TUTase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUK4_LEIMU

TriTrypDb:

LmxM.20.0600

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AUK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUK4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0031123	RNA 3'-end processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071076	RNA 3' uridylation	8	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016779	nucleotidyltransferase activity	4	10
GO:0050265	RNA uridylyltransferase activity	4	10
GO:0070569	uridylyltransferase activity	5	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.396
CLV_C14_Caspase3-7	83	87	PF00656	0.490
CLV_NRD_NRD_1	217	219	PF00675	0.237
CLV_NRD_NRD_1	270	272	PF00675	0.337
CLV_NRD_NRD_1	289	291	PF00675	0.399
CLV_NRD_NRD_1	325	327	PF00675	0.289
CLV_NRD_NRD_1	350	352	PF00675	0.357
CLV_NRD_NRD_1	5	7	PF00675	0.431
CLV_PCSK_KEX2_1	168	170	PF00082	0.228
CLV_PCSK_KEX2_1	217	219	PF00082	0.237
CLV_PCSK_KEX2_1	270	272	PF00082	0.337
CLV_PCSK_KEX2_1	291	293	PF00082	0.417
CLV_PCSK_KEX2_1	325	327	PF00082	0.289
CLV_PCSK_KEX2_1	350	352	PF00082	0.357
CLV_PCSK_KEX2_1	365	367	PF00082	0.343
CLV_PCSK_KEX2_1	5	7	PF00082	0.371
CLV_PCSK_KEX2_1	91	93	PF00082	0.351
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.228
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.392
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.421
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.351
CLV_PCSK_SKI1_1	177	181	PF00082	0.441
CLV_PCSK_SKI1_1	217	221	PF00082	0.391
CLV_PCSK_SKI1_1	326	330	PF00082	0.277
DEG_Nend_UBRbox_3	1	3	PF02207	0.473
DEG_SPOP_SBC_1	307	311	PF00917	0.617
DOC_ANK_TNKS_1	349	356	PF00023	0.431
DOC_MAPK_gen_1	356	364	PF00069	0.523
DOC_MAPK_HePTP_8	39	51	PF00069	0.373
DOC_MAPK_MEF2A_6	356	364	PF00069	0.416
DOC_MAPK_MEF2A_6	42	51	PF00069	0.477
DOC_PP2B_LxvP_1	211	214	PF13499	0.391
DOC_PP4_FxxP_1	223	226	PF00568	0.351
DOC_USP7_MATH_1	204	208	PF00917	0.279
DOC_USP7_MATH_1	308	312	PF00917	0.698
DOC_USP7_MATH_1	316	320	PF00917	0.527
DOC_USP7_MATH_1	354	358	PF00917	0.299
DOC_USP7_UBL2_3	164	168	PF12436	0.295
DOC_WW_Pin1_4	73	78	PF00397	0.348
LIG_14-3-3_CanoR_1	20	28	PF00244	0.334
LIG_14-3-3_CanoR_1	270	276	PF00244	0.363
LIG_14-3-3_CanoR_1	306	316	PF00244	0.551
LIG_14-3-3_CanoR_1	331	339	PF00244	0.300
LIG_Actin_WH2_2	236	251	PF00022	0.428
LIG_BRCT_BRCA1_1	311	315	PF00533	0.689
LIG_BRCT_BRCA1_1	379	383	PF00533	0.419
LIG_BRCT_BRCA1_1	68	72	PF00533	0.418
LIG_FHA_1	185	191	PF00498	0.272
LIG_FHA_1	261	267	PF00498	0.296
LIG_FHA_1	333	339	PF00498	0.453
LIG_FHA_1	384	390	PF00498	0.572
LIG_FHA_2	20	26	PF00498	0.507
LIG_FHA_2	210	216	PF00498	0.314
LIG_FHA_2	60	66	PF00498	0.390
LIG_GBD_Chelix_1	28	36	PF00786	0.225
LIG_LIR_Apic_2	221	226	PF02991	0.355
LIG_LIR_Gen_1	252	259	PF02991	0.381
LIG_LIR_Gen_1	274	284	PF02991	0.351
LIG_LIR_Nem_3	154	159	PF02991	0.320
LIG_LIR_Nem_3	205	211	PF02991	0.321
LIG_LIR_Nem_3	241	247	PF02991	0.296
LIG_LIR_Nem_3	252	257	PF02991	0.281
LIG_LIR_Nem_3	274	279	PF02991	0.352
LIG_LIR_Nem_3	294	298	PF02991	0.391
LIG_LIR_Nem_3	340	345	PF02991	0.298
LIG_LIR_Nem_3	363	367	PF02991	0.332
LIG_LIR_Nem_3	69	75	PF02991	0.312
LIG_PCNA_yPIPBox_3	372	383	PF02747	0.277
LIG_SH2_CRK	276	280	PF00017	0.456
LIG_SH2_GRB2like	345	348	PF00017	0.303
LIG_SH2_PTP2	159	162	PF00017	0.275
LIG_SH2_STAP1	276	280	PF00017	0.340
LIG_SH2_STAT5	159	162	PF00017	0.283
LIG_SH2_STAT5	244	247	PF00017	0.329
LIG_SH2_STAT5	298	301	PF00017	0.475
LIG_SH2_STAT5	345	348	PF00017	0.326
LIG_SH3_3	169	175	PF00018	0.324
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.411
LIG_SUMO_SIM_anti_2	263	268	PF11976	0.295
LIG_SUMO_SIM_anti_2	80	86	PF11976	0.322
LIG_SUMO_SIM_par_1	35	41	PF11976	0.438
LIG_TRAF2_1	319	322	PF00917	0.438
LIG_TRFH_1	223	227	PF08558	0.384
LIG_WRC_WIRS_1	180	185	PF05994	0.295
LIG_WRC_WIRS_1	402	407	PF05994	0.456
LIG_WW_1	226	229	PF00397	0.363
MOD_CK1_1	19	25	PF00069	0.417
MOD_CK1_1	309	315	PF00069	0.623
MOD_CK1_1	54	60	PF00069	0.311
MOD_CK2_1	204	210	PF00069	0.388
MOD_CK2_1	316	322	PF00069	0.601
MOD_CK2_1	397	403	PF00069	0.532
MOD_CK2_1	77	83	PF00069	0.384
MOD_Cter_Amidation	3	6	PF01082	0.419
MOD_Cter_Amidation	348	351	PF01082	0.343
MOD_GlcNHglycan	124	127	PF01048	0.401
MOD_GlcNHglycan	294	298	PF01048	0.419
MOD_GlcNHglycan	79	82	PF01048	0.370
MOD_GSK3_1	16	23	PF00069	0.412
MOD_GSK3_1	179	186	PF00069	0.302
MOD_GSK3_1	306	313	PF00069	0.634
MOD_GSK3_1	316	323	PF00069	0.467
MOD_GSK3_1	385	392	PF00069	0.437
MOD_GSK3_1	397	404	PF00069	0.613
MOD_GSK3_1	54	61	PF00069	0.444
MOD_GSK3_1	73	80	PF00069	0.390
MOD_N-GLC_1	260	265	PF02516	0.397
MOD_N-GLC_1	375	380	PF02516	0.538
MOD_N-GLC_1	392	397	PF02516	0.493
MOD_N-GLC_1	73	78	PF02516	0.330
MOD_NEK2_1	179	184	PF00069	0.409
MOD_NEK2_1	320	325	PF00069	0.453
MOD_NEK2_1	383	388	PF00069	0.622
MOD_NEK2_1	51	56	PF00069	0.342
MOD_NEK2_1	68	73	PF00069	0.222
MOD_PKA_2	16	22	PF00069	0.345
MOD_PKA_2	355	361	PF00069	0.442
MOD_Plk_1	129	135	PF00069	0.296
MOD_Plk_1	209	215	PF00069	0.355
MOD_Plk_1	293	299	PF00069	0.495
MOD_Plk_1	316	322	PF00069	0.416
MOD_Plk_1	375	381	PF00069	0.580
MOD_Plk_1	66	72	PF00069	0.288
MOD_Plk_4	186	192	PF00069	0.405
MOD_Plk_4	262	268	PF00069	0.333
MOD_ProDKin_1	73	79	PF00069	0.342
MOD_SUMO_rev_2	357	367	PF00179	0.512
TRG_DiLeu_BaEn_1	106	111	PF01217	0.320
TRG_ENDOCYTIC_2	159	162	PF00928	0.275
TRG_ENDOCYTIC_2	208	211	PF00928	0.369
TRG_ENDOCYTIC_2	229	232	PF00928	0.339
TRG_ENDOCYTIC_2	244	247	PF00928	0.328
TRG_ENDOCYTIC_2	254	257	PF00928	0.343
TRG_ENDOCYTIC_2	276	279	PF00928	0.327
TRG_ENDOCYTIC_2	368	371	PF00928	0.467
TRG_ER_diArg_1	216	218	PF00400	0.230
TRG_ER_diArg_1	269	271	PF00400	0.323
TRG_ER_diArg_1	324	326	PF00400	0.287
TRG_ER_diArg_1	350	352	PF00400	0.357
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7H1	Leptomonas seymouri	63%	100%
A0A0S4J0S6	Bodo saltans	56%	100%
A0A1X0NX27	Trypanosomatidae	55%	100%
A0A3Q8IDK5	Leishmania donovani	89%	100%
A0A422NJM7	Trypanosoma rangeli	53%	88%
A4HYQ1	Leishmania infantum	89%	100%
C7AJA4	Trypanosoma brucei brucei	52%	100%
C9ZI80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
Q4QCY0	Leishmania major	88%	100%