Nudix hydrolase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AUI2_LEIMU

TriTrypDb:

LmxM.20.0380

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUI2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.507
CLV_C14_Caspase3-7	367	371	PF00656	0.557
CLV_C14_Caspase3-7	397	401	PF00656	0.648
CLV_NRD_NRD_1	138	140	PF00675	0.557
CLV_NRD_NRD_1	276	278	PF00675	0.444
CLV_PCSK_KEX2_1	138	140	PF00082	0.557
CLV_PCSK_KEX2_1	276	278	PF00082	0.444
CLV_PCSK_KEX2_1	50	52	PF00082	0.422
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.422
CLV_PCSK_SKI1_1	172	176	PF00082	0.631
CLV_PCSK_SKI1_1	31	35	PF00082	0.707
CLV_PCSK_SKI1_1	90	94	PF00082	0.636
CLV_PCSK_SKI1_1	95	99	PF00082	0.699
DEG_APCC_KENBOX_2	39	43	PF00400	0.380
DEG_ODPH_VHL_1	287	300	PF01847	0.518
DOC_CKS1_1	173	178	PF01111	0.580
DOC_CYCLIN_yCln2_LP_2	315	321	PF00134	0.467
DOC_MAPK_gen_1	54	63	PF00069	0.376
DOC_MAPK_MEF2A_6	40	48	PF00069	0.542
DOC_PP2B_LxvP_1	287	290	PF13499	0.403
DOC_PP4_FxxP_1	354	357	PF00568	0.501
DOC_USP7_MATH_1	168	172	PF00917	0.677
DOC_USP7_MATH_1	184	188	PF00917	0.367
DOC_USP7_MATH_1	197	201	PF00917	0.420
DOC_USP7_MATH_1	211	215	PF00917	0.371
DOC_USP7_MATH_1	330	334	PF00917	0.547
DOC_USP7_UBL2_3	50	54	PF12436	0.458
DOC_WW_Pin1_4	172	177	PF00397	0.664
DOC_WW_Pin1_4	193	198	PF00397	0.461
DOC_WW_Pin1_4	267	272	PF00397	0.407
DOC_WW_Pin1_4	314	319	PF00397	0.671
LIG_14-3-3_CanoR_1	11	17	PF00244	0.413
LIG_14-3-3_CanoR_1	142	150	PF00244	0.465
LIG_14-3-3_CanoR_1	198	203	PF00244	0.481
LIG_Actin_WH2_2	175	191	PF00022	0.467
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BRCT_BRCA1_1	281	285	PF00533	0.474
LIG_deltaCOP1_diTrp_1	146	152	PF00928	0.501
LIG_eIF4E_1	207	213	PF01652	0.380
LIG_FHA_1	13	19	PF00498	0.391
LIG_FHA_1	131	137	PF00498	0.347
LIG_FHA_1	164	170	PF00498	0.669
LIG_FHA_1	289	295	PF00498	0.390
LIG_FHA_2	341	347	PF00498	0.689
LIG_FHA_2	395	401	PF00498	0.647
LIG_FHA_2	96	102	PF00498	0.672
LIG_LIR_Apic_2	265	271	PF02991	0.399
LIG_LIR_Apic_2	353	357	PF02991	0.463
LIG_LIR_Apic_2	370	376	PF02991	0.660
LIG_LIR_Gen_1	206	217	PF02991	0.397
LIG_LIR_Gen_1	291	300	PF02991	0.401
LIG_LIR_Gen_1	303	312	PF02991	0.440
LIG_LIR_Gen_1	328	338	PF02991	0.460
LIG_LIR_Nem_3	201	207	PF02991	0.440
LIG_LIR_Nem_3	291	295	PF02991	0.383
LIG_LIR_Nem_3	328	334	PF02991	0.469
LIG_Pex14_2	386	390	PF04695	0.605
LIG_Rb_LxCxE_1	332	353	PF01857	0.539
LIG_SH2_CRK	209	213	PF00017	0.374
LIG_SH2_CRK	331	335	PF00017	0.451
LIG_SH2_PTP2	62	65	PF00017	0.391
LIG_SH2_STAP1	180	184	PF00017	0.387
LIG_SH2_STAP1	204	208	PF00017	0.405
LIG_SH2_STAP1	209	213	PF00017	0.374
LIG_SH2_STAP1	331	335	PF00017	0.451
LIG_SH2_STAT5	207	210	PF00017	0.384
LIG_SH2_STAT5	292	295	PF00017	0.501
LIG_SH2_STAT5	360	363	PF00017	0.565
LIG_SH2_STAT5	373	376	PF00017	0.609
LIG_SH2_STAT5	62	65	PF00017	0.410
LIG_SH2_STAT5	80	83	PF00017	0.532
LIG_SH3_3	170	176	PF00018	0.558
LIG_SH3_3	20	26	PF00018	0.472
LIG_SH3_3	315	321	PF00018	0.657
LIG_SH3_3	4	10	PF00018	0.485
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.423
LIG_TRAF2_1	110	113	PF00917	0.574
LIG_TRAF2_1	250	253	PF00917	0.581
LIG_TRFH_1	285	289	PF08558	0.397
LIG_TYR_ITIM	329	334	PF00017	0.465
LIG_WW_1	289	292	PF00397	0.512
MOD_CDK_SPK_2	193	198	PF00069	0.461
MOD_CK1_1	183	189	PF00069	0.411
MOD_CK1_1	261	267	PF00069	0.558
MOD_CK1_1	303	309	PF00069	0.523
MOD_CK1_1	342	348	PF00069	0.569
MOD_CK2_1	107	113	PF00069	0.597
MOD_CK2_1	142	148	PF00069	0.403
MOD_CK2_1	233	239	PF00069	0.702
MOD_CK2_1	340	346	PF00069	0.643
MOD_CMANNOS	149	152	PF00535	0.563
MOD_DYRK1A_RPxSP_1	172	176	PF00069	0.551
MOD_GlcNHglycan	1	4	PF01048	0.569
MOD_GlcNHglycan	109	112	PF01048	0.648
MOD_GlcNHglycan	181	185	PF01048	0.361
MOD_GlcNHglycan	214	217	PF01048	0.609
MOD_GlcNHglycan	235	238	PF01048	0.541
MOD_GlcNHglycan	400	403	PF01048	0.458
MOD_GSK3_1	163	170	PF00069	0.656
MOD_GSK3_1	180	187	PF00069	0.398
MOD_GSK3_1	193	200	PF00069	0.471
MOD_GSK3_1	212	219	PF00069	0.576
MOD_GSK3_1	228	235	PF00069	0.537
MOD_GSK3_1	279	286	PF00069	0.468
MOD_GSK3_1	296	303	PF00069	0.473
MOD_GSK3_1	394	401	PF00069	0.482
MOD_LATS_1	88	94	PF00433	0.433
MOD_N-GLC_1	283	288	PF02516	0.307
MOD_N-GLC_1	36	41	PF02516	0.524
MOD_NEK2_1	102	107	PF00069	0.638
MOD_NEK2_1	12	17	PF00069	0.418
MOD_NEK2_1	212	217	PF00069	0.529
MOD_NEK2_1	361	366	PF00069	0.748
MOD_NEK2_2	184	189	PF00069	0.537
MOD_PIKK_1	229	235	PF00454	0.704
MOD_PIKK_1	96	102	PF00454	0.701
MOD_PKA_2	197	203	PF00069	0.553
MOD_PKA_2	398	404	PF00069	0.465
MOD_Plk_1	180	186	PF00069	0.390
MOD_Plk_1	283	289	PF00069	0.300
MOD_Plk_4	12	18	PF00069	0.413
MOD_Plk_4	203	209	PF00069	0.408
MOD_Plk_4	288	294	PF00069	0.391
MOD_Plk_4	330	336	PF00069	0.548
MOD_Plk_4	406	412	PF00069	0.590
MOD_ProDKin_1	172	178	PF00069	0.651
MOD_ProDKin_1	193	199	PF00069	0.466
MOD_ProDKin_1	267	273	PF00069	0.414
MOD_ProDKin_1	314	320	PF00069	0.675
TRG_DiLeu_BaEn_1	262	267	PF01217	0.427
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.563
TRG_ENDOCYTIC_2	209	212	PF00928	0.377
TRG_ENDOCYTIC_2	292	295	PF00928	0.509
TRG_ENDOCYTIC_2	331	334	PF00928	0.460
TRG_ER_diArg_1	137	139	PF00400	0.532
TRG_ER_diArg_1	275	277	PF00400	0.441
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIQ0	Leptomonas seymouri	51%	100%
A0A3S7WVU6	Leishmania donovani	89%	100%
A4HYN2	Leishmania infantum	89%	100%
E9AI97	Leishmania braziliensis	73%	100%
Q4QD02	Leishmania major	88%	100%