Enkurin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enkuring domain-containig protein

Species:

Leishmania mexicana

UniProt:

E9AUG8_LEIMU

TriTrypDb:

LmxM.20.0270

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUG8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005516	calmodulin binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.649
CLV_NRD_NRD_1	115	117	PF00675	0.616
CLV_NRD_NRD_1	220	222	PF00675	0.490
CLV_NRD_NRD_1	230	232	PF00675	0.492
CLV_NRD_NRD_1	291	293	PF00675	0.408
CLV_NRD_NRD_1	312	314	PF00675	0.285
CLV_PCSK_FUR_1	243	247	PF00082	0.389
CLV_PCSK_KEX2_1	219	221	PF00082	0.496
CLV_PCSK_KEX2_1	245	247	PF00082	0.370
CLV_PCSK_KEX2_1	290	292	PF00082	0.449
CLV_PCSK_KEX2_1	314	316	PF00082	0.278
CLV_PCSK_KEX2_1	9	11	PF00082	0.504
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.513
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.389
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.318
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.504
CLV_PCSK_SKI1_1	199	203	PF00082	0.553
CLV_PCSK_SKI1_1	26	30	PF00082	0.486
CLV_PCSK_SKI1_1	335	339	PF00082	0.450
CLV_PCSK_SKI1_1	47	51	PF00082	0.475
CLV_PCSK_SKI1_1	73	77	PF00082	0.514
DEG_Nend_UBRbox_1	1	4	PF02207	0.503
DOC_ANK_TNKS_1	102	109	PF00023	0.414
DOC_ANK_TNKS_1	77	84	PF00023	0.544
DOC_CYCLIN_RxL_1	6	16	PF00134	0.451
DOC_MAPK_gen_1	331	340	PF00069	0.316
DOC_MAPK_MEF2A_6	321	330	PF00069	0.416
DOC_PP1_RVXF_1	7	14	PF00149	0.469
DOC_USP7_MATH_1	160	164	PF00917	0.567
DOC_USP7_MATH_1	165	169	PF00917	0.537
DOC_USP7_MATH_1	170	174	PF00917	0.514
DOC_USP7_MATH_1	239	243	PF00917	0.290
DOC_USP7_MATH_1	363	367	PF00917	0.540
DOC_USP7_UBL2_3	113	117	PF12436	0.520
DOC_USP7_UBL2_3	32	36	PF12436	0.741
DOC_USP7_UBL2_3	357	361	PF12436	0.520
DOC_WW_Pin1_4	121	126	PF00397	0.615
DOC_WW_Pin1_4	134	139	PF00397	0.523
DOC_WW_Pin1_4	234	239	PF00397	0.315
DOC_WW_Pin1_4	36	41	PF00397	0.705
LIG_14-3-3_CanoR_1	231	235	PF00244	0.523
LIG_Actin_WH2_2	83	99	PF00022	0.528
LIG_APCC_ABBA_1	338	343	PF00400	0.433
LIG_BIR_III_4	145	149	PF00653	0.576
LIG_BRCT_BRCA1_1	122	126	PF00533	0.741
LIG_BRCT_BRCA1_1	57	61	PF00533	0.544
LIG_BRCT_BRCA1_2	57	63	PF00533	0.539
LIG_FHA_2	255	261	PF00498	0.196
LIG_FHA_2	320	326	PF00498	0.396
LIG_FHA_2	48	54	PF00498	0.565
LIG_FHA_2	57	63	PF00498	0.564
LIG_LIR_Apic_2	112	118	PF02991	0.573
LIG_LIR_Gen_1	56	61	PF02991	0.585
LIG_LIR_Nem_3	18	24	PF02991	0.586
LIG_LIR_Nem_3	38	44	PF02991	0.731
LIG_LIR_Nem_3	56	60	PF02991	0.501
LIG_MLH1_MIPbox_1	57	61	PF16413	0.544
LIG_REV1ctd_RIR_1	58	67	PF16727	0.523
LIG_REV1ctd_RIR_1	72	82	PF16727	0.654
LIG_SH2_CRK	115	119	PF00017	0.662
LIG_SH2_CRK	41	45	PF00017	0.577
LIG_SH2_PTP2	104	107	PF00017	0.512
LIG_SH2_PTP2	273	276	PF00017	0.409
LIG_SH2_STAP1	24	28	PF00017	0.506
LIG_SH2_STAP1	45	49	PF00017	0.541
LIG_SH2_STAP1	57	61	PF00017	0.512
LIG_SH2_STAT5	104	107	PF00017	0.652
LIG_SH2_STAT5	273	276	PF00017	0.351
LIG_SH2_STAT5	41	44	PF00017	0.542
LIG_SH2_STAT5	95	98	PF00017	0.639
LIG_SH3_3	49	55	PF00018	0.600
LIG_SUMO_SIM_par_1	208	214	PF11976	0.561
LIG_TRAF2_1	109	112	PF00917	0.562
LIG_TRAF2_1	257	260	PF00917	0.385
LIG_TRAF2_1	278	281	PF00917	0.423
LIG_UBA3_1	20	26	PF00899	0.551
LIG_WRC_WIRS_1	57	62	PF05994	0.525
MOD_CK1_1	16	22	PF00069	0.565
MOD_CK1_1	230	236	PF00069	0.541
MOD_CK1_1	306	312	PF00069	0.329
MOD_CK1_1	39	45	PF00069	0.577
MOD_CK1_1	56	62	PF00069	0.456
MOD_CK2_1	230	236	PF00069	0.638
MOD_CK2_1	24	30	PF00069	0.548
MOD_CK2_1	254	260	PF00069	0.367
MOD_CK2_1	32	38	PF00069	0.512
MOD_CK2_1	47	53	PF00069	0.505
MOD_CK2_1	56	62	PF00069	0.563
MOD_GlcNHglycan	131	134	PF01048	0.699
MOD_GlcNHglycan	138	141	PF01048	0.585
MOD_GlcNHglycan	15	18	PF01048	0.583
MOD_GlcNHglycan	162	165	PF01048	0.720
MOD_GlcNHglycan	172	175	PF01048	0.699
MOD_GlcNHglycan	183	186	PF01048	0.527
MOD_GlcNHglycan	26	29	PF01048	0.587
MOD_GSK3_1	120	127	PF00069	0.761
MOD_GSK3_1	195	202	PF00069	0.622
MOD_GSK3_1	226	233	PF00069	0.491
MOD_GSK3_1	32	39	PF00069	0.654
MOD_N-GLC_1	121	126	PF02516	0.625
MOD_N-GLC_1	154	159	PF02516	0.593
MOD_NEK2_1	205	210	PF00069	0.435
MOD_NEK2_1	254	259	PF00069	0.293
MOD_NEK2_1	285	290	PF00069	0.293
MOD_NEK2_1	319	324	PF00069	0.317
MOD_PIKK_1	124	130	PF00454	0.678
MOD_PKA_2	230	236	PF00069	0.519
MOD_PKA_2	86	92	PF00069	0.425
MOD_Plk_1	319	325	PF00069	0.312
MOD_Plk_4	16	22	PF00069	0.569
MOD_Plk_4	56	62	PF00069	0.538
MOD_ProDKin_1	121	127	PF00069	0.618
MOD_ProDKin_1	134	140	PF00069	0.522
MOD_ProDKin_1	234	240	PF00069	0.315
MOD_ProDKin_1	36	42	PF00069	0.706
MOD_SUMO_for_1	244	247	PF00179	0.294
MOD_SUMO_rev_2	247	254	PF00179	0.479
MOD_SUMO_rev_2	256	263	PF00179	0.427
MOD_SUMO_rev_2	27	34	PF00179	0.559
TRG_DiLeu_BaEn_1	281	286	PF01217	0.342
TRG_DiLeu_BaEn_2	249	255	PF01217	0.290
TRG_ENDOCYTIC_2	273	276	PF00928	0.409
TRG_ENDOCYTIC_2	41	44	PF00928	0.654
TRG_ENDOCYTIC_2	57	60	PF00928	0.448
TRG_ER_diArg_1	289	292	PF00400	0.451
TRG_ER_diArg_1	312	315	PF00400	0.301
TRG_NLS_MonoCore_2	218	223	PF00514	0.506
TRG_NLS_MonoCore_2	312	317	PF00514	0.409
TRG_NLS_MonoExtC_3	312	318	PF00514	0.409
TRG_NLS_MonoExtN_4	218	223	PF00514	0.545
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJA5	Leptomonas seymouri	56%	100%
A0A1X0NWL2	Trypanosomatidae	38%	96%
A0A3R7MDK6	Trypanosoma rangeli	38%	93%
A0A3S5H782	Leishmania donovani	92%	100%
A0A3S7WY66	Leishmania donovani	27%	100%
A4HYL9	Leishmania infantum	92%	100%
C9ZHT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	98%
E9AH22	Leishmania infantum	27%	100%
E9AI83	Leishmania braziliensis	77%	100%
E9AWK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4QAX0	Leishmania major	26%	98%
Q4QD16	Leishmania major	93%	100%
V5DS69	Trypanosoma cruzi	39%	93%