LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Major facilitator family transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Major facilitator family transporter
Gene product:
major facilitator superfamily, putative
Species:
Leishmania mexicana
UniProt:
E9AUH8_LEIMU
TriTrypDb:
LmxM.20.0350
Length:
726

Annotations

LeishMANIAdb annotations

A transporter protein family expanded in Kinetoplastids. Distantly similar to animal hem transporters (human FLVCR).

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 14
GO:0110165 cellular anatomical entity 1 14
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

E9AUH8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUH8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 13
GO:0022857 transmembrane transporter activity 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 13 15 PF00675 0.191
CLV_NRD_NRD_1 239 241 PF00675 0.538
CLV_NRD_NRD_1 364 366 PF00675 0.372
CLV_NRD_NRD_1 388 390 PF00675 0.348
CLV_NRD_NRD_1 584 586 PF00675 0.398
CLV_NRD_NRD_1 81 83 PF00675 0.326
CLV_PCSK_KEX2_1 13 15 PF00082 0.191
CLV_PCSK_KEX2_1 238 240 PF00082 0.551
CLV_PCSK_KEX2_1 364 366 PF00082 0.366
CLV_PCSK_KEX2_1 388 390 PF00082 0.348
CLV_PCSK_KEX2_1 584 586 PF00082 0.410
CLV_PCSK_KEX2_1 635 637 PF00082 0.618
CLV_PCSK_KEX2_1 81 83 PF00082 0.283
CLV_PCSK_PC1ET2_1 635 637 PF00082 0.419
CLV_PCSK_PC7_1 77 83 PF00082 0.269
CLV_PCSK_SKI1_1 358 362 PF00082 0.465
CLV_PCSK_SKI1_1 43 47 PF00082 0.483
CLV_PCSK_SKI1_1 677 681 PF00082 0.514
CLV_PCSK_SKI1_1 82 86 PF00082 0.397
DEG_SPOP_SBC_1 168 172 PF00917 0.269
DEG_SPOP_SBC_1 551 555 PF00917 0.328
DOC_CDC14_PxL_1 97 105 PF14671 0.385
DOC_CKS1_1 126 131 PF01111 0.363
DOC_MAPK_gen_1 13 20 PF00069 0.391
DOC_MAPK_gen_1 388 394 PF00069 0.478
DOC_MAPK_gen_1 452 462 PF00069 0.516
DOC_MAPK_JIP1_4 105 111 PF00069 0.269
DOC_MAPK_MEF2A_6 105 113 PF00069 0.269
DOC_MAPK_MEF2A_6 13 20 PF00069 0.425
DOC_MAPK_MEF2A_6 455 462 PF00069 0.507
DOC_PP1_SILK_1 94 99 PF00149 0.385
DOC_PP2B_LxvP_1 111 114 PF13499 0.385
DOC_PP2B_LxvP_1 161 164 PF13499 0.328
DOC_PP2B_LxvP_1 477 480 PF13499 0.428
DOC_PP4_FxxP_1 162 165 PF00568 0.365
DOC_PP4_FxxP_1 205 208 PF00568 0.512
DOC_USP7_MATH_1 293 297 PF00917 0.766
DOC_USP7_MATH_1 304 308 PF00917 0.647
DOC_USP7_MATH_1 552 556 PF00917 0.374
DOC_USP7_MATH_1 92 96 PF00917 0.385
DOC_WW_Pin1_4 125 130 PF00397 0.363
DOC_WW_Pin1_4 199 204 PF00397 0.216
DOC_WW_Pin1_4 339 344 PF00397 0.680
DOC_WW_Pin1_4 637 642 PF00397 0.741
DOC_WW_Pin1_4 706 711 PF00397 0.760
LIG_14-3-3_CanoR_1 286 294 PF00244 0.728
LIG_14-3-3_CanoR_1 305 314 PF00244 0.650
LIG_14-3-3_CanoR_1 365 375 PF00244 0.494
LIG_Actin_WH2_2 83 100 PF00022 0.370
LIG_BRCT_BRCA1_1 201 205 PF00533 0.391
LIG_BRCT_BRCA1_1 341 345 PF00533 0.749
LIG_Clathr_ClatBox_1 181 185 PF01394 0.385
LIG_eIF4E_1 454 460 PF01652 0.483
LIG_FHA_1 108 114 PF00498 0.329
LIG_FHA_1 126 132 PF00498 0.335
LIG_FHA_1 191 197 PF00498 0.385
LIG_FHA_1 379 385 PF00498 0.531
LIG_FHA_1 48 54 PF00498 0.332
LIG_FHA_1 650 656 PF00498 0.622
LIG_FHA_1 707 713 PF00498 0.693
LIG_FHA_2 172 178 PF00498 0.269
LIG_FHA_2 332 338 PF00498 0.785
LIG_FHA_2 345 351 PF00498 0.756
LIG_FHA_2 372 378 PF00498 0.557
LIG_FHA_2 644 650 PF00498 0.698
LIG_FHA_2 687 693 PF00498 0.616
LIG_FHA_2 699 705 PF00498 0.674
LIG_FHA_2 71 77 PF00498 0.385
LIG_GBD_Chelix_1 459 467 PF00786 0.282
LIG_LIR_Apic_2 202 208 PF02991 0.527
LIG_LIR_Apic_2 451 457 PF02991 0.574
LIG_LIR_Apic_2 514 520 PF02991 0.534
LIG_LIR_Gen_1 175 186 PF02991 0.293
LIG_LIR_Gen_1 317 325 PF02991 0.608
LIG_LIR_Gen_1 34 41 PF02991 0.329
LIG_LIR_Gen_1 374 383 PF02991 0.579
LIG_LIR_Gen_1 390 398 PF02991 0.344
LIG_LIR_Gen_1 407 416 PF02991 0.365
LIG_LIR_Gen_1 491 500 PF02991 0.403
LIG_LIR_Gen_1 57 68 PF02991 0.340
LIG_LIR_Nem_3 175 181 PF02991 0.293
LIG_LIR_Nem_3 185 191 PF02991 0.356
LIG_LIR_Nem_3 317 321 PF02991 0.609
LIG_LIR_Nem_3 34 38 PF02991 0.262
LIG_LIR_Nem_3 361 366 PF02991 0.612
LIG_LIR_Nem_3 374 378 PF02991 0.555
LIG_LIR_Nem_3 381 386 PF02991 0.555
LIG_LIR_Nem_3 390 394 PF02991 0.340
LIG_LIR_Nem_3 407 411 PF02991 0.237
LIG_LIR_Nem_3 42 48 PF02991 0.259
LIG_LIR_Nem_3 491 495 PF02991 0.366
LIG_LIR_Nem_3 57 63 PF02991 0.275
LIG_LYPXL_yS_3 456 459 PF13949 0.496
LIG_Pex14_2 178 182 PF04695 0.334
LIG_Pex14_2 345 349 PF04695 0.678
LIG_Pex14_2 492 496 PF04695 0.403
LIG_Rb_LxCxE_1 177 193 PF01857 0.329
LIG_SH2_CRK 35 39 PF00017 0.283
LIG_SH2_CRK 408 412 PF00017 0.438
LIG_SH2_CRK 454 458 PF00017 0.537
LIG_SH2_CRK 60 64 PF00017 0.385
LIG_SH2_NCK_1 35 39 PF00017 0.326
LIG_SH2_STAP1 35 39 PF00017 0.326
LIG_SH2_STAP1 408 412 PF00017 0.438
LIG_SH2_STAP1 614 618 PF00017 0.634
LIG_SH2_STAT3 332 335 PF00017 0.699
LIG_SH2_STAT5 108 111 PF00017 0.311
LIG_SH2_STAT5 136 139 PF00017 0.526
LIG_SH2_STAT5 346 349 PF00017 0.699
LIG_SH2_STAT5 383 386 PF00017 0.582
LIG_SH2_STAT5 442 445 PF00017 0.355
LIG_SH2_STAT5 494 497 PF00017 0.434
LIG_SH2_STAT5 603 606 PF00017 0.517
LIG_SH2_STAT5 69 72 PF00017 0.368
LIG_SH3_3 619 625 PF00018 0.736
LIG_SUMO_SIM_par_1 164 172 PF11976 0.326
LIG_SUMO_SIM_par_1 536 541 PF11976 0.350
LIG_SUMO_SIM_par_1 559 565 PF11976 0.408
LIG_TRAF2_1 701 704 PF00917 0.647
LIG_TYR_ITIM 33 38 PF00017 0.326
LIG_TYR_ITSM 379 386 PF00017 0.434
LIG_UBA3_1 472 478 PF00899 0.403
LIG_UBA3_1 573 581 PF00899 0.268
LIG_WRC_WIRS_1 372 377 PF05994 0.601
LIG_WRC_WIRS_1 489 494 PF05994 0.403
LIG_WW_2 624 627 PF00397 0.674
MOD_CDK_SPxxK_3 199 206 PF00069 0.196
MOD_CK1_1 171 177 PF00069 0.269
MOD_CK1_1 296 302 PF00069 0.796
MOD_CK1_1 307 313 PF00069 0.622
MOD_CK1_1 37 43 PF00069 0.326
MOD_CK1_1 401 407 PF00069 0.421
MOD_CK1_1 541 547 PF00069 0.363
MOD_CK1_1 616 622 PF00069 0.588
MOD_CK2_1 171 177 PF00069 0.269
MOD_CK2_1 259 265 PF00069 0.791
MOD_CK2_1 371 377 PF00069 0.589
MOD_CK2_1 647 653 PF00069 0.695
MOD_CK2_1 698 704 PF00069 0.682
MOD_CK2_1 70 76 PF00069 0.385
MOD_GlcNHglycan 217 220 PF01048 0.487
MOD_GlcNHglycan 224 227 PF01048 0.579
MOD_GlcNHglycan 24 27 PF01048 0.306
MOD_GlcNHglycan 262 265 PF01048 0.586
MOD_GlcNHglycan 309 312 PF01048 0.591
MOD_GlcNHglycan 554 557 PF01048 0.621
MOD_GlcNHglycan 598 601 PF01048 0.498
MOD_GlcNHglycan 628 631 PF01048 0.573
MOD_GlcNHglycan 632 635 PF01048 0.565
MOD_GSK3_1 167 174 PF00069 0.269
MOD_GSK3_1 251 258 PF00069 0.738
MOD_GSK3_1 293 300 PF00069 0.625
MOD_GSK3_1 33 40 PF00069 0.385
MOD_GSK3_1 331 338 PF00069 0.775
MOD_GSK3_1 478 485 PF00069 0.385
MOD_GSK3_1 603 610 PF00069 0.656
MOD_GSK3_1 626 633 PF00069 0.664
MOD_GSK3_1 643 650 PF00069 0.655
MOD_N-GLC_1 307 312 PF02516 0.501
MOD_N-GLC_1 46 51 PF02516 0.497
MOD_N-GLC_2 533 535 PF02516 0.403
MOD_NEK2_1 124 129 PF00069 0.359
MOD_NEK2_1 398 403 PF00069 0.403
MOD_NEK2_1 425 430 PF00069 0.406
MOD_NEK2_1 46 51 PF00069 0.334
MOD_NEK2_1 462 467 PF00069 0.353
MOD_NEK2_1 500 505 PF00069 0.403
MOD_NEK2_1 513 518 PF00069 0.578
MOD_NEK2_1 55 60 PF00069 0.398
MOD_NEK2_1 70 75 PF00069 0.319
MOD_NEK2_2 41 46 PF00069 0.233
MOD_PIKK_1 206 212 PF00454 0.563
MOD_PIKK_1 331 337 PF00454 0.767
MOD_PKA_2 259 265 PF00069 0.754
MOD_PKA_2 285 291 PF00069 0.752
MOD_PKA_2 304 310 PF00069 0.651
MOD_PKA_2 350 356 PF00069 0.700
MOD_PKA_2 647 653 PF00069 0.731
MOD_PKA_2 698 704 PF00069 0.673
MOD_Plk_1 268 274 PF00069 0.783
MOD_Plk_1 335 341 PF00069 0.691
MOD_Plk_1 513 519 PF00069 0.553
MOD_Plk_1 614 620 PF00069 0.593
MOD_Plk_1 686 692 PF00069 0.584
MOD_Plk_2-3 649 655 PF00069 0.696
MOD_Plk_4 1 7 PF00069 0.653
MOD_Plk_4 107 113 PF00069 0.326
MOD_Plk_4 358 364 PF00069 0.642
MOD_Plk_4 378 384 PF00069 0.418
MOD_Plk_4 401 407 PF00069 0.391
MOD_Plk_4 438 444 PF00069 0.350
MOD_Plk_4 462 468 PF00069 0.403
MOD_Plk_4 488 494 PF00069 0.403
MOD_Plk_4 533 539 PF00069 0.405
MOD_Plk_4 541 547 PF00069 0.390
MOD_Plk_4 55 61 PF00069 0.363
MOD_Plk_4 675 681 PF00069 0.626
MOD_Plk_4 92 98 PF00069 0.385
MOD_ProDKin_1 125 131 PF00069 0.363
MOD_ProDKin_1 199 205 PF00069 0.216
MOD_ProDKin_1 339 345 PF00069 0.681
MOD_ProDKin_1 637 643 PF00069 0.744
MOD_ProDKin_1 706 712 PF00069 0.762
TRG_DiLeu_BaLyEn_6 127 132 PF01217 0.397
TRG_DiLeu_BaLyEn_6 162 167 PF01217 0.385
TRG_DiLeu_BaLyEn_6 454 459 PF01217 0.560
TRG_ENDOCYTIC_2 108 111 PF00928 0.326
TRG_ENDOCYTIC_2 346 349 PF00928 0.677
TRG_ENDOCYTIC_2 35 38 PF00928 0.314
TRG_ENDOCYTIC_2 383 386 PF00928 0.582
TRG_ENDOCYTIC_2 408 411 PF00928 0.440
TRG_ENDOCYTIC_2 456 459 PF00928 0.500
TRG_ENDOCYTIC_2 60 63 PF00928 0.348
TRG_ER_diArg_1 12 14 PF00400 0.462
TRG_ER_diArg_1 238 240 PF00400 0.737
TRG_ER_diArg_1 363 365 PF00400 0.583
TRG_ER_diArg_1 583 585 PF00400 0.622
TRG_ER_diArg_1 80 82 PF00400 0.532

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I416 Leptomonas seymouri 63% 100%
A0A0N1IHM9 Leptomonas seymouri 25% 100%
A0A0S4J2T0 Bodo saltans 26% 100%
A0A3Q8IBI9 Leishmania donovani 87% 99%
A0A3S5H541 Leishmania donovani 27% 100%
A4H3K8 Leishmania braziliensis 25% 100%
A4HRV1 Leishmania infantum 27% 100%
A4HYN7 Leishmania infantum 87% 99%
E9ACI6 Leishmania major 26% 100%
E9AI92 Leishmania braziliensis 68% 100%
E9AJS4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
Q4QD06 Leishmania major 86% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS