Chaperone protein DNAJ-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DNAJ-like protein

Species:

Leishmania mexicana

UniProt:

E9AUJ9_LEIMU

TriTrypDb:

LmxM.20.0550

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AUJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUJ9

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	14
GO:0009987	cellular process	1	14
GO:0006458	'de novo' protein folding	3	2
GO:0006950	response to stress	2	3
GO:0009266	response to temperature stimulus	3	3
GO:0009408	response to heat	3	3
GO:0009628	response to abiotic stimulus	2	3
GO:0042026	protein refolding	3	2
GO:0050896	response to stimulus	1	3
GO:0051084	'de novo' post-translational protein folding	4	2
GO:0051085	chaperone cofactor-dependent protein refolding	4	2
GO:0061077	chaperone-mediated protein folding	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0005515	protein binding	2	14
GO:0031072	heat shock protein binding	3	14
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0051082	unfolded protein binding	3	14
GO:0000166	nucleotide binding	3	3
GO:0005524	ATP binding	5	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.384
CLV_NRD_NRD_1	283	285	PF00675	0.246
CLV_NRD_NRD_1	306	308	PF00675	0.327
CLV_NRD_NRD_1	43	45	PF00675	0.576
CLV_NRD_NRD_1	76	78	PF00675	0.407
CLV_NRD_NRD_1	88	90	PF00675	0.370
CLV_PCSK_KEX2_1	104	106	PF00082	0.508
CLV_PCSK_KEX2_1	306	308	PF00082	0.327
CLV_PCSK_KEX2_1	43	45	PF00082	0.576
CLV_PCSK_KEX2_1	76	78	PF00082	0.436
CLV_PCSK_KEX2_1	88	90	PF00082	0.494
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.544
CLV_PCSK_SKI1_1	208	212	PF00082	0.558
CLV_PCSK_SKI1_1	268	272	PF00082	0.303
CLV_PCSK_SKI1_1	475	479	PF00082	0.438
CLV_PCSK_SKI1_1	83	87	PF00082	0.571
DEG_Nend_Nbox_1	1	3	PF02207	0.540
DOC_CKS1_1	280	285	PF01111	0.460
DOC_CKS1_1	511	516	PF01111	0.510
DOC_CYCLIN_yClb1_LxF_4	61	66	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	396	402	PF00134	0.356
DOC_MAPK_DCC_7	427	436	PF00069	0.269
DOC_MAPK_gen_1	473	480	PF00069	0.408
DOC_MAPK_MEF2A_6	427	436	PF00069	0.269
DOC_PP1_RVXF_1	3	10	PF00149	0.532
DOC_PP1_RVXF_1	61	67	PF00149	0.512
DOC_PP2B_LxvP_1	396	399	PF13499	0.322
DOC_USP7_MATH_1	182	186	PF00917	0.727
DOC_USP7_MATH_1	192	196	PF00917	0.606
DOC_USP7_MATH_1	220	224	PF00917	0.616
DOC_USP7_MATH_1	386	390	PF00917	0.311
DOC_USP7_MATH_1	483	487	PF00917	0.538
DOC_USP7_MATH_1	506	510	PF00917	0.610
DOC_USP7_MATH_1	514	518	PF00917	0.782
DOC_USP7_MATH_1	532	536	PF00917	0.597
DOC_USP7_MATH_1	56	60	PF00917	0.613
DOC_USP7_UBL2_3	534	538	PF12436	0.582
DOC_WW_Pin1_4	185	190	PF00397	0.462
DOC_WW_Pin1_4	279	284	PF00397	0.460
DOC_WW_Pin1_4	316	321	PF00397	0.398
DOC_WW_Pin1_4	382	387	PF00397	0.446
DOC_WW_Pin1_4	510	515	PF00397	0.605
LIG_14-3-3_CanoR_1	105	113	PF00244	0.526
LIG_14-3-3_CanoR_1	14	23	PF00244	0.703
LIG_14-3-3_CanoR_1	247	251	PF00244	0.275
LIG_14-3-3_CanoR_1	445	453	PF00244	0.594
LIG_14-3-3_CanoR_1	500	505	PF00244	0.564
LIG_14-3-3_CanoR_1	76	86	PF00244	0.503
LIG_BIR_III_4	232	236	PF00653	0.490
LIG_CSL_BTD_1	32	35	PF09270	0.526
LIG_FHA_1	241	247	PF00498	0.350
LIG_FHA_1	299	305	PF00498	0.451
LIG_FHA_1	371	377	PF00498	0.297
LIG_FHA_1	417	423	PF00498	0.430
LIG_FHA_1	77	83	PF00498	0.423
LIG_FHA_2	156	162	PF00498	0.679
LIG_FHA_2	489	495	PF00498	0.687
LIG_HCF-1_HBM_1	378	381	PF13415	0.269
LIG_Integrin_RGD_1	466	468	PF01839	0.469
LIG_LIR_Apic_2	435	440	PF02991	0.258
LIG_LIR_Gen_1	111	121	PF02991	0.465
LIG_LIR_Gen_1	58	67	PF02991	0.426
LIG_LIR_Nem_3	111	116	PF02991	0.407
LIG_LIR_Nem_3	58	64	PF02991	0.434
LIG_OCRL_FandH_1	351	363	PF00620	0.388
LIG_PTB_Apo_2	346	353	PF02174	0.405
LIG_SH2_CRK	113	117	PF00017	0.359
LIG_SH2_CRK	458	462	PF00017	0.364
LIG_SH2_CRK	61	65	PF00017	0.502
LIG_SH2_SRC	159	162	PF00017	0.698
LIG_SH2_STAP1	125	129	PF00017	0.471
LIG_SH2_STAT5	113	116	PF00017	0.461
LIG_SH2_STAT5	159	162	PF00017	0.698
LIG_SH2_STAT5	310	313	PF00017	0.441
LIG_SH2_STAT5	381	384	PF00017	0.444
LIG_SH3_1	29	35	PF00018	0.416
LIG_SH3_2	318	323	PF14604	0.527
LIG_SH3_3	29	35	PF00018	0.533
LIG_SH3_3	314	320	PF00018	0.492
LIG_SH3_3	333	339	PF00018	0.163
LIG_SH3_3	406	412	PF00018	0.303
LIG_SH3_3	417	423	PF00018	0.287
LIG_SH3_3	447	453	PF00018	0.564
LIG_SH3_3	459	465	PF00018	0.394
LIG_SH3_3	94	100	PF00018	0.415
LIG_SUMO_SIM_anti_2	401	406	PF11976	0.356
LIG_SUMO_SIM_par_1	372	378	PF11976	0.297
LIG_TYR_ITIM	456	461	PF00017	0.362
MOD_CDC14_SPxK_1	385	388	PF00782	0.269
MOD_CDK_SPK_2	279	284	PF00069	0.311
MOD_CDK_SPxK_1	279	285	PF00069	0.311
MOD_CDK_SPxK_1	382	388	PF00069	0.269
MOD_CDK_SPxxK_3	316	323	PF00069	0.243
MOD_CK1_1	15	21	PF00069	0.686
MOD_CK1_1	185	191	PF00069	0.682
MOD_CK1_1	218	224	PF00069	0.616
MOD_CK1_1	486	492	PF00069	0.610
MOD_CK1_1	516	522	PF00069	0.576
MOD_CK2_1	488	494	PF00069	0.629
MOD_CK2_1	75	81	PF00069	0.427
MOD_CMANNOS	33	36	PF00535	0.638
MOD_GlcNHglycan	17	20	PF01048	0.617
MOD_GlcNHglycan	184	187	PF01048	0.734
MOD_GlcNHglycan	215	218	PF01048	0.631
MOD_GlcNHglycan	274	277	PF01048	0.351
MOD_GlcNHglycan	293	296	PF01048	0.297
MOD_GlcNHglycan	298	301	PF01048	0.283
MOD_GlcNHglycan	446	449	PF01048	0.440
MOD_GlcNHglycan	470	473	PF01048	0.463
MOD_GlcNHglycan	488	491	PF01048	0.472
MOD_GlcNHglycan	516	519	PF01048	0.753
MOD_GSK3_1	120	127	PF00069	0.538
MOD_GSK3_1	13	20	PF00069	0.543
MOD_GSK3_1	192	199	PF00069	0.675
MOD_GSK3_1	215	222	PF00069	0.579
MOD_GSK3_1	246	253	PF00069	0.272
MOD_GSK3_1	268	275	PF00069	0.408
MOD_GSK3_1	343	350	PF00069	0.325
MOD_GSK3_1	370	377	PF00069	0.405
MOD_GSK3_1	382	389	PF00069	0.405
MOD_GSK3_1	440	447	PF00069	0.513
MOD_GSK3_1	506	513	PF00069	0.722
MOD_N-GLC_1	12	17	PF02516	0.425
MOD_N-GLC_1	208	213	PF02516	0.562
MOD_N-GLC_1	223	228	PF02516	0.522
MOD_N-GLC_1	237	242	PF02516	0.440
MOD_NEK2_1	250	255	PF00069	0.298
MOD_NEK2_1	347	352	PF00069	0.400
MOD_NEK2_1	370	375	PF00069	0.262
MOD_NEK2_1	498	503	PF00069	0.435
MOD_NEK2_1	526	531	PF00069	0.461
MOD_NEK2_1	533	538	PF00069	0.417
MOD_NEK2_2	17	22	PF00069	0.482
MOD_NEK2_2	416	421	PF00069	0.269
MOD_NEK2_2	56	61	PF00069	0.549
MOD_OFUCOSY	10	17	PF10250	0.424
MOD_PIKK_1	506	512	PF00454	0.731
MOD_PKA_1	104	110	PF00069	0.576
MOD_PKA_1	76	82	PF00069	0.430
MOD_PKA_2	104	110	PF00069	0.398
MOD_PKA_2	13	19	PF00069	0.667
MOD_PKA_2	165	171	PF00069	0.667
MOD_PKA_2	246	252	PF00069	0.278
MOD_PKA_2	272	278	PF00069	0.331
MOD_PKA_2	291	297	PF00069	0.318
MOD_PKA_2	444	450	PF00069	0.648
MOD_PKA_2	75	81	PF00069	0.441
MOD_Plk_1	223	229	PF00069	0.671
MOD_Plk_1	240	246	PF00069	0.309
MOD_Plk_1	250	256	PF00069	0.301
MOD_Plk_4	347	353	PF00069	0.405
MOD_Plk_4	35	41	PF00069	0.629
MOD_Plk_4	370	376	PF00069	0.278
MOD_Plk_4	56	62	PF00069	0.475
MOD_ProDKin_1	185	191	PF00069	0.464
MOD_ProDKin_1	279	285	PF00069	0.311
MOD_ProDKin_1	316	322	PF00069	0.225
MOD_ProDKin_1	382	388	PF00069	0.446
MOD_ProDKin_1	510	516	PF00069	0.605
MOD_SUMO_rev_2	107	112	PF00179	0.484
MOD_SUMO_rev_2	91	96	PF00179	0.511
MOD_SUMO_rev_2	99	106	PF00179	0.479
TRG_ENDOCYTIC_2	113	116	PF00928	0.434
TRG_ENDOCYTIC_2	458	461	PF00928	0.426
TRG_ENDOCYTIC_2	61	64	PF00928	0.499
TRG_ER_diArg_1	352	355	PF00400	0.302
TRG_ER_diArg_1	75	77	PF00400	0.439
TRG_ER_diArg_1	87	89	PF00400	0.437
TRG_NES_CRM1_1	241	251	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZS2	Leptomonas seymouri	63%	100%
A0A0S4J3B2	Bodo saltans	34%	100%
A0A1X0NLD4	Trypanosomatidae	26%	100%
A0A1X0NWP1	Trypanosomatidae	45%	100%
A0A3Q8IET3	Leishmania donovani	93%	100%
A0A3R7KX88	Trypanosoma rangeli	40%	100%
A0A3S7WNT6	Leishmania donovani	26%	100%
A0A422N924	Trypanosoma rangeli	26%	100%
A4H3Y7	Leishmania braziliensis	27%	100%
A4HS91	Leishmania infantum	26%	100%
A4HYQ6	Leishmania infantum	93%	100%
A8GMF8	Rickettsia akari (strain Hartford)	24%	100%
B5YAR4	Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)	27%	100%
C9ZI72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZY84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AIB2	Leishmania braziliensis	86%	100%
E9AK75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O97016	Leishmania major	27%	100%
Q493S6	Blochmannia pennsylvanicus (strain BPEN)	22%	100%
Q4QCY5	Leishmania major	92%	100%
Q8DKR7	Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)	25%	100%
V5AY81	Trypanosoma cruzi	25%	100%