ER membrane protein complex subunit 10

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane protein, putative

Species:

Leishmania mexicana

UniProt:

E9AUG4_LEIMU

TriTrypDb:

LmxM.20.0240

Length:

261

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 3
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AUG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.420
CLV_NRD_NRD_1	189	191	PF00675	0.556
CLV_PCSK_KEX2_1	217	219	PF00082	0.719
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.700
CLV_PCSK_SKI1_1	155	159	PF00082	0.584
CLV_PCSK_SKI1_1	237	241	PF00082	0.487
DEG_ODPH_VHL_1	132	145	PF01847	0.267
DOC_CDC14_PxL_1	130	138	PF14671	0.262
DOC_CKS1_1	106	111	PF01111	0.409
DOC_CYCLIN_yCln2_LP_2	182	188	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	247	253	PF00134	0.416
DOC_MAPK_DCC_7	179	188	PF00069	0.501
DOC_MAPK_MEF2A_6	169	176	PF00069	0.441
DOC_MAPK_MEF2A_6	242	251	PF00069	0.426
DOC_MAPK_MEF2A_6	6	14	PF00069	0.522
DOC_MAPK_NFAT4_5	242	250	PF00069	0.486
DOC_PP2B_LxvP_1	247	250	PF13499	0.417
DOC_USP7_MATH_1	118	122	PF00917	0.316
DOC_USP7_MATH_1	99	103	PF00917	0.567
DOC_USP7_MATH_2	233	239	PF00917	0.504
DOC_USP7_UBL2_3	187	191	PF12436	0.656
DOC_USP7_UBL2_3	208	212	PF12436	0.448
DOC_USP7_UBL2_3	96	100	PF12436	0.508
DOC_WW_Pin1_4	105	110	PF00397	0.347
LIG_14-3-3_CanoR_1	52	61	PF00244	0.443
LIG_Actin_WH2_2	173	189	PF00022	0.576
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_deltaCOP1_diTrp_1	39	48	PF00928	0.453
LIG_FHA_1	101	107	PF00498	0.524
LIG_FHA_1	121	127	PF00498	0.223
LIG_FHA_1	171	177	PF00498	0.486
LIG_FHA_1	187	193	PF00498	0.537
LIG_FHA_1	5	11	PF00498	0.475
LIG_FHA_2	199	205	PF00498	0.607
LIG_LIR_Gen_1	39	50	PF02991	0.410
LIG_LIR_Nem_3	3	8	PF02991	0.541
LIG_LIR_Nem_3	39	45	PF02991	0.385
LIG_REV1ctd_RIR_1	149	159	PF16727	0.581
LIG_SH2_STAT3	90	93	PF00017	0.517
LIG_SH2_STAT5	246	249	PF00017	0.472
LIG_SH2_STAT5	30	33	PF00017	0.347
LIG_SH3_3	103	109	PF00018	0.430
LIG_SH3_4	96	103	PF00018	0.497
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.536
LIG_SUMO_SIM_par_1	102	108	PF11976	0.496
LIG_SUMO_SIM_par_1	120	128	PF11976	0.252
LIG_TRAF2_1	233	236	PF00917	0.647
LIG_TRAF2_1	72	75	PF00917	0.599
LIG_TRAF2_1	91	94	PF00917	0.461
LIG_TYR_ITIM	192	197	PF00017	0.594
LIG_WRC_WIRS_1	45	50	PF05994	0.378
MOD_CK1_1	146	152	PF00069	0.508
MOD_CK1_1	51	57	PF00069	0.409
MOD_CK2_1	198	204	PF00069	0.617
MOD_CK2_1	35	41	PF00069	0.505
MOD_CK2_1	69	75	PF00069	0.503
MOD_GSK3_1	101	108	PF00069	0.397
MOD_GSK3_1	40	47	PF00069	0.400
MOD_GSK3_1	48	55	PF00069	0.352
MOD_GSK3_1	6	13	PF00069	0.483
MOD_N-GLC_1	136	141	PF02516	0.402
MOD_NEK2_1	10	15	PF00069	0.450
MOD_NEK2_1	136	141	PF00069	0.359
MOD_NEK2_1	186	191	PF00069	0.543
MOD_NEK2_1	26	31	PF00069	0.343
MOD_NEK2_1	4	9	PF00069	0.485
MOD_NEK2_1	48	53	PF00069	0.362
MOD_PIKK_1	24	30	PF00454	0.437
MOD_PIKK_1	52	58	PF00454	0.578
MOD_PIKK_1	60	66	PF00454	0.389
MOD_PKA_2	51	57	PF00069	0.427
MOD_PKA_2	59	65	PF00069	0.428
MOD_Plk_1	136	142	PF00069	0.365
MOD_Plk_1	162	168	PF00069	0.375
MOD_Plk_1	235	241	PF00069	0.478
MOD_Plk_1	40	46	PF00069	0.480
MOD_Plk_1	67	73	PF00069	0.485
MOD_Plk_4	101	107	PF00069	0.398
MOD_Plk_4	108	114	PF00069	0.316
MOD_Plk_4	120	126	PF00069	0.266
MOD_Plk_4	136	142	PF00069	0.329
MOD_Plk_4	251	257	PF00069	0.425
MOD_Plk_4	26	32	PF00069	0.237
MOD_Plk_4	6	12	PF00069	0.465
MOD_ProDKin_1	105	111	PF00069	0.350
MOD_SUMO_rev_2	117	124	PF00179	0.447
MOD_SUMO_rev_2	202	209	PF00179	0.524
TRG_DiLeu_BaEn_2	234	240	PF01217	0.495
TRG_DiLeu_BaEn_4	235	241	PF01217	0.491
TRG_DiLeu_BaEn_4	74	80	PF01217	0.378
TRG_ENDOCYTIC_2	194	197	PF00928	0.463
TRG_ENDOCYTIC_2	246	249	PF00928	0.448
TRG_NLS_Bipartite_1	190	211	PF00514	0.427
TRG_NLS_MonoExtC_3	189	195	PF00514	0.544
TRG_NLS_MonoExtN_4	187	194	PF00514	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK3	Leptomonas seymouri	68%	100%
A0A0S4J8Z8	Bodo saltans	31%	100%
A0A1X0NWH6	Trypanosomatidae	44%	96%
A0A3R7KYG2	Trypanosoma rangeli	38%	93%
A0A3S7WVR1	Leishmania donovani	93%	100%
A4HYL5	Leishmania infantum	93%	100%
C9ZHW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	97%
E9AI78	Leishmania braziliensis	78%	100%
Q4QD20	Leishmania major	95%	100%
V5BQW5	Trypanosoma cruzi	38%	94%