Tubulin nucleotide-binding domain-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tubulin/FtsZ family, putative

Species:

Leishmania mexicana

UniProt:

E9AUL6_LEIMU

TriTrypDb:

LmxM.20.0780

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.686
CLV_C14_Caspase3-7	133	137	PF00656	0.652
CLV_C14_Caspase3-7	146	150	PF00656	0.732
CLV_C14_Caspase3-7	250	254	PF00656	0.497
CLV_C14_Caspase3-7	272	276	PF00656	0.421
CLV_NRD_NRD_1	167	169	PF00675	0.809
CLV_NRD_NRD_1	185	187	PF00675	0.531
CLV_NRD_NRD_1	256	258	PF00675	0.506
CLV_NRD_NRD_1	326	328	PF00675	0.401
CLV_NRD_NRD_1	80	82	PF00675	0.582
CLV_PCSK_FUR_1	324	328	PF00082	0.495
CLV_PCSK_KEX2_1	167	169	PF00082	0.770
CLV_PCSK_KEX2_1	185	187	PF00082	0.424
CLV_PCSK_KEX2_1	256	258	PF00082	0.507
CLV_PCSK_KEX2_1	326	328	PF00082	0.401
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.515
CLV_PCSK_SKI1_1	112	116	PF00082	0.574
CLV_PCSK_SKI1_1	186	190	PF00082	0.495
CLV_PCSK_SKI1_1	533	537	PF00082	0.567
CLV_PCSK_SKI1_1	590	594	PF00082	0.557
CLV_PCSK_SKI1_1	61	65	PF00082	0.333
CLV_PCSK_SKI1_1	642	646	PF00082	0.464
DEG_APCC_DBOX_1	589	597	PF00400	0.607
DEG_Nend_Nbox_1	1	3	PF02207	0.543
DOC_CDC14_PxL_1	456	464	PF14671	0.625
DOC_CDC14_PxL_1	606	614	PF14671	0.415
DOC_CKS1_1	295	300	PF01111	0.519
DOC_CYCLIN_RxL_1	180	191	PF00134	0.517
DOC_CYCLIN_RxL_1	56	66	PF00134	0.492
DOC_MAPK_gen_1	324	333	PF00069	0.373
DOC_MAPK_gen_1	419	429	PF00069	0.498
DOC_MAPK_MEF2A_6	344	353	PF00069	0.392
DOC_MAPK_MEF2A_6	422	429	PF00069	0.496
DOC_MAPK_MEF2A_6	5	12	PF00069	0.303
DOC_MAPK_NFAT4_5	5	13	PF00069	0.446
DOC_PP2B_LxvP_1	308	311	PF13499	0.336
DOC_PP2B_LxvP_1	65	68	PF13499	0.371
DOC_PP4_FxxP_1	564	567	PF00568	0.531
DOC_USP7_MATH_1	228	232	PF00917	0.501
DOC_USP7_MATH_1	423	427	PF00917	0.474
DOC_USP7_MATH_1	467	471	PF00917	0.729
DOC_USP7_MATH_1	571	575	PF00917	0.656
DOC_USP7_MATH_1	68	72	PF00917	0.580
DOC_USP7_MATH_1	87	91	PF00917	0.522
DOC_USP7_UBL2_3	84	88	PF12436	0.536
DOC_WW_Pin1_4	294	299	PF00397	0.495
DOC_WW_Pin1_4	364	369	PF00397	0.636
LIG_14-3-3_CanoR_1	168	174	PF00244	0.525
LIG_14-3-3_CanoR_1	244	251	PF00244	0.438
LIG_14-3-3_CanoR_1	344	353	PF00244	0.474
LIG_14-3-3_CanoR_1	379	385	PF00244	0.446
LIG_14-3-3_CanoR_1	539	544	PF00244	0.629
LIG_Actin_WH2_2	381	399	PF00022	0.431
LIG_Actin_WH2_2	517	535	PF00022	0.567
LIG_APCC_ABBA_1	649	654	PF00400	0.505
LIG_APCC_ABBAyCdc20_2	185	191	PF00400	0.523
LIG_BRCT_BRCA1_1	554	558	PF00533	0.497
LIG_Clathr_ClatBox_1	62	66	PF01394	0.339
LIG_deltaCOP1_diTrp_1	357	362	PF00928	0.463
LIG_deltaCOP1_diTrp_1	445	449	PF00928	0.509
LIG_FHA_1	201	207	PF00498	0.508
LIG_FHA_1	295	301	PF00498	0.485
LIG_FHA_1	337	343	PF00498	0.335
LIG_FHA_1	344	350	PF00498	0.361
LIG_FHA_1	379	385	PF00498	0.443
LIG_FHA_1	558	564	PF00498	0.533
LIG_FHA_2	270	276	PF00498	0.442
LIG_LIR_Apic_2	561	567	PF02991	0.526
LIG_LIR_Gen_1	304	313	PF02991	0.485
LIG_LIR_Gen_1	356	365	PF02991	0.488
LIG_LIR_Gen_1	415	425	PF02991	0.504
LIG_LIR_Gen_1	444	455	PF02991	0.505
LIG_LIR_Gen_1	71	80	PF02991	0.609
LIG_LIR_Nem_3	195	201	PF02991	0.556
LIG_LIR_Nem_3	304	308	PF02991	0.349
LIG_LIR_Nem_3	347	353	PF02991	0.413
LIG_LIR_Nem_3	356	361	PF02991	0.430
LIG_LIR_Nem_3	415	420	PF02991	0.507
LIG_LIR_Nem_3	444	450	PF02991	0.506
LIG_LIR_Nem_3	540	546	PF02991	0.466
LIG_LIR_Nem_3	71	76	PF02991	0.601
LIG_LIR_Nem_3	9	15	PF02991	0.394
LIG_NRBOX	332	338	PF00104	0.358
LIG_PDZ_Class_2	671	676	PF00595	0.445
LIG_Pex14_1	358	362	PF04695	0.383
LIG_Pex14_1	79	83	PF04695	0.617
LIG_SH2_CRK	15	19	PF00017	0.308
LIG_SH2_CRK	534	538	PF00017	0.503
LIG_SH2_NCK_1	606	610	PF00017	0.432
LIG_SH2_NCK_1	655	659	PF00017	0.541
LIG_SH2_NCK_1	69	73	PF00017	0.468
LIG_SH2_PTP2	350	353	PF00017	0.387
LIG_SH2_SRC	350	353	PF00017	0.369
LIG_SH2_STAP1	15	19	PF00017	0.308
LIG_SH2_STAP1	69	73	PF00017	0.584
LIG_SH2_STAT5	201	204	PF00017	0.429
LIG_SH2_STAT5	238	241	PF00017	0.566
LIG_SH2_STAT5	350	353	PF00017	0.339
LIG_SH2_STAT5	543	546	PF00017	0.455
LIG_SH2_STAT5	630	633	PF00017	0.477
LIG_SH2_STAT5	634	637	PF00017	0.426
LIG_SH3_3	292	298	PF00018	0.443
LIG_SH3_3	309	315	PF00018	0.278
LIG_SH3_3	346	352	PF00018	0.312
LIG_SH3_3	417	423	PF00018	0.474
LIG_SH3_3	451	457	PF00018	0.619
LIG_SH3_3	54	60	PF00018	0.456
LIG_SH3_3	547	553	PF00018	0.675
LIG_SUMO_SIM_par_1	61	66	PF11976	0.327
LIG_TRAF2_1	89	92	PF00917	0.658
LIG_TRAF2_1	95	98	PF00917	0.724
LIG_TRAF2_2	216	221	PF00917	0.629
LIG_UBA3_1	611	618	PF00899	0.428
LIG_WRC_WIRS_1	229	234	PF05994	0.401
MOD_CK1_1	210	216	PF00069	0.521
MOD_CK1_1	343	349	PF00069	0.334
MOD_CK1_1	400	406	PF00069	0.609
MOD_CK1_1	441	447	PF00069	0.632
MOD_CK1_1	494	500	PF00069	0.589
MOD_CK1_1	580	586	PF00069	0.591
MOD_CK1_1	588	594	PF00069	0.489
MOD_CK2_1	364	370	PF00069	0.568
MOD_CK2_1	658	664	PF00069	0.506
MOD_CK2_1	86	92	PF00069	0.655
MOD_CK2_1	93	99	PF00069	0.593
MOD_Cter_Amidation	165	168	PF01082	0.541
MOD_GlcNHglycan	126	130	PF01048	0.723
MOD_GlcNHglycan	346	349	PF01048	0.384
MOD_GlcNHglycan	402	405	PF01048	0.671
MOD_GlcNHglycan	42	45	PF01048	0.540
MOD_GlcNHglycan	440	443	PF01048	0.615
MOD_GlcNHglycan	478	481	PF01048	0.735
MOD_GlcNHglycan	51	54	PF01048	0.493
MOD_GlcNHglycan	573	576	PF01048	0.678
MOD_GlcNHglycan	579	582	PF01048	0.622
MOD_GlcNHglycan	70	73	PF01048	0.623
MOD_GSK3_1	169	176	PF00069	0.719
MOD_GSK3_1	336	343	PF00069	0.303
MOD_GSK3_1	36	43	PF00069	0.454
MOD_GSK3_1	400	407	PF00069	0.597
MOD_GSK3_1	436	443	PF00069	0.633
MOD_GSK3_1	487	494	PF00069	0.397
MOD_GSK3_1	496	503	PF00069	0.485
MOD_GSK3_1	548	555	PF00069	0.556
MOD_GSK3_1	580	587	PF00069	0.651
MOD_GSK3_1	588	595	PF00069	0.527
MOD_GSK3_1	601	608	PF00069	0.396
MOD_N-GLC_1	124	129	PF02516	0.732
MOD_N-GLC_1	13	18	PF02516	0.347
MOD_N-GLC_1	192	197	PF02516	0.579
MOD_N-GLC_1	24	29	PF02516	0.385
MOD_NEK2_1	336	341	PF00069	0.304
MOD_NEK2_1	489	494	PF00069	0.421
MOD_NEK2_1	538	543	PF00069	0.592
MOD_NEK2_2	585	590	PF00069	0.640
MOD_PIKK_1	404	410	PF00454	0.560
MOD_PKA_2	169	175	PF00069	0.731
MOD_PKA_2	243	249	PF00069	0.432
MOD_PKA_2	343	349	PF00069	0.468
MOD_PKA_2	378	384	PF00069	0.528
MOD_PKA_2	400	406	PF00069	0.644
MOD_PKA_2	467	473	PF00069	0.508
MOD_PKA_2	538	544	PF00069	0.632
MOD_Plk_1	13	19	PF00069	0.405
MOD_Plk_1	192	198	PF00069	0.568
MOD_Plk_1	548	554	PF00069	0.614
MOD_Plk_4	14	20	PF00069	0.318
MOD_Plk_4	33	39	PF00069	0.336
MOD_Plk_4	520	526	PF00069	0.635
MOD_Plk_4	539	545	PF00069	0.607
MOD_ProDKin_1	294	300	PF00069	0.490
MOD_ProDKin_1	364	370	PF00069	0.636
MOD_SUMO_rev_2	85	90	PF00179	0.691
TRG_DiLeu_BaEn_1	98	103	PF01217	0.504
TRG_DiLeu_BaEn_2	444	450	PF01217	0.623
TRG_DiLeu_BaEn_4	98	104	PF01217	0.549
TRG_DiLeu_BaLyEn_6	451	456	PF01217	0.507
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.532
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.440
TRG_ENDOCYTIC_2	15	18	PF00928	0.308
TRG_ENDOCYTIC_2	350	353	PF00928	0.308
TRG_ENDOCYTIC_2	543	546	PF00928	0.455
TRG_ER_diArg_1	167	170	PF00400	0.775
TRG_ER_diArg_1	255	257	PF00400	0.475
TRG_ER_diArg_1	326	328	PF00400	0.407
TRG_NLS_Bipartite_1	167	189	PF00514	0.540
TRG_NLS_MonoExtC_3	184	190	PF00514	0.628
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U7	Leptomonas seymouri	53%	92%
A0A0S4J688	Bodo saltans	30%	100%
A0A1X0NWM5	Trypanosomatidae	41%	100%
A0A3R7MKD9	Trypanosoma rangeli	39%	100%
A0A3S7WVZ9	Leishmania donovani	89%	97%
A4HYP0	Leishmania infantum	89%	97%
C9ZI95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AIC9	Leishmania braziliensis	78%	100%
Q4QCW8	Leishmania major	88%	100%
V5C080	Trypanosoma cruzi	40%	100%