SMP-LTD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUK3_LEIMU

TriTrypDb:

LmxM.20.0590

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	391	395	PF00656	0.678
CLV_C14_Caspase3-7	584	588	PF00656	0.641
CLV_NRD_NRD_1	32	34	PF00675	0.493
CLV_NRD_NRD_1	38	40	PF00675	0.498
CLV_NRD_NRD_1	524	526	PF00675	0.515
CLV_PCSK_KEX2_1	32	34	PF00082	0.493
CLV_PCSK_KEX2_1	38	40	PF00082	0.498
CLV_PCSK_KEX2_1	523	525	PF00082	0.523
CLV_PCSK_SKI1_1	332	336	PF00082	0.546
CLV_PCSK_SKI1_1	495	499	PF00082	0.390
DEG_Nend_Nbox_1	1	3	PF02207	0.335
DEG_SPOP_SBC_1	512	516	PF00917	0.681
DOC_ANK_TNKS_1	37	44	PF00023	0.633
DOC_CDC14_PxL_1	127	135	PF14671	0.622
DOC_CDC14_PxL_1	487	495	PF14671	0.566
DOC_CYCLIN_RxL_1	167	177	PF00134	0.633
DOC_CYCLIN_yClb5_NLxxxL_5	267	276	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.609
DOC_MAPK_gen_1	417	425	PF00069	0.652
DOC_MAPK_MEF2A_6	417	425	PF00069	0.652
DOC_MAPK_RevD_3	8	23	PF00069	0.312
DOC_PP4_FxxP_1	103	106	PF00568	0.684
DOC_PP4_FxxP_1	488	491	PF00568	0.574
DOC_USP7_MATH_1	194	198	PF00917	0.731
DOC_USP7_MATH_1	234	238	PF00917	0.625
DOC_USP7_MATH_1	297	301	PF00917	0.672
DOC_USP7_MATH_1	361	365	PF00917	0.797
DOC_USP7_MATH_1	474	478	PF00917	0.544
DOC_USP7_MATH_1	512	516	PF00917	0.681
DOC_USP7_MATH_1	528	532	PF00917	0.830
DOC_USP7_MATH_1	551	555	PF00917	0.711
DOC_USP7_MATH_1	597	601	PF00917	0.771
DOC_USP7_MATH_1	80	84	PF00917	0.755
DOC_USP7_MATH_1	94	98	PF00917	0.661
DOC_WW_Pin1_4	257	262	PF00397	0.767
DOC_WW_Pin1_4	355	360	PF00397	0.683
DOC_WW_Pin1_4	449	454	PF00397	0.645
DOC_WW_Pin1_4	515	520	PF00397	0.638
DOC_WW_Pin1_4	81	86	PF00397	0.766
LIG_14-3-3_CanoR_1	381	390	PF00244	0.702
LIG_14-3-3_CanoR_1	406	410	PF00244	0.580
LIG_14-3-3_CanoR_1	438	444	PF00244	0.570
LIG_14-3-3_CanoR_1	598	608	PF00244	0.730
LIG_14-3-3_CanoR_1	77	83	PF00244	0.711
LIG_Actin_WH2_2	11	29	PF00022	0.389
LIG_Actin_WH2_2	426	442	PF00022	0.642
LIG_BIR_III_4	571	575	PF00653	0.696
LIG_BRCT_BRCA1_1	401	405	PF00533	0.570
LIG_BRCT_BRCA1_1	99	103	PF00533	0.782
LIG_FHA_1	367	373	PF00498	0.614
LIG_FHA_1	385	391	PF00498	0.661
LIG_FHA_1	42	48	PF00498	0.596
LIG_FHA_1	460	466	PF00498	0.552
LIG_FHA_1	68	74	PF00498	0.546
LIG_FHA_2	110	116	PF00498	0.752
LIG_LIR_Apic_2	100	106	PF02991	0.687
LIG_LIR_Apic_2	486	491	PF02991	0.576
LIG_LIR_Gen_1	155	161	PF02991	0.577
LIG_LIR_Gen_1	266	277	PF02991	0.611
LIG_LIR_Gen_1	590	601	PF02991	0.677
LIG_LIR_Nem_3	155	159	PF02991	0.576
LIG_LIR_Nem_3	266	272	PF02991	0.614
LIG_LIR_Nem_3	486	490	PF02991	0.566
LIG_LIR_Nem_3	590	596	PF02991	0.709
LIG_NRBOX	1	7	PF00104	0.377
LIG_NRBOX	14	20	PF00104	0.354
LIG_PCNA_PIPBox_1	481	490	PF02747	0.559
LIG_PCNA_yPIPBox_3	481	495	PF02747	0.556
LIG_Pex14_1	46	50	PF04695	0.671
LIG_Pex14_2	471	475	PF04695	0.539
LIG_Pex14_2	497	501	PF04695	0.568
LIG_PTB_Apo_2	607	614	PF02174	0.605
LIG_REV1ctd_RIR_1	494	504	PF16727	0.587
LIG_SH2_CRK	269	273	PF00017	0.692
LIG_SH2_GRB2like	269	272	PF00017	0.737
LIG_SH2_NCK_1	445	449	PF00017	0.618
LIG_SH2_PTP2	424	427	PF00017	0.627
LIG_SH2_SRC	445	448	PF00017	0.616
LIG_SH2_STAP1	269	273	PF00017	0.658
LIG_SH2_STAT5	175	178	PF00017	0.700
LIG_SH2_STAT5	269	272	PF00017	0.737
LIG_SH2_STAT5	420	423	PF00017	0.565
LIG_SH2_STAT5	424	427	PF00017	0.647
LIG_SH2_STAT5	458	461	PF00017	0.587
LIG_SH2_STAT5	612	615	PF00017	0.730
LIG_SH3_3	199	205	PF00018	0.762
LIG_SH3_3	447	453	PF00018	0.642
LIG_SH3_3	576	582	PF00018	0.730
LIG_SH3_3	79	85	PF00018	0.790
LIG_SH3_3	88	94	PF00018	0.789
LIG_SUMO_SIM_anti_2	389	394	PF11976	0.616
LIG_SxIP_EBH_1	29	39	PF03271	0.632
LIG_UBA3_1	15	23	PF00899	0.335
LIG_UBA3_1	498	505	PF00899	0.485
LIG_WRC_WIRS_1	153	158	PF05994	0.657
MOD_CK1_1	120	126	PF00069	0.630
MOD_CK1_1	195	201	PF00069	0.807
MOD_CK1_1	212	218	PF00069	0.650
MOD_CK1_1	260	266	PF00069	0.710
MOD_CK1_1	287	293	PF00069	0.724
MOD_CK1_1	305	311	PF00069	0.644
MOD_CK1_1	345	351	PF00069	0.691
MOD_CK1_1	477	483	PF00069	0.565
MOD_CK1_1	515	521	PF00069	0.663
MOD_CK1_1	552	558	PF00069	0.702
MOD_CK1_1	570	576	PF00069	0.748
MOD_CK1_1	81	87	PF00069	0.763
MOD_CK1_1	97	103	PF00069	0.719
MOD_CK2_1	119	125	PF00069	0.764
MOD_CK2_1	312	318	PF00069	0.731
MOD_CK2_1	597	603	PF00069	0.687
MOD_GlcNHglycan	122	125	PF01048	0.541
MOD_GlcNHglycan	144	147	PF01048	0.474
MOD_GlcNHglycan	194	197	PF01048	0.438
MOD_GlcNHglycan	198	201	PF01048	0.478
MOD_GlcNHglycan	221	224	PF01048	0.582
MOD_GlcNHglycan	241	244	PF01048	0.512
MOD_GlcNHglycan	262	265	PF01048	0.464
MOD_GlcNHglycan	288	292	PF01048	0.473
MOD_GlcNHglycan	299	302	PF01048	0.532
MOD_GlcNHglycan	314	317	PF01048	0.476
MOD_GlcNHglycan	318	321	PF01048	0.476
MOD_GlcNHglycan	340	343	PF01048	0.587
MOD_GlcNHglycan	344	347	PF01048	0.627
MOD_GlcNHglycan	400	404	PF01048	0.373
MOD_GlcNHglycan	459	462	PF01048	0.459
MOD_GlcNHglycan	530	533	PF01048	0.584
MOD_GlcNHglycan	537	540	PF01048	0.475
MOD_GlcNHglycan	542	545	PF01048	0.426
MOD_GlcNHglycan	549	552	PF01048	0.531
MOD_GlcNHglycan	571	575	PF01048	0.411
MOD_GSK3_1	105	112	PF00069	0.691
MOD_GSK3_1	192	199	PF00069	0.742
MOD_GSK3_1	215	222	PF00069	0.644
MOD_GSK3_1	263	270	PF00069	0.735
MOD_GSK3_1	302	309	PF00069	0.696
MOD_GSK3_1	312	319	PF00069	0.698
MOD_GSK3_1	330	337	PF00069	0.691
MOD_GSK3_1	338	345	PF00069	0.817
MOD_GSK3_1	362	369	PF00069	0.700
MOD_GSK3_1	370	377	PF00069	0.702
MOD_GSK3_1	380	387	PF00069	0.733
MOD_GSK3_1	507	514	PF00069	0.647
MOD_GSK3_1	547	554	PF00069	0.720
MOD_GSK3_1	94	101	PF00069	0.768
MOD_N-GLC_1	97	102	PF02516	0.464
MOD_NEK2_1	1	6	PF00069	0.335
MOD_NEK2_1	174	179	PF00069	0.698
MOD_NEK2_1	267	272	PF00069	0.784
MOD_NEK2_1	276	281	PF00069	0.677
MOD_NEK2_1	306	311	PF00069	0.746
MOD_NEK2_1	338	343	PF00069	0.795
MOD_NEK2_1	344	349	PF00069	0.732
MOD_NEK2_1	405	410	PF00069	0.561
MOD_NEK2_1	459	464	PF00069	0.558
MOD_NEK2_1	475	480	PF00069	0.589
MOD_NEK2_1	501	506	PF00069	0.658
MOD_PIKK_1	245	251	PF00454	0.732
MOD_PIKK_1	477	483	PF00454	0.565
MOD_PIKK_1	507	513	PF00454	0.685
MOD_PK_1	330	336	PF00069	0.624
MOD_PK_1	388	394	PF00069	0.625
MOD_PKA_2	284	290	PF00069	0.695
MOD_PKA_2	31	37	PF00069	0.655
MOD_PKA_2	312	318	PF00069	0.661
MOD_PKA_2	342	348	PF00069	0.689
MOD_PKA_2	380	386	PF00069	0.643
MOD_PKA_2	405	411	PF00069	0.471
MOD_PKA_2	439	445	PF00069	0.586
MOD_PKA_2	506	512	PF00069	0.641
MOD_PKA_2	597	603	PF00069	0.772
MOD_PKA_2	67	73	PF00069	0.542
MOD_Plk_1	330	336	PF00069	0.655
MOD_Plk_2-3	446	452	PF00069	0.634
MOD_Plk_4	1	7	PF00069	0.335
MOD_Plk_4	302	308	PF00069	0.782
MOD_Plk_4	388	394	PF00069	0.625
MOD_Plk_4	41	47	PF00069	0.604
MOD_Plk_4	459	465	PF00069	0.553
MOD_ProDKin_1	257	263	PF00069	0.766
MOD_ProDKin_1	355	361	PF00069	0.683
MOD_ProDKin_1	449	455	PF00069	0.643
MOD_ProDKin_1	515	521	PF00069	0.637
MOD_ProDKin_1	81	87	PF00069	0.768
MOD_SUMO_rev_2	145	153	PF00179	0.671
TRG_ENDOCYTIC_2	269	272	PF00928	0.612
TRG_ENDOCYTIC_2	420	423	PF00928	0.560
TRG_ENDOCYTIC_2	424	427	PF00928	0.546
TRG_ER_diArg_1	37	39	PF00400	0.710
TRG_ER_diArg_1	417	420	PF00400	0.603
TRG_ER_diArg_1	437	440	PF00400	0.567
TRG_ER_diArg_1	523	525	PF00400	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1B3	Leptomonas seymouri	49%	99%
A0A3S7WVW3	Leishmania donovani	87%	100%
A4HYQ2	Leishmania infantum	87%	100%
E9AIB6	Leishmania braziliensis	75%	98%
Q4QCY1	Leishmania major	87%	100%