Acetyltransf_13 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ESCO acetyltransferase domain-containing protein

Species:

Leishmania mexicana

UniProt:

E9AUH7_LEIMU

TriTrypDb:

LmxM.20.0346

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUH7

Function

Biological processes
Term	Name	Level	Count
GO:0000070	mitotic sister chromatid segregation	4	10
GO:0000819	sister chromatid segregation	4	10
GO:0006996	organelle organization	4	11
GO:0007059	chromosome segregation	2	11
GO:0007062	sister chromatid cohesion	3	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022402	cell cycle process	2	11
GO:0022414	reproductive process	1	11
GO:0045132	meiotic chromosome segregation	3	11
GO:0051276	chromosome organization	5	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0098813	nuclear chromosome segregation	3	11
GO:1903046	meiotic cell cycle process	2	11
GO:1903047	mitotic cell cycle process	3	11
GO:0007064	mitotic sister chromatid cohesion	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016407	acetyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0008080	N-acetyltransferase activity	6	1
GO:0016410	N-acyltransferase activity	5	1
GO:0034212	peptide N-acetyltransferase activity	7	1
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.467
CLV_C14_Caspase3-7	8	12	PF00656	0.652
CLV_NRD_NRD_1	256	258	PF00675	0.179
CLV_NRD_NRD_1	27	29	PF00675	0.339
CLV_NRD_NRD_1	297	299	PF00675	0.291
CLV_NRD_NRD_1	72	74	PF00675	0.694
CLV_PCSK_KEX2_1	256	258	PF00082	0.173
CLV_PCSK_KEX2_1	297	299	PF00082	0.314
CLV_PCSK_KEX2_1	74	76	PF00082	0.650
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.610
CLV_PCSK_PC7_1	70	76	PF00082	0.625
CLV_PCSK_SKI1_1	29	33	PF00082	0.478
DEG_SPOP_SBC_1	196	200	PF00917	0.475
DOC_PP1_RVXF_1	245	251	PF00149	0.548
DOC_PP4_FxxP_1	276	279	PF00568	0.464
DOC_PP4_FxxP_1	285	288	PF00568	0.449
DOC_USP7_MATH_1	124	128	PF00917	0.474
DOC_USP7_MATH_1	16	20	PF00917	0.489
DOC_USP7_MATH_1	189	193	PF00917	0.641
DOC_USP7_MATH_1	195	199	PF00917	0.675
DOC_USP7_MATH_1	290	294	PF00917	0.543
DOC_USP7_MATH_1	57	61	PF00917	0.346
DOC_WW_Pin1_4	127	132	PF00397	0.622
DOC_WW_Pin1_4	153	158	PF00397	0.664
DOC_WW_Pin1_4	184	189	PF00397	0.598
DOC_WW_Pin1_4	238	243	PF00397	0.489
DOC_WW_Pin1_4	249	254	PF00397	0.461
DOC_WW_Pin1_4	30	35	PF00397	0.574
LIG_14-3-3_CanoR_1	182	188	PF00244	0.596
LIG_14-3-3_CanoR_1	98	106	PF00244	0.531
LIG_Actin_WH2_2	138	155	PF00022	0.314
LIG_FHA_2	146	152	PF00498	0.430
LIG_FHA_2	201	207	PF00498	0.718
LIG_FHA_2	6	12	PF00498	0.605
LIG_LIR_Nem_3	19	24	PF02991	0.502
LIG_LIR_Nem_3	304	308	PF02991	0.470
LIG_MYND_3	1	5	PF01753	0.467
LIG_REV1ctd_RIR_1	64	74	PF16727	0.510
LIG_SH2_CRK	274	278	PF00017	0.590
LIG_SH2_NCK_1	262	266	PF00017	0.511
LIG_SH2_STAT5	36	39	PF00017	0.512
LIG_SH3_3	28	34	PF00018	0.478
LIG_SUMO_SIM_anti_2	138	144	PF11976	0.264
LIG_TYR_ITIM	260	265	PF00017	0.542
LIG_TYR_ITIM	272	277	PF00017	0.559
MOD_CDK_SPxxK_3	249	256	PF00069	0.543
MOD_CK1_1	107	113	PF00069	0.492
MOD_CK1_1	127	133	PF00069	0.302
MOD_CK1_1	156	162	PF00069	0.665
MOD_CK1_1	213	219	PF00069	0.664
MOD_CK1_1	252	258	PF00069	0.541
MOD_CK1_1	286	292	PF00069	0.490
MOD_CK2_1	195	201	PF00069	0.661
MOD_CK2_1	260	266	PF00069	0.486
MOD_GlcNHglycan	109	112	PF01048	0.484
MOD_GlcNHglycan	114	117	PF01048	0.424
MOD_GlcNHglycan	212	215	PF01048	0.621
MOD_GlcNHglycan	292	295	PF01048	0.363
MOD_GlcNHglycan	50	53	PF01048	0.631
MOD_GlcNHglycan	89	93	PF01048	0.696
MOD_GSK3_1	100	107	PF00069	0.682
MOD_GSK3_1	16	23	PF00069	0.353
MOD_GSK3_1	184	191	PF00069	0.603
MOD_GSK3_1	195	202	PF00069	0.670
MOD_GSK3_1	209	216	PF00069	0.738
MOD_GSK3_1	286	293	PF00069	0.514
MOD_NEK2_1	210	215	PF00069	0.505
MOD_NEK2_2	109	114	PF00069	0.446
MOD_OFUCOSY	211	218	PF10250	0.517
MOD_PKA_2	100	106	PF00069	0.606
MOD_Plk_2-3	5	11	PF00069	0.520
MOD_Plk_4	260	266	PF00069	0.514
MOD_Plk_4	57	63	PF00069	0.430
MOD_ProDKin_1	127	133	PF00069	0.620
MOD_ProDKin_1	153	159	PF00069	0.660
MOD_ProDKin_1	184	190	PF00069	0.603
MOD_ProDKin_1	238	244	PF00069	0.477
MOD_ProDKin_1	249	255	PF00069	0.461
MOD_ProDKin_1	30	36	PF00069	0.573
TRG_DiLeu_BaEn_4	5	11	PF01217	0.440
TRG_ENDOCYTIC_2	181	184	PF00928	0.536
TRG_ENDOCYTIC_2	262	265	PF00928	0.542
TRG_ENDOCYTIC_2	274	277	PF00928	0.547
TRG_ENDOCYTIC_2	64	67	PF00928	0.383
TRG_ER_diArg_1	297	299	PF00400	0.514
TRG_NLS_MonoExtC_3	72	77	PF00514	0.647
TRG_NLS_MonoExtN_4	70	77	PF00514	0.629
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N8	Leptomonas seymouri	35%	100%
A0A1X0NWH5	Trypanosomatidae	33%	93%
A0A3S7WVV5	Leishmania donovani	82%	100%
A0A422MWP0	Trypanosoma rangeli	35%	100%
A4HYS2	Leishmania infantum	82%	100%
C9ZIA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AI91	Leishmania braziliensis	68%	100%
Q4QD07	Leishmania major	85%	100%
V5DS57	Trypanosoma cruzi	33%	100%