Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

wd40 repeat domain-containing protein

Species:

Leishmania mexicana

UniProt:

E9AUF6_LEIMU

TriTrypDb:

LmxM.20.0160

Length:

805

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	448	452	PF00656	0.580
CLV_C14_Caspase3-7	479	483	PF00656	0.576
CLV_C14_Caspase3-7	579	583	PF00656	0.632
CLV_C14_Caspase3-7	601	605	PF00656	0.517
CLV_NRD_NRD_1	122	124	PF00675	0.421
CLV_NRD_NRD_1	442	444	PF00675	0.459
CLV_NRD_NRD_1	492	494	PF00675	0.560
CLV_NRD_NRD_1	499	501	PF00675	0.500
CLV_NRD_NRD_1	580	582	PF00675	0.698
CLV_PCSK_KEX2_1	122	124	PF00082	0.421
CLV_PCSK_KEX2_1	442	444	PF00082	0.459
CLV_PCSK_KEX2_1	492	494	PF00082	0.519
CLV_PCSK_KEX2_1	499	501	PF00082	0.496
CLV_PCSK_KEX2_1	580	582	PF00082	0.613
CLV_PCSK_KEX2_1	655	657	PF00082	0.453
CLV_PCSK_KEX2_1	662	664	PF00082	0.487
CLV_PCSK_KEX2_1	784	786	PF00082	0.557
CLV_PCSK_PC1ET2_1	655	657	PF00082	0.503
CLV_PCSK_PC1ET2_1	662	664	PF00082	0.560
CLV_PCSK_PC1ET2_1	784	786	PF00082	0.527
CLV_PCSK_PC7_1	495	501	PF00082	0.467
CLV_PCSK_SKI1_1	259	263	PF00082	0.454
CLV_PCSK_SKI1_1	381	385	PF00082	0.471
CLV_PCSK_SKI1_1	442	446	PF00082	0.604
CLV_PCSK_SKI1_1	478	482	PF00082	0.545
CLV_PCSK_SKI1_1	617	621	PF00082	0.596
CLV_PCSK_SKI1_1	656	660	PF00082	0.505
CLV_PCSK_SKI1_1	721	725	PF00082	0.493
DEG_APCC_DBOX_1	121	129	PF00400	0.403
DEG_APCC_DBOX_1	130	138	PF00400	0.332
DEG_APCC_DBOX_1	380	388	PF00400	0.461
DEG_APCC_DBOX_1	477	485	PF00400	0.532
DEG_Nend_Nbox_1	1	3	PF02207	0.534
DOC_ANK_TNKS_1	499	506	PF00023	0.561
DOC_CYCLIN_RxL_1	439	448	PF00134	0.599
DOC_CYCLIN_RxL_1	653	660	PF00134	0.365
DOC_MAPK_FxFP_2	363	366	PF00069	0.417
DOC_MAPK_gen_1	564	572	PF00069	0.571
DOC_MAPK_gen_1	662	669	PF00069	0.401
DOC_MAPK_gen_1	784	793	PF00069	0.454
DOC_MAPK_MEF2A_6	285	292	PF00069	0.439
DOC_MAPK_MEF2A_6	60	68	PF00069	0.440
DOC_MAPK_RevD_3	565	581	PF00069	0.490
DOC_PP4_FxxP_1	363	366	PF00568	0.417
DOC_USP7_MATH_1	118	122	PF00917	0.472
DOC_USP7_MATH_1	343	347	PF00917	0.506
DOC_USP7_MATH_1	503	507	PF00917	0.586
DOC_USP7_MATH_1	542	546	PF00917	0.613
DOC_USP7_MATH_1	575	579	PF00917	0.543
DOC_USP7_MATH_1	706	710	PF00917	0.520
DOC_WW_Pin1_4	144	149	PF00397	0.590
DOC_WW_Pin1_4	307	312	PF00397	0.609
DOC_WW_Pin1_4	77	82	PF00397	0.525
LIG_14-3-3_CanoR_1	104	109	PF00244	0.431
LIG_14-3-3_CanoR_1	321	330	PF00244	0.449
LIG_14-3-3_CanoR_1	707	711	PF00244	0.636
LIG_14-3-3_CanoR_1	726	734	PF00244	0.396
LIG_14-3-3_CanoR_1	757	767	PF00244	0.463
LIG_Actin_WH2_2	480	497	PF00022	0.488
LIG_BIR_III_4	218	222	PF00653	0.493
LIG_BIR_III_4	470	474	PF00653	0.521
LIG_BRCT_BRCA1_1	361	365	PF00533	0.389
LIG_BRCT_BRCA1_1	672	676	PF00533	0.549
LIG_Clathr_ClatBox_1	222	226	PF01394	0.478
LIG_DLG_GKlike_1	104	111	PF00625	0.338
LIG_FAT_LD_1	533	541	PF03623	0.572
LIG_FHA_1	187	193	PF00498	0.399
LIG_FHA_1	245	251	PF00498	0.440
LIG_FHA_1	277	283	PF00498	0.406
LIG_FHA_1	292	298	PF00498	0.414
LIG_FHA_1	322	328	PF00498	0.502
LIG_FHA_1	354	360	PF00498	0.353
LIG_FHA_1	398	404	PF00498	0.559
LIG_FHA_1	507	513	PF00498	0.416
LIG_FHA_1	638	644	PF00498	0.429
LIG_FHA_2	241	247	PF00498	0.410
LIG_FHA_2	34	40	PF00498	0.457
LIG_FHA_2	411	417	PF00498	0.744
LIG_FHA_2	519	525	PF00498	0.627
LIG_FHA_2	549	555	PF00498	0.567
LIG_FHA_2	728	734	PF00498	0.572
LIG_FHA_2	738	744	PF00498	0.404
LIG_FHA_2	98	104	PF00498	0.601
LIG_LIR_Apic_2	273	278	PF02991	0.440
LIG_LIR_Apic_2	362	366	PF02991	0.411
LIG_LIR_Apic_2	42	48	PF02991	0.577
LIG_LIR_Gen_1	133	141	PF02991	0.457
LIG_LIR_Gen_1	185	196	PF02991	0.401
LIG_LIR_Gen_1	201	211	PF02991	0.538
LIG_LIR_Gen_1	80	91	PF02991	0.446
LIG_LIR_Nem_3	103	109	PF02991	0.507
LIG_LIR_Nem_3	185	191	PF02991	0.403
LIG_LIR_Nem_3	201	206	PF02991	0.531
LIG_LIR_Nem_3	251	255	PF02991	0.477
LIG_LIR_Nem_3	262	268	PF02991	0.426
LIG_LIR_Nem_3	28	33	PF02991	0.507
LIG_LIR_Nem_3	286	292	PF02991	0.402
LIG_LIR_Nem_3	80	86	PF02991	0.438
LIG_NRBOX	440	446	PF00104	0.567
LIG_PALB2_WD40_1	788	796	PF16756	0.452
LIG_Pex14_2	30	34	PF04695	0.565
LIG_SH2_CRK	265	269	PF00017	0.469
LIG_SH2_CRK	275	279	PF00017	0.321
LIG_SH2_CRK	83	87	PF00017	0.415
LIG_SH2_NCK_1	83	87	PF00017	0.463
LIG_SH2_SRC	157	160	PF00017	0.488
LIG_SH2_STAP1	26	30	PF00017	0.478
LIG_SH2_STAP1	83	87	PF00017	0.463
LIG_SH2_STAT3	523	526	PF00017	0.532
LIG_SH2_STAT5	519	522	PF00017	0.457
LIG_SH3_3	11	17	PF00018	0.491
LIG_SH3_3	134	140	PF00018	0.473
LIG_SUMO_SIM_anti_2	235	243	PF11976	0.345
LIG_SUMO_SIM_anti_2	557	564	PF11976	0.580
LIG_SUMO_SIM_par_1	193	199	PF11976	0.344
LIG_SUMO_SIM_par_1	239	247	PF11976	0.355
LIG_SUMO_SIM_par_1	594	601	PF11976	0.425
LIG_TRAF2_1	156	159	PF00917	0.479
LIG_TRAF2_1	413	416	PF00917	0.667
LIG_TRAF2_1	712	715	PF00917	0.482
LIG_UBA3_1	2	11	PF00899	0.514
LIG_WRC_WIRS_1	749	754	PF05994	0.560
MOD_CDC14_SPxK_1	147	150	PF00782	0.446
MOD_CDK_SPxK_1	144	150	PF00069	0.448
MOD_CK1_1	107	113	PF00069	0.454
MOD_CK1_1	205	211	PF00069	0.490
MOD_CK1_1	325	331	PF00069	0.451
MOD_CK1_1	334	340	PF00069	0.513
MOD_CK1_1	506	512	PF00069	0.422
MOD_CK1_1	545	551	PF00069	0.599
MOD_CK1_1	632	638	PF00069	0.527
MOD_CK1_1	657	663	PF00069	0.426
MOD_CK1_1	670	676	PF00069	0.549
MOD_CK1_1	77	83	PF00069	0.554
MOD_CK2_1	195	201	PF00069	0.501
MOD_CK2_1	410	416	PF00069	0.754
MOD_CK2_1	511	517	PF00069	0.571
MOD_CK2_1	518	524	PF00069	0.559
MOD_CK2_1	548	554	PF00069	0.513
MOD_CK2_1	671	677	PF00069	0.503
MOD_CK2_1	756	762	PF00069	0.583
MOD_GlcNHglycan	198	201	PF01048	0.595
MOD_GlcNHglycan	207	210	PF01048	0.618
MOD_GlcNHglycan	256	259	PF01048	0.630
MOD_GlcNHglycan	315	318	PF01048	0.483
MOD_GlcNHglycan	345	348	PF01048	0.487
MOD_GlcNHglycan	367	370	PF01048	0.454
MOD_GlcNHglycan	470	474	PF01048	0.569
MOD_GlcNHglycan	691	695	PF01048	0.528
MOD_GlcNHglycan	743	748	PF01048	0.444
MOD_GSK3_1	126	133	PF00069	0.409
MOD_GSK3_1	240	247	PF00069	0.448
MOD_GSK3_1	321	328	PF00069	0.402
MOD_GSK3_1	334	341	PF00069	0.364
MOD_GSK3_1	388	395	PF00069	0.521
MOD_GSK3_1	397	404	PF00069	0.535
MOD_GSK3_1	406	413	PF00069	0.650
MOD_GSK3_1	433	440	PF00069	0.552
MOD_GSK3_1	541	548	PF00069	0.663
MOD_GSK3_1	64	71	PF00069	0.742
MOD_GSK3_1	667	674	PF00069	0.564
MOD_N-GLC_1	406	411	PF02516	0.610
MOD_N-GLC_2	142	144	PF02516	0.422
MOD_N-GLC_2	541	543	PF02516	0.396
MOD_NEK2_1	233	238	PF00069	0.450
MOD_NEK2_1	264	269	PF00069	0.494
MOD_NEK2_1	283	288	PF00069	0.251
MOD_NEK2_1	313	318	PF00069	0.549
MOD_NEK2_1	331	336	PF00069	0.390
MOD_NEK2_1	359	364	PF00069	0.430
MOD_NEK2_1	397	402	PF00069	0.529
MOD_NEK2_1	433	438	PF00069	0.541
MOD_NEK2_1	487	492	PF00069	0.509
MOD_NEK2_1	6	11	PF00069	0.465
MOD_NEK2_1	654	659	PF00069	0.639
MOD_NEK2_1	682	687	PF00069	0.475
MOD_NEK2_2	706	711	PF00069	0.489
MOD_NEK2_2	748	753	PF00069	0.504
MOD_OFUCOSY	543	549	PF10250	0.420
MOD_PIKK_1	283	289	PF00454	0.257
MOD_PIKK_1	397	403	PF00454	0.539
MOD_PIKK_1	406	412	PF00454	0.577
MOD_PIKK_1	6	12	PF00454	0.499
MOD_PIKK_1	632	638	PF00454	0.527
MOD_PIKK_1	682	688	PF00454	0.511
MOD_PIKK_1	727	733	PF00454	0.525
MOD_PKA_1	580	586	PF00069	0.646
MOD_PKA_2	130	136	PF00069	0.395
MOD_PKA_2	325	331	PF00069	0.448
MOD_PKA_2	527	533	PF00069	0.482
MOD_PKA_2	580	586	PF00069	0.681
MOD_PKA_2	706	712	PF00069	0.593
MOD_PKA_2	756	762	PF00069	0.434
MOD_PKB_1	412	420	PF00069	0.595
MOD_Plk_1	259	265	PF00069	0.461
MOD_Plk_1	545	551	PF00069	0.718
MOD_Plk_1	670	676	PF00069	0.507
MOD_Plk_1	778	784	PF00069	0.496
MOD_Plk_2-3	511	517	PF00069	0.567
MOD_Plk_2-3	671	677	PF00069	0.544
MOD_Plk_2-3	737	743	PF00069	0.506
MOD_Plk_4	104	110	PF00069	0.447
MOD_Plk_4	233	239	PF00069	0.462
MOD_Plk_4	359	365	PF00069	0.451
MOD_Plk_4	392	398	PF00069	0.539
MOD_Plk_4	511	517	PF00069	0.584
MOD_Plk_4	518	524	PF00069	0.634
MOD_Plk_4	671	677	PF00069	0.559
MOD_Plk_4	695	701	PF00069	0.518
MOD_Plk_4	737	743	PF00069	0.532
MOD_ProDKin_1	144	150	PF00069	0.592
MOD_ProDKin_1	307	313	PF00069	0.610
MOD_ProDKin_1	77	83	PF00069	0.517
MOD_SUMO_for_1	694	697	PF00179	0.411
MOD_SUMO_rev_2	614	621	PF00179	0.417
TRG_DiLeu_BaEn_1	532	537	PF01217	0.695
TRG_DiLeu_BaEn_1	558	563	PF01217	0.578
TRG_DiLeu_BaEn_4	558	564	PF01217	0.580
TRG_DiLeu_BaEn_4	614	620	PF01217	0.562
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.571
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.560
TRG_ENDOCYTIC_2	157	160	PF00928	0.488
TRG_ENDOCYTIC_2	265	268	PF00928	0.323
TRG_ENDOCYTIC_2	430	433	PF00928	0.538
TRG_ENDOCYTIC_2	83	86	PF00928	0.419
TRG_ER_diArg_1	13	16	PF00400	0.429
TRG_ER_diArg_1	441	443	PF00400	0.433
TRG_ER_diArg_1	491	493	PF00400	0.516
TRG_ER_diArg_1	499	501	PF00400	0.520
TRG_ER_diArg_1	563	566	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	443	448	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	617	622	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	726	731	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVC8	Leptomonas seymouri	40%	99%
A0A3Q8IKB9	Leishmania donovani	89%	100%
A0A422MW62	Trypanosoma rangeli	25%	100%
A4HBI4	Leishmania braziliensis	73%	100%
A4HYK7	Leishmania infantum	90%	100%
Q4QD28	Leishmania major	89%	100%