Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUG0_LEIMU

TriTrypDb:

LmxM.20.0200

Length:

859

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUG0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.477
CLV_C14_Caspase3-7	64	68	PF00656	0.468
CLV_C14_Caspase3-7	76	80	PF00656	0.508
CLV_NRD_NRD_1	19	21	PF00675	0.437
CLV_NRD_NRD_1	275	277	PF00675	0.781
CLV_NRD_NRD_1	393	395	PF00675	0.507
CLV_NRD_NRD_1	397	399	PF00675	0.518
CLV_NRD_NRD_1	536	538	PF00675	0.569
CLV_NRD_NRD_1	693	695	PF00675	0.610
CLV_NRD_NRD_1	710	712	PF00675	0.386
CLV_NRD_NRD_1	844	846	PF00675	0.530
CLV_PCSK_FUR_1	534	538	PF00082	0.333
CLV_PCSK_KEX2_1	19	21	PF00082	0.437
CLV_PCSK_KEX2_1	206	208	PF00082	0.573
CLV_PCSK_KEX2_1	275	277	PF00082	0.781
CLV_PCSK_KEX2_1	397	399	PF00082	0.569
CLV_PCSK_KEX2_1	536	538	PF00082	0.418
CLV_PCSK_KEX2_1	693	695	PF00082	0.610
CLV_PCSK_KEX2_1	710	712	PF00082	0.386
CLV_PCSK_KEX2_1	844	846	PF00082	0.530
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.573
CLV_PCSK_PC7_1	15	21	PF00082	0.407
CLV_PCSK_SKI1_1	207	211	PF00082	0.476
CLV_PCSK_SKI1_1	614	618	PF00082	0.594
CLV_PCSK_SKI1_1	640	644	PF00082	0.314
CLV_PCSK_SKI1_1	668	672	PF00082	0.500
CLV_Separin_Metazoa	240	244	PF03568	0.639
DEG_APCC_DBOX_1	347	355	PF00400	0.555
DEG_APCC_DBOX_1	413	421	PF00400	0.335
DEG_SPOP_SBC_1	37	41	PF00917	0.426
DEG_SPOP_SBC_1	744	748	PF00917	0.685
DOC_CKS1_1	580	585	PF01111	0.641
DOC_CYCLIN_RxL_1	665	673	PF00134	0.494
DOC_CYCLIN_RxL_1	801	812	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	609	615	PF00134	0.492
DOC_CYCLIN_yCln2_LP_2	643	649	PF00134	0.681
DOC_MAPK_gen_1	135	143	PF00069	0.603
DOC_MAPK_gen_1	206	212	PF00069	0.576
DOC_MAPK_gen_1	214	223	PF00069	0.487
DOC_MAPK_gen_1	536	545	PF00069	0.441
DOC_MAPK_MEF2A_6	135	143	PF00069	0.603
DOC_PP2B_LxvP_1	587	590	PF13499	0.532
DOC_PP4_FxxP_1	356	359	PF00568	0.560
DOC_USP7_MATH_1	11	15	PF00917	0.584
DOC_USP7_MATH_1	152	156	PF00917	0.466
DOC_USP7_MATH_1	32	36	PF00917	0.720
DOC_USP7_MATH_1	363	367	PF00917	0.493
DOC_USP7_MATH_1	378	382	PF00917	0.631
DOC_USP7_MATH_1	387	391	PF00917	0.662
DOC_USP7_MATH_1	450	454	PF00917	0.358
DOC_USP7_MATH_1	500	504	PF00917	0.462
DOC_USP7_MATH_1	626	630	PF00917	0.557
DOC_USP7_MATH_1	680	684	PF00917	0.501
DOC_USP7_MATH_1	84	88	PF00917	0.550
DOC_USP7_MATH_1	854	858	PF00917	0.713
DOC_WW_Pin1_4	28	33	PF00397	0.687
DOC_WW_Pin1_4	288	293	PF00397	0.693
DOC_WW_Pin1_4	412	417	PF00397	0.463
DOC_WW_Pin1_4	492	497	PF00397	0.560
DOC_WW_Pin1_4	561	566	PF00397	0.666
DOC_WW_Pin1_4	579	584	PF00397	0.327
DOC_WW_Pin1_4	676	681	PF00397	0.324
DOC_WW_Pin1_4	814	819	PF00397	0.514
DOC_WW_Pin1_4	833	838	PF00397	0.516
LIG_14-3-3_CanoR_1	107	113	PF00244	0.495
LIG_14-3-3_CanoR_1	19	25	PF00244	0.507
LIG_14-3-3_CanoR_1	220	224	PF00244	0.514
LIG_14-3-3_CanoR_1	275	284	PF00244	0.652
LIG_14-3-3_CanoR_1	316	322	PF00244	0.599
LIG_14-3-3_CanoR_1	342	351	PF00244	0.551
LIG_14-3-3_CanoR_1	360	368	PF00244	0.664
LIG_14-3-3_CanoR_1	434	442	PF00244	0.589
LIG_14-3-3_CanoR_1	518	526	PF00244	0.506
LIG_14-3-3_CanoR_1	594	603	PF00244	0.465
LIG_14-3-3_CanoR_1	655	665	PF00244	0.494
LIG_14-3-3_CanoR_1	674	679	PF00244	0.341
LIG_14-3-3_CanoR_1	711	719	PF00244	0.510
LIG_14-3-3_CanoR_1	793	801	PF00244	0.592
LIG_14-3-3_CanoR_1	804	809	PF00244	0.396
LIG_Actin_WH2_2	328	344	PF00022	0.593
LIG_Actin_WH2_2	94	109	PF00022	0.491
LIG_APCC_ABBA_1	459	464	PF00400	0.405
LIG_BIR_III_2	447	451	PF00653	0.411
LIG_BRCT_BRCA1_1	108	112	PF00533	0.499
LIG_BRCT_BRCA1_1	13	17	PF00533	0.602
LIG_BRCT_BRCA1_1	251	255	PF00533	0.457
LIG_CSL_BTD_1	815	818	PF09270	0.517
LIG_deltaCOP1_diTrp_1	452	462	PF00928	0.532
LIG_deltaCOP1_diTrp_1	479	484	PF00928	0.468
LIG_DLG_GKlike_1	804	812	PF00625	0.598
LIG_EH1_1	398	406	PF00400	0.556
LIG_EH1_1	822	830	PF00400	0.503
LIG_eIF4E_1	823	829	PF01652	0.497
LIG_FHA_1	188	194	PF00498	0.472
LIG_FHA_1	296	302	PF00498	0.618
LIG_FHA_1	304	310	PF00498	0.600
LIG_FHA_1	327	333	PF00498	0.636
LIG_FHA_1	49	55	PF00498	0.491
LIG_FHA_1	546	552	PF00498	0.494
LIG_FHA_1	590	596	PF00498	0.430
LIG_FHA_1	707	713	PF00498	0.515
LIG_FHA_1	719	725	PF00498	0.482
LIG_FHA_1	750	756	PF00498	0.468
LIG_FHA_1	834	840	PF00498	0.620
LIG_FHA_2	175	181	PF00498	0.573
LIG_FHA_2	254	260	PF00498	0.784
LIG_FHA_2	318	324	PF00498	0.671
LIG_FHA_2	38	44	PF00498	0.510
LIG_FHA_2	755	761	PF00498	0.456
LIG_FHA_2	769	775	PF00498	0.496
LIG_FHA_2	808	814	PF00498	0.537
LIG_LIR_Apic_2	264	270	PF02991	0.731
LIG_LIR_Gen_1	163	174	PF02991	0.500
LIG_LIR_Gen_1	252	262	PF02991	0.484
LIG_LIR_Gen_1	452	462	PF02991	0.507
LIG_LIR_Gen_1	664	671	PF02991	0.458
LIG_LIR_Gen_1	701	712	PF02991	0.588
LIG_LIR_LC3C_4	331	336	PF02991	0.618
LIG_LIR_Nem_3	163	169	PF02991	0.488
LIG_LIR_Nem_3	252	258	PF02991	0.475
LIG_LIR_Nem_3	452	458	PF02991	0.618
LIG_LIR_Nem_3	664	669	PF02991	0.458
LIG_LIR_Nem_3	701	707	PF02991	0.567
LIG_LIR_Nem_3	813	819	PF02991	0.624
LIG_NRBOX	403	409	PF00104	0.381
LIG_NRBOX	666	672	PF00104	0.489
LIG_NRBOX	754	760	PF00104	0.444
LIG_NRP_CendR_1	856	859	PF00754	0.502
LIG_SH2_NCK_1	179	183	PF00017	0.475
LIG_SH2_SRC	823	826	PF00017	0.502
LIG_SH2_STAT5	233	236	PF00017	0.456
LIG_SH2_STAT5	490	493	PF00017	0.474
LIG_SH2_STAT5	558	561	PF00017	0.641
LIG_SH2_STAT5	638	641	PF00017	0.481
LIG_SH2_STAT5	666	669	PF00017	0.558
LIG_SH2_STAT5	823	826	PF00017	0.502
LIG_SH3_3	26	32	PF00018	0.675
LIG_SH3_3	410	416	PF00018	0.578
LIG_SH3_3	439	445	PF00018	0.543
LIG_SH3_3	609	615	PF00018	0.596
LIG_SH3_3	719	725	PF00018	0.584
LIG_SUMO_SIM_anti_2	219	225	PF11976	0.440
LIG_SUMO_SIM_anti_2	415	421	PF11976	0.461
LIG_SUMO_SIM_anti_2	567	575	PF11976	0.555
LIG_SUMO_SIM_anti_2	756	763	PF11976	0.454
LIG_SUMO_SIM_par_1	317	323	PF11976	0.705
LIG_SUMO_SIM_par_1	415	421	PF11976	0.312
LIG_SUMO_SIM_par_1	53	58	PF11976	0.503
LIG_TRAF2_1	328	331	PF00917	0.637
LIG_TRAF2_1	772	775	PF00917	0.600
LIG_TRFH_1	28	32	PF08558	0.609
LIG_UBA3_1	318	324	PF00899	0.421
LIG_WW_3	88	92	PF00397	0.584
MOD_CDK_SPxxK_3	814	821	PF00069	0.502
MOD_CK1_1	219	225	PF00069	0.485
MOD_CK1_1	249	255	PF00069	0.443
MOD_CK1_1	279	285	PF00069	0.816
MOD_CK1_1	288	294	PF00069	0.675
MOD_CK1_1	310	316	PF00069	0.645
MOD_CK1_1	317	323	PF00069	0.604
MOD_CK1_1	35	41	PF00069	0.600
MOD_CK1_1	42	48	PF00069	0.494
MOD_CK1_1	495	501	PF00069	0.684
MOD_CK1_1	508	514	PF00069	0.630
MOD_CK1_1	521	527	PF00069	0.382
MOD_CK1_1	60	66	PF00069	0.383
MOD_CK1_1	717	723	PF00069	0.366
MOD_CK1_1	807	813	PF00069	0.540
MOD_CK2_1	234	240	PF00069	0.630
MOD_CK2_1	277	283	PF00069	0.543
MOD_CK2_1	317	323	PF00069	0.705
MOD_CK2_1	341	347	PF00069	0.406
MOD_CK2_1	498	504	PF00069	0.498
MOD_CK2_1	511	517	PF00069	0.555
MOD_CK2_1	768	774	PF00069	0.516
MOD_CK2_1	807	813	PF00069	0.540
MOD_DYRK1A_RPxSP_1	492	496	PF00069	0.543
MOD_GlcNHglycan	108	111	PF01048	0.605
MOD_GlcNHglycan	409	412	PF01048	0.701
MOD_GlcNHglycan	464	468	PF01048	0.585
MOD_GlcNHglycan	476	479	PF01048	0.449
MOD_GlcNHglycan	497	500	PF01048	0.584
MOD_GlcNHglycan	513	516	PF01048	0.561
MOD_GlcNHglycan	596	599	PF01048	0.464
MOD_GlcNHglycan	628	631	PF01048	0.568
MOD_GlcNHglycan	63	66	PF01048	0.616
MOD_GlcNHglycan	729	732	PF01048	0.524
MOD_GlcNHglycan	794	797	PF01048	0.548
MOD_GSK3_1	20	27	PF00069	0.683
MOD_GSK3_1	246	253	PF00069	0.658
MOD_GSK3_1	28	35	PF00069	0.591
MOD_GSK3_1	282	289	PF00069	0.731
MOD_GSK3_1	291	298	PF00069	0.673
MOD_GSK3_1	303	310	PF00069	0.642
MOD_GSK3_1	322	329	PF00069	0.629
MOD_GSK3_1	337	344	PF00069	0.491
MOD_GSK3_1	359	366	PF00069	0.629
MOD_GSK3_1	38	45	PF00069	0.428
MOD_GSK3_1	46	53	PF00069	0.383
MOD_GSK3_1	495	502	PF00069	0.719
MOD_GSK3_1	505	512	PF00069	0.582
MOD_GSK3_1	520	527	PF00069	0.411
MOD_GSK3_1	550	557	PF00069	0.595
MOD_GSK3_1	561	568	PF00069	0.476
MOD_GSK3_1	57	64	PF00069	0.490
MOD_GSK3_1	622	629	PF00069	0.637
MOD_GSK3_1	676	683	PF00069	0.502
MOD_GSK3_1	714	721	PF00069	0.515
MOD_GSK3_1	735	742	PF00069	0.607
MOD_GSK3_1	743	750	PF00069	0.570
MOD_GSK3_1	804	811	PF00069	0.513
MOD_N-GLC_1	276	281	PF02516	0.545
MOD_NEK2_1	106	111	PF00069	0.489
MOD_NEK2_1	142	147	PF00069	0.485
MOD_NEK2_1	200	205	PF00069	0.453
MOD_NEK2_1	210	215	PF00069	0.496
MOD_NEK2_1	228	233	PF00069	0.396
MOD_NEK2_1	234	239	PF00069	0.566
MOD_NEK2_1	286	291	PF00069	0.758
MOD_NEK2_1	295	300	PF00069	0.590
MOD_NEK2_1	302	307	PF00069	0.496
MOD_NEK2_1	314	319	PF00069	0.617
MOD_NEK2_1	341	346	PF00069	0.612
MOD_NEK2_1	354	359	PF00069	0.496
MOD_NEK2_1	36	41	PF00069	0.639
MOD_NEK2_1	407	412	PF00069	0.463
MOD_NEK2_1	462	467	PF00069	0.509
MOD_NEK2_1	509	514	PF00069	0.646
MOD_NEK2_1	520	525	PF00069	0.402
MOD_NEK2_1	57	62	PF00069	0.492
MOD_NEK2_1	706	711	PF00069	0.481
MOD_NEK2_1	712	717	PF00069	0.536
MOD_NEK2_1	718	723	PF00069	0.480
MOD_NEK2_1	735	740	PF00069	0.483
MOD_NEK2_1	753	758	PF00069	0.413
MOD_NEK2_1	791	796	PF00069	0.622
MOD_NEK2_2	337	342	PF00069	0.555
MOD_PIKK_1	152	158	PF00454	0.502
MOD_PIKK_1	193	199	PF00454	0.616
MOD_PIKK_1	234	240	PF00454	0.587
MOD_PIKK_1	296	302	PF00454	0.618
MOD_PIKK_1	354	360	PF00454	0.653
MOD_PIKK_1	55	61	PF00454	0.574
MOD_PIKK_1	550	556	PF00454	0.489
MOD_PIKK_1	846	852	PF00454	0.764
MOD_PKA_2	106	112	PF00069	0.490
MOD_PKA_2	11	17	PF00069	0.545
MOD_PKA_2	18	24	PF00069	0.527
MOD_PKA_2	216	222	PF00069	0.539
MOD_PKA_2	249	255	PF00069	0.637
MOD_PKA_2	277	283	PF00069	0.642
MOD_PKA_2	341	347	PF00069	0.555
MOD_PKA_2	359	365	PF00069	0.708
MOD_PKA_2	433	439	PF00069	0.561
MOD_PKA_2	530	536	PF00069	0.551
MOD_PKA_2	626	632	PF00069	0.538
MOD_PKA_2	656	662	PF00069	0.502
MOD_PKA_2	692	698	PF00069	0.532
MOD_PKA_2	792	798	PF00069	0.608
MOD_Plk_1	253	259	PF00069	0.777
MOD_Plk_1	310	316	PF00069	0.575
MOD_Plk_1	387	393	PF00069	0.583
MOD_Plk_1	78	84	PF00069	0.486
MOD_Plk_1	812	818	PF00069	0.553
MOD_Plk_2-3	254	260	PF00069	0.784
MOD_Plk_2-3	326	332	PF00069	0.431
MOD_Plk_4	1	7	PF00069	0.611
MOD_Plk_4	180	186	PF00069	0.543
MOD_Plk_4	219	225	PF00069	0.537
MOD_Plk_4	229	235	PF00069	0.441
MOD_Plk_4	310	316	PF00069	0.679
MOD_Plk_4	32	38	PF00069	0.565
MOD_Plk_4	387	393	PF00069	0.583
MOD_Plk_4	450	456	PF00069	0.643
MOD_Plk_4	714	720	PF00069	0.564
MOD_Plk_4	749	755	PF00069	0.510
MOD_Plk_4	804	810	PF00069	0.469
MOD_ProDKin_1	28	34	PF00069	0.688
MOD_ProDKin_1	288	294	PF00069	0.686
MOD_ProDKin_1	412	418	PF00069	0.461
MOD_ProDKin_1	492	498	PF00069	0.566
MOD_ProDKin_1	561	567	PF00069	0.666
MOD_ProDKin_1	579	585	PF00069	0.334
MOD_ProDKin_1	676	682	PF00069	0.317
MOD_ProDKin_1	814	820	PF00069	0.507
MOD_ProDKin_1	833	839	PF00069	0.511
TRG_AP2beta_CARGO_1	701	711	PF09066	0.578
TRG_DiLeu_BaEn_1	330	335	PF01217	0.707
TRG_DiLeu_BaEn_1	388	393	PF01217	0.577
TRG_DiLeu_BaLyEn_6	591	596	PF01217	0.459
TRG_DiLeu_BaLyEn_6	665	670	PF01217	0.417
TRG_ENDOCYTIC_2	666	669	PF00928	0.558
TRG_ER_diArg_1	137	140	PF00400	0.509
TRG_ER_diArg_1	274	276	PF00400	0.760
TRG_ER_diArg_1	536	539	PF00400	0.308
TRG_ER_diArg_1	655	658	PF00400	0.528
TRG_ER_diArg_1	710	712	PF00400	0.520
TRG_ER_diArg_1	843	845	PF00400	0.493
TRG_NLS_MonoExtC_3	393	398	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	668	672	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.251
TRG_Pf-PMV_PEXEL_1	710	714	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK8	Leptomonas seymouri	47%	99%
A0A3Q8IBG3	Leishmania donovani	87%	100%
A4HYL1	Leishmania infantum	87%	100%
E9AI74	Leishmania braziliensis	73%	100%
Q4QD24	Leishmania major	87%	100%