Gamma-glutamylcyclotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AIG2-like family, putative

Species:

Leishmania mexicana

UniProt:

E9AUI8_LEIMU

TriTrypDb:

LmxM.20.0440

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUI8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0003839	gamma-glutamylcyclotransferase activity	5	7
GO:0016829	lyase activity	2	7
GO:0016840	carbon-nitrogen lyase activity	3	7
GO:0016842	amidine-lyase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.590
CLV_C14_Caspase3-7	414	418	PF00656	0.389
CLV_NRD_NRD_1	165	167	PF00675	0.494
CLV_NRD_NRD_1	328	330	PF00675	0.399
CLV_NRD_NRD_1	479	481	PF00675	0.700
CLV_PCSK_KEX2_1	165	167	PF00082	0.424
CLV_PCSK_KEX2_1	24	26	PF00082	0.312
CLV_PCSK_KEX2_1	328	330	PF00082	0.399
CLV_PCSK_KEX2_1	477	479	PF00082	0.700
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.402
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.314
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.637
CLV_PCSK_SKI1_1	105	109	PF00082	0.355
CLV_PCSK_SKI1_1	185	189	PF00082	0.423
CLV_PCSK_SKI1_1	329	333	PF00082	0.385
CLV_PCSK_SKI1_1	42	46	PF00082	0.550
CLV_PCSK_SKI1_1	50	54	PF00082	0.535
CLV_PCSK_SKI1_1	97	101	PF00082	0.563
DEG_APCC_DBOX_1	104	112	PF00400	0.363
DEG_APCC_DBOX_1	49	57	PF00400	0.423
DEG_Nend_UBRbox_2	1	3	PF02207	0.500
DEG_SCF_TRCP1_1	2	7	PF00400	0.403
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.297
DOC_MAPK_gen_1	242	252	PF00069	0.512
DOC_MAPK_gen_1	328	339	PF00069	0.391
DOC_MAPK_MEF2A_6	245	252	PF00069	0.639
DOC_MAPK_MEF2A_6	62	70	PF00069	0.334
DOC_MAPK_NFAT4_5	245	253	PF00069	0.576
DOC_PP2B_LxvP_1	159	162	PF13499	0.458
DOC_USP7_MATH_1	125	129	PF00917	0.336
DOC_USP7_MATH_1	198	202	PF00917	0.466
DOC_USP7_MATH_1	265	269	PF00917	0.696
DOC_USP7_MATH_1	28	32	PF00917	0.490
DOC_USP7_MATH_1	308	312	PF00917	0.485
DOC_USP7_UBL2_3	167	171	PF12436	0.403
DOC_USP7_UBL2_3	477	481	PF12436	0.644
DOC_WW_Pin1_4	201	206	PF00397	0.613
DOC_WW_Pin1_4	207	212	PF00397	0.632
DOC_WW_Pin1_4	257	262	PF00397	0.495
DOC_WW_Pin1_4	418	423	PF00397	0.278
DOC_WW_Pin1_4	469	474	PF00397	0.526
DOC_WW_Pin1_4	89	94	PF00397	0.516
LIG_14-3-3_CanoR_1	166	174	PF00244	0.558
LIG_14-3-3_CanoR_1	25	31	PF00244	0.299
LIG_BRCT_BRCA1_1	147	151	PF00533	0.434
LIG_BRCT_BRCA1_1	5	9	PF00533	0.508
LIG_FHA_1	134	140	PF00498	0.377
LIG_FHA_1	302	308	PF00498	0.411
LIG_FHA_1	340	346	PF00498	0.384
LIG_FHA_1	465	471	PF00498	0.442
LIG_FHA_2	112	118	PF00498	0.428
LIG_FHA_2	14	20	PF00498	0.421
LIG_FHA_2	391	397	PF00498	0.214
LIG_FHA_2	419	425	PF00498	0.398
LIG_FHA_2	431	437	PF00498	0.337
LIG_FHA_2	90	96	PF00498	0.585
LIG_LIR_Gen_1	148	159	PF02991	0.404
LIG_LIR_Gen_1	233	244	PF02991	0.620
LIG_LIR_Gen_1	246	254	PF02991	0.466
LIG_LIR_Gen_1	314	322	PF02991	0.424
LIG_LIR_Gen_1	424	431	PF02991	0.335
LIG_LIR_Nem_3	126	132	PF02991	0.464
LIG_LIR_Nem_3	148	154	PF02991	0.413
LIG_LIR_Nem_3	233	239	PF02991	0.627
LIG_LIR_Nem_3	241	247	PF02991	0.508
LIG_LIR_Nem_3	304	309	PF02991	0.398
LIG_LIR_Nem_3	314	318	PF02991	0.423
LIG_LIR_Nem_3	424	429	PF02991	0.335
LIG_LIR_Nem_3	6	12	PF02991	0.551
LIG_MYND_1	43	47	PF01753	0.518
LIG_PCNA_yPIPBox_3	183	197	PF02747	0.601
LIG_PCNA_yPIPBox_3	62	74	PF02747	0.335
LIG_Pex14_1	305	309	PF04695	0.377
LIG_SH2_CRK	132	136	PF00017	0.426
LIG_SH2_CRK	236	240	PF00017	0.581
LIG_SH2_CRK	49	53	PF00017	0.447
LIG_SH2_GRB2like	355	358	PF00017	0.508
LIG_SH2_PTP2	336	339	PF00017	0.373
LIG_SH2_PTP2	428	431	PF00017	0.214
LIG_SH2_SRC	17	20	PF00017	0.406
LIG_SH2_SRC	388	391	PF00017	0.335
LIG_SH2_STAP1	109	113	PF00017	0.444
LIG_SH2_STAP1	236	240	PF00017	0.491
LIG_SH2_STAP1	280	284	PF00017	0.664
LIG_SH2_STAP1	405	409	PF00017	0.381
LIG_SH2_STAT5	11	14	PF00017	0.387
LIG_SH2_STAT5	138	141	PF00017	0.445
LIG_SH2_STAT5	17	20	PF00017	0.443
LIG_SH2_STAT5	247	250	PF00017	0.665
LIG_SH2_STAT5	306	309	PF00017	0.371
LIG_SH2_STAT5	336	339	PF00017	0.373
LIG_SH2_STAT5	382	385	PF00017	0.335
LIG_SH2_STAT5	428	431	PF00017	0.335
LIG_SH2_STAT5	458	461	PF00017	0.511
LIG_SH3_1	463	469	PF00018	0.420
LIG_SH3_2	466	471	PF14604	0.517
LIG_SH3_3	208	214	PF00018	0.655
LIG_SH3_3	370	376	PF00018	0.520
LIG_SH3_3	463	469	PF00018	0.570
LIG_Sin3_3	151	158	PF02671	0.296
LIG_SUMO_SIM_anti_2	393	400	PF11976	0.214
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.338
LIG_SUMO_SIM_par_1	359	365	PF11976	0.460
LIG_TRAF2_1	433	436	PF00917	0.306
LIG_TYR_ITIM	334	339	PF00017	0.511
LIG_WW_1	455	458	PF00397	0.313
MOD_CDK_SPK_2	469	474	PF00069	0.608
MOD_CDK_SPK_2	89	94	PF00069	0.445
MOD_CK1_1	201	207	PF00069	0.591
MOD_CK1_1	26	32	PF00069	0.463
MOD_CK1_1	268	274	PF00069	0.608
MOD_CK1_1	279	285	PF00069	0.507
MOD_CK1_1	3	9	PF00069	0.533
MOD_CK1_1	311	317	PF00069	0.480
MOD_CK1_1	416	422	PF00069	0.409
MOD_CK2_1	111	117	PF00069	0.424
MOD_CK2_1	390	396	PF00069	0.214
MOD_CK2_1	418	424	PF00069	0.325
MOD_CK2_1	430	436	PF00069	0.309
MOD_CK2_1	89	95	PF00069	0.590
MOD_GlcNHglycan	110	114	PF01048	0.459
MOD_GlcNHglycan	151	154	PF01048	0.328
MOD_GlcNHglycan	168	171	PF01048	0.376
MOD_GlcNHglycan	2	5	PF01048	0.439
MOD_GlcNHglycan	200	203	PF01048	0.535
MOD_GlcNHglycan	206	209	PF01048	0.460
MOD_GlcNHglycan	268	271	PF01048	0.758
MOD_GlcNHglycan	31	34	PF01048	0.556
MOD_GlcNHglycan	39	42	PF01048	0.412
MOD_GlcNHglycan	56	59	PF01048	0.507
MOD_GSK3_1	145	152	PF00069	0.501
MOD_GSK3_1	197	204	PF00069	0.753
MOD_GSK3_1	259	266	PF00069	0.734
MOD_GSK3_1	341	348	PF00069	0.453
MOD_GSK3_1	374	381	PF00069	0.321
MOD_N-GLC_1	311	316	PF02516	0.316
MOD_N-GLC_1	431	436	PF02516	0.214
MOD_N-GLC_1	66	71	PF02516	0.309
MOD_NEK2_1	111	116	PF00069	0.410
MOD_NEK2_1	23	28	PF00069	0.466
MOD_NEK2_2	133	138	PF00069	0.545
MOD_NEK2_2	224	229	PF00069	0.708
MOD_PIKK_1	145	151	PF00454	0.504
MOD_PIKK_1	230	236	PF00454	0.604
MOD_PIKK_1	388	394	PF00454	0.453
MOD_PKA_1	166	172	PF00069	0.500
MOD_PKA_2	410	416	PF00069	0.389
MOD_Plk_1	311	317	PF00069	0.446
MOD_Plk_1	66	72	PF00069	0.321
MOD_Plk_4	13	19	PF00069	0.372
MOD_Plk_4	301	307	PF00069	0.432
MOD_Plk_4	378	384	PF00069	0.284
MOD_Plk_4	69	75	PF00069	0.535
MOD_ProDKin_1	201	207	PF00069	0.616
MOD_ProDKin_1	257	263	PF00069	0.499
MOD_ProDKin_1	418	424	PF00069	0.278
MOD_ProDKin_1	469	475	PF00069	0.528
MOD_ProDKin_1	89	95	PF00069	0.518
MOD_SUMO_rev_2	19	26	PF00179	0.302
MOD_SUMO_rev_2	296	304	PF00179	0.513
MOD_SUMO_rev_2	359	369	PF00179	0.495
MOD_SUMO_rev_2	90	99	PF00179	0.641
TRG_DiLeu_BaEn_1	368	373	PF01217	0.346
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.412
TRG_ENDOCYTIC_2	132	135	PF00928	0.436
TRG_ENDOCYTIC_2	236	239	PF00928	0.645
TRG_ENDOCYTIC_2	247	250	PF00928	0.558
TRG_ENDOCYTIC_2	336	339	PF00928	0.373
TRG_ENDOCYTIC_2	355	358	PF00928	0.390
TRG_ENDOCYTIC_2	428	431	PF00928	0.214
TRG_ENDOCYTIC_2	49	52	PF00928	0.439
TRG_ER_diArg_1	328	330	PF00400	0.454
TRG_NLS_MonoExtN_4	162	169	PF00514	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P468	Leptomonas seymouri	54%	95%
A0A3Q8IAR7	Leishmania donovani	85%	99%
A4HYM3	Leishmania infantum	85%	99%
E9AIA3	Leishmania braziliensis	71%	100%
Q4QCZ6	Leishmania major	85%	100%