Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUF8_LEIMU

TriTrypDb:

LmxM.20.0180

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.751
CLV_C14_Caspase3-7	390	394	PF00656	0.453
CLV_C14_Caspase3-7	645	649	PF00656	0.502
CLV_NRD_NRD_1	209	211	PF00675	0.730
CLV_NRD_NRD_1	35	37	PF00675	0.599
CLV_NRD_NRD_1	357	359	PF00675	0.667
CLV_NRD_NRD_1	376	378	PF00675	0.726
CLV_NRD_NRD_1	49	51	PF00675	0.460
CLV_NRD_NRD_1	492	494	PF00675	0.580
CLV_NRD_NRD_1	503	505	PF00675	0.498
CLV_NRD_NRD_1	731	733	PF00675	0.487
CLV_PCSK_FUR_1	210	214	PF00082	0.581
CLV_PCSK_KEX2_1	209	211	PF00082	0.730
CLV_PCSK_KEX2_1	212	214	PF00082	0.676
CLV_PCSK_KEX2_1	322	324	PF00082	0.648
CLV_PCSK_KEX2_1	35	37	PF00082	0.580
CLV_PCSK_KEX2_1	492	494	PF00082	0.582
CLV_PCSK_KEX2_1	503	505	PF00082	0.406
CLV_PCSK_KEX2_1	545	547	PF00082	0.580
CLV_PCSK_KEX2_1	731	733	PF00082	0.487
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.489
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.648
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.497
CLV_PCSK_SKI1_1	319	323	PF00082	0.766
CLV_PCSK_SKI1_1	371	375	PF00082	0.787
CLV_PCSK_SKI1_1	493	497	PF00082	0.489
CLV_PCSK_SKI1_1	504	508	PF00082	0.463
CLV_PCSK_SKI1_1	534	538	PF00082	0.439
CLV_PCSK_SKI1_1	768	772	PF00082	0.396
CLV_Separin_Metazoa	32	36	PF03568	0.563
DEG_APCC_DBOX_1	133	141	PF00400	0.527
DEG_SCF_FBW7_1	298	305	PF00400	0.654
DEG_SPOP_SBC_1	309	313	PF00917	0.538
DOC_ANK_TNKS_1	49	56	PF00023	0.376
DOC_CKS1_1	299	304	PF01111	0.657
DOC_CKS1_1	725	730	PF01111	0.655
DOC_CYCLIN_RxL_1	763	774	PF00134	0.313
DOC_MAPK_gen_1	481	489	PF00069	0.453
DOC_MAPK_gen_1	507	516	PF00069	0.382
DOC_MAPK_MEF2A_6	567	574	PF00069	0.402
DOC_PP2B_LxvP_1	570	573	PF13499	0.500
DOC_USP7_MATH_1	114	118	PF00917	0.800
DOC_USP7_MATH_1	122	126	PF00917	0.651
DOC_USP7_MATH_1	183	187	PF00917	0.592
DOC_USP7_MATH_1	25	29	PF00917	0.461
DOC_USP7_MATH_1	292	296	PF00917	0.726
DOC_USP7_MATH_1	302	306	PF00917	0.742
DOC_USP7_MATH_1	348	352	PF00917	0.621
DOC_USP7_MATH_1	464	468	PF00917	0.529
DOC_USP7_MATH_1	549	553	PF00917	0.516
DOC_USP7_MATH_1	627	631	PF00917	0.570
DOC_USP7_MATH_1	63	67	PF00917	0.734
DOC_USP7_MATH_1	662	666	PF00917	0.677
DOC_USP7_UBL2_3	776	780	PF12436	0.592
DOC_WW_Pin1_4	112	117	PF00397	0.763
DOC_WW_Pin1_4	194	199	PF00397	0.621
DOC_WW_Pin1_4	273	278	PF00397	0.699
DOC_WW_Pin1_4	287	292	PF00397	0.771
DOC_WW_Pin1_4	298	303	PF00397	0.727
DOC_WW_Pin1_4	3	8	PF00397	0.467
DOC_WW_Pin1_4	442	447	PF00397	0.648
DOC_WW_Pin1_4	587	592	PF00397	0.370
DOC_WW_Pin1_4	603	608	PF00397	0.446
DOC_WW_Pin1_4	631	636	PF00397	0.636
DOC_WW_Pin1_4	724	729	PF00397	0.663
LIG_14-3-3_CanoR_1	148	156	PF00244	0.557
LIG_14-3-3_CanoR_1	363	369	PF00244	0.731
LIG_14-3-3_CanoR_1	427	431	PF00244	0.601
LIG_14-3-3_CanoR_1	484	490	PF00244	0.591
LIG_14-3-3_CanoR_1	629	635	PF00244	0.413
LIG_14-3-3_CanoR_1	641	651	PF00244	0.504
LIG_14-3-3_CanoR_1	653	661	PF00244	0.487
LIG_14-3-3_CanoR_1	680	686	PF00244	0.636
LIG_Actin_WH2_2	133	150	PF00022	0.548
LIG_AP2alpha_1	410	414	PF02296	0.588
LIG_BRCT_BRCA1_1	526	530	PF00533	0.531
LIG_Clathr_ClatBox_1	770	774	PF01394	0.555
LIG_eIF4E_1	765	771	PF01652	0.488
LIG_FHA_1	133	139	PF00498	0.535
LIG_FHA_1	185	191	PF00498	0.670
LIG_FHA_1	219	225	PF00498	0.436
LIG_FHA_1	382	388	PF00498	0.643
LIG_FHA_1	496	502	PF00498	0.583
LIG_FHA_1	604	610	PF00498	0.589
LIG_FHA_1	619	625	PF00498	0.398
LIG_FHA_1	702	708	PF00498	0.472
LIG_FHA_1	756	762	PF00498	0.507
LIG_FHA_2	121	127	PF00498	0.760
LIG_FHA_2	311	317	PF00498	0.760
LIG_FHA_2	407	413	PF00498	0.415
LIG_FHA_2	643	649	PF00498	0.537
LIG_GBD_Chelix_1	432	440	PF00786	0.577
LIG_IRF3_LxIS_1	304	311	PF10401	0.530
LIG_LIR_Apic_2	81	86	PF02991	0.809
LIG_LIR_Gen_1	409	417	PF02991	0.417
LIG_LIR_Nem_3	17	22	PF02991	0.445
LIG_LIR_Nem_3	407	413	PF02991	0.441
LIG_Pex14_2	406	410	PF04695	0.590
LIG_Pex14_2	736	740	PF04695	0.441
LIG_PTAP_UEV_1	303	308	PF05743	0.681
LIG_REV1ctd_RIR_1	411	419	PF16727	0.607
LIG_SH2_CRK	144	148	PF00017	0.569
LIG_SH2_NCK_1	83	87	PF00017	0.507
LIG_SH2_SRC	22	25	PF00017	0.452
LIG_SH2_STAP1	228	232	PF00017	0.641
LIG_SH2_STAT3	685	688	PF00017	0.560
LIG_SH2_STAT5	166	169	PF00017	0.602
LIG_SH2_STAT5	246	249	PF00017	0.710
LIG_SH2_STAT5	287	290	PF00017	0.654
LIG_SH2_STAT5	562	565	PF00017	0.334
LIG_SH3_3	1	7	PF00018	0.594
LIG_SH3_3	113	119	PF00018	0.707
LIG_SH3_3	187	193	PF00018	0.556
LIG_SH3_3	301	307	PF00018	0.739
LIG_SH3_3	325	331	PF00018	0.750
LIG_SH3_3	609	615	PF00018	0.571
LIG_SH3_3	649	655	PF00018	0.555
LIG_SH3_3	722	728	PF00018	0.683
LIG_SH3_3	85	91	PF00018	0.716
LIG_SUMO_SIM_anti_2	264	273	PF11976	0.528
LIG_SUMO_SIM_par_1	264	273	PF11976	0.748
LIG_SUMO_SIM_par_1	383	388	PF11976	0.510
LIG_SUMO_SIM_par_1	74	79	PF11976	0.630
LIG_TRAF2_1	186	189	PF00917	0.823
LIG_TRAF2_1	313	316	PF00917	0.755
LIG_UBA3_1	15	21	PF00899	0.602
LIG_WRC_WIRS_1	417	422	PF05994	0.552
MOD_CDC14_SPxK_1	445	448	PF00782	0.682
MOD_CDK_SPK_2	631	636	PF00069	0.650
MOD_CDK_SPxK_1	442	448	PF00069	0.657
MOD_CDK_SPxxK_3	724	731	PF00069	0.660
MOD_CK1_1	103	109	PF00069	0.643
MOD_CK1_1	227	233	PF00069	0.641
MOD_CK1_1	3	9	PF00069	0.645
MOD_CK1_1	311	317	PF00069	0.787
MOD_CK1_1	333	339	PF00069	0.668
MOD_CK1_1	367	373	PF00069	0.764
MOD_CK1_1	381	387	PF00069	0.657
MOD_CK1_1	395	401	PF00069	0.337
MOD_CK1_1	457	463	PF00069	0.674
MOD_CK1_1	485	491	PF00069	0.565
MOD_CK1_1	630	636	PF00069	0.475
MOD_CK1_1	642	648	PF00069	0.794
MOD_CK1_1	81	87	PF00069	0.741
MOD_CK2_1	120	126	PF00069	0.773
MOD_CK2_1	183	189	PF00069	0.696
MOD_CK2_1	194	200	PF00069	0.747
MOD_CK2_1	310	316	PF00069	0.765
MOD_CK2_1	457	463	PF00069	0.670
MOD_CK2_1	464	470	PF00069	0.443
MOD_CK2_1	55	61	PF00069	0.531
MOD_CK2_1	680	686	PF00069	0.639
MOD_CK2_1	79	85	PF00069	0.535
MOD_GlcNHglycan	213	216	PF01048	0.741
MOD_GlcNHglycan	304	307	PF01048	0.812
MOD_GlcNHglycan	332	335	PF01048	0.728
MOD_GlcNHglycan	364	367	PF01048	0.674
MOD_GlcNHglycan	380	383	PF01048	0.698
MOD_GlcNHglycan	466	469	PF01048	0.534
MOD_GlcNHglycan	526	529	PF01048	0.537
MOD_GlcNHglycan	551	554	PF01048	0.412
MOD_GlcNHglycan	57	60	PF01048	0.580
MOD_GlcNHglycan	616	619	PF01048	0.475
MOD_GlcNHglycan	625	628	PF01048	0.478
MOD_GlcNHglycan	70	73	PF01048	0.607
MOD_GSK3_1	128	135	PF00069	0.450
MOD_GSK3_1	184	191	PF00069	0.814
MOD_GSK3_1	265	272	PF00069	0.748
MOD_GSK3_1	298	305	PF00069	0.683
MOD_GSK3_1	310	317	PF00069	0.640
MOD_GSK3_1	330	337	PF00069	0.671
MOD_GSK3_1	381	388	PF00069	0.503
MOD_GSK3_1	392	399	PF00069	0.532
MOD_GSK3_1	614	621	PF00069	0.479
MOD_GSK3_1	623	630	PF00069	0.451
MOD_GSK3_1	642	649	PF00069	0.481
MOD_GSK3_1	74	81	PF00069	0.780
MOD_GSK3_1	90	97	PF00069	0.590
MOD_N-GLC_1	741	746	PF02516	0.448
MOD_N-GLC_1	94	99	PF02516	0.749
MOD_NEK2_1	147	152	PF00069	0.606
MOD_NEK2_1	396	401	PF00069	0.547
MOD_NEK2_1	406	411	PF00069	0.388
MOD_NEK2_1	497	502	PF00069	0.522
MOD_NEK2_1	508	513	PF00069	0.453
MOD_NEK2_1	600	605	PF00069	0.588
MOD_NEK2_1	78	83	PF00069	0.763
MOD_NEK2_2	562	567	PF00069	0.627
MOD_PIKK_1	147	153	PF00454	0.566
MOD_PIKK_1	311	317	PF00454	0.822
MOD_PIKK_1	337	343	PF00454	0.676
MOD_PIKK_1	482	488	PF00454	0.557
MOD_PIKK_1	619	625	PF00454	0.515
MOD_PIKK_1	654	660	PF00454	0.776
MOD_PK_1	431	437	PF00069	0.529
MOD_PKA_2	103	109	PF00069	0.513
MOD_PKA_2	147	153	PF00069	0.566
MOD_PKA_2	208	214	PF00069	0.724
MOD_PKA_2	362	368	PF00069	0.785
MOD_PKA_2	400	406	PF00069	0.517
MOD_PKA_2	426	432	PF00069	0.602
MOD_PKA_2	640	646	PF00069	0.597
MOD_PKA_2	679	685	PF00069	0.580
MOD_Plk_1	128	134	PF00069	0.453
MOD_Plk_1	188	194	PF00069	0.812
MOD_Plk_1	217	223	PF00069	0.391
MOD_Plk_1	392	398	PF00069	0.594
MOD_Plk_1	406	412	PF00069	0.396
MOD_Plk_1	454	460	PF00069	0.631
MOD_Plk_1	647	653	PF00069	0.497
MOD_Plk_1	693	699	PF00069	0.517
MOD_Plk_1	755	761	PF00069	0.517
MOD_Plk_1	94	100	PF00069	0.743
MOD_Plk_2-3	120	126	PF00069	0.587
MOD_Plk_2-3	184	190	PF00069	0.765
MOD_Plk_2-3	79	85	PF00069	0.535
MOD_Plk_4	103	109	PF00069	0.615
MOD_Plk_4	262	268	PF00069	0.770
MOD_Plk_4	406	412	PF00069	0.565
MOD_Plk_4	431	437	PF00069	0.526
MOD_Plk_4	497	503	PF00069	0.560
MOD_Plk_4	647	653	PF00069	0.516
MOD_ProDKin_1	112	118	PF00069	0.763
MOD_ProDKin_1	194	200	PF00069	0.619
MOD_ProDKin_1	273	279	PF00069	0.702
MOD_ProDKin_1	287	293	PF00069	0.772
MOD_ProDKin_1	298	304	PF00069	0.721
MOD_ProDKin_1	3	9	PF00069	0.461
MOD_ProDKin_1	442	448	PF00069	0.657
MOD_ProDKin_1	587	593	PF00069	0.365
MOD_ProDKin_1	603	609	PF00069	0.443
MOD_ProDKin_1	631	637	PF00069	0.651
MOD_ProDKin_1	724	730	PF00069	0.655
MOD_SUMO_for_1	283	286	PF00179	0.718
MOD_SUMO_for_1	566	569	PF00179	0.609
TRG_DiLeu_BaEn_1	470	475	PF01217	0.467
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.530
TRG_DiLeu_BaLyEn_6	605	610	PF01217	0.637
TRG_ENDOCYTIC_2	144	147	PF00928	0.572
TRG_ENDOCYTIC_2	411	414	PF00928	0.595
TRG_ER_diArg_1	133	136	PF00400	0.543
TRG_ER_diArg_1	34	36	PF00400	0.571
TRG_ER_diArg_1	492	494	PF00400	0.583
TRG_ER_diArg_1	502	504	PF00400	0.453
TRG_ER_diArg_1	757	760	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	245	250	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	472	477	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	481	486	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBL2	Leishmania donovani	74%	91%
A0A422MW33	Trypanosoma rangeli	23%	100%
A4HYK9	Leishmania infantum	74%	91%
E9AI72	Leishmania braziliensis	46%	100%
Q4QD26	Leishmania major	72%	100%