Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUG2_LEIMU

TriTrypDb:

LmxM.20.0220

Length:

949

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.632
CLV_C14_Caspase3-7	580	584	PF00656	0.397
CLV_C14_Caspase3-7	742	746	PF00656	0.562
CLV_C14_Caspase3-7	832	836	PF00656	0.558
CLV_MEL_PAP_1	210	216	PF00089	0.233
CLV_NRD_NRD_1	120	122	PF00675	0.555
CLV_NRD_NRD_1	174	176	PF00675	0.467
CLV_NRD_NRD_1	182	184	PF00675	0.411
CLV_NRD_NRD_1	187	189	PF00675	0.380
CLV_NRD_NRD_1	727	729	PF00675	0.553
CLV_NRD_NRD_1	838	840	PF00675	0.503
CLV_NRD_NRD_1	95	97	PF00675	0.535
CLV_PCSK_FUR_1	725	729	PF00082	0.543
CLV_PCSK_KEX2_1	120	122	PF00082	0.555
CLV_PCSK_KEX2_1	174	176	PF00082	0.467
CLV_PCSK_KEX2_1	182	184	PF00082	0.411
CLV_PCSK_KEX2_1	187	189	PF00082	0.380
CLV_PCSK_KEX2_1	727	729	PF00082	0.553
CLV_PCSK_KEX2_1	838	840	PF00082	0.503
CLV_PCSK_KEX2_1	95	97	PF00082	0.535
CLV_PCSK_PC7_1	183	189	PF00082	0.523
CLV_PCSK_SKI1_1	121	125	PF00082	0.531
CLV_PCSK_SKI1_1	182	186	PF00082	0.498
CLV_PCSK_SKI1_1	220	224	PF00082	0.482
CLV_PCSK_SKI1_1	420	424	PF00082	0.506
CLV_PCSK_SKI1_1	503	507	PF00082	0.512
CLV_PCSK_SKI1_1	55	59	PF00082	0.495
DEG_APCC_DBOX_1	219	227	PF00400	0.337
DEG_SCF_FBW7_1	618	623	PF00400	0.476
DEG_SCF_FBW7_2	381	388	PF00400	0.584
DOC_ANK_TNKS_1	173	180	PF00023	0.543
DOC_ANK_TNKS_1	452	459	PF00023	0.566
DOC_CKS1_1	382	387	PF01111	0.616
DOC_CYCLIN_RxL_1	217	224	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.552
DOC_CYCLIN_yCln2_LP_2	763	769	PF00134	0.306
DOC_MAPK_MEF2A_6	158	167	PF00069	0.474
DOC_MAPK_MEF2A_6	593	602	PF00069	0.543
DOC_MAPK_RevD_3	161	175	PF00069	0.489
DOC_PP2B_LxvP_1	357	360	PF13499	0.574
DOC_PP2B_LxvP_1	763	766	PF13499	0.239
DOC_PP4_FxxP_1	782	785	PF00568	0.548
DOC_PP4_FxxP_1	803	806	PF00568	0.508
DOC_USP7_MATH_1	110	114	PF00917	0.538
DOC_USP7_MATH_1	177	181	PF00917	0.557
DOC_USP7_MATH_1	258	262	PF00917	0.553
DOC_USP7_MATH_1	410	414	PF00917	0.545
DOC_USP7_MATH_1	550	554	PF00917	0.585
DOC_USP7_MATH_1	581	585	PF00917	0.658
DOC_USP7_MATH_1	620	624	PF00917	0.546
DOC_USP7_MATH_1	63	67	PF00917	0.525
DOC_USP7_MATH_1	637	641	PF00917	0.529
DOC_USP7_MATH_1	723	727	PF00917	0.585
DOC_USP7_MATH_2	268	274	PF00917	0.342
DOC_WW_Pin1_4	197	202	PF00397	0.510
DOC_WW_Pin1_4	259	264	PF00397	0.618
DOC_WW_Pin1_4	381	386	PF00397	0.552
DOC_WW_Pin1_4	40	45	PF00397	0.602
DOC_WW_Pin1_4	616	621	PF00397	0.574
DOC_WW_Pin1_4	684	689	PF00397	0.599
DOC_WW_Pin1_4	807	812	PF00397	0.480
LIG_14-3-3_CanoR_1	120	130	PF00244	0.482
LIG_14-3-3_CanoR_1	158	162	PF00244	0.341
LIG_14-3-3_CanoR_1	182	190	PF00244	0.419
LIG_14-3-3_CanoR_1	213	221	PF00244	0.453
LIG_14-3-3_CanoR_1	344	353	PF00244	0.538
LIG_14-3-3_CanoR_1	433	439	PF00244	0.559
LIG_14-3-3_CanoR_1	480	488	PF00244	0.516
LIG_14-3-3_CanoR_1	64	72	PF00244	0.429
LIG_14-3-3_CanoR_1	656	660	PF00244	0.515
LIG_14-3-3_CanoR_1	780	785	PF00244	0.573
LIG_14-3-3_CanoR_1	914	923	PF00244	0.539
LIG_14-3-3_CanoR_1	932	940	PF00244	0.607
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_CaM_NSCaTE_8	929	936	PF13499	0.592
LIG_Clathr_ClatBox_1	131	135	PF01394	0.482
LIG_Clathr_ClatBox_1	195	199	PF01394	0.467
LIG_eIF4E_1	674	680	PF01652	0.492
LIG_FHA_1	122	128	PF00498	0.500
LIG_FHA_1	241	247	PF00498	0.486
LIG_FHA_1	327	333	PF00498	0.467
LIG_FHA_1	362	368	PF00498	0.557
LIG_FHA_1	376	382	PF00498	0.588
LIG_FHA_1	425	431	PF00498	0.553
LIG_FHA_1	480	486	PF00498	0.541
LIG_FHA_1	617	623	PF00498	0.498
LIG_FHA_1	628	634	PF00498	0.594
LIG_FHA_1	673	679	PF00498	0.492
LIG_FHA_1	685	691	PF00498	0.546
LIG_FHA_1	758	764	PF00498	0.528
LIG_FHA_1	790	796	PF00498	0.514
LIG_FHA_1	860	866	PF00498	0.509
LIG_FHA_2	18	24	PF00498	0.595
LIG_FHA_2	234	240	PF00498	0.546
LIG_FHA_2	264	270	PF00498	0.525
LIG_FHA_2	474	480	PF00498	0.389
LIG_FHA_2	566	572	PF00498	0.587
LIG_FHA_2	649	655	PF00498	0.485
LIG_FHA_2	740	746	PF00498	0.518
LIG_FHA_2	830	836	PF00498	0.504
LIG_FHA_2	893	899	PF00498	0.733
LIG_GBD_Chelix_1	598	606	PF00786	0.501
LIG_GBD_Chelix_1	649	657	PF00786	0.468
LIG_LIR_Apic_2	224	230	PF02991	0.463
LIG_LIR_Apic_2	779	785	PF02991	0.517
LIG_LIR_Apic_2	800	806	PF02991	0.480
LIG_LIR_Gen_1	236	246	PF02991	0.509
LIG_LIR_Gen_1	313	322	PF02991	0.510
LIG_LIR_Gen_1	396	402	PF02991	0.509
LIG_LIR_Gen_1	476	485	PF02991	0.414
LIG_LIR_Gen_1	623	633	PF02991	0.543
LIG_LIR_Gen_1	672	681	PF02991	0.504
LIG_LIR_Gen_1	71	80	PF02991	0.415
LIG_LIR_Gen_1	938	946	PF02991	0.544
LIG_LIR_Nem_3	236	241	PF02991	0.439
LIG_LIR_Nem_3	313	317	PF02991	0.537
LIG_LIR_Nem_3	396	401	PF02991	0.517
LIG_LIR_Nem_3	442	447	PF02991	0.620
LIG_LIR_Nem_3	476	481	PF02991	0.404
LIG_LIR_Nem_3	623	629	PF02991	0.411
LIG_LIR_Nem_3	672	677	PF02991	0.502
LIG_LIR_Nem_3	71	75	PF02991	0.457
LIG_LIR_Nem_3	779	784	PF02991	0.469
LIG_NRBOX	129	135	PF00104	0.400
LIG_NRBOX	352	358	PF00104	0.576
LIG_NRBOX	480	486	PF00104	0.411
LIG_NRBOX	648	654	PF00104	0.517
LIG_NRBOX	739	745	PF00104	0.557
LIG_NRBOX	99	105	PF00104	0.508
LIG_PTB_Apo_2	74	81	PF02174	0.378
LIG_SH2_CRK	674	678	PF00017	0.477
LIG_SH2_PTP2	72	75	PF00017	0.469
LIG_SH2_SRC	569	572	PF00017	0.535
LIG_SH2_STAP1	674	678	PF00017	0.490
LIG_SH2_STAT5	450	453	PF00017	0.466
LIG_SH2_STAT5	674	677	PF00017	0.446
LIG_SH2_STAT5	72	75	PF00017	0.447
LIG_SH3_3	297	303	PF00018	0.539
LIG_SH3_3	357	363	PF00018	0.571
LIG_SH3_3	630	636	PF00018	0.665
LIG_Sin3_3	289	296	PF02671	0.538
LIG_Sin3_3	524	531	PF02671	0.474
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.461
LIG_SUMO_SIM_anti_2	71	77	PF11976	0.340
LIG_SUMO_SIM_par_1	107	113	PF11976	0.325
LIG_SUMO_SIM_par_1	129	136	PF11976	0.412
LIG_SUMO_SIM_par_1	194	200	PF11976	0.489
LIG_TRAF2_1	26	29	PF00917	0.584
LIG_TRAF2_1	440	443	PF00917	0.633
LIG_TRAF2_1	489	492	PF00917	0.329
LIG_TRAF2_1	568	571	PF00917	0.593
LIG_TRAF2_1	707	710	PF00917	0.634
LIG_Vh1_VBS_1	470	488	PF01044	0.471
MOD_CK1_1	200	206	PF00069	0.585
MOD_CK1_1	375	381	PF00069	0.489
MOD_CK1_1	542	548	PF00069	0.670
MOD_CK1_1	577	583	PF00069	0.643
MOD_CK1_1	638	644	PF00069	0.552
MOD_CK1_1	686	692	PF00069	0.591
MOD_CK1_1	787	793	PF00069	0.594
MOD_CK1_1	810	816	PF00069	0.527
MOD_CK1_1	827	833	PF00069	0.411
MOD_CK1_1	917	923	PF00069	0.600
MOD_CK2_1	150	156	PF00069	0.634
MOD_CK2_1	23	29	PF00069	0.621
MOD_CK2_1	233	239	PF00069	0.544
MOD_CK2_1	263	269	PF00069	0.552
MOD_CK2_1	473	479	PF00069	0.365
MOD_CK2_1	486	492	PF00069	0.466
MOD_CK2_1	565	571	PF00069	0.550
MOD_CK2_1	648	654	PF00069	0.574
MOD_CK2_1	704	710	PF00069	0.612
MOD_CK2_1	788	794	PF00069	0.612
MOD_CK2_1	857	863	PF00069	0.513
MOD_GlcNHglycan	2	5	PF01048	0.730
MOD_GlcNHglycan	293	296	PF01048	0.480
MOD_GlcNHglycan	307	310	PF01048	0.617
MOD_GlcNHglycan	347	350	PF01048	0.446
MOD_GlcNHglycan	374	377	PF01048	0.541
MOD_GlcNHglycan	413	416	PF01048	0.567
MOD_GlcNHglycan	510	513	PF01048	0.606
MOD_GlcNHglycan	529	532	PF01048	0.518
MOD_GlcNHglycan	542	545	PF01048	0.439
MOD_GlcNHglycan	552	555	PF01048	0.492
MOD_GlcNHglycan	576	579	PF01048	0.673
MOD_GlcNHglycan	583	586	PF01048	0.556
MOD_GlcNHglycan	622	625	PF01048	0.478
MOD_GlcNHglycan	630	633	PF01048	0.544
MOD_GlcNHglycan	637	640	PF01048	0.466
MOD_GlcNHglycan	65	68	PF01048	0.464
MOD_GlcNHglycan	731	734	PF01048	0.529
MOD_GlcNHglycan	794	798	PF01048	0.501
MOD_GlcNHglycan	878	881	PF01048	0.550
MOD_GlcNHglycan	916	919	PF01048	0.545
MOD_GlcNHglycan	924	927	PF01048	0.507
MOD_GlcNHglycan	934	937	PF01048	0.323
MOD_GSK3_1	17	24	PF00069	0.617
MOD_GSK3_1	259	266	PF00069	0.647
MOD_GSK3_1	331	338	PF00069	0.547
MOD_GSK3_1	577	584	PF00069	0.700
MOD_GSK3_1	59	66	PF00069	0.467
MOD_GSK3_1	616	623	PF00069	0.565
MOD_GSK3_1	679	686	PF00069	0.486
MOD_GSK3_1	739	746	PF00069	0.558
MOD_GSK3_1	776	783	PF00069	0.513
MOD_GSK3_1	784	791	PF00069	0.490
MOD_GSK3_1	910	917	PF00069	0.534
MOD_NEK2_1	16	21	PF00069	0.410
MOD_NEK2_1	325	330	PF00069	0.601
MOD_NEK2_1	345	350	PF00069	0.393
MOD_NEK2_1	434	439	PF00069	0.623
MOD_NEK2_1	508	513	PF00069	0.594
MOD_NEK2_1	527	532	PF00069	0.501
MOD_NEK2_1	58	63	PF00069	0.478
MOD_NEK2_1	589	594	PF00069	0.341
MOD_NEK2_1	679	684	PF00069	0.508
MOD_NEK2_1	696	701	PF00069	0.500
MOD_NEK2_1	743	748	PF00069	0.453
MOD_NEK2_1	824	829	PF00069	0.361
MOD_NEK2_2	177	182	PF00069	0.552
MOD_PIKK_1	121	127	PF00454	0.487
MOD_PIKK_1	182	188	PF00454	0.450
MOD_PIKK_1	331	337	PF00454	0.600
MOD_PIKK_1	375	381	PF00454	0.493
MOD_PIKK_1	672	678	PF00454	0.494
MOD_PIKK_1	822	828	PF00454	0.518
MOD_PKA_1	182	188	PF00069	0.450
MOD_PKA_2	157	163	PF00069	0.280
MOD_PKA_2	182	188	PF00069	0.438
MOD_PKA_2	212	218	PF00069	0.450
MOD_PKA_2	432	438	PF00069	0.546
MOD_PKA_2	479	485	PF00069	0.476
MOD_PKA_2	508	514	PF00069	0.510
MOD_PKA_2	63	69	PF00069	0.457
MOD_PKA_2	655	661	PF00069	0.286
MOD_PKA_2	787	793	PF00069	0.310
MOD_Plk_1	34	40	PF00069	0.560
MOD_Plk_1	793	799	PF00069	0.507
MOD_Plk_2-3	457	463	PF00069	0.501
MOD_Plk_2-3	648	654	PF00069	0.481
MOD_Plk_4	233	239	PF00069	0.509
MOD_Plk_4	242	248	PF00069	0.352
MOD_Plk_4	270	276	PF00069	0.440
MOD_Plk_4	280	286	PF00069	0.417
MOD_Plk_4	307	313	PF00069	0.601
MOD_Plk_4	648	654	PF00069	0.405
MOD_Plk_4	655	661	PF00069	0.432
MOD_Plk_4	68	74	PF00069	0.404
MOD_Plk_4	739	745	PF00069	0.489
MOD_ProDKin_1	197	203	PF00069	0.520
MOD_ProDKin_1	259	265	PF00069	0.614
MOD_ProDKin_1	381	387	PF00069	0.557
MOD_ProDKin_1	40	46	PF00069	0.588
MOD_ProDKin_1	616	622	PF00069	0.570
MOD_ProDKin_1	684	690	PF00069	0.593
MOD_ProDKin_1	807	813	PF00069	0.473
MOD_SUMO_for_1	901	904	PF00179	0.520
TRG_DiLeu_BaEn_1	648	653	PF01217	0.551
TRG_DiLeu_BaEn_4	101	107	PF01217	0.440
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.558
TRG_ENDOCYTIC_2	478	481	PF00928	0.389
TRG_ENDOCYTIC_2	674	677	PF00928	0.476
TRG_ENDOCYTIC_2	72	75	PF00928	0.469
TRG_ENDOCYTIC_2	940	943	PF00928	0.547
TRG_ER_diArg_1	174	176	PF00400	0.464
TRG_ER_diArg_1	181	183	PF00400	0.425
TRG_ER_diArg_1	725	728	PF00400	0.533
TRG_ER_diArg_1	837	839	PF00400	0.448
TRG_ER_diArg_1	95	97	PF00400	0.535
TRG_NES_CRM1_1	122	136	PF08389	0.435
TRG_NES_CRM1_1	479	492	PF08389	0.497
TRG_NES_CRM1_1	647	662	PF08389	0.494
TRG_NES_CRM1_1	753	768	PF08389	0.362
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	720	724	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	841	845	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	848	852	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N6	Leptomonas seymouri	52%	100%
A0A1X0NXX2	Trypanosomatidae	25%	100%
A0A3R7KCN8	Trypanosoma rangeli	28%	100%
A0A3S7WVU2	Leishmania donovani	91%	100%
A4HYL3	Leishmania infantum	90%	100%
E9AI76	Leishmania braziliensis	79%	100%
Q4QD22	Leishmania major	90%	100%
V5BAE6	Trypanosoma cruzi	28%	100%