Cytochrome c oxidase assembly factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

electron transport protein SCO1/2, putative

Species:

Leishmania mexicana

UniProt:

E9AUM2_LEIMU

TriTrypDb:

LmxM.20.0840

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2

Expansion

Sequence features

E9AUM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUM2

Function

Biological processes
Term	Name	Level	Count
GO:0008535	respiratory chain complex IV assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0017004	cytochrome complex assembly	6	1
GO:0022607	cellular component assembly	4	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0033617	mitochondrial cytochrome c oxidase assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016491	oxidoreductase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.378
CLV_NRD_NRD_1	6	8	PF00675	0.618
CLV_PCSK_SKI1_1	196	200	PF00082	0.364
CLV_PCSK_SKI1_1	45	49	PF00082	0.375
DEG_MDM2_SWIB_1	53	60	PF02201	0.273
DEG_Nend_UBRbox_3	1	3	PF02207	0.632
DEG_ODPH_VHL_1	14	26	PF01847	0.523
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.273
DOC_MAPK_MEF2A_6	100	109	PF00069	0.284
LIG_BRCT_BRCA1_1	107	111	PF00533	0.365
LIG_FHA_2	134	140	PF00498	0.365
LIG_FHA_2	155	161	PF00498	0.289
LIG_FHA_2	46	52	PF00498	0.279
LIG_LIR_Gen_1	17	26	PF02991	0.550
LIG_LIR_Nem_3	58	64	PF02991	0.279
LIG_MYND_1	12	16	PF01753	0.494
LIG_Pex14_1	147	151	PF04695	0.273
LIG_Pex14_1	57	61	PF04695	0.292
LIG_Pex14_2	53	57	PF04695	0.285
LIG_REV1ctd_RIR_1	196	205	PF16727	0.398
LIG_SH2_GRB2like	4	7	PF00017	0.633
LIG_SH2_NCK_1	151	155	PF00017	0.289
LIG_SH2_NCK_1	216	220	PF00017	0.547
LIG_SH2_STAP1	216	220	PF00017	0.547
LIG_SH2_STAT5	187	190	PF00017	0.285
LIG_SH2_STAT5	46	49	PF00017	0.285
LIG_SH2_STAT5	61	64	PF00017	0.239
LIG_SH3_3	166	172	PF00018	0.372
LIG_SH3_4	27	34	PF00018	0.571
LIG_TRAF2_1	136	139	PF00917	0.394
LIG_TRAF2_1	157	160	PF00917	0.282
LIG_TRAF2_1	48	51	PF00917	0.212
LIG_TRAF2_1	96	99	PF00917	0.411
LIG_TYR_ITIM	149	154	PF00017	0.289
LIG_TYR_ITIM	214	219	PF00017	0.513
MOD_CK1_1	20	26	PF00069	0.547
MOD_CK1_1	65	71	PF00069	0.322
MOD_CK2_1	133	139	PF00069	0.342
MOD_CK2_1	150	156	PF00069	0.171
MOD_CK2_1	45	51	PF00069	0.290
MOD_GlcNHglycan	183	186	PF01048	0.289
MOD_GSK3_1	150	157	PF00069	0.285
MOD_NEK2_1	180	185	PF00069	0.296
MOD_NEK2_1	205	210	PF00069	0.524
MOD_NEK2_1	222	227	PF00069	0.486
MOD_NEK2_1	38	43	PF00069	0.285
MOD_NEK2_1	62	67	PF00069	0.292
MOD_PKA_2	38	44	PF00069	0.289
MOD_Plk_1	174	180	PF00069	0.274
MOD_SUMO_rev_2	86	96	PF00179	0.341
TRG_ENDOCYTIC_2	151	154	PF00928	0.308
TRG_ENDOCYTIC_2	216	219	PF00928	0.532
TRG_ENDOCYTIC_2	61	64	PF00928	0.273
TRG_ER_diArg_1	128	131	PF00400	0.289
TRG_ER_diArg_1	36	39	PF00400	0.308
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R3	Leptomonas seymouri	31%	75%
A0A0N1I6S1	Leptomonas seymouri	78%	82%
A0A0S4J8R8	Bodo saltans	32%	78%
A0A0S4KH84	Bodo saltans	60%	71%
A0A1X0NLN8	Trypanosomatidae	31%	86%
A0A1X0NWD3	Trypanosomatidae	68%	77%
A0A3R7L4G0	Trypanosoma rangeli	69%	80%
A0A3R7RML7	Trypanosoma rangeli	32%	100%
A0A3S5H5E9	Leishmania donovani	31%	75%
A0A3S5H786	Leishmania donovani	94%	100%
A1A4J8	Bos taurus	34%	76%
A4H427	Leishmania braziliensis	30%	100%
A4HF41	Leishmania braziliensis	32%	100%
A4HSB1	Leishmania infantum	31%	75%
A4HYS6	Leishmania infantum	95%	100%
C9ZI98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	77%
C9ZYA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	85%
E9AID5	Leishmania braziliensis	86%	100%
E9AK94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AYH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	81%
O42899	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	88%
O43819	Homo sapiens	30%	87%
O75880	Homo sapiens	34%	77%
O97196	Leishmania major	32%	100%
P23833	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	78%
P38072	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	77%
P47206	Pseudonocardia sediminis	25%	100%
Q1RIN4	Rickettsia bellii (strain RML369-C)	29%	100%
Q4Q8Z5	Leishmania major	33%	100%
Q4QCW2	Leishmania major	96%	100%
Q4UKW2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	27%	100%
Q52720	Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)	30%	100%
Q5RH02	Danio rerio	32%	83%
Q5SUC9	Mus musculus	34%	81%
Q68WF1	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	23%	100%
Q8LAL0	Arabidopsis thaliana	28%	84%
Q8VCL2	Mus musculus	34%	91%
Q8VYP0	Arabidopsis thaliana	32%	69%
Q92H76	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	27%	100%
Q9ZCW7	Rickettsia prowazekii (strain Madrid E)	25%	100%
Q9ZEB4	Rickettsia prowazekii (strain Madrid E)	23%	100%
V5BI84	Trypanosoma cruzi	31%	86%
V5BQS4	Trypanosoma cruzi	67%	69%