DUF775 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF775), putative

Species:

Leishmania mexicana

UniProt:

E9AUL1_LEIMU

TriTrypDb:

LmxM.20.0680

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUL1

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1

Molecular functions
Term	Name	Level	Count
GO:0061608	nuclear import signal receptor activity	3	1
GO:0140104	molecular carrier activity	1	1
GO:0140142	nucleocytoplasmic carrier activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.431
CLV_PCSK_SKI1_1	115	119	PF00082	0.271
CLV_PCSK_SKI1_1	167	171	PF00082	0.361
CLV_PCSK_SKI1_1	206	210	PF00082	0.235
DEG_COP1_1	98	106	PF00400	0.371
DEG_MDM2_SWIB_1	195	203	PF02201	0.471
DEG_Nend_UBRbox_3	1	3	PF02207	0.692
DEG_SPOP_SBC_1	17	21	PF00917	0.599
DOC_MAPK_MEF2A_6	115	122	PF00069	0.527
DOC_MAPK_MEF2A_6	46	53	PF00069	0.522
DOC_MAPK_NFAT4_5	115	123	PF00069	0.537
DOC_PP2B_LxvP_1	10	13	PF13499	0.649
DOC_WW_Pin1_4	18	23	PF00397	0.663
DOC_WW_Pin1_4	37	42	PF00397	0.512
LIG_14-3-3_CanoR_1	167	172	PF00244	0.504
LIG_14-3-3_CanoR_1	46	52	PF00244	0.503
LIG_14-3-3_CanoR_1	96	104	PF00244	0.504
LIG_EVH1_2	22	26	PF00568	0.504
LIG_FHA_1	103	109	PF00498	0.411
LIG_FHA_1	175	181	PF00498	0.491
LIG_FHA_1	191	197	PF00498	0.483
LIG_FHA_1	46	52	PF00498	0.445
LIG_FHA_2	168	174	PF00498	0.353
LIG_FHA_2	179	185	PF00498	0.505
LIG_FHA_2	61	67	PF00498	0.537
LIG_GBD_Chelix_1	150	158	PF00786	0.288
LIG_LIR_Gen_1	156	166	PF02991	0.354
LIG_LIR_Gen_1	187	196	PF02991	0.537
LIG_LIR_Gen_1	56	64	PF02991	0.561
LIG_LIR_Gen_1	83	92	PF02991	0.459
LIG_LIR_Nem_3	156	162	PF02991	0.471
LIG_LIR_Nem_3	56	61	PF02991	0.511
LIG_LIR_Nem_3	83	89	PF02991	0.459
LIG_Pex14_2	195	199	PF04695	0.471
LIG_PTB_Apo_2	127	134	PF02174	0.505
LIG_SH2_CRK	159	163	PF00017	0.471
LIG_SH2_NCK_1	14	18	PF00017	0.692
LIG_SH2_STAP1	159	163	PF00017	0.502
LIG_SH2_STAP1	165	169	PF00017	0.515
LIG_SH2_STAT3	33	36	PF00017	0.491
LIG_SH2_STAT5	188	191	PF00017	0.492
LIG_SH2_STAT5	88	91	PF00017	0.499
LIG_SH3_3	186	192	PF00018	0.471
LIG_SH3_3	25	31	PF00018	0.505
LIG_SH3_3	64	70	PF00018	0.489
LIG_SH3_3	98	104	PF00018	0.524
LIG_WRC_WIRS_1	158	163	PF05994	0.425
MOD_CK2_1	178	184	PF00069	0.537
MOD_CK2_1	60	66	PF00069	0.537
MOD_GSK3_1	13	20	PF00069	0.712
MOD_GSK3_1	139	146	PF00069	0.570
MOD_GSK3_1	157	164	PF00069	0.374
MOD_GSK3_1	174	181	PF00069	0.554
MOD_GSK3_1	37	44	PF00069	0.524
MOD_NEK2_1	139	144	PF00069	0.570
MOD_NEK2_1	161	166	PF00069	0.448
MOD_PIKK_1	139	145	PF00454	0.506
MOD_PIKK_1	90	96	PF00454	0.510
MOD_PK_1	96	102	PF00069	0.446
MOD_PKA_2	45	51	PF00069	0.408
MOD_PKA_2	95	101	PF00069	0.472
MOD_PKB_1	200	208	PF00069	0.510
MOD_Plk_1	80	86	PF00069	0.537
MOD_Plk_4	157	163	PF00069	0.381
MOD_Plk_4	191	197	PF00069	0.470
MOD_Plk_4	54	60	PF00069	0.456
MOD_Plk_4	96	102	PF00069	0.451
MOD_ProDKin_1	18	24	PF00069	0.656
MOD_ProDKin_1	37	43	PF00069	0.512
TRG_DiLeu_BaEn_4	126	132	PF01217	0.537
TRG_ENDOCYTIC_2	159	162	PF00928	0.457
TRG_ENDOCYTIC_2	188	191	PF00928	0.512
TRG_ER_diArg_1	199	202	PF00400	0.517
TRG_NES_CRM1_1	112	126	PF08389	0.528
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS8	Leptomonas seymouri	70%	93%
A0A0S4J2E1	Bodo saltans	37%	100%
A0A1X0NWD7	Trypanosomatidae	45%	91%
A0A3Q8IBJ8	Leishmania donovani	90%	100%
A0A422NJN3	Trypanosoma rangeli	49%	100%
A4HYP4	Leishmania infantum	90%	100%
C9ZI87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AIC4	Leishmania braziliensis	81%	100%
O60175	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q4QCX3	Leishmania major	90%	100%
Q9W0C7	Drosophila melanogaster	25%	100%