Transmembrane protein 231

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transmembrane protein 231, putative

Species:

Leishmania mexicana

UniProt:

E9AUJ0_LEIMU

TriTrypDb:

LmxM.20.0460

Length:

375

Annotations

LeishMANIAdb annotations

Homologous to mammalian TMEM231 protein. Probably flagellar and required for its maintenance, based on homology.. Localization: Flagellar membrane (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0031253	cell projection membrane	4	11
GO:0035869	ciliary transition zone	2	1
GO:0060170	ciliary membrane	5	11
GO:0098588	bounding membrane of organelle	4	11
GO:0098590	plasma membrane region	3	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

E9AUJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUJ0

Function

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Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0032879	regulation of localization	3	1
GO:0032880	regulation of protein localization	5	1
GO:0044782	cilium organization	5	1
GO:0050789	regulation of biological process	2	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.311
CLV_C14_Caspase3-7	140	144	PF00656	0.494
CLV_C14_Caspase3-7	151	155	PF00656	0.389
CLV_NRD_NRD_1	187	189	PF00675	0.657
CLV_NRD_NRD_1	289	291	PF00675	0.672
CLV_NRD_NRD_1	372	374	PF00675	0.500
CLV_PCSK_FUR_1	185	189	PF00082	0.649
CLV_PCSK_KEX2_1	187	189	PF00082	0.646
CLV_PCSK_KEX2_1	289	291	PF00082	0.672
CLV_PCSK_KEX2_1	372	374	PF00082	0.500

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFJ2	Leptomonas seymouri	65%	97%
A0A0S4J387	Bodo saltans	31%	100%
A0A1X0NXU0	Trypanosomatidae	44%	100%
A0A3S7WW02	Leishmania donovani	91%	100%
A0A422NCH0	Trypanosoma rangeli	46%	100%
A4HYR5	Leishmania infantum	91%	100%
C9ZI65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4QCZ4	Leishmania major	93%	100%
V5DS46	Trypanosoma cruzi	45%	100%

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