Kelch domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kelch domain-containing protein

Species:

Leishmania mexicana

UniProt:

E9AUG1_LEIMU

TriTrypDb:

LmxM.20.0210

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.401
CLV_NRD_NRD_1	76	78	PF00675	0.457
CLV_NRD_NRD_1	79	81	PF00675	0.421
CLV_PCSK_KEX2_1	147	149	PF00082	0.401
CLV_PCSK_KEX2_1	76	78	PF00082	0.457
CLV_PCSK_SKI1_1	408	412	PF00082	0.575
DEG_MDM2_SWIB_1	297	305	PF02201	0.460
DOC_CKS1_1	163	168	PF01111	0.549
DOC_CKS1_1	261	266	PF01111	0.248
DOC_CKS1_1	34	39	PF01111	0.402
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.340
DOC_CYCLIN_yCln2_LP_2	350	356	PF00134	0.508
DOC_MAPK_MEF2A_6	250	259	PF00069	0.161
DOC_PP1_RVXF_1	10	17	PF00149	0.513
DOC_PP2B_LxvP_1	350	353	PF13499	0.543
DOC_PP2B_LxvP_1	395	398	PF13499	0.356
DOC_PP4_FxxP_1	361	364	PF00568	0.487
DOC_PP4_MxPP_1	35	38	PF00568	0.533
DOC_PP4_MxPP_1	88	91	PF00568	0.570
DOC_USP7_MATH_1	2	6	PF00917	0.573
DOC_USP7_MATH_1	288	292	PF00917	0.565
DOC_USP7_MATH_1	334	338	PF00917	0.432
DOC_USP7_MATH_1	83	87	PF00917	0.559
DOC_USP7_MATH_1	94	98	PF00917	0.426
DOC_WW_Pin1_4	111	116	PF00397	0.426
DOC_WW_Pin1_4	137	142	PF00397	0.565
DOC_WW_Pin1_4	162	167	PF00397	0.521
DOC_WW_Pin1_4	230	235	PF00397	0.380
DOC_WW_Pin1_4	260	265	PF00397	0.333
DOC_WW_Pin1_4	33	38	PF00397	0.440
LIG_14-3-3_CanoR_1	130	134	PF00244	0.462
LIG_14-3-3_CanoR_1	250	255	PF00244	0.452
LIG_14-3-3_CanoR_1	269	275	PF00244	0.235
LIG_14-3-3_CanoR_1	335	339	PF00244	0.474
LIG_14-3-3_CanoR_1	374	381	PF00244	0.563
LIG_APCC_ABBA_1	303	308	PF00400	0.227
LIG_APCC_ABBAyCdc20_2	302	308	PF00400	0.223
LIG_BRCT_BRCA1_1	293	297	PF00533	0.526
LIG_BRCT_BRCA1_1	335	339	PF00533	0.423
LIG_CSL_BTD_1	253	256	PF09270	0.161
LIG_eIF4E_1	48	54	PF01652	0.321
LIG_FHA_1	389	395	PF00498	0.615
LIG_FHA_2	195	201	PF00498	0.684
LIG_LIR_Apic_2	359	364	PF02991	0.454
LIG_LIR_Gen_1	128	139	PF02991	0.406
LIG_LIR_Gen_1	181	191	PF02991	0.423
LIG_LIR_Gen_1	278	288	PF02991	0.447
LIG_LIR_Gen_1	294	305	PF02991	0.311
LIG_LIR_Gen_1	311	320	PF02991	0.489
LIG_LIR_Gen_1	390	398	PF02991	0.361
LIG_LIR_Gen_1	50	56	PF02991	0.340
LIG_LIR_Nem_3	128	134	PF02991	0.392
LIG_LIR_Nem_3	181	187	PF02991	0.410
LIG_LIR_Nem_3	253	257	PF02991	0.311
LIG_LIR_Nem_3	278	283	PF02991	0.460
LIG_LIR_Nem_3	294	300	PF02991	0.281
LIG_LIR_Nem_3	311	315	PF02991	0.440
LIG_LIR_Nem_3	336	341	PF02991	0.383
LIG_LIR_Nem_3	390	395	PF02991	0.366
LIG_LIR_Nem_3	50	55	PF02991	0.340
LIG_MLH1_MIPbox_1	293	297	PF16413	0.526
LIG_MLH1_MIPbox_1	335	339	PF16413	0.210
LIG_Pex14_2	16	20	PF04695	0.680
LIG_Pex14_2	297	301	PF04695	0.360
LIG_PTAP_UEV_1	165	170	PF05743	0.398
LIG_PTB_Apo_2	239	246	PF02174	0.321
LIG_PTB_Apo_2	63	70	PF02174	0.340
LIG_PTB_Phospho_1	63	69	PF10480	0.317
LIG_SH2_GRB2like	240	243	PF00017	0.340
LIG_SH2_PTP2	280	283	PF00017	0.444
LIG_SH2_SRC	118	121	PF00017	0.379
LIG_SH2_SRC	240	243	PF00017	0.355
LIG_SH2_STAP1	118	122	PF00017	0.426
LIG_SH2_STAP1	270	274	PF00017	0.334
LIG_SH2_STAP1	356	360	PF00017	0.328
LIG_SH2_STAT3	107	110	PF00017	0.362
LIG_SH2_STAT3	367	370	PF00017	0.635
LIG_SH2_STAT5	160	163	PF00017	0.357
LIG_SH2_STAT5	176	179	PF00017	0.344
LIG_SH2_STAT5	220	223	PF00017	0.314
LIG_SH2_STAT5	240	243	PF00017	0.452
LIG_SH2_STAT5	280	283	PF00017	0.391
LIG_SH2_STAT5	296	299	PF00017	0.299
LIG_SH2_STAT5	331	334	PF00017	0.394
LIG_SH2_STAT5	52	55	PF00017	0.430
LIG_SH2_STAT5	69	72	PF00017	0.309
LIG_SH3_1	258	264	PF00018	0.547
LIG_SH3_3	138	144	PF00018	0.491
LIG_SH3_3	163	169	PF00018	0.561
LIG_SH3_3	258	264	PF00018	0.467
LIG_SH3_3	31	37	PF00018	0.411
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.326
LIG_SUMO_SIM_par_1	119	125	PF11976	0.428
LIG_SUMO_SIM_par_1	393	400	PF11976	0.361
LIG_TRAF2_1	410	413	PF00917	0.628
LIG_TYR_ITIM	116	121	PF00017	0.426
LIG_TYR_ITIM	174	179	PF00017	0.492
LIG_WW_3	89	93	PF00397	0.452
MOD_CDK_SPK_2	260	265	PF00069	0.333
MOD_CK1_1	194	200	PF00069	0.465
MOD_CK1_1	212	218	PF00069	0.397
MOD_CK1_1	27	33	PF00069	0.628
MOD_CK1_1	291	297	PF00069	0.551
MOD_CK1_1	324	330	PF00069	0.360
MOD_CK1_1	393	399	PF00069	0.570
MOD_CK1_1	44	50	PF00069	0.238
MOD_CK2_1	194	200	PF00069	0.695
MOD_CK2_1	393	399	PF00069	0.636
MOD_GlcNHglycan	193	196	PF01048	0.526
MOD_GlcNHglycan	211	214	PF01048	0.321
MOD_GlcNHglycan	24	27	PF01048	0.662
MOD_GlcNHglycan	326	329	PF01048	0.318
MOD_GlcNHglycan	367	370	PF01048	0.638
MOD_GlcNHglycan	96	99	PF01048	0.302
MOD_GSK3_1	125	132	PF00069	0.382
MOD_GSK3_1	187	194	PF00069	0.556
MOD_GSK3_1	208	215	PF00069	0.392
MOD_GSK3_1	291	298	PF00069	0.529
MOD_GSK3_1	329	336	PF00069	0.406
MOD_GSK3_1	365	372	PF00069	0.534
MOD_GSK3_1	72	79	PF00069	0.325
MOD_N-GLC_1	288	293	PF02516	0.567
MOD_NEK2_1	365	370	PF00069	0.516
MOD_NEK2_1	373	378	PF00069	0.540
MOD_NEK2_1	93	98	PF00069	0.372
MOD_NEK2_2	240	245	PF00069	0.321
MOD_NEK2_2	334	339	PF00069	0.408
MOD_NEK2_2	369	374	PF00069	0.607
MOD_PKA_1	76	82	PF00069	0.459
MOD_PKA_2	129	135	PF00069	0.458
MOD_PKA_2	27	33	PF00069	0.699
MOD_PKA_2	334	340	PF00069	0.427
MOD_PKA_2	373	379	PF00069	0.580
MOD_PKA_2	388	394	PF00069	0.585
MOD_PKA_2	76	82	PF00069	0.390
MOD_Plk_1	291	297	PF00069	0.515
MOD_Plk_1	348	354	PF00069	0.574
MOD_Plk_4	240	246	PF00069	0.333
MOD_Plk_4	250	256	PF00069	0.346
MOD_Plk_4	291	297	PF00069	0.553
MOD_Plk_4	334	340	PF00069	0.387
MOD_Plk_4	41	47	PF00069	0.288
MOD_ProDKin_1	111	117	PF00069	0.426
MOD_ProDKin_1	137	143	PF00069	0.557
MOD_ProDKin_1	162	168	PF00069	0.529
MOD_ProDKin_1	230	236	PF00069	0.380
MOD_ProDKin_1	260	266	PF00069	0.323
MOD_ProDKin_1	33	39	PF00069	0.438
TRG_DiLeu_BaEn_1	390	395	PF01217	0.366
TRG_ENDOCYTIC_2	118	121	PF00928	0.376
TRG_ENDOCYTIC_2	160	163	PF00928	0.357
TRG_ENDOCYTIC_2	176	179	PF00928	0.344
TRG_ENDOCYTIC_2	280	283	PF00928	0.403
TRG_ENDOCYTIC_2	52	55	PF00928	0.452
TRG_ER_diArg_1	147	149	PF00400	0.402
TRG_ER_diArg_1	76	78	PF00400	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I272	Leptomonas seymouri	51%	100%
A0A0S4JFE6	Bodo saltans	33%	100%
A0A1X0NY29	Trypanosomatidae	41%	100%
A0A3S5H781	Leishmania donovani	91%	100%
A0A422NEH9	Trypanosoma rangeli	42%	100%
A4HYL2	Leishmania infantum	91%	100%
C9ZHV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
E9AI75	Leishmania braziliensis	83%	100%
Q0IIC2	Bos taurus	24%	94%
Q10AZ7	Oryza sativa subsp. japonica	23%	83%
Q3KRE6	Rattus norvegicus	25%	100%
Q4G5Y1	Mus musculus	25%	100%
Q4QD23	Leishmania major	92%	100%
Q58CV6	Bos taurus	24%	100%
Q5R8W1	Pongo abelii	25%	80%
Q5U3Y0	Rattus norvegicus	25%	100%
Q6AYI2	Rattus norvegicus	24%	100%
Q6PAR0	Mus musculus	25%	95%
Q6PID8	Homo sapiens	24%	94%
Q8RY71	Arabidopsis thaliana	24%	100%
Q8VEM9	Mus musculus	24%	100%
Q9BQ90	Homo sapiens	27%	100%
Q9Y2U9	Homo sapiens	25%	100%
V5BAH1	Trypanosoma cruzi	23%	100%
V5DS74	Trypanosoma cruzi	42%	100%