Leucine_Rich_repeat_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 49, putative

Species:

Leishmania mexicana

UniProt:

E9AUH3_LEIMU

TriTrypDb:

LmxM.20.0320

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AUH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.424
CLV_C14_Caspase3-7	231	235	PF00656	0.616
CLV_C14_Caspase3-7	245	249	PF00656	0.699
CLV_C14_Caspase3-7	500	504	PF00656	0.593
CLV_NRD_NRD_1	159	161	PF00675	0.524
CLV_NRD_NRD_1	263	265	PF00675	0.629
CLV_NRD_NRD_1	285	287	PF00675	0.571
CLV_NRD_NRD_1	301	303	PF00675	0.467
CLV_NRD_NRD_1	320	322	PF00675	0.281
CLV_NRD_NRD_1	382	384	PF00675	0.310
CLV_NRD_NRD_1	49	51	PF00675	0.351
CLV_NRD_NRD_1	535	537	PF00675	0.611
CLV_NRD_NRD_1	539	541	PF00675	0.609
CLV_NRD_NRD_1	573	575	PF00675	0.600
CLV_NRD_NRD_1	597	599	PF00675	0.681
CLV_PCSK_KEX2_1	159	161	PF00082	0.524
CLV_PCSK_KEX2_1	262	264	PF00082	0.803
CLV_PCSK_KEX2_1	301	303	PF00082	0.571
CLV_PCSK_KEX2_1	382	384	PF00082	0.331
CLV_PCSK_KEX2_1	539	541	PF00082	0.674
CLV_PCSK_KEX2_1	573	575	PF00082	0.600
CLV_PCSK_KEX2_1	597	599	PF00082	0.681
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.632
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.681
CLV_PCSK_SKI1_1	26	30	PF00082	0.350
CLV_PCSK_SKI1_1	302	306	PF00082	0.400
CLV_PCSK_SKI1_1	336	340	PF00082	0.410
CLV_PCSK_SKI1_1	453	457	PF00082	0.440
CLV_PCSK_SKI1_1	576	580	PF00082	0.605
DEG_APCC_DBOX_1	335	343	PF00400	0.384
DEG_SPOP_SBC_1	419	423	PF00917	0.527
DOC_CYCLIN_RxL_1	23	31	PF00134	0.343
DOC_CYCLIN_RxL_1	316	329	PF00134	0.369
DOC_CYCLIN_RxL_1	435	444	PF00134	0.311
DOC_CYCLIN_RxL_1	47	58	PF00134	0.395
DOC_CYCLIN_yCln2_LP_2	128	134	PF00134	0.362
DOC_CYCLIN_yCln2_LP_2	307	313	PF00134	0.360
DOC_MAPK_gen_1	10	18	PF00069	0.391
DOC_MAPK_gen_1	262	271	PF00069	0.575
DOC_MAPK_gen_1	301	307	PF00069	0.409
DOC_MAPK_gen_1	32	38	PF00069	0.348
DOC_MAPK_gen_1	382	392	PF00069	0.294
DOC_MAPK_gen_1	438	448	PF00069	0.440
DOC_MAPK_gen_1	573	579	PF00069	0.602
DOC_MAPK_MEF2A_6	11	20	PF00069	0.390
DOC_MAPK_RevD_3	18	33	PF00069	0.362
DOC_USP7_MATH_1	102	106	PF00917	0.323
DOC_USP7_MATH_1	276	280	PF00917	0.542
DOC_USP7_MATH_1	37	41	PF00917	0.392
DOC_USP7_MATH_1	426	430	PF00917	0.498
DOC_USP7_MATH_1	584	588	PF00917	0.662
DOC_WW_Pin1_4	127	132	PF00397	0.345
DOC_WW_Pin1_4	2	7	PF00397	0.488
DOC_WW_Pin1_4	289	294	PF00397	0.559
DOC_WW_Pin1_4	490	495	PF00397	0.584
DOC_WW_Pin1_4	530	535	PF00397	0.656
DOC_WW_Pin1_4	60	65	PF00397	0.368
DOC_WW_Pin1_4	600	605	PF00397	0.680
LIG_14-3-3_CanoR_1	159	169	PF00244	0.559
LIG_14-3-3_CanoR_1	316	323	PF00244	0.387
LIG_14-3-3_CanoR_1	453	460	PF00244	0.369
LIG_14-3-3_CanoR_1	467	475	PF00244	0.376
LIG_14-3-3_CanoR_1	513	522	PF00244	0.577
LIG_14-3-3_CanoR_1	81	86	PF00244	0.338
LIG_Actin_WH2_2	332	348	PF00022	0.325
LIG_BRCT_BRCA1_1	371	375	PF00533	0.205
LIG_CaM_IQ_9	462	478	PF13499	0.462
LIG_CtBP_PxDLS_1	155	159	PF00389	0.481
LIG_DLG_GKlike_1	81	88	PF00625	0.327
LIG_FHA_1	186	192	PF00498	0.344
LIG_FHA_1	23	29	PF00498	0.420
LIG_FHA_1	279	285	PF00498	0.506
LIG_FHA_2	138	144	PF00498	0.529
LIG_FHA_2	409	415	PF00498	0.556
LIG_Integrin_isoDGR_2	79	81	PF01839	0.329
LIG_IRF3_LxIS_1	365	371	PF10401	0.304
LIG_IRF3_LxIS_1	93	99	PF10401	0.312
LIG_LIR_Gen_1	234	242	PF02991	0.511
LIG_LIR_Gen_1	312	320	PF02991	0.369
LIG_LIR_Gen_1	372	381	PF02991	0.237
LIG_LIR_Gen_1	99	106	PF02991	0.371
LIG_LIR_Nem_3	312	317	PF02991	0.365
LIG_LIR_Nem_3	372	378	PF02991	0.267
LIG_LIR_Nem_3	99	103	PF02991	0.367
LIG_PCNA_PIPBox_1	436	445	PF02747	0.417
LIG_PCNA_yPIPBox_3	193	201	PF02747	0.384
LIG_PCNA_yPIPBox_3	436	447	PF02747	0.416
LIG_PCNA_yPIPBox_3	614	628	PF02747	0.606
LIG_PTB_Apo_2	94	101	PF02174	0.367
LIG_SH2_STAT3	386	389	PF00017	0.304
LIG_SH2_STAT5	386	389	PF00017	0.333
LIG_SH3_3	270	276	PF00018	0.509
LIG_SH3_3	33	39	PF00018	0.356
LIG_SH3_3	488	494	PF00018	0.511
LIG_SH3_3	554	560	PF00018	0.600
LIG_SH3_3	601	607	PF00018	0.592
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.324
LIG_SUMO_SIM_par_1	187	192	PF11976	0.346
LIG_SUMO_SIM_par_1	309	315	PF11976	0.359
LIG_SUMO_SIM_par_1	366	372	PF11976	0.320
LIG_UBA3_1	439	447	PF00899	0.429
LIG_WRC_WIRS_1	180	185	PF05994	0.371
MOD_CDC14_SPxK_1	533	536	PF00782	0.632
MOD_CDK_SPxK_1	530	536	PF00069	0.640
MOD_CDK_SPxxK_3	530	537	PF00069	0.639
MOD_CK1_1	162	168	PF00069	0.560
MOD_CK1_1	192	198	PF00069	0.356
MOD_CK1_1	377	383	PF00069	0.333
MOD_CK1_1	421	427	PF00069	0.608
MOD_CK1_1	5	11	PF00069	0.419
MOD_CK1_1	508	514	PF00069	0.773
MOD_CK1_1	606	612	PF00069	0.484
MOD_CK1_1	624	630	PF00069	0.446
MOD_CK2_1	309	315	PF00069	0.359
MOD_CK2_1	323	329	PF00069	0.354
MOD_CK2_1	408	414	PF00069	0.541
MOD_CK2_1	468	474	PF00069	0.532
MOD_CK2_1	513	519	PF00069	0.533
MOD_Cter_Amidation	252	255	PF01082	0.658
MOD_GlcNHglycan	164	167	PF01048	0.554
MOD_GlcNHglycan	215	219	PF01048	0.570
MOD_GlcNHglycan	220	223	PF01048	0.596
MOD_GlcNHglycan	240	243	PF01048	0.761
MOD_GlcNHglycan	248	251	PF01048	0.761
MOD_GlcNHglycan	258	261	PF01048	0.538
MOD_GlcNHglycan	275	279	PF01048	0.500
MOD_GlcNHglycan	325	328	PF01048	0.346
MOD_GlcNHglycan	424	427	PF01048	0.665
MOD_GlcNHglycan	428	431	PF01048	0.642
MOD_GlcNHglycan	470	473	PF01048	0.593
MOD_GlcNHglycan	53	57	PF01048	0.312
MOD_GlcNHglycan	542	545	PF01048	0.731
MOD_GlcNHglycan	586	589	PF01048	0.630
MOD_GlcNHglycan	88	91	PF01048	0.346
MOD_GSK3_1	1	8	PF00069	0.482
MOD_GSK3_1	154	161	PF00069	0.542
MOD_GSK3_1	185	192	PF00069	0.339
MOD_GSK3_1	214	221	PF00069	0.498
MOD_GSK3_1	274	281	PF00069	0.663
MOD_GSK3_1	418	425	PF00069	0.620
MOD_GSK3_1	477	484	PF00069	0.441
MOD_GSK3_1	508	515	PF00069	0.674
MOD_GSK3_1	526	533	PF00069	0.521
MOD_GSK3_1	559	566	PF00069	0.588
MOD_GSK3_1	60	67	PF00069	0.367
MOD_GSK3_1	602	609	PF00069	0.629
MOD_N-GLC_1	96	101	PF02516	0.316
MOD_NEK2_1	1	6	PF00069	0.560
MOD_NEK2_1	109	114	PF00069	0.355
MOD_NEK2_1	12	17	PF00069	0.450
MOD_NEK2_1	158	163	PF00069	0.519
MOD_NEK2_1	28	33	PF00069	0.284
MOD_NEK2_1	323	328	PF00069	0.345
MOD_NEK2_1	368	373	PF00069	0.307
MOD_NEK2_1	374	379	PF00069	0.314
MOD_NEK2_1	52	57	PF00069	0.332
MOD_NEK2_1	621	626	PF00069	0.539
MOD_NEK2_1	88	93	PF00069	0.432
MOD_NEK2_1	96	101	PF00069	0.299
MOD_PIKK_1	315	321	PF00454	0.369
MOD_PKA_1	159	165	PF00069	0.531
MOD_PKA_1	321	327	PF00069	0.363
MOD_PKA_2	158	164	PF00069	0.569
MOD_PKA_2	192	198	PF00069	0.370
MOD_PKA_2	218	224	PF00069	0.624
MOD_PKA_2	256	262	PF00069	0.645
MOD_PKA_2	315	321	PF00069	0.447
MOD_PKA_2	512	518	PF00069	0.651
MOD_PKA_2	624	630	PF00069	0.466
MOD_Plk_1	109	115	PF00069	0.297
MOD_Plk_1	96	102	PF00069	0.404
MOD_Plk_2-3	14	20	PF00069	0.402
MOD_Plk_2-3	226	232	PF00069	0.682
MOD_Plk_4	185	191	PF00069	0.341
MOD_Plk_4	309	315	PF00069	0.373
MOD_Plk_4	559	565	PF00069	0.589
MOD_Plk_4	606	612	PF00069	0.484
MOD_Plk_4	91	97	PF00069	0.324
MOD_ProDKin_1	127	133	PF00069	0.350
MOD_ProDKin_1	2	8	PF00069	0.474
MOD_ProDKin_1	289	295	PF00069	0.551
MOD_ProDKin_1	490	496	PF00069	0.583
MOD_ProDKin_1	530	536	PF00069	0.655
MOD_ProDKin_1	60	66	PF00069	0.371
MOD_ProDKin_1	600	606	PF00069	0.677
MOD_SUMO_rev_2	549	555	PF00179	0.566
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.401
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.369
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.418
TRG_ENDOCYTIC_2	177	180	PF00928	0.348
TRG_ER_diArg_1	158	160	PF00400	0.496
TRG_ER_diArg_1	381	383	PF00400	0.304
TRG_ER_diArg_1	539	541	PF00400	0.554
TRG_ER_diArg_1	572	574	PF00400	0.598
TRG_NES_CRM1_1	315	329	PF08389	0.370
TRG_NES_CRM1_1	437	450	PF08389	0.314
TRG_NLS_MonoExtC_3	535	540	PF00514	0.676
TRG_NLS_MonoExtN_4	252	258	PF00514	0.656
TRG_NLS_MonoExtN_4	534	540	PF00514	0.672
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N9	Leptomonas seymouri	54%	98%
A0A3Q8IBM2	Leishmania donovani	90%	100%
A4HYR8	Leishmania infantum	88%	100%
E9AI88	Leishmania braziliensis	74%	98%
Q4QD11	Leishmania major	89%	100%