Leucine-rich repeat-containing protein 75B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat-containing protein

Species:

Leishmania mexicana

UniProt:

E9AUF7_LEIMU

TriTrypDb:

LmxM.20.0170

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

E9AUF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUF7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.439
CLV_NRD_NRD_1	324	326	PF00675	0.501
CLV_NRD_NRD_1	36	38	PF00675	0.546
CLV_PCSK_KEX2_1	276	278	PF00082	0.481
CLV_PCSK_KEX2_1	324	326	PF00082	0.501
CLV_PCSK_KEX2_1	36	38	PF00082	0.546
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.520
CLV_PCSK_SKI1_1	194	198	PF00082	0.389
CLV_PCSK_SKI1_1	276	280	PF00082	0.381
CLV_Separin_Metazoa	220	224	PF03568	0.493
DEG_Nend_UBRbox_2	1	3	PF02207	0.449
DEG_SCF_FBW7_1	358	365	PF00400	0.522
DEG_SCF_FBW7_1	38	45	PF00400	0.503
DEG_SPOP_SBC_1	330	334	PF00917	0.399
DOC_CYCLIN_RxL_1	194	202	PF00134	0.304
DOC_CYCLIN_yCln2_LP_2	363	369	PF00134	0.597
DOC_MAPK_gen_1	141	150	PF00069	0.450
DOC_MAPK_HePTP_8	138	150	PF00069	0.384
DOC_MAPK_MEF2A_6	141	150	PF00069	0.387
DOC_USP7_MATH_1	42	46	PF00917	0.454
DOC_USP7_UBL2_3	237	241	PF12436	0.468
DOC_WW_Pin1_4	180	185	PF00397	0.473
DOC_WW_Pin1_4	23	28	PF00397	0.313
DOC_WW_Pin1_4	243	248	PF00397	0.329
DOC_WW_Pin1_4	358	363	PF00397	0.506
DOC_WW_Pin1_4	38	43	PF00397	0.434
LIG_14-3-3_CanoR_1	325	335	PF00244	0.572
LIG_14-3-3_CanoR_1	6	12	PF00244	0.502
LIG_14-3-3_CanoR_1	87	92	PF00244	0.479
LIG_APCC_ABBA_1	231	236	PF00400	0.474
LIG_BRCT_BRCA1_1	89	93	PF00533	0.451
LIG_CaM_IQ_9	160	176	PF13499	0.242
LIG_Clathr_ClatBox_1	259	263	PF01394	0.476
LIG_deltaCOP1_diTrp_1	336	340	PF00928	0.321
LIG_EH1_1	255	263	PF00400	0.463
LIG_FHA_1	2	8	PF00498	0.495
LIG_FHA_1	226	232	PF00498	0.470
LIG_FHA_1	330	336	PF00498	0.381
LIG_FHA_2	264	270	PF00498	0.440
LIG_FHA_2	331	337	PF00498	0.513
LIG_FHA_2	59	65	PF00498	0.443
LIG_LIR_Gen_1	215	224	PF02991	0.455
LIG_LIR_Gen_1	236	247	PF02991	0.445
LIG_LIR_Gen_1	254	262	PF02991	0.356
LIG_LIR_Gen_1	29	38	PF02991	0.327
LIG_LIR_Gen_1	334	345	PF02991	0.325
LIG_LIR_Nem_3	101	107	PF02991	0.430
LIG_LIR_Nem_3	215	221	PF02991	0.453
LIG_LIR_Nem_3	236	242	PF02991	0.436
LIG_LIR_Nem_3	254	259	PF02991	0.331
LIG_LIR_Nem_3	29	34	PF02991	0.293
LIG_LIR_Nem_3	334	340	PF02991	0.317
LIG_NRBOX	256	262	PF00104	0.453
LIG_SH2_CRK	31	35	PF00017	0.406
LIG_SH2_NCK_1	13	17	PF00017	0.367
LIG_SH2_PTP2	147	150	PF00017	0.376
LIG_SH2_STAT3	105	108	PF00017	0.363
LIG_SH2_STAT5	105	108	PF00017	0.300
LIG_SH2_STAT5	126	129	PF00017	0.468
LIG_SH2_STAT5	147	150	PF00017	0.470
LIG_SH2_STAT5	296	299	PF00017	0.455
LIG_SH2_STAT5	342	345	PF00017	0.375
LIG_SH2_STAT5	69	72	PF00017	0.350
LIG_SH2_STAT5	97	100	PF00017	0.324
LIG_SH3_1	182	188	PF00018	0.561
LIG_SH3_3	182	188	PF00018	0.524
LIG_SH3_3	283	289	PF00018	0.524
LIG_SH3_3	340	346	PF00018	0.476
LIG_SH3_3	45	51	PF00018	0.395
LIG_SUMO_SIM_par_1	257	263	PF11976	0.426
LIG_TYR_ITIM	145	150	PF00017	0.370
MOD_CDK_SPK_2	23	28	PF00069	0.327
MOD_CK1_1	153	159	PF00069	0.432
MOD_CK1_1	225	231	PF00069	0.517
MOD_CK1_1	312	318	PF00069	0.550
MOD_CK1_1	99	105	PF00069	0.466
MOD_CK2_1	119	125	PF00069	0.357
MOD_CK2_1	213	219	PF00069	0.495
MOD_CK2_1	23	29	PF00069	0.301
MOD_CK2_1	263	269	PF00069	0.443
MOD_CK2_1	362	368	PF00069	0.647
MOD_GlcNHglycan	120	124	PF01048	0.478
MOD_GlcNHglycan	129	132	PF01048	0.490
MOD_GlcNHglycan	152	155	PF01048	0.521
MOD_GlcNHglycan	209	212	PF01048	0.410
MOD_GlcNHglycan	215	218	PF01048	0.462
MOD_GlcNHglycan	224	227	PF01048	0.395
MOD_GlcNHglycan	44	47	PF01048	0.495
MOD_GSK3_1	150	157	PF00069	0.420
MOD_GSK3_1	170	177	PF00069	0.401
MOD_GSK3_1	209	216	PF00069	0.389
MOD_GSK3_1	263	270	PF00069	0.445
MOD_GSK3_1	326	333	PF00069	0.525
MOD_GSK3_1	358	365	PF00069	0.651
MOD_GSK3_1	38	45	PF00069	0.503
MOD_GSK3_1	59	66	PF00069	0.441
MOD_N-GLC_1	99	104	PF02516	0.336
MOD_NEK2_1	106	111	PF00069	0.352
MOD_NEK2_1	150	155	PF00069	0.439
MOD_NEK2_1	199	204	PF00069	0.432
MOD_NEK2_1	213	218	PF00069	0.470
MOD_NEK2_1	222	227	PF00069	0.500
MOD_NEK2_1	63	68	PF00069	0.394
MOD_PIKK_1	69	75	PF00454	0.471
MOD_PKA_2	150	156	PF00069	0.402
MOD_PKA_2	222	228	PF00069	0.520
MOD_PKA_2	312	318	PF00069	0.564
MOD_Plk_1	267	273	PF00069	0.425
MOD_Plk_1	317	323	PF00069	0.454
MOD_Plk_1	330	336	PF00069	0.296
MOD_Plk_1	99	105	PF00069	0.334
MOD_Plk_2-3	263	269	PF00069	0.534
MOD_Plk_2-3	331	337	PF00069	0.459
MOD_Plk_4	209	215	PF00069	0.453
MOD_Plk_4	87	93	PF00069	0.429
MOD_Plk_4	99	105	PF00069	0.352
MOD_ProDKin_1	180	186	PF00069	0.480
MOD_ProDKin_1	23	29	PF00069	0.316
MOD_ProDKin_1	243	249	PF00069	0.332
MOD_ProDKin_1	358	364	PF00069	0.509
MOD_ProDKin_1	38	44	PF00069	0.436
TRG_DiLeu_BaEn_1	3	8	PF01217	0.371
TRG_DiLeu_LyEn_5	3	8	PF01217	0.371
TRG_ENDOCYTIC_2	147	150	PF00928	0.376
TRG_ENDOCYTIC_2	31	34	PF00928	0.249
TRG_ER_diArg_1	324	326	PF00400	0.521
TRG_ER_diArg_1	36	39	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDI3	Leptomonas seymouri	61%	93%
A0A0S4JE69	Bodo saltans	35%	98%
A0A1X0NWJ3	Trypanosomatidae	43%	98%
A0A3S5H780	Leishmania donovani	94%	100%
A0A422MW34	Trypanosoma rangeli	41%	99%
A0A422NVZ8	Trypanosoma rangeli	28%	74%
A4HYK8	Leishmania infantum	93%	100%
C9ZHV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	98%
E9AI71	Leishmania braziliensis	80%	100%
Q4QD27	Leishmania major	93%	100%
V5BQX0	Trypanosoma cruzi	42%	88%