Phosphopantetheinyl transferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphopantetheinyl transferase-like protein

Species:

Leishmania mexicana

UniProt:

E9AUM1_LEIMU

TriTrypDb:

LmxM.20.0830

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUM1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006553	lysine metabolic process	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008652	amino acid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009066	aspartate family amino acid metabolic process	5	1
GO:0009067	aspartate family amino acid biosynthetic process	6	1
GO:0009085	lysine biosynthetic process	7	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0019878	lysine biosynthetic process via aminoadipic acid	8	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901605	alpha-amino acid metabolic process	4	1
GO:1901607	alpha-amino acid biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0008897	holo-[acyl-carrier-protein] synthase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.359
CLV_NRD_NRD_1	156	158	PF00675	0.302
CLV_NRD_NRD_1	33	35	PF00675	0.599
CLV_PCSK_KEX2_1	33	35	PF00082	0.556
CLV_PCSK_KEX2_1	83	85	PF00082	0.586
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.586
CLV_PCSK_PC7_1	79	85	PF00082	0.563
CLV_PCSK_SKI1_1	62	66	PF00082	0.472
CLV_PCSK_SKI1_1	95	99	PF00082	0.462
DOC_CYCLIN_RxL_1	171	184	PF00134	0.468
DOC_CYCLIN_RxL_1	56	70	PF00134	0.489
DOC_MAPK_gen_1	217	224	PF00069	0.431
DOC_MAPK_gen_1	83	90	PF00069	0.359
DOC_MAPK_MEF2A_6	217	224	PF00069	0.498
DOC_MAPK_MEF2A_6	83	90	PF00069	0.350
DOC_PP2B_LxvP_1	97	100	PF13499	0.481
DOC_PP4_FxxP_1	237	240	PF00568	0.475
DOC_PP4_FxxP_1	264	267	PF00568	0.460
DOC_PP4_FxxP_1	93	96	PF00568	0.305
DOC_USP7_MATH_1	134	138	PF00917	0.460
DOC_USP7_MATH_1	35	39	PF00917	0.577
DOC_USP7_MATH_1	7	11	PF00917	0.355
DOC_WW_Pin1_4	12	17	PF00397	0.535
DOC_WW_Pin1_4	263	268	PF00397	0.542
LIG_14-3-3_CanoR_1	219	225	PF00244	0.472
LIG_14-3-3_CanoR_1	87	97	PF00244	0.527
LIG_BIR_II_1	1	5	PF00653	0.392
LIG_BRCT_BRCA1_1	136	140	PF00533	0.550
LIG_FHA_1	137	143	PF00498	0.421
LIG_FHA_2	167	173	PF00498	0.550
LIG_IRF3_LxIS_1	86	91	PF10401	0.344
LIG_LIR_Apic_2	211	216	PF02991	0.564
LIG_LIR_Apic_2	235	240	PF02991	0.470
LIG_LIR_Apic_2	261	267	PF02991	0.465
LIG_LIR_Apic_2	91	96	PF02991	0.429
LIG_LIR_Gen_1	162	170	PF02991	0.502
LIG_LIR_Nem_3	162	167	PF02991	0.453
LIG_PAM2_1	159	171	PF00658	0.502
LIG_Pex14_1	160	164	PF04695	0.431
LIG_Pex14_2	164	168	PF04695	0.468
LIG_SH2_CRK	213	217	PF00017	0.437
LIG_SH2_SRC	101	104	PF00017	0.304
LIG_SH2_STAT5	213	216	PF00017	0.442
LIG_SH3_3	237	243	PF00018	0.492
LIG_SH3_3	83	89	PF00018	0.433
LIG_Sin3_3	2	9	PF02671	0.258
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.471
LIG_TRAF2_1	145	148	PF00917	0.550
LIG_UBA3_1	163	171	PF00899	0.423
LIG_UBA3_1	220	229	PF00899	0.588
MOD_CK1_1	211	217	PF00069	0.448
MOD_CK1_1	266	272	PF00069	0.382
MOD_CK1_1	72	78	PF00069	0.469
MOD_CK2_1	142	148	PF00069	0.328
MOD_CK2_1	166	172	PF00069	0.426
MOD_CK2_1	18	24	PF00069	0.471
MOD_GlcNHglycan	136	139	PF01048	0.428
MOD_GlcNHglycan	20	23	PF01048	0.536
MOD_GlcNHglycan	37	40	PF01048	0.344
MOD_GlcNHglycan	41	44	PF01048	0.581
MOD_GlcNHglycan	71	74	PF01048	0.373
MOD_GlcNHglycan	9	12	PF01048	0.466
MOD_GlcNHglycan	90	93	PF01048	0.452
MOD_GSK3_1	134	141	PF00069	0.364
MOD_GSK3_1	35	42	PF00069	0.580
MOD_N-GLC_1	104	109	PF02516	0.418
MOD_N-GLC_1	199	204	PF02516	0.426
MOD_N-GLC_1	7	12	PF02516	0.351
MOD_NEK2_1	166	171	PF00069	0.410
MOD_NEK2_1	180	185	PF00069	0.225
MOD_NEK2_1	220	225	PF00069	0.517
MOD_NEK2_1	69	74	PF00069	0.531
MOD_NEK2_2	192	197	PF00069	0.359
MOD_NEK2_2	232	237	PF00069	0.460
MOD_PIKK_1	72	78	PF00454	0.569
MOD_PK_1	28	34	PF00069	0.536
MOD_PKA_2	39	45	PF00069	0.564
MOD_Plk_1	104	110	PF00069	0.420
MOD_Plk_1	199	205	PF00069	0.359
MOD_Plk_1	28	34	PF00069	0.470
MOD_Plk_1	7	13	PF00069	0.359
MOD_Plk_4	159	165	PF00069	0.367
MOD_Plk_4	199	205	PF00069	0.359
MOD_Plk_4	208	214	PF00069	0.276
MOD_Plk_4	245	251	PF00069	0.385
MOD_ProDKin_1	12	18	PF00069	0.540
MOD_ProDKin_1	263	269	PF00069	0.548
MOD_SUMO_for_1	196	199	PF00179	0.355
MOD_SUMO_rev_2	48	57	PF00179	0.593
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.392
TRG_ER_diArg_1	32	34	PF00400	0.535
TRG_NES_CRM1_1	253	268	PF08389	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I553	Leptomonas seymouri	37%	100%
A0A3S7WW00	Leishmania donovani	88%	100%
A4HYS5	Leishmania infantum	89%	100%
E9AID4	Leishmania braziliensis	66%	100%
Q4QCW3	Leishmania major	88%	100%
Q5NVE1	Pongo abelii	23%	88%
Q9NRN7	Homo sapiens	23%	88%