Ribosomal RNA-processing protein 8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal RNA-processing protein 8, putative

Species:

Leishmania mexicana

UniProt:

E9AUI6_LEIMU

TriTrypDb:

LmxM.20.0420

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AUI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUI6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.453
CLV_NRD_NRD_1	200	202	PF00675	0.250
CLV_NRD_NRD_1	313	315	PF00675	0.272
CLV_NRD_NRD_1	47	49	PF00675	0.649
CLV_NRD_NRD_1	73	75	PF00675	0.538
CLV_NRD_NRD_1	8	10	PF00675	0.569
CLV_NRD_NRD_1	88	90	PF00675	0.427
CLV_PCSK_KEX2_1	120	122	PF00082	0.482
CLV_PCSK_KEX2_1	200	202	PF00082	0.235
CLV_PCSK_KEX2_1	298	300	PF00082	0.286
CLV_PCSK_KEX2_1	47	49	PF00082	0.677
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.250
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.677
CLV_PCSK_SKI1_1	121	125	PF00082	0.518
CLV_PCSK_SKI1_1	18	22	PF00082	0.503
CLV_PCSK_SKI1_1	286	290	PF00082	0.298
CLV_PCSK_SKI1_1	293	297	PF00082	0.244
CLV_PCSK_SKI1_1	298	302	PF00082	0.224
DEG_COP1_1	358	367	PF00400	0.380
DEG_Nend_Nbox_1	1	3	PF02207	0.531
DOC_AGCK_PIF_2	337	342	PF00069	0.235
DOC_CYCLIN_RxL_1	283	290	PF00134	0.269
DOC_CYCLIN_RxL_1	293	305	PF00134	0.198
DOC_MAPK_gen_1	293	303	PF00069	0.263
DOC_USP7_MATH_1	112	116	PF00917	0.562
DOC_USP7_MATH_1	31	35	PF00917	0.670
DOC_USP7_MATH_1	57	61	PF00917	0.505
DOC_USP7_UBL2_3	10	14	PF12436	0.527
DOC_USP7_UBL2_3	17	21	PF12436	0.510
DOC_USP7_UBL2_3	298	302	PF12436	0.250
DOC_USP7_UBL2_3	82	86	PF12436	0.646
LIG_14-3-3_CanoR_1	139	148	PF00244	0.257
LIG_Actin_WH2_2	288	304	PF00022	0.235
LIG_BRCT_BRCA1_1	244	248	PF00533	0.250
LIG_FHA_1	142	148	PF00498	0.236
LIG_FHA_1	188	194	PF00498	0.245
LIG_FHA_1	258	264	PF00498	0.328
LIG_FHA_1	280	286	PF00498	0.315
LIG_FHA_2	167	173	PF00498	0.271
LIG_FHA_2	254	260	PF00498	0.411
LIG_LIR_Apic_2	150	156	PF02991	0.318
LIG_LIR_Gen_1	219	225	PF02991	0.135
LIG_LIR_Gen_1	245	254	PF02991	0.318
LIG_LIR_Gen_1	287	297	PF02991	0.276
LIG_LIR_Gen_1	326	337	PF02991	0.320
LIG_LIR_Nem_3	143	148	PF02991	0.237
LIG_LIR_Nem_3	167	173	PF02991	0.239
LIG_LIR_Nem_3	219	223	PF02991	0.135
LIG_LIR_Nem_3	245	251	PF02991	0.318
LIG_LIR_Nem_3	287	292	PF02991	0.243
LIG_LIR_Nem_3	326	332	PF02991	0.273
LIG_LIR_Nem_3	335	340	PF02991	0.232
LIG_NRP_CendR_1	369	371	PF00754	0.235
LIG_Pex14_2	312	316	PF04695	0.299
LIG_SH2_CRK	153	157	PF00017	0.318
LIG_SH2_CRK	97	101	PF00017	0.643
LIG_SH2_NCK_1	153	157	PF00017	0.328
LIG_SH2_NCK_1	329	333	PF00017	0.331
LIG_SH2_STAP1	329	333	PF00017	0.406
LIG_SH2_STAT3	177	180	PF00017	0.235
LIG_SH2_STAT5	241	244	PF00017	0.275
LIG_SH2_STAT5	284	287	PF00017	0.243
LIG_SH2_STAT5	336	339	PF00017	0.271
LIG_SH3_3	182	188	PF00018	0.236
LIG_SH3_3	307	313	PF00018	0.276
LIG_SH3_3	359	365	PF00018	0.294
LIG_SUMO_SIM_anti_2	276	283	PF11976	0.235
LIG_SUMO_SIM_par_1	189	195	PF11976	0.245
LIG_SUMO_SIM_par_1	253	261	PF11976	0.383
LIG_SUMO_SIM_par_1	302	308	PF11976	0.283
LIG_TYR_ITIM	327	332	PF00017	0.362
LIG_WRC_WIRS_1	243	248	PF05994	0.235
MOD_CK1_1	35	41	PF00069	0.707
MOD_CK1_1	67	73	PF00069	0.522
MOD_CK2_1	284	290	PF00069	0.310
MOD_GlcNHglycan	115	118	PF01048	0.473
MOD_GlcNHglycan	34	37	PF01048	0.671
MOD_GlcNHglycan	69	72	PF01048	0.468
MOD_GSK3_1	154	161	PF00069	0.380
MOD_GSK3_1	253	260	PF00069	0.349
MOD_GSK3_1	275	282	PF00069	0.235
MOD_GSK3_1	31	38	PF00069	0.673
MOD_N-GLC_1	140	145	PF02516	0.374
MOD_NEK2_1	140	145	PF00069	0.243
MOD_NEK2_1	275	280	PF00069	0.249
MOD_NEK2_2	284	289	PF00069	0.380
MOD_PIKK_1	158	164	PF00454	0.168
MOD_PIKK_1	21	27	PF00454	0.659
MOD_PIKK_1	350	356	PF00454	0.380
MOD_PKA_1	21	27	PF00069	0.577
MOD_PKA_2	67	73	PF00069	0.491
MOD_Plk_1	140	146	PF00069	0.352
MOD_Plk_1	165	171	PF00069	0.354
MOD_Plk_1	49	55	PF00069	0.394
MOD_Plk_2-3	166	172	PF00069	0.235
MOD_Plk_4	187	193	PF00069	0.408
MOD_Plk_4	216	222	PF00069	0.250
MOD_Plk_4	275	281	PF00069	0.235
MOD_Plk_4	284	290	PF00069	0.235
MOD_Plk_4	363	369	PF00069	0.235
MOD_SUMO_rev_2	80	87	PF00179	0.606
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.235
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.235
TRG_ENDOCYTIC_2	329	332	PF00928	0.331
TRG_ENDOCYTIC_2	97	100	PF00928	0.643
TRG_ER_diArg_1	120	122	PF00400	0.556
TRG_ER_diArg_1	200	203	PF00400	0.238
TRG_ER_diArg_1	306	309	PF00400	0.256
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.235
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD61	Leptomonas seymouri	82%	100%
A0A0S4J2L3	Bodo saltans	55%	71%
A0A1X0NWQ8	Trypanosomatidae	60%	100%
A0A3Q8IAH5	Leishmania donovani	94%	100%
A0A422NCI5	Trypanosoma rangeli	58%	100%
A4HYM5	Leishmania infantum	94%	100%
A8XI07	Caenorhabditis briggsae	36%	100%
C9ZI63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AIA1	Leishmania braziliensis	90%	100%
O44410	Caenorhabditis elegans	32%	100%
Q10257	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q4QCZ8	Leishmania major	94%	100%
Q54CP1	Dictyostelium discoideum	35%	95%
Q84JC0	Arabidopsis thaliana	35%	100%
V5C0A6	Trypanosoma cruzi	63%	100%