Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUM4_LEIMU

TriTrypDb:

LmxM.20.0860

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AUM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.485
CLV_NRD_NRD_1	206	208	PF00675	0.571
CLV_NRD_NRD_1	307	309	PF00675	0.472
CLV_NRD_NRD_1	325	327	PF00675	0.358
CLV_NRD_NRD_1	45	47	PF00675	0.373
CLV_PCSK_FUR_1	43	47	PF00082	0.436
CLV_PCSK_KEX2_1	15	17	PF00082	0.439
CLV_PCSK_KEX2_1	240	242	PF00082	0.502
CLV_PCSK_KEX2_1	302	304	PF00082	0.397
CLV_PCSK_KEX2_1	307	309	PF00082	0.468
CLV_PCSK_KEX2_1	45	47	PF00082	0.374
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.502
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.427
CLV_PCSK_PC7_1	11	17	PF00082	0.459
CLV_PCSK_PC7_1	303	309	PF00082	0.352
CLV_PCSK_SKI1_1	183	187	PF00082	0.643
CLV_PCSK_SKI1_1	240	244	PF00082	0.671
CLV_PCSK_SKI1_1	46	50	PF00082	0.351
CLV_PCSK_SKI1_1	73	77	PF00082	0.392
DEG_APCC_DBOX_1	317	325	PF00400	0.425
DEG_Nend_Nbox_1	1	3	PF02207	0.417
DEG_SCF_FBW7_1	185	190	PF00400	0.542
DEG_SCF_TRCP1_1	204	210	PF00400	0.527
DOC_CDC14_PxL_1	85	93	PF14671	0.347
DOC_CYCLIN_RxL_1	42	53	PF00134	0.486
DOC_CYCLIN_RxL_1	82	94	PF00134	0.345
DOC_MAPK_gen_1	15	22	PF00069	0.380
DOC_MAPK_gen_1	316	324	PF00069	0.496
DOC_MAPK_gen_1	326	332	PF00069	0.369
DOC_MAPK_gen_1	59	69	PF00069	0.529
DOC_MAPK_MEF2A_6	15	22	PF00069	0.301
DOC_PP2B_LxvP_1	150	153	PF13499	0.485
DOC_USP7_MATH_1	103	107	PF00917	0.427
DOC_USP7_MATH_1	194	198	PF00917	0.566
DOC_USP7_UBL2_3	239	243	PF12436	0.485
DOC_WW_Pin1_4	104	109	PF00397	0.424
DOC_WW_Pin1_4	176	181	PF00397	0.604
DOC_WW_Pin1_4	183	188	PF00397	0.675
DOC_WW_Pin1_4	50	55	PF00397	0.650
LIG_14-3-3_CanoR_1	307	317	PF00244	0.499
LIG_14-3-3_CanoR_1	335	343	PF00244	0.411
LIG_eIF4E_1	85	91	PF01652	0.349
LIG_FHA_1	154	160	PF00498	0.468
LIG_FHA_1	180	186	PF00498	0.560
LIG_FHA_1	211	217	PF00498	0.491
LIG_FHA_1	250	256	PF00498	0.344
LIG_FHA_2	111	117	PF00498	0.379
LIG_FHA_2	143	149	PF00498	0.476
LIG_FHA_2	249	255	PF00498	0.329
LIG_FHA_2	309	315	PF00498	0.324
LIG_LIR_Gen_1	273	284	PF02991	0.447
LIG_LIR_Gen_1	4	13	PF02991	0.461
LIG_LIR_Gen_1	74	83	PF02991	0.413
LIG_LIR_Gen_1	96	104	PF02991	0.377
LIG_LIR_Nem_3	139	144	PF02991	0.356
LIG_LIR_Nem_3	273	279	PF02991	0.370
LIG_LIR_Nem_3	36	42	PF02991	0.440
LIG_LIR_Nem_3	4	9	PF02991	0.465
LIG_LIR_Nem_3	74	78	PF02991	0.405
LIG_REV1ctd_RIR_1	138	146	PF16727	0.386
LIG_SH2_CRK	6	10	PF00017	0.470
LIG_SH2_CRK	85	89	PF00017	0.420
LIG_SH2_NCK_1	333	337	PF00017	0.430
LIG_SH2_SRC	341	344	PF00017	0.454
LIG_SH2_STAP1	341	345	PF00017	0.371
LIG_SH2_STAP1	6	10	PF00017	0.470
LIG_SH2_STAT3	144	147	PF00017	0.340
LIG_SH2_STAT5	144	147	PF00017	0.407
LIG_SH3_3	105	111	PF00018	0.465
LIG_SH3_3	55	61	PF00018	0.548
LIG_SH3_3	7	13	PF00018	0.460
LIG_TRAF2_1	145	148	PF00917	0.457
LIG_TRFH_1	85	89	PF08558	0.399
LIG_UBA3_1	321	327	PF00899	0.324
LIG_WRC_WIRS_1	72	77	PF05994	0.388
MOD_CDK_SPxxK_3	176	183	PF00069	0.447
MOD_CK1_1	107	113	PF00069	0.441
MOD_CK1_1	197	203	PF00069	0.596
MOD_CK1_1	210	216	PF00069	0.509
MOD_CK1_1	5	11	PF00069	0.472
MOD_CK2_1	142	148	PF00069	0.420
MOD_CK2_1	288	294	PF00069	0.400
MOD_CK2_1	334	340	PF00069	0.377
MOD_CK2_1	90	96	PF00069	0.386
MOD_Cter_Amidation	205	208	PF01082	0.568
MOD_GlcNHglycan	204	207	PF01048	0.594
MOD_GlcNHglycan	209	212	PF01048	0.558
MOD_GlcNHglycan	282	285	PF01048	0.375
MOD_GSK3_1	103	110	PF00069	0.313
MOD_GSK3_1	175	182	PF00069	0.575
MOD_GSK3_1	183	190	PF00069	0.636
MOD_N-GLC_1	25	30	PF02516	0.362
MOD_NEK2_1	2	7	PF00069	0.469
MOD_NEK2_1	234	239	PF00069	0.546
MOD_NEK2_1	25	30	PF00069	0.454
MOD_NEK2_1	256	261	PF00069	0.347
MOD_PIKK_1	117	123	PF00454	0.539
MOD_PIKK_1	143	149	PF00454	0.349
MOD_PIKK_1	259	265	PF00454	0.357
MOD_PK_1	288	294	PF00069	0.384
MOD_PKA_1	207	213	PF00069	0.554
MOD_PKA_2	125	131	PF00069	0.388
MOD_PKA_2	2	8	PF00069	0.480
MOD_PKA_2	306	312	PF00069	0.497
MOD_PKA_2	334	340	PF00069	0.441
MOD_Plk_2-3	334	340	PF00069	0.377
MOD_Plk_4	25	31	PF00069	0.362
MOD_Plk_4	256	262	PF00069	0.333
MOD_Plk_4	5	11	PF00069	0.517
MOD_Plk_4	71	77	PF00069	0.448
MOD_ProDKin_1	104	110	PF00069	0.422
MOD_ProDKin_1	176	182	PF00069	0.610
MOD_ProDKin_1	183	189	PF00069	0.675
MOD_ProDKin_1	50	56	PF00069	0.652
TRG_DiLeu_BaEn_2	293	299	PF01217	0.359
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.478
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.344
TRG_ENDOCYTIC_2	276	279	PF00928	0.343
TRG_ENDOCYTIC_2	333	336	PF00928	0.446
TRG_ENDOCYTIC_2	6	9	PF00928	0.468
TRG_ENDOCYTIC_2	72	75	PF00928	0.414
TRG_ENDOCYTIC_2	85	88	PF00928	0.377
TRG_ER_diArg_1	306	308	PF00400	0.519
TRG_ER_diArg_1	315	318	PF00400	0.558
TRG_ER_diArg_1	42	45	PF00400	0.443
TRG_NLS_MonoExtC_3	238	243	PF00514	0.483
TRG_NLS_MonoExtN_4	239	244	PF00514	0.464
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD57	Leptomonas seymouri	49%	100%
A0A1X0NWC4	Trypanosomatidae	35%	100%
A0A3S5IRL1	Trypanosoma rangeli	35%	100%
A0A3S7WVX4	Leishmania donovani	90%	100%
A0A3S7XA59	Leishmania donovani	28%	100%
A4HYS8	Leishmania infantum	91%	100%
A4IC46	Leishmania infantum	28%	100%
E9AG01	Leishmania major	28%	100%
E9AID7	Leishmania braziliensis	77%	100%
Q4QCW0	Leishmania major	88%	100%