MORN repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol-4-phosphate 5-kinase related

Species:

Leishmania mexicana

UniProt:

E9AUF3_LEIMU

TriTrypDb:

LmxM.20.0130

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUF3

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.325
CLV_C14_Caspase3-7	190	194	PF00656	0.372
CLV_NRD_NRD_1	197	199	PF00675	0.431
CLV_NRD_NRD_1	3	5	PF00675	0.579
CLV_NRD_NRD_1	388	390	PF00675	0.619
CLV_PCSK_FUR_1	195	199	PF00082	0.321
CLV_PCSK_KEX2_1	197	199	PF00082	0.419
CLV_PCSK_KEX2_1	3	5	PF00082	0.579
CLV_PCSK_KEX2_1	388	390	PF00082	0.619
CLV_PCSK_PC7_1	384	390	PF00082	0.524
CLV_PCSK_SKI1_1	154	158	PF00082	0.315
CLV_PCSK_SKI1_1	35	39	PF00082	0.492
CLV_PCSK_SKI1_1	353	357	PF00082	0.563
CLV_PCSK_SKI1_1	407	411	PF00082	0.539
CLV_PCSK_SKI1_1	438	442	PF00082	0.605
DEG_Nend_Nbox_1	1	3	PF02207	0.512
DEG_SCF_FBW7_1	201	207	PF00400	0.396
DOC_ANK_TNKS_1	216	223	PF00023	0.281
DOC_CKS1_1	201	206	PF01111	0.398
DOC_PP1_RVXF_1	152	158	PF00149	0.281
DOC_PP1_RVXF_1	230	236	PF00149	0.382
DOC_PP1_RVXF_1	382	388	PF00149	0.697
DOC_PP4_FxxP_1	412	415	PF00568	0.640
DOC_PP4_FxxP_1	56	59	PF00568	0.565
DOC_USP7_UBL2_3	410	414	PF12436	0.663
DOC_WW_Pin1_4	200	205	PF00397	0.389
DOC_WW_Pin1_4	438	443	PF00397	0.607
LIG_14-3-3_CanoR_1	232	236	PF00244	0.497
LIG_14-3-3_CanoR_1	4	10	PF00244	0.623
LIG_14-3-3_CanoR_1	407	413	PF00244	0.538
LIG_BRCT_BRCA1_1	6	10	PF00533	0.657
LIG_FHA_1	102	108	PF00498	0.442
LIG_FHA_1	112	118	PF00498	0.307
LIG_FHA_1	223	229	PF00498	0.547
LIG_FHA_1	276	282	PF00498	0.439
LIG_FHA_2	120	126	PF00498	0.397
LIG_FHA_2	132	138	PF00498	0.349
LIG_FHA_2	319	325	PF00498	0.616
LIG_FHA_2	397	403	PF00498	0.477
LIG_LIR_Apic_2	411	415	PF02991	0.636
LIG_LIR_Apic_2	53	59	PF02991	0.562
LIG_LIR_Gen_1	182	192	PF02991	0.353
LIG_LIR_Gen_1	402	412	PF02991	0.539
LIG_LIR_Gen_1	7	15	PF02991	0.377
LIG_LIR_Nem_3	182	188	PF02991	0.363
LIG_LIR_Nem_3	234	238	PF02991	0.504
LIG_LIR_Nem_3	362	366	PF02991	0.558
LIG_LIR_Nem_3	402	408	PF02991	0.539
LIG_LIR_Nem_3	7	13	PF02991	0.609
LIG_Pex14_2	235	239	PF04695	0.404
LIG_Pex14_2	408	412	PF04695	0.536
LIG_Pex14_2	74	78	PF04695	0.408
LIG_REV1ctd_RIR_1	165	174	PF16727	0.400
LIG_SH2_STAP1	305	309	PF00017	0.524
LIG_SH2_STAT5	187	190	PF00017	0.327
LIG_SH2_STAT5	202	205	PF00017	0.392
LIG_SH2_STAT5	206	209	PF00017	0.375
LIG_SH2_STAT5	226	229	PF00017	0.426
LIG_SH2_STAT5	286	289	PF00017	0.611
LIG_SH3_3	105	111	PF00018	0.426
LIG_SH3_3	24	30	PF00018	0.452
LIG_SH3_3	416	422	PF00018	0.587
LIG_TRAF2_1	161	164	PF00917	0.341
LIG_WRC_WIRS_1	409	414	PF05994	0.544
MOD_CDK_SPxK_1	438	444	PF00069	0.612
MOD_CK1_1	285	291	PF00069	0.631
MOD_CK2_1	142	148	PF00069	0.435
MOD_CK2_1	301	307	PF00069	0.643
MOD_CK2_1	58	64	PF00069	0.448
MOD_GlcNHglycan	254	257	PF01048	0.581
MOD_GlcNHglycan	287	290	PF01048	0.547
MOD_GlcNHglycan	367	370	PF01048	0.734
MOD_GlcNHglycan	394	399	PF01048	0.612
MOD_GlcNHglycan	46	49	PF01048	0.469
MOD_GlcNHglycan	53	56	PF01048	0.523
MOD_GSK3_1	200	207	PF00069	0.434
MOD_GSK3_1	233	240	PF00069	0.541
MOD_GSK3_1	271	278	PF00069	0.687
MOD_GSK3_1	46	53	PF00069	0.495
MOD_GSK3_1	5	12	PF00069	0.560
MOD_N-GLC_1	111	116	PF02516	0.461
MOD_N-GLC_1	16	21	PF02516	0.519
MOD_N-GLC_1	378	383	PF02516	0.469
MOD_NEK2_1	119	124	PF00069	0.491
MOD_NEK2_1	233	238	PF00069	0.387
MOD_NEK2_1	301	306	PF00069	0.564
MOD_NEK2_1	408	413	PF00069	0.650
MOD_NEK2_1	5	10	PF00069	0.565
MOD_PIKK_1	131	137	PF00454	0.381
MOD_PIKK_1	58	64	PF00454	0.557
MOD_PKA_1	197	203	PF00069	0.502
MOD_PKA_1	413	419	PF00069	0.449
MOD_PKA_2	197	203	PF00069	0.502
MOD_PKA_2	231	237	PF00069	0.486
MOD_PKB_1	195	203	PF00069	0.255
MOD_Plk_1	378	384	PF00069	0.451
MOD_Plk_4	16	22	PF00069	0.474
MOD_Plk_4	163	169	PF00069	0.420
MOD_Plk_4	197	203	PF00069	0.469
MOD_Plk_4	222	228	PF00069	0.281
MOD_Plk_4	5	11	PF00069	0.657
MOD_ProDKin_1	200	206	PF00069	0.391
MOD_ProDKin_1	438	444	PF00069	0.612
TRG_DiLeu_BaEn_4	64	70	PF01217	0.562
TRG_ER_diArg_1	195	198	PF00400	0.433
TRG_ER_diArg_1	2	4	PF00400	0.585
TRG_ER_diArg_1	387	389	PF00400	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S2	Leptomonas seymouri	77%	100%
A0A0S4JFV2	Bodo saltans	50%	100%
A0A1X0NX05	Trypanosomatidae	59%	100%
A0A3S7WVR3	Leishmania donovani	95%	100%
A0A422N7V9	Trypanosoma rangeli	58%	100%
A4HBI1	Leishmania braziliensis	88%	100%
A4HYK3	Leishmania infantum	95%	100%
C9ZHV2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
Q4QD31	Leishmania major	93%	100%
V5C0D1	Trypanosoma cruzi	60%	100%