RWD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RWD domain-containing protein

Species:

Leishmania mexicana

UniProt:

E9AUJ8_LEIMU

TriTrypDb:

LmxM.20.0540

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005844	polysome	3	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AUJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUJ8

Function

Biological processes
Term	Name	Level	Count
GO:0002181	cytoplasmic translation	5	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.593
CLV_NRD_NRD_1	160	162	PF00675	0.567
CLV_NRD_NRD_1	74	76	PF00675	0.235
CLV_PCSK_KEX2_1	123	125	PF00082	0.550
CLV_PCSK_KEX2_1	134	136	PF00082	0.574
CLV_PCSK_KEX2_1	74	76	PF00082	0.235
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.633
CLV_PCSK_SKI1_1	153	157	PF00082	0.516
CLV_PCSK_SKI1_1	177	181	PF00082	0.663
DOC_CYCLIN_RxL_1	150	160	PF00134	0.540
DOC_MAPK_gen_1	174	181	PF00069	0.649
DOC_PP2B_PxIxI_1	142	148	PF00149	0.611
DOC_USP7_UBL2_3	176	180	PF12436	0.554
LIG_14-3-3_CanoR_1	24	32	PF00244	0.500
LIG_CaM_NSCaTE_8	192	199	PF13499	0.589
LIG_deltaCOP1_diTrp_1	200	204	PF00928	0.528
LIG_FHA_1	142	148	PF00498	0.546
LIG_FHA_1	150	156	PF00498	0.453
LIG_FHA_1	80	86	PF00498	0.551
LIG_FHA_2	206	212	PF00498	0.516
LIG_FHA_2	37	43	PF00498	0.461
LIG_FHA_2	86	92	PF00498	0.519
LIG_LIR_Gen_1	198	207	PF02991	0.549
LIG_LIR_Gen_1	20	30	PF02991	0.476
LIG_LIR_Nem_3	198	204	PF02991	0.537
LIG_LIR_Nem_3	20	25	PF02991	0.476
LIG_PTB_Apo_2	212	219	PF02174	0.629
LIG_Rb_pABgroove_1	13	21	PF01858	0.466
LIG_SH2_STAT5	32	35	PF00017	0.532
LIG_SUMO_SIM_anti_2	97	103	PF11976	0.444
LIG_SUMO_SIM_par_1	63	68	PF11976	0.522
LIG_TRAF2_1	112	115	PF00917	0.647
LIG_TRAF2_1	138	141	PF00917	0.727
LIG_TRAF2_1	53	56	PF00917	0.500
LIG_TRAF2_1	88	91	PF00917	0.519
LIG_WW_1	29	32	PF00397	0.466
MOD_CK1_1	184	190	PF00069	0.601
MOD_CK1_1	195	201	PF00069	0.598
MOD_CK2_1	36	42	PF00069	0.503
MOD_CK2_1	85	91	PF00069	0.530
MOD_GlcNHglycan	181	184	PF01048	0.612
MOD_GlcNHglycan	186	189	PF01048	0.566
MOD_GlcNHglycan	197	200	PF01048	0.512
MOD_GlcNHglycan	59	62	PF01048	0.355
MOD_GSK3_1	28	35	PF00069	0.469
MOD_NEK2_2	192	197	PF00069	0.586
MOD_PIKK_1	36	42	PF00454	0.551
MOD_PKA_2	23	29	PF00069	0.500
MOD_Plk_1	192	198	PF00069	0.587
MOD_Plk_2-3	217	223	PF00069	0.614
MOD_Plk_2-3	23	29	PF00069	0.529
MOD_Plk_4	94	100	PF00069	0.452
MOD_SUMO_rev_2	110	119	PF00179	0.530
MOD_SUMO_rev_2	170	179	PF00179	0.546
TRG_DiLeu_BaEn_1	117	122	PF01217	0.647
TRG_ENDOCYTIC_2	22	25	PF00928	0.469
TRG_ER_diArg_1	122	124	PF00400	0.661
TRG_ER_diArg_1	74	76	PF00400	0.435
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT1	Leptomonas seymouri	78%	100%
A0A0S4IZT9	Bodo saltans	48%	97%
A0A1X0NWI2	Trypanosomatidae	59%	97%
A0A3Q8IA02	Leishmania donovani	95%	100%
A0A422NCD6	Trypanosoma rangeli	51%	100%
A4HYQ7	Leishmania infantum	95%	100%
C9ZI71	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AIB1	Leishmania braziliensis	86%	100%
Q4QCY6	Leishmania major	94%	100%
Q99ND9	Rattus norvegicus	30%	95%
Q9CQK7	Mus musculus	30%	95%
Q9H446	Homo sapiens	30%	95%