Zinc finger, C3HC4 type (RING finger) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUH5_LEIMU

TriTrypDb:

LmxM.20.0340

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.422
CLV_NRD_NRD_1	211	213	PF00675	0.710
CLV_NRD_NRD_1	228	230	PF00675	0.502
CLV_NRD_NRD_1	98	100	PF00675	0.444
CLV_PCSK_KEX2_1	209	211	PF00082	0.582
CLV_PCSK_KEX2_1	228	230	PF00082	0.526
CLV_PCSK_KEX2_1	98	100	PF00082	0.444
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.549
CLV_PCSK_SKI1_1	337	341	PF00082	0.473
CLV_PCSK_SKI1_1	343	347	PF00082	0.380
CLV_PCSK_SKI1_1	82	86	PF00082	0.406
DEG_Nend_UBRbox_3	1	3	PF02207	0.472
DEG_SPOP_SBC_1	73	77	PF00917	0.455
DOC_CKS1_1	380	385	PF01111	0.619
DOC_CKS1_1	92	97	PF01111	0.480
DOC_CYCLIN_yCln2_LP_2	328	334	PF00134	0.447
DOC_MAPK_gen_1	209	216	PF00069	0.661
DOC_MAPK_gen_1	340	350	PF00069	0.485
DOC_PIKK_1	253	261	PF02985	0.414
DOC_PP1_RVXF_1	347	354	PF00149	0.347
DOC_PP1_RVXF_1	63	70	PF00149	0.443
DOC_PP2B_LxvP_1	328	331	PF13499	0.485
DOC_PP4_FxxP_1	377	380	PF00568	0.551
DOC_USP7_MATH_1	172	176	PF00917	0.645
DOC_USP7_MATH_1	223	227	PF00917	0.665
DOC_USP7_MATH_1	32	36	PF00917	0.574
DOC_USP7_MATH_1	73	77	PF00917	0.503
DOC_WW_Pin1_4	303	308	PF00397	0.395
DOC_WW_Pin1_4	370	375	PF00397	0.633
DOC_WW_Pin1_4	379	384	PF00397	0.588
DOC_WW_Pin1_4	69	74	PF00397	0.480
DOC_WW_Pin1_4	91	96	PF00397	0.428
LIG_14-3-3_CanoR_1	363	372	PF00244	0.608
LIG_Actin_WH2_2	344	362	PF00022	0.504
LIG_FHA_1	380	386	PF00498	0.574
LIG_FHA_1	75	81	PF00498	0.635
LIG_FHA_2	137	143	PF00498	0.467
LIG_IRF3_LxIS_1	53	60	PF10401	0.459
LIG_LIR_Gen_1	44	53	PF02991	0.447
LIG_LIR_Gen_1	86	95	PF02991	0.513
LIG_LIR_Nem_3	119	125	PF02991	0.464
LIG_LIR_Nem_3	44	49	PF02991	0.451
LIG_LIR_Nem_3	86	90	PF02991	0.515
LIG_MYND_1	376	380	PF01753	0.626
LIG_SH2_CRK	283	287	PF00017	0.458
LIG_SH2_CRK	46	50	PF00017	0.570
LIG_SH2_STAP1	140	144	PF00017	0.565
LIG_SH2_STAP1	46	50	PF00017	0.630
LIG_SH2_STAP1	96	100	PF00017	0.475
LIG_SH2_STAT3	352	355	PF00017	0.409
LIG_SH2_STAT5	352	355	PF00017	0.485
LIG_SH3_3	302	308	PF00018	0.439
LIG_SH3_3	324	330	PF00018	0.479
LIG_SH3_3	369	375	PF00018	0.488
LIG_SH3_3	377	383	PF00018	0.571
LIG_SH3_3	47	53	PF00018	0.495
LIG_SH3_3	89	95	PF00018	0.451
LIG_SUMO_SIM_anti_2	240	248	PF11976	0.464
LIG_SUMO_SIM_par_1	286	291	PF11976	0.369
LIG_SUMO_SIM_par_1	75	81	PF11976	0.578
LIG_TYR_ITSM	42	49	PF00017	0.451
LIG_WRC_WIRS_1	84	89	PF05994	0.370
MOD_CDK_SPK_2	384	389	PF00069	0.704
MOD_CDK_SPxxK_3	91	98	PF00069	0.373
MOD_CK1_1	196	202	PF00069	0.646
MOD_CK1_1	224	230	PF00069	0.636
MOD_CK1_1	232	238	PF00069	0.564
MOD_CK1_1	248	254	PF00069	0.374
MOD_CK1_1	28	34	PF00069	0.568
MOD_CK1_1	370	376	PF00069	0.533
MOD_CK1_1	72	78	PF00069	0.478
MOD_CK2_1	136	142	PF00069	0.634
MOD_CK2_1	330	336	PF00069	0.529
MOD_GlcNHglycan	182	185	PF01048	0.599
MOD_GlcNHglycan	247	250	PF01048	0.522
MOD_GlcNHglycan	313	316	PF01048	0.526
MOD_GlcNHglycan	365	368	PF01048	0.586
MOD_GlcNHglycan	46	49	PF01048	0.660
MOD_GlcNHglycan	59	62	PF01048	0.370
MOD_GSK3_1	266	273	PF00069	0.479
MOD_GSK3_1	28	35	PF00069	0.697
MOD_GSK3_1	286	293	PF00069	0.339
MOD_GSK3_1	359	366	PF00069	0.469
MOD_GSK3_1	69	76	PF00069	0.484
MOD_N-GLC_1	180	185	PF02516	0.513
MOD_NEK2_1	230	235	PF00069	0.483
MOD_NEK2_1	270	275	PF00069	0.424
MOD_NEK2_1	288	293	PF00069	0.496
MOD_NEK2_1	359	364	PF00069	0.611
MOD_NEK2_1	57	62	PF00069	0.466
MOD_NEK2_1	74	79	PF00069	0.493
MOD_PKA_2	224	230	PF00069	0.741
MOD_PKA_2	28	34	PF00069	0.520
MOD_PKA_2	359	365	PF00069	0.459
MOD_Plk_1	270	276	PF00069	0.414
MOD_Plk_4	232	238	PF00069	0.589
MOD_ProDKin_1	303	309	PF00069	0.405
MOD_ProDKin_1	370	376	PF00069	0.631
MOD_ProDKin_1	379	385	PF00069	0.586
MOD_ProDKin_1	69	75	PF00069	0.481
MOD_ProDKin_1	91	97	PF00069	0.435
MOD_SUMO_rev_2	248	258	PF00179	0.452
MOD_SUMO_rev_2	260	268	PF00179	0.434
MOD_SUMO_rev_2	333	342	PF00179	0.516
TRG_DiLeu_BaEn_1	257	262	PF01217	0.405
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.383
TRG_ENDOCYTIC_2	46	49	PF00928	0.573
TRG_ER_diArg_1	210	212	PF00400	0.713
TRG_ER_diArg_1	228	230	PF00400	0.669
TRG_NLS_MonoCore_2	208	213	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWV5	Leptomonas seymouri	56%	95%
A0A3S7WVR4	Leishmania donovani	90%	100%
A4HYS0	Leishmania infantum	90%	100%
E9AI90	Leishmania braziliensis	77%	100%
Q4QD09	Leishmania major	90%	100%