Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AUK1_LEIMU

TriTrypDb:

LmxM.20.0570

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AUK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	551	555	PF00656	0.545
CLV_C14_Caspase3-7	748	752	PF00656	0.434
CLV_NRD_NRD_1	431	433	PF00675	0.634
CLV_NRD_NRD_1	54	56	PF00675	0.624
CLV_NRD_NRD_1	548	550	PF00675	0.824
CLV_NRD_NRD_1	619	621	PF00675	0.640
CLV_NRD_NRD_1	685	687	PF00675	0.700
CLV_NRD_NRD_1	730	732	PF00675	0.643
CLV_NRD_NRD_1	86	88	PF00675	0.684
CLV_PCSK_FUR_1	84	88	PF00082	0.680
CLV_PCSK_KEX2_1	547	549	PF00082	0.718
CLV_PCSK_KEX2_1	619	621	PF00082	0.640
CLV_PCSK_KEX2_1	685	687	PF00082	0.700
CLV_PCSK_KEX2_1	730	732	PF00082	0.643
CLV_PCSK_KEX2_1	776	778	PF00082	0.678
CLV_PCSK_KEX2_1	86	88	PF00082	0.674
CLV_PCSK_PC1ET2_1	776	778	PF00082	0.645
CLV_PCSK_SKI1_1	223	227	PF00082	0.632
CLV_PCSK_SKI1_1	238	242	PF00082	0.671
CLV_PCSK_SKI1_1	250	254	PF00082	0.602
CLV_PCSK_SKI1_1	305	309	PF00082	0.615
CLV_PCSK_SKI1_1	356	360	PF00082	0.303
CLV_PCSK_SKI1_1	367	371	PF00082	0.309
CLV_PCSK_SKI1_1	815	819	PF00082	0.623
DEG_APCC_DBOX_1	355	363	PF00400	0.303
DEG_Nend_UBRbox_2	1	3	PF02207	0.534
DEG_ODPH_VHL_1	345	357	PF01847	0.303
DEG_SCF_TRCP1_1	554	560	PF00400	0.506
DEG_SPOP_SBC_1	154	158	PF00917	0.450
DOC_CDC14_PxL_1	230	238	PF14671	0.485
DOC_CKS1_1	467	472	PF01111	0.458
DOC_CKS1_1	99	104	PF01111	0.430
DOC_CYCLIN_yCln2_LP_2	609	615	PF00134	0.593
DOC_MAPK_gen_1	403	413	PF00069	0.588
DOC_MAPK_gen_1	685	691	PF00069	0.440
DOC_MAPK_JIP1_4	657	663	PF00069	0.431
DOC_MAPK_MEF2A_6	192	199	PF00069	0.418
DOC_MAPK_MEF2A_6	403	411	PF00069	0.622
DOC_MAPK_RevD_3	417	433	PF00069	0.225
DOC_PP1_RVXF_1	377	384	PF00149	0.595
DOC_PP2B_LxvP_1	307	310	PF13499	0.490
DOC_PP2B_LxvP_1	609	612	PF13499	0.586
DOC_PP4_FxxP_1	494	497	PF00568	0.519
DOC_USP7_MATH_1	148	152	PF00917	0.510
DOC_USP7_MATH_1	154	158	PF00917	0.483
DOC_USP7_MATH_1	160	164	PF00917	0.445
DOC_USP7_MATH_1	182	186	PF00917	0.487
DOC_USP7_MATH_1	339	343	PF00917	0.425
DOC_USP7_MATH_1	365	369	PF00917	0.491
DOC_USP7_MATH_1	391	395	PF00917	0.649
DOC_USP7_MATH_1	514	518	PF00917	0.482
DOC_USP7_MATH_1	539	543	PF00917	0.511
DOC_USP7_MATH_1	570	574	PF00917	0.482
DOC_USP7_MATH_1	643	647	PF00917	0.449
DOC_USP7_MATH_1	712	716	PF00917	0.488
DOC_USP7_MATH_1	828	832	PF00917	0.489
DOC_USP7_UBL2_3	204	208	PF12436	0.437
DOC_USP7_UBL2_3	520	524	PF12436	0.419
DOC_WW_Pin1_4	135	140	PF00397	0.463
DOC_WW_Pin1_4	150	155	PF00397	0.496
DOC_WW_Pin1_4	156	161	PF00397	0.476
DOC_WW_Pin1_4	175	180	PF00397	0.432
DOC_WW_Pin1_4	466	471	PF00397	0.480
DOC_WW_Pin1_4	500	505	PF00397	0.479
DOC_WW_Pin1_4	542	547	PF00397	0.599
DOC_WW_Pin1_4	592	597	PF00397	0.431
DOC_WW_Pin1_4	639	644	PF00397	0.500
DOC_WW_Pin1_4	680	685	PF00397	0.456
DOC_WW_Pin1_4	730	735	PF00397	0.468
DOC_WW_Pin1_4	790	795	PF00397	0.509
DOC_WW_Pin1_4	98	103	PF00397	0.425
LIG_14-3-3_CanoR_1	192	196	PF00244	0.420
LIG_14-3-3_CanoR_1	238	247	PF00244	0.438
LIG_14-3-3_CanoR_1	279	285	PF00244	0.412
LIG_14-3-3_CanoR_1	305	310	PF00244	0.467
LIG_14-3-3_CanoR_1	432	441	PF00244	0.429
LIG_14-3-3_CanoR_1	512	521	PF00244	0.505
LIG_14-3-3_CanoR_1	692	697	PF00244	0.534
LIG_14-3-3_CanoR_1	71	76	PF00244	0.403
LIG_14-3-3_CanoR_1	785	789	PF00244	0.460
LIG_Actin_WH2_2	355	373	PF00022	0.326
LIG_BIR_III_4	751	755	PF00653	0.442
LIG_BRCT_BRCA1_1	241	245	PF00533	0.476
LIG_BRCT_BRCA1_1	414	418	PF00533	0.355
LIG_BRCT_BRCA1_1	706	710	PF00533	0.426
LIG_BRCT_BRCA1_1	732	736	PF00533	0.461
LIG_BRCT_BRCA1_1	740	744	PF00533	0.482
LIG_Clathr_ClatBox_1	380	384	PF01394	0.615
LIG_Clathr_ClatBox_1	829	833	PF01394	0.413
LIG_deltaCOP1_diTrp_1	263	268	PF00928	0.458
LIG_deltaCOP1_diTrp_1	82	88	PF00928	0.384
LIG_Dynein_DLC8_1	431	437	PF01221	0.390
LIG_EH1_1	352	360	PF00400	0.303
LIG_eIF4E_1	353	359	PF01652	0.303
LIG_eIF4E_1	364	370	PF01652	0.400
LIG_FHA_1	162	168	PF00498	0.493
LIG_FHA_1	239	245	PF00498	0.479
LIG_FHA_1	414	420	PF00498	0.303
LIG_FHA_1	433	439	PF00498	0.427
LIG_FHA_1	516	522	PF00498	0.481
LIG_FHA_1	593	599	PF00498	0.474
LIG_FHA_1	604	610	PF00498	0.475
LIG_FHA_1	7	13	PF00498	0.512
LIG_FHA_2	102	108	PF00498	0.534
LIG_FHA_2	447	453	PF00498	0.474
LIG_FHA_2	645	651	PF00498	0.442
LIG_FHA_2	712	718	PF00498	0.490
LIG_FHA_2	746	752	PF00498	0.574
LIG_FHA_2	818	824	PF00498	0.468
LIG_FXI_DFP_1	253	257	PF00024	0.647
LIG_IRF3_LxIS_1	609	616	PF10401	0.484
LIG_LIR_Apic_2	492	497	PF02991	0.515
LIG_LIR_Gen_1	262	272	PF02991	0.447
LIG_LIR_Gen_1	415	426	PF02991	0.355
LIG_LIR_Gen_1	72	83	PF02991	0.431
LIG_LIR_Nem_3	262	268	PF02991	0.455
LIG_LIR_Nem_3	415	421	PF02991	0.355
LIG_LIR_Nem_3	51	57	PF02991	0.436
LIG_LIR_Nem_3	523	529	PF02991	0.479
LIG_LIR_Nem_3	72	78	PF02991	0.407
LIG_NRBOX	365	371	PF00104	0.503
LIG_PTB_Apo_2	229	236	PF02174	0.407
LIG_PTB_Apo_2	690	697	PF02174	0.437
LIG_PTB_Phospho_1	229	235	PF10480	0.409
LIG_RPA_C_Fungi	442	454	PF08784	0.422
LIG_SH2_CRK	800	804	PF00017	0.523
LIG_SH2_NCK_1	482	486	PF00017	0.516
LIG_SH2_NCK_1	62	66	PF00017	0.568
LIG_SH2_NCK_1	800	804	PF00017	0.523
LIG_SH2_PTP2	528	531	PF00017	0.592
LIG_SH2_SRC	528	531	PF00017	0.643
LIG_SH2_SRC	60	63	PF00017	0.572
LIG_SH2_STAP1	353	357	PF00017	0.303
LIG_SH2_STAP1	434	438	PF00017	0.510
LIG_SH2_STAP1	62	66	PF00017	0.568
LIG_SH2_STAT3	277	280	PF00017	0.550
LIG_SH2_STAT5	19	22	PF00017	0.642
LIG_SH2_STAT5	198	201	PF00017	0.506
LIG_SH2_STAT5	235	238	PF00017	0.608
LIG_SH2_STAT5	434	437	PF00017	0.581
LIG_SH2_STAT5	528	531	PF00017	0.643
LIG_SH2_STAT5	60	63	PF00017	0.572
LIG_SH3_1	800	806	PF00018	0.524
LIG_SH3_3	241	247	PF00018	0.455
LIG_SH3_3	341	347	PF00018	0.497
LIG_SH3_3	464	470	PF00018	0.545
LIG_SH3_3	494	500	PF00018	0.518
LIG_SH3_3	593	599	PF00018	0.657
LIG_SH3_3	800	806	PF00018	0.602
LIG_SH3_3	96	102	PF00018	0.505
LIG_SUMO_SIM_par_1	101	107	PF11976	0.652
LIG_SUMO_SIM_par_1	610	617	PF11976	0.599
LIG_SUMO_SIM_par_1	66	72	PF11976	0.532
LIG_SUMO_SIM_par_1	9	18	PF11976	0.558
LIG_TRAF2_1	122	125	PF00917	0.642
LIG_TRFH_1	800	804	PF08558	0.523
LIG_UBA3_1	395	403	PF00899	0.509
LIG_Vh1_VBS_1	348	366	PF01044	0.303
MOD_CDC14_SPxK_1	545	548	PF00782	0.590
MOD_CDK_SPK_2	542	547	PF00069	0.759
MOD_CDK_SPK_2	592	597	PF00069	0.524
MOD_CDK_SPK_2	680	685	PF00069	0.613
MOD_CDK_SPxK_1	542	548	PF00069	0.762
MOD_CDK_SPxK_1	680	686	PF00069	0.614
MOD_CDK_SPxxK_3	542	549	PF00069	0.590
MOD_CDK_SPxxK_3	790	797	PF00069	0.617
MOD_CK1_1	115	121	PF00069	0.533
MOD_CK1_1	149	155	PF00069	0.635
MOD_CK1_1	156	162	PF00069	0.579
MOD_CK1_1	287	293	PF00069	0.629
MOD_CK1_1	301	307	PF00069	0.594
MOD_CK1_1	326	332	PF00069	0.573
MOD_CK1_1	486	492	PF00069	0.742
MOD_CK1_1	515	521	PF00069	0.516
MOD_CK1_1	541	547	PF00069	0.659
MOD_CK1_1	550	556	PF00069	0.578
MOD_CK1_1	601	607	PF00069	0.590
MOD_CK1_1	629	635	PF00069	0.652
MOD_CK1_1	652	658	PF00069	0.602
MOD_CK1_1	678	684	PF00069	0.619
MOD_CK1_1	711	717	PF00069	0.610
MOD_CK1_1	77	83	PF00069	0.593
MOD_CK2_1	446	452	PF00069	0.498
MOD_CK2_1	562	568	PF00069	0.629
MOD_CK2_1	644	650	PF00069	0.542
MOD_CK2_1	712	718	PF00069	0.528
MOD_CK2_1	817	823	PF00069	0.579
MOD_CMANNOS	288	291	PF00535	0.574
MOD_CMANNOS	85	88	PF00535	0.464
MOD_GlcNHglycan	148	151	PF01048	0.554
MOD_GlcNHglycan	291	294	PF01048	0.646
MOD_GlcNHglycan	328	331	PF01048	0.489
MOD_GlcNHglycan	33	36	PF01048	0.627
MOD_GlcNHglycan	341	344	PF01048	0.491
MOD_GlcNHglycan	43	46	PF01048	0.587
MOD_GlcNHglycan	471	474	PF01048	0.696
MOD_GlcNHglycan	483	486	PF01048	0.621
MOD_GlcNHglycan	488	491	PF01048	0.744
MOD_GlcNHglycan	50	53	PF01048	0.500
MOD_GlcNHglycan	505	508	PF01048	0.547
MOD_GlcNHglycan	541	544	PF01048	0.750
MOD_GlcNHglycan	554	557	PF01048	0.689
MOD_GlcNHglycan	565	568	PF01048	0.687
MOD_GlcNHglycan	631	634	PF01048	0.589
MOD_GlcNHglycan	678	681	PF01048	0.778
MOD_GlcNHglycan	710	713	PF01048	0.663
MOD_GlcNHglycan	720	723	PF01048	0.726
MOD_GlcNHglycan	79	82	PF01048	0.583
MOD_GSK3_1	103	110	PF00069	0.638
MOD_GSK3_1	146	153	PF00069	0.625
MOD_GSK3_1	154	161	PF00069	0.578
MOD_GSK3_1	162	169	PF00069	0.528
MOD_GSK3_1	182	189	PF00069	0.512
MOD_GSK3_1	259	266	PF00069	0.455
MOD_GSK3_1	280	287	PF00069	0.554
MOD_GSK3_1	301	308	PF00069	0.599
MOD_GSK3_1	31	38	PF00069	0.623
MOD_GSK3_1	391	398	PF00069	0.542
MOD_GSK3_1	499	506	PF00069	0.628
MOD_GSK3_1	538	545	PF00069	0.751
MOD_GSK3_1	550	557	PF00069	0.622
MOD_GSK3_1	588	595	PF00069	0.706
MOD_GSK3_1	603	610	PF00069	0.683
MOD_GSK3_1	625	632	PF00069	0.624
MOD_GSK3_1	639	646	PF00069	0.545
MOD_GSK3_1	648	655	PF00069	0.564
MOD_GSK3_1	671	678	PF00069	0.613
MOD_GSK3_1	692	699	PF00069	0.704
MOD_GSK3_1	704	711	PF00069	0.619
MOD_GSK3_1	811	818	PF00069	0.601
MOD_N-GLC_1	169	174	PF02516	0.613
MOD_N-GLC_1	223	228	PF02516	0.623
MOD_N-GLC_1	263	268	PF02516	0.509
MOD_N-GLC_1	316	321	PF02516	0.556
MOD_N-GLC_1	486	491	PF02516	0.681
MOD_N-GLC_1	607	612	PF02516	0.509
MOD_N-GLC_1	629	634	PF02516	0.626
MOD_N-GLC_1	652	657	PF02516	0.608
MOD_N-GLC_1	659	664	PF02516	0.569
MOD_N-GLC_1	692	697	PF02516	0.533
MOD_NEK2_1	108	113	PF00069	0.657
MOD_NEK2_1	323	328	PF00069	0.512
MOD_NEK2_1	33	38	PF00069	0.639
MOD_NEK2_1	383	388	PF00069	0.517
MOD_NEK2_1	412	417	PF00069	0.355
MOD_NEK2_1	47	52	PF00069	0.544
MOD_NEK2_1	481	486	PF00069	0.597
MOD_NEK2_1	626	631	PF00069	0.600
MOD_NEK2_1	649	654	PF00069	0.611
MOD_NEK2_1	661	666	PF00069	0.543
MOD_NEK2_1	710	715	PF00069	0.544
MOD_NEK2_2	272	277	PF00069	0.523
MOD_NEK2_2	298	303	PF00069	0.500
MOD_NEK2_2	570	575	PF00069	0.594
MOD_NEK2_2	817	822	PF00069	0.580
MOD_PIKK_1	169	175	PF00454	0.615
MOD_PIKK_1	432	438	PF00454	0.464
MOD_PIKK_1	560	566	PF00454	0.630
MOD_PIKK_1	815	821	PF00454	0.507
MOD_PKA_1	432	438	PF00069	0.516
MOD_PKA_1	547	553	PF00069	0.561
MOD_PKA_2	182	188	PF00069	0.617
MOD_PKA_2	191	197	PF00069	0.537
MOD_PKA_2	446	452	PF00069	0.666
MOD_PKA_2	547	553	PF00069	0.675
MOD_PKA_2	784	790	PF00069	0.562
MOD_PKB_1	430	438	PF00069	0.517
MOD_PKB_1	547	555	PF00069	0.637
MOD_PKB_1	692	700	PF00069	0.605
MOD_Plk_1	263	269	PF00069	0.558
MOD_Plk_1	557	563	PF00069	0.680
MOD_Plk_1	607	613	PF00069	0.513
MOD_Plk_1	659	665	PF00069	0.605
MOD_Plk_1	692	698	PF00069	0.532
MOD_Plk_1	738	744	PF00069	0.526
MOD_Plk_2-3	13	19	PF00069	0.509
MOD_Plk_2-3	554	560	PF00069	0.603
MOD_Plk_4	162	168	PF00069	0.611
MOD_Plk_4	272	278	PF00069	0.533
MOD_Plk_4	284	290	PF00069	0.485
MOD_Plk_4	298	304	PF00069	0.470
MOD_Plk_4	316	322	PF00069	0.452
MOD_Plk_4	391	397	PF00069	0.543
MOD_Plk_4	489	495	PF00069	0.514
MOD_Plk_4	557	563	PF00069	0.631
MOD_Plk_4	644	650	PF00069	0.542
MOD_Plk_4	71	77	PF00069	0.486
MOD_Plk_4	732	738	PF00069	0.519
MOD_ProDKin_1	135	141	PF00069	0.573
MOD_ProDKin_1	150	156	PF00069	0.614
MOD_ProDKin_1	175	181	PF00069	0.627
MOD_ProDKin_1	466	472	PF00069	0.594
MOD_ProDKin_1	500	506	PF00069	0.594
MOD_ProDKin_1	542	548	PF00069	0.762
MOD_ProDKin_1	592	598	PF00069	0.524
MOD_ProDKin_1	639	645	PF00069	0.620
MOD_ProDKin_1	680	686	PF00069	0.559
MOD_ProDKin_1	730	736	PF00069	0.574
MOD_ProDKin_1	790	796	PF00069	0.631
MOD_ProDKin_1	98	104	PF00069	0.518
MOD_SUMO_rev_2	196	205	PF00179	0.510
TRG_DiLeu_BaEn_1	248	253	PF01217	0.567
TRG_ENDOCYTIC_2	528	531	PF00928	0.592
TRG_ER_diArg_1	462	465	PF00400	0.595
TRG_ER_diArg_1	546	549	PF00400	0.638
TRG_ER_diArg_1	574	577	PF00400	0.625
TRG_ER_diArg_1	618	620	PF00400	0.528
TRG_ER_diArg_1	684	686	PF00400	0.607
TRG_ER_diArg_1	691	694	PF00400	0.580
TRG_ER_diArg_1	85	87	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WVX7	Leishmania donovani	77%	98%
A4HYQ4	Leishmania infantum	78%	99%
E9AIB4	Leishmania braziliensis	56%	98%