Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUM0_LEIMU

TriTrypDb:

LmxM.20.0820

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.462
CLV_C14_Caspase3-7	49	53	PF00656	0.502
CLV_PCSK_FUR_1	261	265	PF00082	0.487
CLV_PCSK_KEX2_1	260	262	PF00082	0.450
CLV_PCSK_KEX2_1	263	265	PF00082	0.524
CLV_PCSK_KEX2_1	34	36	PF00082	0.508
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.450
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.524
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.405
CLV_PCSK_SKI1_1	200	204	PF00082	0.382
CLV_PCSK_SKI1_1	24	28	PF00082	0.678
CLV_PCSK_SKI1_1	31	35	PF00082	0.395
DEG_SPOP_SBC_1	16	20	PF00917	0.476
DOC_CYCLIN_RxL_1	197	205	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	325	331	PF00134	0.630
DOC_PP1_RVXF_1	143	149	PF00149	0.490
DOC_PP1_RVXF_1	198	204	PF00149	0.478
DOC_PP2B_LxvP_1	11	14	PF13499	0.462
DOC_PP2B_PxIxI_1	280	286	PF00149	0.456
DOC_USP7_MATH_1	126	130	PF00917	0.563
DOC_USP7_MATH_1	17	21	PF00917	0.524
DOC_USP7_MATH_1	174	178	PF00917	0.699
DOC_USP7_MATH_1	262	266	PF00917	0.516
DOC_USP7_MATH_1	45	49	PF00917	0.579
DOC_USP7_MATH_1	81	85	PF00917	0.741
DOC_WW_Pin1_4	161	166	PF00397	0.397
DOC_WW_Pin1_4	219	224	PF00397	0.611
LIG_14-3-3_CanoR_1	200	210	PF00244	0.459
LIG_eIF4E_1	100	106	PF01652	0.478
LIG_FHA_1	100	106	PF00498	0.478
LIG_FHA_1	129	135	PF00498	0.438
LIG_FHA_1	220	226	PF00498	0.615
LIG_FHA_1	240	246	PF00498	0.243
LIG_FHA_1	49	55	PF00498	0.487
LIG_FHA_2	171	177	PF00498	0.482
LIG_LIR_Gen_1	290	299	PF02991	0.390
LIG_LIR_Gen_1	303	313	PF02991	0.296
LIG_LIR_Gen_1	52	63	PF02991	0.511
LIG_LIR_Nem_3	290	294	PF02991	0.413
LIG_LIR_Nem_3	303	309	PF02991	0.306
LIG_LIR_Nem_3	52	58	PF02991	0.511
LIG_Pex14_2	113	117	PF04695	0.388
LIG_Pex14_2	148	152	PF04695	0.387
LIG_SH2_SRC	332	335	PF00017	0.616
LIG_SH2_STAT5	159	162	PF00017	0.314
LIG_SH2_STAT5	196	199	PF00017	0.467
LIG_SH3_3	229	235	PF00018	0.585
LIG_SH3_3	256	262	PF00018	0.373
LIG_SH3_3	9	15	PF00018	0.630
LIG_Sin3_3	55	62	PF02671	0.557
LIG_SUMO_SIM_par_1	128	135	PF11976	0.503
LIG_TRAF2_1	276	279	PF00917	0.570
MOD_CK1_1	181	187	PF00069	0.528
MOD_CK1_1	300	306	PF00069	0.369
MOD_CK1_1	48	54	PF00069	0.566
MOD_CK1_1	7	13	PF00069	0.700
MOD_CK1_1	79	85	PF00069	0.633
MOD_CK2_1	170	176	PF00069	0.631
MOD_CK2_1	262	268	PF00069	0.600
MOD_CMANNOS	311	314	PF00535	0.412
MOD_GlcNHglycan	142	145	PF01048	0.542
MOD_GlcNHglycan	180	183	PF01048	0.667
MOD_GlcNHglycan	19	22	PF01048	0.692
MOD_GlcNHglycan	264	267	PF01048	0.630
MOD_GlcNHglycan	78	81	PF01048	0.763
MOD_GSK3_1	128	135	PF00069	0.547
MOD_GSK3_1	147	154	PF00069	0.294
MOD_GSK3_1	170	177	PF00069	0.545
MOD_GSK3_1	201	208	PF00069	0.380
MOD_GSK3_1	239	246	PF00069	0.483
MOD_GSK3_1	262	269	PF00069	0.477
MOD_GSK3_1	3	10	PF00069	0.687
MOD_GSK3_1	75	82	PF00069	0.771
MOD_N-GLC_1	217	222	PF02516	0.422
MOD_NEK2_1	139	144	PF00069	0.419
MOD_NEK2_1	151	156	PF00069	0.284
MOD_OFUCOSY	156	163	PF10250	0.398
MOD_PKA_1	85	91	PF00069	0.663
MOD_Plk_1	127	133	PF00069	0.491
MOD_Plk_1	7	13	PF00069	0.463
MOD_Plk_4	128	134	PF00069	0.470
MOD_Plk_4	147	153	PF00069	0.321
MOD_Plk_4	205	211	PF00069	0.343
MOD_Plk_4	244	250	PF00069	0.427
MOD_Plk_4	7	13	PF00069	0.515
MOD_Plk_4	85	91	PF00069	0.614
MOD_ProDKin_1	161	167	PF00069	0.407
MOD_ProDKin_1	219	225	PF00069	0.602
MOD_SUMO_for_1	73	76	PF00179	0.469
TRG_NLS_MonoCore_2	259	264	PF00514	0.445
TRG_NLS_MonoExtC_3	259	264	PF00514	0.445
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P7	Leptomonas seymouri	53%	100%
A0A1X0NWT5	Trypanosomatidae	33%	100%
A0A3R7NTG5	Trypanosoma rangeli	34%	100%
A0A3S7WW35	Leishmania donovani	89%	100%
A4HYS4	Leishmania infantum	90%	100%
E9AID3	Leishmania braziliensis	77%	100%
Q4QCW4	Leishmania major	90%	100%
V5BA94	Trypanosoma cruzi	35%	93%