MgtE_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AUL8_LEIMU

TriTrypDb:

LmxM.20.0800

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.581
CLV_NRD_NRD_1	23	25	PF00675	0.604
CLV_NRD_NRD_1	70	72	PF00675	0.613
CLV_PCSK_KEX2_1	22	24	PF00082	0.594
CLV_PCSK_KEX2_1	72	74	PF00082	0.622
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.459
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.542
CLV_PCSK_SKI1_1	273	277	PF00082	0.473
CLV_PCSK_SKI1_1	64	68	PF00082	0.579
CLV_PCSK_SKI1_1	75	79	PF00082	0.494
CLV_Separin_Metazoa	211	215	PF03568	0.475
DOC_CYCLIN_RxL_1	270	280	PF00134	0.423
DOC_MAPK_gen_1	250	259	PF00069	0.357
DOC_MAPK_JIP1_4	317	323	PF00069	0.507
DOC_USP7_MATH_1	198	202	PF00917	0.649
DOC_USP7_UBL2_3	346	350	PF12436	0.502
DOC_WW_Pin1_4	16	21	PF00397	0.695
DOC_WW_Pin1_4	278	283	PF00397	0.528
DOC_WW_Pin1_4	4	9	PF00397	0.690
LIG_BIR_III_2	156	160	PF00653	0.602
LIG_eIF4E_1	207	213	PF01652	0.529
LIG_FHA_1	168	174	PF00498	0.511
LIG_FHA_1	290	296	PF00498	0.485
LIG_FHA_2	46	52	PF00498	0.554
LIG_RPA_C_Fungi	125	137	PF08784	0.521
LIG_SH2_STAT5	248	251	PF00017	0.522
LIG_SH3_CIN85_PxpxPR_1	6	11	PF14604	0.591
LIG_SUMO_SIM_anti_2	319	326	PF11976	0.508
LIG_SUMO_SIM_par_1	292	298	PF11976	0.421
LIG_TRAF2_1	120	123	PF00917	0.655
LIG_TRAF2_1	208	211	PF00917	0.607
LIG_TRAF2_1	258	261	PF00917	0.486
LIG_WRC_WIRS_1	138	143	PF05994	0.505
MOD_CDK_SPK_2	6	11	PF00069	0.652
MOD_CDK_SPxK_1	16	22	PF00069	0.475
MOD_CDK_SPxK_1	278	284	PF00069	0.532
MOD_CDK_SPxxK_3	16	23	PF00069	0.606
MOD_CDK_SPxxK_3	4	11	PF00069	0.638
MOD_CK1_1	201	207	PF00069	0.565
MOD_CK1_1	308	314	PF00069	0.474
MOD_CK1_1	319	325	PF00069	0.371
MOD_CK1_1	4	10	PF00069	0.799
MOD_CK2_1	329	335	PF00069	0.533
MOD_CK2_1	351	357	PF00069	0.515
MOD_CK2_1	45	51	PF00069	0.560
MOD_GlcNHglycan	184	187	PF01048	0.641
MOD_GlcNHglycan	3	6	PF01048	0.666
MOD_GlcNHglycan	318	321	PF01048	0.335
MOD_GSK3_1	198	205	PF00069	0.573
MOD_GSK3_1	301	308	PF00069	0.404
MOD_N-GLC_1	198	203	PF02516	0.702
MOD_NEK2_1	1	6	PF00069	0.818
MOD_NEK2_1	300	305	PF00069	0.485
MOD_NEK2_2	198	203	PF00069	0.646
MOD_PIKK_1	329	335	PF00454	0.494
MOD_PIKK_1	9	15	PF00454	0.802
MOD_PKB_1	43	51	PF00069	0.549
MOD_Plk_1	198	204	PF00069	0.587
MOD_Plk_2-3	151	157	PF00069	0.583
MOD_Plk_4	137	143	PF00069	0.505
MOD_Plk_4	242	248	PF00069	0.369
MOD_Plk_4	319	325	PF00069	0.516
MOD_ProDKin_1	16	22	PF00069	0.690
MOD_ProDKin_1	278	284	PF00069	0.532
MOD_ProDKin_1	4	10	PF00069	0.690
TRG_DiLeu_BaEn_1	296	301	PF01217	0.416
TRG_DiLeu_BaEn_4	121	127	PF01217	0.549
TRG_ER_diArg_1	42	45	PF00400	0.621
TRG_NLS_MonoExtN_4	20	26	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL3	Leptomonas seymouri	52%	100%
A0A3Q8IAT4	Leishmania donovani	90%	100%
A4HYN8	Leishmania infantum	90%	100%
E9AID1	Leishmania braziliensis	75%	95%
Q4QCW6	Leishmania major	87%	100%