Protein-serine/threonine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

developmentally regulated phosphoprotein-like protein

Species:

Leishmania mexicana

UniProt:

E9AUG9_LEIMU

TriTrypDb:

LmxM.20.0280

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AUG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUG9

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0044237	cellular metabolic process	2	11
GO:0006109	regulation of carbohydrate metabolic process	5	1
GO:0006468	protein phosphorylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0010675	obsolete regulation of cellular carbohydrate metabolic process	5	1
GO:0010906	regulation of glucose metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.319
CLV_NRD_NRD_1	3	5	PF00675	0.562
CLV_NRD_NRD_1	63	65	PF00675	0.524
CLV_PCSK_KEX2_1	181	183	PF00082	0.337
CLV_PCSK_KEX2_1	3	5	PF00082	0.562
CLV_PCSK_KEX2_1	325	327	PF00082	0.455
CLV_PCSK_KEX2_1	67	69	PF00082	0.532
CLV_PCSK_KEX2_1	72	74	PF00082	0.506
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.455
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.539
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.461
CLV_PCSK_PC7_1	68	74	PF00082	0.457
CLV_PCSK_SKI1_1	160	164	PF00082	0.200
CLV_PCSK_SKI1_1	181	185	PF00082	0.289
CLV_PCSK_SKI1_1	232	236	PF00082	0.288
CLV_PCSK_SKI1_1	3	7	PF00082	0.579
CLV_PCSK_SKI1_1	313	317	PF00082	0.310
CLV_PCSK_SKI1_1	382	386	PF00082	0.353
CLV_PCSK_SKI1_1	64	68	PF00082	0.560
CLV_PCSK_SKI1_1	72	76	PF00082	0.527
DEG_APCC_DBOX_1	159	167	PF00400	0.419
DEG_APCC_DBOX_1	180	188	PF00400	0.561
DOC_CYCLIN_RxL_1	157	165	PF00134	0.477
DOC_MAPK_FxFP_2	295	298	PF00069	0.551
DOC_MAPK_gen_1	181	187	PF00069	0.568
DOC_MAPK_gen_1	64	71	PF00069	0.546
DOC_MAPK_MEF2A_6	248	257	PF00069	0.538
DOC_PP4_FxxP_1	295	298	PF00568	0.551
DOC_USP7_MATH_1	113	117	PF00917	0.466
DOC_USP7_MATH_1	216	220	PF00917	0.561
DOC_USP7_MATH_1	298	302	PF00917	0.392
DOC_USP7_UBL2_3	42	46	PF12436	0.541
DOC_WW_Pin1_4	22	27	PF00397	0.362
DOC_WW_Pin1_4	395	400	PF00397	0.354
LIG_14-3-3_CanoR_1	121	125	PF00244	0.488
LIG_14-3-3_CanoR_1	222	228	PF00244	0.554
LIG_14-3-3_CanoR_1	317	321	PF00244	0.309
LIG_14-3-3_CanoR_1	393	399	PF00244	0.241
LIG_APCC_ABBA_1	75	80	PF00400	0.526
LIG_BIR_III_2	443	447	PF00653	0.591
LIG_BRCT_BRCA1_1	230	234	PF00533	0.561
LIG_BRCT_BRCA1_1	291	295	PF00533	0.538
LIG_EH1_1	305	313	PF00400	0.330
LIG_eIF4E_1	306	312	PF01652	0.310
LIG_FHA_1	13	19	PF00498	0.565
LIG_FHA_1	26	32	PF00498	0.468
LIG_FHA_1	6	12	PF00498	0.591
LIG_FHA_2	100	106	PF00498	0.509
LIG_FHA_2	204	210	PF00498	0.508
LIG_FHA_2	282	288	PF00498	0.552
LIG_FHA_2	331	337	PF00498	0.455
LIG_LIR_Apic_2	292	298	PF02991	0.590
LIG_LIR_Apic_2	80	86	PF02991	0.455
LIG_LIR_Gen_1	127	136	PF02991	0.566
LIG_LIR_Gen_1	191	199	PF02991	0.545
LIG_LIR_Gen_1	206	215	PF02991	0.522
LIG_LIR_Gen_1	226	235	PF02991	0.325
LIG_LIR_Gen_1	303	312	PF02991	0.305
LIG_LIR_Gen_1	376	385	PF02991	0.455
LIG_LIR_Nem_3	127	131	PF02991	0.460
LIG_LIR_Nem_3	165	171	PF02991	0.561
LIG_LIR_Nem_3	191	197	PF02991	0.526
LIG_LIR_Nem_3	206	210	PF02991	0.513
LIG_LIR_Nem_3	226	230	PF02991	0.325
LIG_LIR_Nem_3	303	309	PF02991	0.305
LIG_LIR_Nem_3	376	380	PF02991	0.455
LIG_LIR_Nem_3	433	439	PF02991	0.302
LIG_SH2_CRK	227	231	PF00017	0.457
LIG_SH2_CRK	377	381	PF00017	0.353
LIG_SH2_CRK	407	411	PF00017	0.455
LIG_SH2_CRK	83	87	PF00017	0.561
LIG_SH2_NCK_1	207	211	PF00017	0.561
LIG_SH2_NCK_1	377	381	PF00017	0.422
LIG_SH2_PTP2	306	309	PF00017	0.310
LIG_SH2_PTP2	438	441	PF00017	0.353
LIG_SH2_SRC	207	210	PF00017	0.561
LIG_SH2_STAP1	415	419	PF00017	0.310
LIG_SH2_STAT5	176	179	PF00017	0.528
LIG_SH2_STAT5	306	309	PF00017	0.314
LIG_SH2_STAT5	377	380	PF00017	0.353
LIG_SH2_STAT5	438	441	PF00017	0.313
LIG_SH3_3	377	383	PF00018	0.342
LIG_SH3_4	382	389	PF00018	0.455
LIG_SUMO_SIM_par_1	169	175	PF11976	0.477
LIG_SUMO_SIM_par_1	251	256	PF11976	0.596
LIG_TYR_ITIM	205	210	PF00017	0.552
LIG_TYR_ITIM	225	230	PF00017	0.325
LIG_TYR_ITIM	304	309	PF00017	0.310
LIG_UBA3_1	1	10	PF00899	0.508
LIG_UBA3_1	170	174	PF00899	0.488
LIG_UBA3_1	307	313	PF00899	0.422
LIG_WRC_WIRS_1	125	130	PF05994	0.471
MOD_CK1_1	19	25	PF00069	0.643
MOD_CK1_1	376	382	PF00069	0.455
MOD_CK2_1	203	209	PF00069	0.516
MOD_CK2_1	281	287	PF00069	0.558
MOD_GlcNHglycan	108	111	PF01048	0.361
MOD_GlcNHglycan	389	392	PF01048	0.426
MOD_GSK3_1	12	19	PF00069	0.597
MOD_GSK3_1	120	127	PF00069	0.465
MOD_GSK3_1	193	200	PF00069	0.505
MOD_GSK3_1	393	400	PF00069	0.455
MOD_N-GLC_2	221	223	PF02516	0.361
MOD_NEK2_1	11	16	PF00069	0.650
MOD_NEK2_1	124	129	PF00069	0.496
MOD_NEK2_1	162	167	PF00069	0.561
MOD_NEK2_1	20	25	PF00069	0.521
MOD_NEK2_1	300	305	PF00069	0.330
MOD_NEK2_1	373	378	PF00069	0.362
MOD_NEK2_1	48	53	PF00069	0.481
MOD_NEK2_1	60	65	PF00069	0.328
MOD_PK_1	193	199	PF00069	0.561
MOD_PKA_1	188	194	PF00069	0.539
MOD_PKA_2	120	126	PF00069	0.488
MOD_PKA_2	316	322	PF00069	0.310
MOD_Plk_4	113	119	PF00069	0.462
MOD_Plk_4	120	126	PF00069	0.451
MOD_ProDKin_1	22	28	PF00069	0.353
MOD_ProDKin_1	395	401	PF00069	0.354
MOD_SUMO_rev_2	268	273	PF00179	0.416
MOD_SUMO_rev_2	285	295	PF00179	0.492
MOD_SUMO_rev_2	49	54	PF00179	0.524
TRG_DiLeu_BaLyEn_6	1	6	PF01217	0.420
TRG_ENDOCYTIC_2	207	210	PF00928	0.524
TRG_ENDOCYTIC_2	227	230	PF00928	0.325
TRG_ENDOCYTIC_2	306	309	PF00928	0.310
TRG_ENDOCYTIC_2	377	380	PF00928	0.353
TRG_ENDOCYTIC_2	436	439	PF00928	0.294
TRG_ER_diArg_1	2	4	PF00400	0.557
TRG_NLS_MonoExtC_3	63	68	PF00514	0.559
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.322
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JAB1	Bodo saltans	40%	100%
A0A0S4JGW0	Bodo saltans	22%	99%
A0A1X0NWS5	Trypanosomatidae	47%	100%
A0A3R7K9G7	Trypanosoma rangeli	46%	100%
A0A3S7WVX8	Leishmania donovani	95%	100%
A4HYM0	Leishmania infantum	95%	100%
C9ZHT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AI84	Leishmania braziliensis	91%	100%
O02623	Ascaris suum	31%	100%
O14874	Homo sapiens	25%	100%
O54937	Rattus norvegicus	29%	100%
O55028	Mus musculus	25%	100%
O70571	Mus musculus	29%	100%
O88345	Ictidomys tridecemlineatus	29%	100%
P91622	Drosophila melanogaster	29%	100%
Q00972	Rattus norvegicus	25%	100%
Q02332	Caenorhabditis elegans	30%	100%
Q15118	Homo sapiens	29%	100%
Q15119	Homo sapiens	30%	100%
Q15120	Homo sapiens	29%	100%
Q16654	Homo sapiens	29%	100%
Q1KMR4	Rhinolophus ferrumequinum	30%	100%
Q2KJG8	Bos taurus	25%	100%
Q4QD15	Leishmania major	95%	100%
Q63065	Rattus norvegicus	29%	100%
Q64536	Rattus norvegicus	30%	100%
Q8BFP9	Mus musculus	29%	100%
Q922H2	Mus musculus	29%	100%
Q9JK42	Mus musculus	30%	100%
Q9SBJ1	Arabidopsis thaliana	31%	100%
V5BAE3	Trypanosoma cruzi	49%	100%
V5C0T8	Trypanosoma cruzi	24%	100%