Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9AUH9_LEIMU

TriTrypDb:

LmxM.20.0360

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 16, no: 2
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

E9AUH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.436
CLV_C14_Caspase3-7	277	281	PF00656	0.677
CLV_C14_Caspase3-7	309	313	PF00656	0.632
CLV_NRD_NRD_1	2	4	PF00675	0.531
CLV_PCSK_KEX2_1	2	4	PF00082	0.711
CLV_PCSK_KEX2_1	263	265	PF00082	0.402
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.386
DEG_Nend_UBRbox_1	1	4	PF02207	0.617
DOC_CYCLIN_yClb1_LxF_4	110	116	PF00134	0.404
DOC_MAPK_gen_1	7	15	PF00069	0.455
DOC_MAPK_MEF2A_6	7	15	PF00069	0.506
DOC_WW_Pin1_4	1	6	PF00397	0.642
DOC_WW_Pin1_4	293	298	PF00397	0.734
LIG_14-3-3_CanoR_1	27	32	PF00244	0.174
LIG_14-3-3_CanoR_1	7	12	PF00244	0.534
LIG_Actin_WH2_2	112	128	PF00022	0.397
LIG_eIF4E_1	209	215	PF01652	0.428
LIG_FHA_1	172	178	PF00498	0.320
LIG_FHA_1	21	27	PF00498	0.390
LIG_FHA_1	8	14	PF00498	0.467
LIG_FHA_2	191	197	PF00498	0.394
LIG_FHA_2	275	281	PF00498	0.653
LIG_LIR_Gen_1	131	142	PF02991	0.427
LIG_LIR_Nem_3	114	120	PF02991	0.276
LIG_LIR_Nem_3	131	137	PF02991	0.422
LIG_LIR_Nem_3	179	183	PF02991	0.317
LIG_LIR_Nem_3	189	194	PF02991	0.404
LIG_NRBOX	16	22	PF00104	0.443
LIG_PCNA_yPIPBox_3	165	173	PF02747	0.401
LIG_Pex14_1	176	180	PF04695	0.256
LIG_SH2_CRK	117	121	PF00017	0.286
LIG_SH2_NCK_1	310	314	PF00017	0.626
LIG_SH2_STAP1	173	177	PF00017	0.263
LIG_SH2_STAP1	29	33	PF00017	0.289
LIG_SH2_STAT3	172	175	PF00017	0.388
LIG_SH2_STAT3	181	184	PF00017	0.433
LIG_SH2_STAT3	50	53	PF00017	0.264
LIG_SH2_STAT5	173	176	PF00017	0.286
LIG_SH2_STAT5	261	264	PF00017	0.589
LIG_SH2_STAT5	50	53	PF00017	0.289
LIG_SH3_3	189	195	PF00018	0.461
LIG_SUMO_SIM_anti_2	10	15	PF11976	0.273
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.400
LIG_SUMO_SIM_par_1	238	244	PF11976	0.329
LIG_SUMO_SIM_par_1	248	254	PF11976	0.278
MOD_CDC14_SPxK_1	4	7	PF00782	0.453
MOD_CDK_SPxK_1	1	7	PF00069	0.486
MOD_CK1_1	146	152	PF00069	0.404
MOD_CK1_1	186	192	PF00069	0.613
MOD_CK1_1	56	62	PF00069	0.343
MOD_CK1_1	89	95	PF00069	0.404
MOD_CK2_1	157	163	PF00069	0.335
MOD_CK2_1	308	314	PF00069	0.716
MOD_GlcNHglycan	138	141	PF01048	0.484
MOD_GlcNHglycan	37	40	PF01048	0.388
MOD_GlcNHglycan	54	58	PF01048	0.359
MOD_GlcNHglycan	69	72	PF01048	0.377
MOD_GlcNHglycan	91	94	PF01048	0.602
MOD_GSK3_1	186	193	PF00069	0.497
MOD_GSK3_1	63	70	PF00069	0.369
MOD_GSK3_1	89	96	PF00069	0.395
MOD_N-GLC_1	146	151	PF02516	0.597
MOD_N-GLC_1	97	102	PF02516	0.555
MOD_NEK2_1	143	148	PF00069	0.448
MOD_NEK2_1	20	25	PF00069	0.335
MOD_NEK2_2	121	126	PF00069	0.393
MOD_NEK2_2	302	307	PF00069	0.519
MOD_PIKK_1	171	177	PF00454	0.428
MOD_PIKK_1	216	222	PF00454	0.618
MOD_PIKK_1	284	290	PF00454	0.567
MOD_PK_1	27	33	PF00069	0.263
MOD_PKA_2	216	222	PF00069	0.584
MOD_PKA_2	89	95	PF00069	0.545
MOD_Plk_1	111	117	PF00069	0.387
MOD_Plk_1	146	152	PF00069	0.586
MOD_Plk_1	186	192	PF00069	0.586
MOD_Plk_1	302	308	PF00069	0.632
MOD_Plk_1	97	103	PF00069	0.380
MOD_Plk_2-3	308	314	PF00069	0.660
MOD_Plk_4	111	117	PF00069	0.502
MOD_Plk_4	146	152	PF00069	0.537
MOD_Plk_4	168	174	PF00069	0.357
MOD_Plk_4	186	192	PF00069	0.427
MOD_Plk_4	56	62	PF00069	0.278
MOD_ProDKin_1	1	7	PF00069	0.638
MOD_ProDKin_1	293	299	PF00069	0.686
TRG_ENDOCYTIC_2	117	120	PF00928	0.359
TRG_ENDOCYTIC_2	134	137	PF00928	0.400
TRG_ER_diArg_1	1	3	PF00400	0.431
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P471	Leptomonas seymouri	68%	100%
A0A0N1I022	Leptomonas seymouri	35%	94%
A0A1X0NWG4	Trypanosomatidae	31%	88%
A0A1X0NWG7	Trypanosomatidae	33%	87%
A0A1X0NWG9	Trypanosomatidae	34%	88%
A0A1X0NXT1	Trypanosomatidae	33%	88%
A0A1X0NY10	Trypanosomatidae	31%	100%
A0A3Q8IBH3	Leishmania donovani	93%	100%
A0A3S5H4S6	Leishmania donovani	35%	96%
A4H335	Leishmania braziliensis	33%	100%
A4HRC3	Leishmania infantum	35%	96%
A4HYN5	Leishmania infantum	93%	100%
E9ABZ0	Leishmania major	35%	100%
E9AI94	Leishmania braziliensis	75%	100%
E9AJ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4QD05	Leishmania major	94%	100%
V5DS51	Trypanosoma cruzi	32%	90%