MORN repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AUK2_LEIMU

TriTrypDb:

LmxM.20.0580

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.389
CLV_C14_Caspase3-7	376	380	PF00656	0.657
CLV_C14_Caspase3-7	64	68	PF00656	0.732
CLV_PCSK_KEX2_1	193	195	PF00082	0.284
CLV_PCSK_KEX2_1	209	211	PF00082	0.435
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.284
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.435
CLV_PCSK_SKI1_1	305	309	PF00082	0.462
CLV_PCSK_SKI1_1	373	377	PF00082	0.638
CLV_PCSK_SKI1_1	56	60	PF00082	0.648
DEG_COP1_1	2	9	PF00400	0.695
DEG_SPOP_SBC_1	119	123	PF00917	0.712
DOC_MAPK_gen_1	278	287	PF00069	0.335
DOC_PP1_RVXF_1	142	149	PF00149	0.518
DOC_PP2B_LxvP_1	285	288	PF13499	0.348
DOC_USP7_MATH_1	118	122	PF00917	0.702
DOC_USP7_MATH_1	330	334	PF00917	0.575
DOC_USP7_MATH_1	40	44	PF00917	0.643
DOC_USP7_MATH_1	46	50	PF00917	0.625
DOC_USP7_MATH_1	89	93	PF00917	0.756
DOC_USP7_MATH_1	96	100	PF00917	0.676
DOC_USP7_UBL2_3	252	256	PF12436	0.258
DOC_WW_Pin1_4	114	119	PF00397	0.643
DOC_WW_Pin1_4	183	188	PF00397	0.214
LIG_14-3-3_CanoR_1	213	219	PF00244	0.218
LIG_Actin_WH2_2	150	166	PF00022	0.441
LIG_BIR_II_1	1	5	PF00653	0.699
LIG_DLG_GKlike_1	363	371	PF00625	0.544
LIG_FHA_1	141	147	PF00498	0.458
LIG_FHA_1	338	344	PF00498	0.632
LIG_FHA_1	57	63	PF00498	0.636
LIG_FHA_1	67	73	PF00498	0.532
LIG_FHA_1	89	95	PF00498	0.734
LIG_FHA_2	306	312	PF00498	0.473
LIG_FHA_2	356	362	PF00498	0.531
LIG_FHA_2	374	380	PF00498	0.595
LIG_FHA_2	396	402	PF00498	0.680
LIG_FHA_2	59	65	PF00498	0.786
LIG_LIR_Apic_2	405	411	PF02991	0.552
LIG_LIR_Gen_1	238	247	PF02991	0.549
LIG_LIR_Nem_3	149	153	PF02991	0.334
LIG_LIR_Nem_3	238	242	PF02991	0.366
LIG_LIR_Nem_3	301	307	PF02991	0.453
LIG_Pex14_2	270	274	PF04695	0.335
LIG_PTB_Apo_2	270	277	PF02174	0.294
LIG_PTB_Phospho_1	270	276	PF10480	0.294
LIG_REV1ctd_RIR_1	301	309	PF16727	0.454
LIG_RPA_C_Fungi	358	370	PF08784	0.592
LIG_SH2_CRK	239	243	PF00017	0.453
LIG_SH2_NCK_1	408	412	PF00017	0.488
LIG_SH2_SRC	408	411	PF00017	0.483
LIG_SH2_STAT3	153	156	PF00017	0.404
LIG_SH2_STAT3	247	250	PF00017	0.328
LIG_SH2_STAT5	153	156	PF00017	0.404
LIG_SH2_STAT5	178	181	PF00017	0.344
LIG_SH2_STAT5	286	289	PF00017	0.299
LIG_SH3_3	1	7	PF00018	0.694
LIG_SH3_3	31	37	PF00018	0.832
LIG_SH3_3	332	338	PF00018	0.630
LIG_SH3_3	381	387	PF00018	0.560
LIG_SH3_4	232	239	PF00018	0.389
LIG_TRAF2_1	134	137	PF00917	0.576
LIG_WRC_WIRS_1	215	220	PF05994	0.214
MOD_CDC14_SPxK_1	117	120	PF00782	0.515
MOD_CDK_SPxK_1	114	120	PF00069	0.486
MOD_CK1_1	121	127	PF00069	0.666
MOD_CK1_1	15	21	PF00069	0.613
MOD_CK1_1	331	337	PF00069	0.685
MOD_CK1_1	342	348	PF00069	0.524
MOD_CK2_1	127	133	PF00069	0.708
MOD_CK2_1	186	192	PF00069	0.214
MOD_CK2_1	305	311	PF00069	0.471
MOD_CK2_1	355	361	PF00069	0.532
MOD_CK2_1	48	54	PF00069	0.688
MOD_Cter_Amidation	207	210	PF01082	0.335
MOD_Cter_Amidation	276	279	PF01082	0.335
MOD_GlcNHglycan	129	132	PF01048	0.685
MOD_GlcNHglycan	14	17	PF01048	0.747
MOD_GlcNHglycan	210	213	PF01048	0.335
MOD_GlcNHglycan	330	333	PF01048	0.602
MOD_GlcNHglycan	42	45	PF01048	0.685
MOD_GlcNHglycan	48	51	PF01048	0.660
MOD_GlcNHglycan	79	82	PF01048	0.586
MOD_GlcNHglycan	98	101	PF01048	0.759
MOD_GSK3_1	114	121	PF00069	0.602
MOD_GSK3_1	12	19	PF00069	0.678
MOD_GSK3_1	123	130	PF00069	0.690
MOD_GSK3_1	337	344	PF00069	0.570
MOD_GSK3_1	391	398	PF00069	0.684
MOD_GSK3_1	40	47	PF00069	0.677
MOD_GSK3_1	56	63	PF00069	0.542
MOD_GSK3_1	84	91	PF00069	0.672
MOD_N-GLC_1	345	350	PF02516	0.541
MOD_N-GLC_2	204	206	PF02516	0.214
MOD_NEK2_1	355	360	PF00069	0.534
MOD_PIKK_1	84	90	PF00454	0.705
MOD_PKA_2	260	266	PF00069	0.282
MOD_Plk_1	345	351	PF00069	0.438
MOD_Plk_2-3	132	138	PF00069	0.692
MOD_Plk_4	412	418	PF00069	0.512
MOD_ProDKin_1	114	120	PF00069	0.652
MOD_ProDKin_1	183	189	PF00069	0.214
MOD_SUMO_rev_2	136	146	PF00179	0.592
MOD_SUMO_rev_2	225	233	PF00179	0.389
MOD_SUMO_rev_2	49	58	PF00179	0.753
TRG_DiLeu_BaEn_1	142	147	PF01217	0.521
TRG_DiLeu_BaEn_4	136	142	PF01217	0.466
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.647
TRG_ENDOCYTIC_2	224	227	PF00928	0.310
TRG_ENDOCYTIC_2	239	242	PF00928	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL7	Leptomonas seymouri	61%	89%
A0A3Q8IAI5	Leishmania donovani	83%	100%
A4HYQ3	Leishmania infantum	83%	100%
E9AIB5	Leishmania braziliensis	63%	100%
Q4QCY2	Leishmania major	83%	100%