Leucine-rich repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat-containing protein

Species:

Leishmania mexicana

UniProt:

E9AUH1_LEIMU

TriTrypDb:

LmxM.20.0300

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AUH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.441
CLV_NRD_NRD_1	198	200	PF00675	0.516
CLV_NRD_NRD_1	281	283	PF00675	0.418
CLV_PCSK_FUR_1	42	46	PF00082	0.425
CLV_PCSK_KEX2_1	198	200	PF00082	0.575
CLV_PCSK_KEX2_1	281	283	PF00082	0.446
CLV_PCSK_KEX2_1	44	46	PF00082	0.602
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.456
CLV_PCSK_SKI1_1	104	108	PF00082	0.342
CLV_PCSK_SKI1_1	122	126	PF00082	0.233
CLV_PCSK_SKI1_1	230	234	PF00082	0.393
CLV_PCSK_SKI1_1	269	273	PF00082	0.506
CLV_PCSK_SKI1_1	282	286	PF00082	0.298
CLV_PCSK_SKI1_1	44	48	PF00082	0.458
DEG_APCC_DBOX_1	121	129	PF00400	0.269
DEG_APCC_DBOX_1	52	60	PF00400	0.455
DEG_Nend_UBRbox_2	1	3	PF02207	0.631
DOC_MAPK_gen_1	101	111	PF00069	0.359
DOC_MAPK_gen_1	198	205	PF00069	0.509
DOC_MAPK_MEF2A_6	198	205	PF00069	0.447
DOC_MAPK_MEF2A_6	303	310	PF00069	0.503
DOC_PP1_RVXF_1	99	106	PF00149	0.369
DOC_USP7_MATH_1	126	130	PF00917	0.412
DOC_USP7_UBL2_3	254	258	PF12436	0.282
DOC_USP7_UBL2_3	44	48	PF12436	0.458
DOC_WW_Pin1_4	19	24	PF00397	0.619
DOC_WW_Pin1_4	197	202	PF00397	0.342
DOC_WW_Pin1_4	253	258	PF00397	0.438
DOC_WW_Pin1_4	297	302	PF00397	0.611
LIG_14-3-3_CanoR_1	104	110	PF00244	0.296
LIG_14-3-3_CanoR_1	188	194	PF00244	0.360
LIG_14-3-3_CanoR_1	269	278	PF00244	0.335
LIG_14-3-3_CanoR_1	62	71	PF00244	0.540
LIG_14-3-3_CanoR_1	93	99	PF00244	0.402
LIG_Actin_WH2_2	91	106	PF00022	0.463
LIG_APCC_ABBA_1	233	238	PF00400	0.387
LIG_Clathr_ClatBox_1	163	167	PF01394	0.434
LIG_eIF4E_1	89	95	PF01652	0.386
LIG_FHA_1	200	206	PF00498	0.319
LIG_FHA_1	220	226	PF00498	0.370
LIG_FHA_1	71	77	PF00498	0.556
LIG_FHA_2	63	69	PF00498	0.563
LIG_LIR_Apic_2	79	85	PF02991	0.450
LIG_LIR_Gen_1	49	59	PF02991	0.462
LIG_LIR_Nem_3	262	267	PF02991	0.442
LIG_LIR_Nem_3	273	278	PF02991	0.400
LIG_LIR_Nem_3	49	54	PF02991	0.472
LIG_NRBOX	228	234	PF00104	0.381
LIG_PCNA_PIPBox_1	153	162	PF02747	0.397
LIG_PDZ_Class_2	305	310	PF00595	0.487
LIG_Pex14_2	160	164	PF04695	0.428
LIG_Pex14_2	260	264	PF04695	0.439
LIG_PTAP_UEV_1	84	89	PF05743	0.424
LIG_PTB_Apo_2	115	122	PF02174	0.279
LIG_SH2_CRK	51	55	PF00017	0.512
LIG_SH2_GRB2like	145	148	PF00017	0.354
LIG_SH2_SRC	237	240	PF00017	0.482
LIG_SH2_STAT5	115	118	PF00017	0.493
LIG_SH2_STAT5	145	148	PF00017	0.354
LIG_SH2_STAT5	162	165	PF00017	0.187
LIG_SH2_STAT5	193	196	PF00017	0.575
LIG_SH2_STAT5	259	262	PF00017	0.382
LIG_SH2_STAT5	263	266	PF00017	0.358
LIG_SH2_STAT5	89	92	PF00017	0.372
LIG_SH3_1	198	204	PF00018	0.505
LIG_SH3_1	82	88	PF00018	0.432
LIG_SH3_2	277	282	PF14604	0.462
LIG_SH3_3	198	204	PF00018	0.432
LIG_SH3_3	274	280	PF00018	0.486
LIG_SH3_3	82	88	PF00018	0.432
LIG_SUMO_SIM_anti_2	208	213	PF11976	0.314
LIG_SUMO_SIM_par_1	210	216	PF11976	0.356
LIG_SUMO_SIM_par_1	72	77	PF11976	0.513
LIG_TRAF2_1	131	134	PF00917	0.322
LIG_TYR_ITSM	271	278	PF00017	0.292
LIG_UBA3_1	94	101	PF00899	0.408
MOD_CDC14_SPxK_1	300	303	PF00782	0.555
MOD_CDK_SPK_2	253	258	PF00069	0.438
MOD_CDK_SPxK_1	297	303	PF00069	0.523
MOD_CDK_SPxxK_3	19	26	PF00069	0.644
MOD_CK1_1	187	193	PF00069	0.544
MOD_CK1_1	197	203	PF00069	0.478
MOD_CK1_1	7	13	PF00069	0.559
MOD_CK2_1	19	25	PF00069	0.622
MOD_CK2_1	62	68	PF00069	0.536
MOD_CK2_1	69	75	PF00069	0.468
MOD_CMANNOS	34	37	PF00535	0.351
MOD_GlcNHglycan	128	131	PF01048	0.475
MOD_GlcNHglycan	13	16	PF01048	0.655
MOD_GSK3_1	120	127	PF00069	0.469
MOD_GSK3_1	297	304	PF00069	0.497
MOD_GSK3_1	4	11	PF00069	0.558
MOD_GSK3_1	58	65	PF00069	0.554
MOD_LATS_1	60	66	PF00433	0.535
MOD_N-GLC_1	265	270	PF02516	0.270
MOD_NEK2_1	124	129	PF00069	0.472
MOD_NEK2_1	245	250	PF00069	0.387
MOD_NEK2_1	4	9	PF00069	0.649
MOD_NEK2_1	76	81	PF00069	0.420
MOD_NEK2_1	94	99	PF00069	0.334
MOD_NEK2_2	105	110	PF00069	0.375
MOD_PIKK_1	172	178	PF00454	0.497
MOD_PIKK_1	62	68	PF00454	0.536
MOD_PKA_1	44	50	PF00069	0.467
MOD_PKA_2	187	193	PF00069	0.546
MOD_PKA_2	44	50	PF00069	0.429
MOD_PKA_2	61	67	PF00069	0.409
MOD_Plk_1	133	139	PF00069	0.474
MOD_Plk_1	4	10	PF00069	0.621
MOD_Plk_4	133	139	PF00069	0.416
MOD_Plk_4	207	213	PF00069	0.409
MOD_Plk_4	271	277	PF00069	0.301
MOD_ProDKin_1	19	25	PF00069	0.617
MOD_ProDKin_1	197	203	PF00069	0.332
MOD_ProDKin_1	253	259	PF00069	0.434
MOD_ProDKin_1	297	303	PF00069	0.612
TRG_DiLeu_BaEn_4	133	139	PF01217	0.376
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.338
TRG_ENDOCYTIC_2	275	278	PF00928	0.408
TRG_ENDOCYTIC_2	51	54	PF00928	0.481
TRG_ER_diArg_1	280	282	PF00400	0.425
TRG_NES_CRM1_1	102	112	PF08389	0.341
TRG_NES_CRM1_1	223	238	PF08389	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4U2	Leptomonas seymouri	69%	75%
A0A3Q8IKD6	Leishmania donovani	90%	100%
A0A422NEI1	Trypanosoma rangeli	53%	73%
A4HYM2	Leishmania infantum	90%	100%
E9AI86	Leishmania braziliensis	79%	100%
Q4QD13	Leishmania major	89%	100%
V5BAD8	Trypanosoma cruzi	49%	75%