CTP_transf_like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUJ4_LEIMU

TriTrypDb:

LmxM.20.0500

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUJ4

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	4
GO:0009058	biosynthetic process	2	4
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009435	NAD biosynthetic process	8	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019359	nicotinamide nucleotide biosynthetic process	7	1
GO:0019362	pyridine nucleotide metabolic process	5	1
GO:0019363	pyridine nucleotide biosynthetic process	6	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway	9	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046496	nicotinamide nucleotide metabolic process	6	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072524	pyridine-containing compound metabolic process	4	1
GO:0072525	pyridine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	6	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1
GO:0070566	adenylyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.513
CLV_NRD_NRD_1	130	132	PF00675	0.525
CLV_NRD_NRD_1	30	32	PF00675	0.512
CLV_NRD_NRD_1	423	425	PF00675	0.314
CLV_NRD_NRD_1	430	432	PF00675	0.287
CLV_NRD_NRD_1	503	505	PF00675	0.296
CLV_PCSK_FUR_1	128	132	PF00082	0.593
CLV_PCSK_KEX2_1	130	132	PF00082	0.525
CLV_PCSK_KEX2_1	30	32	PF00082	0.512
CLV_PCSK_KEX2_1	423	425	PF00082	0.282
CLV_PCSK_KEX2_1	430	432	PF00082	0.265
CLV_PCSK_SKI1_1	223	227	PF00082	0.568
CLV_PCSK_SKI1_1	283	287	PF00082	0.493
CLV_PCSK_SKI1_1	30	34	PF00082	0.518
CLV_PCSK_SKI1_1	40	44	PF00082	0.366
CLV_PCSK_SKI1_1	525	529	PF00082	0.274
DEG_APCC_DBOX_1	282	290	PF00400	0.534
DOC_CKS1_1	396	401	PF01111	0.453
DOC_CYCLIN_RxL_1	34	44	PF00134	0.431
DOC_CYCLIN_yCln2_LP_2	396	402	PF00134	0.453
DOC_MAPK_gen_1	128	138	PF00069	0.502
DOC_MAPK_gen_1	430	439	PF00069	0.510
DOC_MAPK_MEF2A_6	131	140	PF00069	0.505
DOC_MAPK_MEF2A_6	430	439	PF00069	0.385
DOC_PP1_RVXF_1	81	88	PF00149	0.569
DOC_PP2B_LxvP_1	518	521	PF13499	0.496
DOC_USP7_MATH_1	197	201	PF00917	0.276
DOC_USP7_MATH_1	237	241	PF00917	0.618
DOC_USP7_MATH_1	266	270	PF00917	0.710
DOC_USP7_MATH_1	296	300	PF00917	0.603
DOC_USP7_MATH_1	350	354	PF00917	0.656
DOC_USP7_MATH_1	36	40	PF00917	0.477
DOC_USP7_UBL2_3	409	413	PF12436	0.536
DOC_WW_Pin1_4	10	15	PF00397	0.363
DOC_WW_Pin1_4	156	161	PF00397	0.735
DOC_WW_Pin1_4	395	400	PF00397	0.528
LIG_14-3-3_CanoR_1	16	20	PF00244	0.429
LIG_14-3-3_CanoR_1	261	266	PF00244	0.598
LIG_14-3-3_CanoR_1	434	440	PF00244	0.508
LIG_14-3-3_CanoR_1	504	509	PF00244	0.555
LIG_14-3-3_CanoR_1	51	58	PF00244	0.570
LIG_Actin_WH2_2	302	319	PF00022	0.518
LIG_Actin_WH2_2	414	432	PF00022	0.510
LIG_APCC_ABBA_1	321	326	PF00400	0.428
LIG_BIR_II_1	1	5	PF00653	0.439
LIG_CaM_IQ_9	373	389	PF13499	0.510
LIG_Clathr_ClatBox_1	456	460	PF01394	0.536
LIG_deltaCOP1_diTrp_1	305	310	PF00928	0.288
LIG_eIF4E_1	370	376	PF01652	0.555
LIG_FHA_1	109	115	PF00498	0.507
LIG_FHA_1	119	125	PF00498	0.334
LIG_FHA_1	371	377	PF00498	0.562
LIG_FHA_1	378	384	PF00498	0.510
LIG_FHA_1	401	407	PF00498	0.465
LIG_FHA_1	439	445	PF00498	0.526
LIG_FHA_1	487	493	PF00498	0.555
LIG_FHA_2	39	45	PF00498	0.419
LIG_FHA_2	396	402	PF00498	0.442
LIG_FHA_2	471	477	PF00498	0.533
LIG_LIR_Gen_1	224	234	PF02991	0.559
LIG_LIR_LC3C_4	187	190	PF02991	0.448
LIG_LIR_Nem_3	224	229	PF02991	0.517
LIG_LIR_Nem_3	364	368	PF02991	0.484
LIG_SH2_SRC	404	407	PF00017	0.471
LIG_SH2_STAP1	344	348	PF00017	0.639
LIG_SH2_STAP1	404	408	PF00017	0.471
LIG_SH2_STAT5	498	501	PF00017	0.471
LIG_SH3_3	462	468	PF00018	0.536
LIG_SH3_3	526	532	PF00018	0.487
LIG_SH3_3	97	103	PF00018	0.615
LIG_SUMO_SIM_anti_2	183	190	PF11976	0.462
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.522
LIG_SUMO_SIM_par_1	398	403	PF11976	0.498
MOD_CDC14_SPxK_1	13	16	PF00782	0.369
MOD_CDK_SPxK_1	10	16	PF00069	0.362
MOD_CK1_1	129	135	PF00069	0.604
MOD_CK1_1	238	244	PF00069	0.728
MOD_CK1_1	254	260	PF00069	0.659
MOD_CK1_1	264	270	PF00069	0.639
MOD_CK1_1	299	305	PF00069	0.525
MOD_CK1_1	325	331	PF00069	0.487
MOD_CK2_1	129	135	PF00069	0.604
MOD_CK2_1	229	235	PF00069	0.664
MOD_CK2_1	299	305	PF00069	0.499
MOD_CK2_1	38	44	PF00069	0.487
MOD_CK2_1	395	401	PF00069	0.273
MOD_CK2_1	469	475	PF00069	0.432
MOD_CK2_1	538	544	PF00069	0.350
MOD_CMANNOS	307	310	PF00535	0.268
MOD_Cter_Amidation	502	505	PF01082	0.350
MOD_GlcNHglycan	121	124	PF01048	0.421
MOD_GlcNHglycan	147	150	PF01048	0.525
MOD_GlcNHglycan	215	218	PF01048	0.710
MOD_GlcNHglycan	231	234	PF01048	0.658
MOD_GlcNHglycan	237	240	PF01048	0.755
MOD_GlcNHglycan	258	261	PF01048	0.690
MOD_GlcNHglycan	268	271	PF01048	0.723
MOD_GlcNHglycan	277	281	PF01048	0.552
MOD_GlcNHglycan	345	349	PF01048	0.688
MOD_GlcNHglycan	66	69	PF01048	0.476
MOD_GSK3_1	119	126	PF00069	0.433
MOD_GSK3_1	141	148	PF00069	0.440
MOD_GSK3_1	213	220	PF00069	0.617
MOD_GSK3_1	221	228	PF00069	0.499
MOD_GSK3_1	238	245	PF00069	0.770
MOD_GSK3_1	391	398	PF00069	0.382
MOD_N-GLC_1	235	240	PF02516	0.565
MOD_N-GLC_2	550	552	PF02516	0.542
MOD_NEK2_1	484	489	PF00069	0.193
MOD_NEK2_1	79	84	PF00069	0.508
MOD_PIKK_1	51	57	PF00454	0.545
MOD_PK_1	261	267	PF00069	0.636
MOD_PKA_1	30	36	PF00069	0.530
MOD_PKA_1	504	510	PF00069	0.432
MOD_PKA_2	129	135	PF00069	0.578
MOD_PKA_2	15	21	PF00069	0.429
MOD_PKA_2	210	216	PF00069	0.618
MOD_PKA_2	30	36	PF00069	0.504
MOD_PKA_2	50	56	PF00069	0.303
MOD_Plk_1	391	397	PF00069	0.372
MOD_Plk_1	400	406	PF00069	0.236
MOD_Plk_1	513	519	PF00069	0.319
MOD_Plk_4	225	231	PF00069	0.407
MOD_Plk_4	251	257	PF00069	0.702
MOD_Plk_4	438	444	PF00069	0.353
MOD_ProDKin_1	10	16	PF00069	0.362
MOD_ProDKin_1	156	162	PF00069	0.728
MOD_ProDKin_1	395	401	PF00069	0.394
TRG_DiLeu_BaEn_1	184	189	PF01217	0.498
TRG_DiLeu_BaEn_1	417	422	PF01217	0.353
TRG_DiLeu_BaLyEn_6	355	360	PF01217	0.478
TRG_ENDOCYTIC_2	168	171	PF00928	0.560
TRG_ENDOCYTIC_2	498	501	PF00928	0.316
TRG_ER_diArg_1	128	131	PF00400	0.542
TRG_ER_diArg_1	29	31	PF00400	0.516
TRG_ER_diArg_1	383	386	PF00400	0.369
TRG_ER_diArg_1	422	424	PF00400	0.370
TRG_ER_diArg_1	429	431	PF00400	0.314
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7H4	Leptomonas seymouri	54%	100%
A0A0S4ILY4	Bodo saltans	34%	100%
A0A3S7WVU1	Leishmania donovani	89%	100%
A4HYR1	Leishmania infantum	90%	100%
E9AIA7	Leishmania braziliensis	77%	100%
Q4QCZ0	Leishmania major	87%	100%
V5C0A1	Trypanosoma cruzi	34%	100%