759	PF00082	0.701
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.387
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.577
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.531
CLV_PCSK_PC1ET2_1	757	759	PF00082	0.701
CLV_PCSK_PC7_1	141	147	PF00082	0.562
CLV_PCSK_SKI1_1	146	150	PF00082	0.479
CLV_PCSK_SKI1_1	198	202	PF00082	0.603
CLV_PCSK_SKI1_1	43	47	PF00082	0.173
CLV_PCSK_SKI1_1	524	528	PF00082	0.274
CLV_PCSK_SKI1_1	630	634	PF00082	0.435
CLV_PCSK_SKI1_1	73	77	PF00082	0.307
CLV_Separin_Metazoa	142	146	PF03568	0.551
DEG_SCF_TRCP1_1	538	544	PF00400	0.355
DEG_SPOP_SBC_1	666	670	PF00917	0.483
DOC_CKS1_1	212	217	PF01111	0.460
DOC_CKS1_1	738	743	PF01111	0.694
DOC_CYCLIN_RxL_1	220	232	PF00134	0.540
DOC_CYCLIN_RxL_1	522	531	PF00134	0.490
DOC_CYCLIN_RxL_1	85	95	PF00134	0.492
DOC_MAPK_DCC_7	23	33	PF00069	0.526
DOC_MAPK_gen_1	108	117	PF00069	0.527
DOC_MAPK_gen_1	196	202	PF00069	0.344
DOC_MAPK_gen_1	226	235	PF00069	0.540
DOC_MAPK_gen_1	342	351	PF00069	0.614
DOC_MAPK_gen_1	436	444	PF00069	0.621
DOC_MAPK_gen_1	585	594	PF00069	0.550
DOC_MAPK_HePTP_8	200	212	PF00069	0.166
DOC_MAPK_MEF2A_6	203	212	PF00069	0.458
DOC_MAPK_MEF2A_6	229	237	PF00069	0.540
DOC_MAPK_MEF2A_6	407	414	PF00069	0.367
DOC_MAPK_MEF2A_6	588	596	PF00069	0.425
DOC_PP2B_LxvP_1	55	58	PF13499	0.460
DOC_PP4_FxxP_1	290	293	PF00568	0.424
DOC_PP4_FxxP_1	389	392	PF00568	0.394
DOC_USP7_MATH_1	166	170	PF00917	0.769
DOC_USP7_MATH_1	285	289	PF00917	0.521
DOC_USP7_MATH_1	293	297	PF00917	0.510
DOC_USP7_MATH_1	317	321	PF00917	0.355
DOC_USP7_MATH_1	417	421	PF00917	0.514
DOC_USP7_MATH_1	44	48	PF00917	0.507
DOC_USP7_MATH_1	469	473	PF00917	0.641
DOC_USP7_MATH_1	506	510	PF00917	0.561
DOC_USP7_MATH_1	541	545	PF00917	0.530
DOC_USP7_MATH_1	58	62	PF00917	0.397
DOC_USP7_MATH_1	647	651	PF00917	0.714
DOC_USP7_MATH_1	662	666	PF00917	0.783
DOC_USP7_MATH_1	745	749	PF00917	0.642
DOC_USP7_MATH_2	569	575	PF00917	0.540
DOC_WW_Pin1_4	211	216	PF00397	0.460
DOC_WW_Pin1_4	289	294	PF00397	0.513
DOC_WW_Pin1_4	301	306	PF00397	0.471
DOC_WW_Pin1_4	324	329	PF00397	0.430
DOC_WW_Pin1_4	737	742	PF00397	0.711
LIG_14-3-3_CanoR_1	198	203	PF00244	0.559
LIG_14-3-3_CanoR_1	229	234	PF00244	0.563
LIG_14-3-3_CanoR_1	23	28	PF00244	0.523
LIG_14-3-3_CanoR_1	352	357	PF00244	0.445
LIG_14-3-3_CanoR_1	428	438	PF00244	0.591
LIG_14-3-3_CanoR_1	43	50	PF00244	0.427
LIG_14-3-3_CanoR_1	579	589	PF00244	0.454
LIG_14-3-3_CanoR_1	615	621	PF00244	0.525
LIG_14-3-3_CanoR_1	705	711	PF00244	0.586
LIG_14-3-3_CanoR_1	73	82	PF00244	0.530
LIG_14-3-3_CanoR_1	732	739	PF00244	0.741
LIG_14-3-3_CanoR_1	760	770	PF00244	0.703
LIG_Actin_WH2_2	215	231	PF00022	0.540
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BIR_III_2	674	678	PF00653	0.468
LIG_BRCT_BRCA1_1	286	290	PF00533	0.508
LIG_CaM_NSCaTE_8	707	714	PF13499	0.597
LIG_Clathr_ClatBox_1	235	239	PF01394	0.490
LIG_deltaCOP1_diTrp_1	686	695	PF00928	0.598
LIG_DLG_GKlike_1	229	236	PF00625	0.508
LIG_DLG_GKlike_1	352	359	PF00625	0.519
LIG_eIF4E_1	406	412	PF01652	0.382
LIG_FHA_1	223	229	PF00498	0.490
LIG_FHA_1	44	50	PF00498	0.441
LIG_FHA_1	482	488	PF00498	0.513
LIG_FHA_1	621	627	PF00498	0.491
LIG_FHA_1	93	99	PF00498	0.466
LIG_FHA_2	129	135	PF00498	0.649
LIG_FHA_2	392	398	PF00498	0.461
LIG_FHA_2	4	10	PF00498	0.537
LIG_FHA_2	490	496	PF00498	0.490
LIG_LIR_Apic_2	26	30	PF02991	0.596
LIG_LIR_Apic_2	287	293	PF02991	0.424
LIG_LIR_Apic_2	387	392	PF02991	0.447
LIG_LIR_Apic_2	64	70	PF02991	0.460
LIG_LIR_Gen_1	513	521	PF02991	0.476
LIG_LIR_Nem_3	355	359	PF02991	0.516
LIG_LIR_Nem_3	472	478	PF02991	0.609
LIG_LIR_Nem_3	513	517	PF02991	0.476
LIG_LIR_Nem_3	629	635	PF02991	0.500
LIG_LYPXL_yS_3	475	478	PF13949	0.565
LIG_PCNA_yPIPBox_3	269	282	PF02747	0.546
LIG_PTB_Apo_2	350	357	PF02174	0.520
LIG_PTB_Phospho_1	350	356	PF10480	0.522
LIG_REV1ctd_RIR_1	186	196	PF16727	0.446
LIG_REV1ctd_RIR_1	630	638	PF16727	0.631
LIG_RPA_C_Fungi	416	428	PF08784	0.549
LIG_RPA_C_Fungi	492	504	PF08784	0.425
LIG_SH2_CRK	613	617	PF00017	0.531
LIG_SH2_SRC	67	70	PF00017	0.458
LIG_SH2_STAP1	260	264	PF00017	0.425
LIG_SH2_STAP1	628	632	PF00017	0.384
LIG_SH2_STAT5	204	207	PF00017	0.425
LIG_SH2_STAT5	357	360	PF00017	0.520
LIG_SH2_STAT5	576	579	PF00017	0.313
LIG_SH2_STAT5	67	70	PF00017	0.313
LIG_SH3_2	305	310	PF14604	0.166
LIG_SH3_3	144	150	PF00018	0.551
LIG_SH3_3	209	215	PF00018	0.356
LIG_SH3_3	302	308	PF00018	0.166
LIG_SUMO_SIM_anti_2	206	214	PF11976	0.386
LIG_SUMO_SIM_par_1	234	240	PF11976	0.332
LIG_SUMO_SIM_par_1	89	95	PF11976	0.313
LIG_TRAF2_1	394	397	PF00917	0.489
LIG_TRAF2_1	492	495	PF00917	0.356
LIG_TRAF2_1	678	681	PF00917	0.702
LIG_TRFH_1	389	393	PF08558	0.393
LIG_WW_3	638	642	PF00397	0.443
MOD_CDK_SPxK_1	211	217	PF00069	0.313
MOD_CDK_SPxK_1	737	743	PF00069	0.694
MOD_CK1_1	296	302	PF00069	0.398
MOD_CK1_1	3	9	PF00069	0.560
MOD_CK1_1	420	426	PF00069	0.524
MOD_CK1_1	470	476	PF00069	0.532
MOD_CK1_1	61	67	PF00069	0.312
MOD_CK1_1	651	657	PF00069	0.741
MOD_CK1_1	665	671	PF00069	0.711
MOD_CK1_1	761	767	PF00069	0.739
MOD_CK2_1	130	136	PF00069	0.570
MOD_CK2_1	162	168	PF00069	0.742
MOD_CK2_1	289	295	PF00069	0.458
MOD_CK2_1	358	364	PF00069	0.521
MOD_CK2_1	391	397	PF00069	0.465
MOD_CK2_1	489	495	PF00069	0.332
MOD_CK2_1	507	513	PF00069	0.253
MOD_CK2_1	516	522	PF00069	0.260
MOD_CK2_1	536	542	PF00069	0.127
MOD_CK2_1	706	712	PF00069	0.550
MOD_CK2_1	745	751	PF00069	0.760
MOD_Cter_Amidation	754	757	PF01082	0.763
MOD_GlcNHglycan	158	161	PF01048	0.724
MOD_GlcNHglycan	164	167	PF01048	0.724
MOD_GlcNHglycan	317	320	PF01048	0.402
MOD_GlcNHglycan	335	338	PF01048	0.227
MOD_GlcNHglycan	422	425	PF01048	0.483
MOD_GlcNHglycan	431	434	PF01048	0.528
MOD_GlcNHglycan	46	49	PF01048	0.305
MOD_GlcNHglycan	467	470	PF01048	0.621
MOD_GlcNHglycan	538	541	PF01048	0.356
MOD_GlcNHglycan	60	63	PF01048	0.279
MOD_GlcNHglycan	601	604	PF01048	0.519
MOD_GlcNHglycan	650	653	PF01048	0.744
MOD_GlcNHglycan	655	659	PF01048	0.748
MOD_GlcNHglycan	662	665	PF01048	0.732
MOD_GlcNHglycan	671	674	PF01048	0.733
MOD_GlcNHglycan	683	686	PF01048	0.549
MOD_GlcNHglycan	712	715	PF01048	0.545
MOD_GSK3_1	107	114	PF00069	0.332
MOD_GSK3_1	152	159	PF00069	0.695
MOD_GSK3_1	162	169	PF00069	0.736
MOD_GSK3_1	280	287	PF00069	0.404
MOD_GSK3_1	289	296	PF00069	0.398
MOD_GSK3_1	297	304	PF00069	0.324
MOD_GSK3_1	317	324	PF00069	0.316
MOD_GSK3_1	333	340	PF00069	0.320
MOD_GSK3_1	465	472	PF00069	0.618
MOD_GSK3_1	512	519	PF00069	0.324
MOD_GSK3_1	616	623	PF00069	0.454
MOD_GSK3_1	624	631	PF00069	0.468
MOD_GSK3_1	643	650	PF00069	0.658
MOD_GSK3_1	662	669	PF00069	0.718
MOD_GSK3_1	706	713	PF00069	0.556
MOD_N-GLC_1	198	203	PF02516	0.594
MOD_N-GLC_1	352	357	PF02516	0.520
MOD_NEK2_1	188	193	PF00069	0.562
MOD_NEK2_1	222	227	PF00069	0.420
MOD_NEK2_1	512	517	PF00069	0.249
MOD_NEK2_1	594	599	PF00069	0.509
MOD_NEK2_1	616	621	PF00069	0.484
MOD_NEK2_1	696	701	PF00069	0.513
MOD_NEK2_1	75	80	PF00069	0.318
MOD_NEK2_2	628	633	PF00069	0.386
MOD_OFUCOSY	279	284	PF10250	0.263
MOD_PIKK_1	248	254	PF00454	0.402
MOD_PIKK_1	371	377	PF00454	0.750
MOD_PIKK_1	384	390	PF00454	0.638
MOD_PIKK_1	614	620	PF00454	0.414
MOD_PIKK_1	696	702	PF00454	0.518
MOD_PIKK_1	745	751	PF00454	0.767
MOD_PIKK_1	92	98	PF00454	0.361
MOD_PK_1	111	117	PF00069	0.386
MOD_PK_1	706	712	PF00069	0.643
MOD_PK_1	758	764	PF00069	0.771
MOD_PKA_1	429	435	PF00069	0.579
MOD_PKA_1	614	620	PF00069	0.530
MOD_PKA_2	107	113	PF00069	0.318
MOD_PKA_2	344	350	PF00069	0.461
MOD_PKA_2	420	426	PF00069	0.538
MOD_PKA_2	429	435	PF00069	0.558
MOD_PKA_2	614	620	PF00069	0.530
MOD_PKA_2	648	654	PF00069	0.634
MOD_PKA_2	731	737	PF00069	0.691
MOD_PKB_1	196	204	PF00069	0.543
MOD_PKB_1	756	764	PF00069	0.739
MOD_Plk_1	198	204	PF00069	0.549
MOD_Plk_1	293	299	PF00069	0.369
MOD_Plk_1	352	358	PF00069	0.520
MOD_Plk_1	402	408	PF00069	0.537
MOD_Plk_1	51	57	PF00069	0.425
MOD_Plk_1	512	518	PF00069	0.332
MOD_Plk_1	528	534	PF00069	0.332
MOD_Plk_1	541	547	PF00069	0.350
MOD_Plk_1	628	634	PF00069	0.397
MOD_Plk_1	745	751	PF00069	0.785
MOD_Plk_1	758	764	PF00069	0.569
MOD_Plk_4	352	358	PF00069	0.520
MOD_Plk_4	37	43	PF00069	0.454
MOD_Plk_4	507	513	PF00069	0.425
MOD_Plk_4	616	622	PF00069	0.258
MOD_Plk_4	706	712	PF00069	0.643
MOD_ProDKin_1	211	217	PF00069	0.313
MOD_ProDKin_1	289	295	PF00069	0.388
MOD_ProDKin_1	301	307	PF00069	0.329
MOD_ProDKin_1	324	330	PF00069	0.271
MOD_ProDKin_1	737	743	PF00069	0.713
TRG_DiLeu_BaEn_1	139	144	PF01217	0.449
TRG_DiLeu_BaEn_2	396	402	PF01217	0.390
TRG_DiLeu_BaEn_3	170	176	PF01217	0.637
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.313
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.313
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.378
TRG_ENDOCYTIC_2	356	359	PF00928	0.517
TRG_ENDOCYTIC_2	475	478	PF00928	0.565
TRG_ENDOCYTIC_2	613	616	PF00928	0.532
TRG_ER_diArg_1	144	146	PF00400	0.486
TRG_ER_diArg_1	418	421	PF00400	0.539
TRG_ER_diArg_1	436	438	PF00400	0.548
TRG_ER_diArg_1	523	525	PF00400	0.332
TRG_ER_diArg_1	705	707	PF00400	0.657
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	436	441	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	525	529	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKF6	Leptomonas seymouri	65%	100%
A0A0S4JIC9	Bodo saltans	38%	100%
A0A3R7NJH7	Trypanosoma rangeli	41%	100%
A0A3S7WVZ5	Leishmania donovani	87%	100%
A4HYS9	Leishmania infantum	88%	100%
A4QX49	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	22%	94%
C9ZIA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AID8	Leishmania braziliensis	81%	100%
Q4QCV9	Leishmania major	87%	98%
V5DS01	Trypanosoma cruzi	43%	100%