TFIIH_basal_transcription_factor_subunit_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TFIIH basal transcription factor subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AUI4_LEIMU

TriTrypDb:

LmxM.20.0400

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.706
CLV_NRD_NRD_1	158	160	PF00675	0.592
CLV_NRD_NRD_1	258	260	PF00675	0.556
CLV_NRD_NRD_1	341	343	PF00675	0.598
CLV_NRD_NRD_1	541	543	PF00675	0.560
CLV_NRD_NRD_1	558	560	PF00675	0.578
CLV_NRD_NRD_1	587	589	PF00675	0.679
CLV_PCSK_FUR_1	339	343	PF00082	0.619
CLV_PCSK_FUR_1	539	543	PF00082	0.606
CLV_PCSK_FUR_1	556	560	PF00082	0.574
CLV_PCSK_KEX2_1	158	160	PF00082	0.592
CLV_PCSK_KEX2_1	258	260	PF00082	0.556
CLV_PCSK_KEX2_1	341	343	PF00082	0.628
CLV_PCSK_KEX2_1	541	543	PF00082	0.593
CLV_PCSK_KEX2_1	555	557	PF00082	0.595
CLV_PCSK_KEX2_1	558	560	PF00082	0.573
CLV_PCSK_KEX2_1	587	589	PF00082	0.679
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.668
CLV_PCSK_PC7_1	254	260	PF00082	0.639
CLV_PCSK_SKI1_1	254	258	PF00082	0.619
CLV_PCSK_SKI1_1	278	282	PF00082	0.471
CLV_PCSK_SKI1_1	393	397	PF00082	0.516
CLV_PCSK_SKI1_1	435	439	PF00082	0.687
CLV_PCSK_SKI1_1	503	507	PF00082	0.606
CLV_PCSK_SKI1_1	515	519	PF00082	0.543
CLV_PCSK_SKI1_1	571	575	PF00082	0.700
DEG_APCC_DBOX_1	323	331	PF00400	0.460
DEG_SPOP_SBC_1	347	351	PF00917	0.558
DEG_SPOP_SBC_1	459	463	PF00917	0.694
DEG_SPOP_SBC_1	98	102	PF00917	0.683
DOC_MAPK_gen_1	158	165	PF00069	0.569
DOC_MAPK_gen_1	339	347	PF00069	0.628
DOC_PP1_RVXF_1	297	303	PF00149	0.550
DOC_PP2B_LxvP_1	292	295	PF13499	0.616
DOC_PP4_FxxP_1	430	433	PF00568	0.678
DOC_PP4_FxxP_1	580	583	PF00568	0.708
DOC_SPAK_OSR1_1	272	276	PF12202	0.551
DOC_USP7_MATH_1	186	190	PF00917	0.709
DOC_USP7_MATH_1	195	199	PF00917	0.664
DOC_USP7_MATH_1	215	219	PF00917	0.584
DOC_USP7_MATH_1	346	350	PF00917	0.620
DOC_USP7_MATH_1	356	360	PF00917	0.679
DOC_USP7_MATH_1	433	437	PF00917	0.731
DOC_USP7_MATH_1	445	449	PF00917	0.643
DOC_USP7_MATH_1	452	456	PF00917	0.455
DOC_USP7_MATH_1	459	463	PF00917	0.658
DOC_USP7_MATH_1	98	102	PF00917	0.760
DOC_USP7_MATH_2	50	56	PF00917	0.361
DOC_USP7_UBL2_3	175	179	PF12436	0.712
DOC_WW_Pin1_4	129	134	PF00397	0.515
DOC_WW_Pin1_4	354	359	PF00397	0.648
DOC_WW_Pin1_4	493	498	PF00397	0.616
DOC_WW_Pin1_4	6	11	PF00397	0.603
DOC_WW_Pin1_4	94	99	PF00397	0.800
LIG_14-3-3_CanoR_1	519	527	PF00244	0.659
LIG_14-3-3_CanoR_1	71	77	PF00244	0.451
LIG_Actin_WH2_2	377	395	PF00022	0.475
LIG_APCC_ABBA_1	143	148	PF00400	0.490
LIG_BIR_II_1	1	5	PF00653	0.484
LIG_BRCT_BRCA1_1	580	584	PF00533	0.639
LIG_Clathr_ClatBox_1	280	284	PF01394	0.448
LIG_FHA_1	145	151	PF00498	0.446
LIG_FHA_1	214	220	PF00498	0.668
LIG_FHA_1	361	367	PF00498	0.694
LIG_FHA_1	389	395	PF00498	0.453
LIG_FHA_1	516	522	PF00498	0.626
LIG_FHA_1	79	85	PF00498	0.642
LIG_FHA_2	102	108	PF00498	0.692
LIG_FHA_2	120	126	PF00498	0.407
LIG_FHA_2	133	139	PF00498	0.602
LIG_LIR_Apic_2	428	433	PF02991	0.717
LIG_LIR_Apic_2	448	452	PF02991	0.380
LIG_LIR_Apic_2	579	583	PF02991	0.710
LIG_LIR_Gen_1	109	118	PF02991	0.304
LIG_LIR_Gen_1	14	23	PF02991	0.460
LIG_LIR_Gen_1	2	11	PF02991	0.539
LIG_LIR_Gen_1	239	249	PF02991	0.561
LIG_LIR_Gen_1	481	490	PF02991	0.704
LIG_LIR_Gen_1	51	61	PF02991	0.490
LIG_LIR_Gen_1	72	80	PF02991	0.536
LIG_LIR_Nem_3	109	114	PF02991	0.307
LIG_LIR_Nem_3	14	20	PF02991	0.452
LIG_LIR_Nem_3	177	181	PF02991	0.655
LIG_LIR_Nem_3	2	7	PF02991	0.586
LIG_LIR_Nem_3	239	245	PF02991	0.566
LIG_LIR_Nem_3	481	486	PF02991	0.699
LIG_LIR_Nem_3	51	57	PF02991	0.428
LIG_LIR_Nem_3	72	76	PF02991	0.515
LIG_Pex14_1	449	453	PF04695	0.716
LIG_Pex14_2	49	53	PF04695	0.426
LIG_Pex14_2	576	580	PF04695	0.707
LIG_Rb_pABgroove_1	277	285	PF01858	0.508
LIG_SH2_CRK	73	77	PF00017	0.486
LIG_SH2_NCK_1	173	177	PF00017	0.571
LIG_SH2_NCK_1	31	35	PF00017	0.472
LIG_SH2_NCK_1	73	77	PF00017	0.427
LIG_SH2_PTP2	111	114	PF00017	0.574
LIG_SH2_PTP2	242	245	PF00017	0.590
LIG_SH2_STAP1	453	457	PF00017	0.710
LIG_SH2_STAP1	73	77	PF00017	0.504
LIG_SH2_STAT3	507	510	PF00017	0.682
LIG_SH2_STAT5	111	114	PF00017	0.541
LIG_SH2_STAT5	168	171	PF00017	0.493
LIG_SH2_STAT5	242	245	PF00017	0.565
LIG_SH2_STAT5	274	277	PF00017	0.544
LIG_SH2_STAT5	31	34	PF00017	0.429
LIG_SH3_3	24	30	PF00018	0.623
LIG_SH3_3	411	417	PF00018	0.553
LIG_SH3_3	484	490	PF00018	0.707
LIG_SUMO_SIM_anti_2	277	284	PF11976	0.452
LIG_SUMO_SIM_par_1	277	284	PF11976	0.401
LIG_SUMO_SIM_par_1	372	378	PF11976	0.630
LIG_SUMO_SIM_par_1	418	424	PF11976	0.564
LIG_SUMO_SIM_par_1	498	504	PF11976	0.660
LIG_TRAF2_1	262	265	PF00917	0.673
LIG_UBA3_1	282	291	PF00899	0.491
LIG_WRC_WIRS_1	220	225	PF05994	0.477
LIG_WRC_WIRS_1	427	432	PF05994	0.719
LIG_WW_3	560	564	PF00397	0.488
MOD_CK1_1	132	138	PF00069	0.585
MOD_CK1_1	188	194	PF00069	0.731
MOD_CK1_1	203	209	PF00069	0.643
MOD_CK1_1	268	274	PF00069	0.529
MOD_CK1_1	316	322	PF00069	0.721
MOD_CK1_1	359	365	PF00069	0.668
MOD_CK1_1	412	418	PF00069	0.602
MOD_CK1_1	468	474	PF00069	0.658
MOD_CK1_1	523	529	PF00069	0.663
MOD_CK1_1	97	103	PF00069	0.713
MOD_CK2_1	119	125	PF00069	0.406
MOD_CK2_1	215	221	PF00069	0.699
MOD_CK2_1	322	328	PF00069	0.725
MOD_CK2_1	460	466	PF00069	0.657
MOD_CK2_1	52	58	PF00069	0.486
MOD_Cter_Amidation	553	556	PF01082	0.756
MOD_GlcNHglycan	152	155	PF01048	0.526
MOD_GlcNHglycan	188	191	PF01048	0.679
MOD_GlcNHglycan	197	200	PF01048	0.653
MOD_GlcNHglycan	205	208	PF01048	0.553
MOD_GlcNHglycan	350	353	PF01048	0.677
MOD_GlcNHglycan	358	361	PF01048	0.679
MOD_GlcNHglycan	411	414	PF01048	0.585
MOD_GlcNHglycan	462	465	PF01048	0.668
MOD_GlcNHglycan	522	525	PF01048	0.640
MOD_GSK3_1	184	191	PF00069	0.715
MOD_GSK3_1	215	222	PF00069	0.617
MOD_GSK3_1	309	316	PF00069	0.604
MOD_GSK3_1	356	363	PF00069	0.721
MOD_GSK3_1	48	55	PF00069	0.286
MOD_GSK3_1	489	496	PF00069	0.649
MOD_GSK3_1	71	78	PF00069	0.666
MOD_GSK3_1	93	100	PF00069	0.679
MOD_LATS_1	83	89	PF00433	0.486
MOD_N-GLC_1	354	359	PF02516	0.625
MOD_NEK2_1	200	205	PF00069	0.473
MOD_NEK2_1	219	224	PF00069	0.653
MOD_NEK2_1	394	399	PF00069	0.529
MOD_NEK2_1	566	571	PF00069	0.630
MOD_NEK2_1	578	583	PF00069	0.608
MOD_NEK2_1	69	74	PF00069	0.595
MOD_PIKK_1	106	112	PF00454	0.438
MOD_PIKK_1	313	319	PF00454	0.715
MOD_PIKK_1	489	495	PF00454	0.696
MOD_PKA_2	347	353	PF00069	0.642
MOD_PKA_2	409	415	PF00069	0.555
MOD_PKA_2	533	539	PF00069	0.559
MOD_Plk_1	106	112	PF00069	0.337
MOD_Plk_1	238	244	PF00069	0.586
MOD_Plk_1	300	306	PF00069	0.555
MOD_Plk_1	433	439	PF00069	0.615
MOD_Plk_1	503	509	PF00069	0.581
MOD_Plk_1	510	516	PF00069	0.559
MOD_Plk_1	578	584	PF00069	0.617
MOD_Plk_2-3	119	125	PF00069	0.514
MOD_Plk_2-3	52	58	PF00069	0.357
MOD_Plk_4	132	138	PF00069	0.654
MOD_Plk_4	215	221	PF00069	0.697
MOD_Plk_4	238	244	PF00069	0.425
MOD_Plk_4	35	41	PF00069	0.570
MOD_Plk_4	433	439	PF00069	0.653
MOD_Plk_4	452	458	PF00069	0.517
MOD_Plk_4	495	501	PF00069	0.470
MOD_ProDKin_1	129	135	PF00069	0.510
MOD_ProDKin_1	354	360	PF00069	0.649
MOD_ProDKin_1	493	499	PF00069	0.616
MOD_ProDKin_1	6	12	PF00069	0.596
MOD_ProDKin_1	94	100	PF00069	0.798
MOD_SUMO_for_1	380	383	PF00179	0.518
MOD_SUMO_rev_2	171	181	PF00179	0.700
TRG_DiLeu_BaEn_1	277	282	PF01217	0.498
TRG_DiLeu_BaEn_1	52	57	PF01217	0.568
TRG_DiLeu_BaEn_2	17	23	PF01217	0.469
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.604
TRG_ENDOCYTIC_2	111	114	PF00928	0.574
TRG_ENDOCYTIC_2	17	20	PF00928	0.453
TRG_ENDOCYTIC_2	178	181	PF00928	0.682
TRG_ENDOCYTIC_2	242	245	PF00928	0.590
TRG_ENDOCYTIC_2	453	456	PF00928	0.707
TRG_ENDOCYTIC_2	73	76	PF00928	0.671
TRG_ER_diArg_1	126	129	PF00400	0.463
TRG_ER_diArg_1	157	159	PF00400	0.594
TRG_ER_diArg_1	324	327	PF00400	0.733
TRG_ER_diArg_1	338	341	PF00400	0.561
TRG_ER_diArg_1	539	542	PF00400	0.660
TRG_ER_diArg_1	556	559	PF00400	0.558
TRG_NLS_Bipartite_1	541	559	PF00514	0.612
TRG_NLS_MonoCore_2	554	559	PF00514	0.719
TRG_NLS_MonoExtC_3	554	559	PF00514	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC36	Leptomonas seymouri	53%	94%
A0A1X0NWG5	Trypanosomatidae	29%	100%
A0A3R7MIM2	Trypanosoma rangeli	32%	100%
A0A3S7WVS1	Leishmania donovani	87%	100%
A4HYM7	Leishmania infantum	86%	100%
C9ZI60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AI99	Leishmania braziliensis	80%	100%
Q4QD00	Leishmania major	88%	96%
V5BAC8	Trypanosoma cruzi	29%	100%